Showing 1-30 of 38 results for "33454"
Michael D Leise et al.
Mayo Clinic proceedings, 89(1), 95-106 (2014-01-07)
Drug hepatoxicity can be nonidiosyncratic (predictable), as in the case of acetaminophen, or idiosyncratic (unpredictable). This review article focuses primarily on idiosyncratic drug-induced liver injury (DILI). New epidemiologic data suggest that approximately 20 new cases of DILI per 100,000 persons...
B R Smith et al.
Drug intelligence & clinical pharmacy, 19(6), 415-420 (1985-06-01)
Potassium clavulanate is a novel beta-lactamase inhibitor, which, in combination, expands the spectrum of amoxicillin to include many amoxicillin-resistant organisms. Potassium clavulanate is excreted 30-50 percent unchanged renally and its plasma time-course parallels that of amoxicillin. Several studies suggest that...
Eddie Shu-Yin Chan et al.
Chinese medical journal, 125(14), 2432-2435 (2012-08-14)
A prior study showed significant antibiotic resistance to quinolone in our population. In this study we aimed to evaluate and compare the efficacy of a single versus a combined prophylactic antibiotic regimen before transrectal ultrasound-guided prostate biopsy (TRUGPB). A prospective...
Qiongjing Zou et al.
Analytical biochemistry, 494, 4-9 (2015-11-03)
There is a constant need to identify novel inhibitors to combat β-lactamase-mediated antibiotic resistance. In this study, we identify three penicillinase-binding peptides, P1 (DHIHRSYRGEFD), P2 (NIYTTPWGSNWS), and P3 (SHSLPASADLRR), using a phage display library. Surface plasmon resonance (SPR) is utilized...
Oriol Mitjà et al.
The American journal of tropical medicine and hygiene, 86(6), 1043-1045 (2012-06-06)
We report the first documented case of a mycetoma caused by Nocardia yamanashiensis after the initial description of this species. The 16S-rRNA gene sequence analysis was used to identify the novel species, which showed a similarity of 99.9% to the...
Jayanta Biswas et al.
Journal of cancer research and therapeutics, 8(3), 439-441 (2012-11-24)
Radiation recall phenomenon is an inflammatory process occurring at sites of previous radiation subsequent to administration of pharmacologic agents. The most common chemotherapeutic agents implicated with radiation recall phenomenon are anthracyclines and taxanes. Skin is the most common site for...
Mei Li et al.
Antimicrobial agents and chemotherapy, 56(11), 5678-5686 (2012-08-22)
Ambler position 105 in class A β-lactamases is implicated in resistance to clavulanic acid, although no clinical isolates with mutations at this site have been reported. We hypothesized that Y105 is important in resistance to clavulanic acid because changes in...
Judyta Cielecka-Piontek et al.
Pharmaceutical development and technology, 20(2), 146-152 (2013-11-14)
The kinetic and thermodynamic parameters of degradation of clavulanate potassium in the solid state were studied by using a reversed phase high performance liquid chromatography (RP-HPLC) method. The degradation of clavulanate potassium was a first-order reaction depending on the substrate...
[New antimicrobial agent series. XIX: Potassium clavulanate/amoxicillin granules].
R Fujii
The Japanese journal of antibiotics, 40(5), 933-945 (1987-05-01)
Salomone Di Saverio et al.
Annals of surgery, 260(1), 109-117 (2014-03-22)
To assess the safety and efficacy of antibiotics treatment for suspected acute uncomplicated appendicitis and to monitor the long term follow-up of non-operated patients. Right lower quadrant abdominal pain is a common cause of emergency department admission. The natural history...
[New antimicrobial agent series XXXVII: potassium clavulanate/Ticarcillin sodium].
I Fujimori
The Japanese journal of antibiotics, 44(4), 365-387 (1991-04-01)
Yoram Fleissig et al.
Oral surgery, oral medicine, oral pathology and oral radiology, 113(3), e1-e3 (2012-06-09)
A 58-year-old woman presented to the Oral and Maxillofacial Surgery Clinic experiencing severe limited mouth opening and exposed bone in the socket of the right mandibular third molar 8 months following the extraction of the tooth. The patient had been...
Hossein Heidari Torkabadi et al.
Biochemistry, 53(25), 4113-4121 (2014-06-06)
Raman microspectroscopy combined with Raman difference spectroscopy reveals the details of chemical reactions within bacterial cells. The method provides direct quantitative data on penetration of druglike molecules into Escherichia coli cells in situ along with the details of drug-target reactions....
Fernando Domínguez et al.
The Canadian journal of cardiology, 29(9), 1138-1138 (2013-03-19)
Myocarditis is a rare disease with variable clinical presentation and diverse electrocardiographic and echocardiographic features. Viral infection is the most common cause, but myocarditis can also be caused by bacterial infection. The most frequently involved bacterial agent is group A...
Ximena Gonzalo et al.
The Journal of antimicrobial chemotherapy, 68(2), 366-369 (2012-10-17)
To: (i) assess if amoxicillin/clavulanate is a useful option for the management of multidrug-resistant/extensively drug-resistant tuberculosis (MDR/XDR-TB); (ii) assess if meropenem/clavulanate is active against Mycobacterium tuberculosis at concentrations achievable in vivo; and (iii) determine whether there was inhibition of meropenem/clavulanate...
Combined relay therapy with oral cefixime and clavulanate for febrile urinary tract infection caused by extended-spectrum β-lactamase-producing Escherichia coli.
Fouad Madhi et al.
The Pediatric infectious disease journal, 32(1), 96-97 (2012-12-18)
Dejenie Shiferaw Teklu et al.
Antimicrobial resistance and infection control, 8, 39-39 (2019-03-01)
The global emergence and spread of extended-spectrum beta-lactamases (ESBLs) producing Enterobacteriaceae have been threatening the ability to treat an infection. Hence, this study aimed to determine the prevalence of ESBL-producing and multi-drug resistance (MDR) Enterobacteriaceae (ESBLs-E) from different clinical specimens...
Marisa L Winkler et al.
Journal of medicinal chemistry, 56(3), 1084-1097 (2012-12-21)
Inhibitor resistant (IR) class A β-lactamases pose a significant threat to many current antibiotic combinations. The K234R substitution in the SHV β-lactamase, from Klebsiella pneumoniae , results in resistance to ampicillin/clavulanate. After site-saturation mutagenesis of Lys-234 in SHV, microbiological and...
Terhi Tapiainen et al.
JAMA pediatrics, 168(7), 635-641 (2014-05-07)
Antimicrobial treatment reduces the symptoms of acute otitis media (AOM). The effect of antimicrobial treatment on the duration of middle ear effusion (MEE) and concomitant hearing impairment is not known. To determine whether the antimicrobial treatment of AOM reduces the...
Refaat B Hamed et al.
Natural product reports, 30(1), 21-107 (2012-11-09)
The β-lactam antibiotics and related β-lactamase inhibitors are amongst the most important small molecules in clinical use. Most, but not all, β-lactams including penicillins, cephalosporins, and clavulanic acid are produced via fermentation or via modification of fermented intermediates, with important...
Krisztina M Papp-Wallace et al.
Antimicrobial agents and chemotherapy, 56(8), 4428-4438 (2012-06-13)
β-Lactamases are important antibiotic resistance determinants expressed by bacteria. By studying the mechanistic properties of β-lactamases, we can identify opportunities to circumvent resistance through the design of novel inhibitors. Comparative amino acid sequence analysis of class A β-lactamases reveals that...
Gina Chun Kost et al.
Brain research, 1469, 129-135 (2012-07-04)
Clavulanic acid is a psychoactive compound that has been shown to modulate central nervous system activity. Importantly, in neurotoxin-induced animal models, clavulanic acid has been shown to improve motor function (Huh et al., 2010) suggesting that it can be neuroprotective;...
Juanhong Zhang et al.
Cell biochemistry and biophysics, 65(3), 363-372 (2012-10-31)
New oral granules of amoxicillin and clavulanic acid in 8:1 ratio have recently been developed and approved to conduct clinical trial in China. To date, there has been no report studying the pharmacokinetic characteristics of amoxicillin and clavulanic acid in...
Jung-Whan Chon et al.
International journal of food microbiology, 165(1), 7-10 (2013-05-21)
The presence of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E. coli) in raw poultry is one of the most common factors that interfere with the isolation of Campylobacter by cefoperazone-based selective agar. The performance of modified charcoal-cefoperazone-deoxycholate agar (mCCDA) was improved...
Qinghui Yuan et al.
Antimicrobial agents and chemotherapy, 56(10), 5157-5163 (2012-07-25)
New Delhi metallo-β-lactamase 1 (NDM-1) is a key enzyme that the pathogen Klebsiella pneumonia uses to hydrolyze almost all β-lactam antibiotics. It is currently unclear why NDM-1 has a broad spectrum of activity. Docking of the representatives of the β-lactam...
Thomas Kwong et al.
Antimicrobial agents and chemotherapy, 56(9), 4845-4855 (2012-07-04)
Streptomyces clavuligerus produces a collection of five clavam metabolites, including the clinically important β-lactamase inhibitor clavulanic acid, as well as four structurally related metabolites called 5S clavams. The paralogue gene cluster of S. clavuligerus is one of three clusters of...
Winfried V Kern et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(9), 1149-1156 (2013-01-30)
This double-blind, multicenter trial compared the efficacy and safety of a single daily oral dose of moxifloxacin with oral combination therapy in low-risk febrile neutropenic patients with cancer. Inclusion criteria were cancer, febrile neutropenia, low risk of complications as predicted...
Tuba Celik et al.
Seminars in ophthalmology, 28(2), 91-93 (2013-03-02)
To describe an unusual case of oculoglandular tularemia associated with unilateral acute dacryocystitis and purulent conjunctivitis with 18 weeks pregnancy. It is difficult to culture francisella tularensis on media so serological tests such as micro-agglutination methods are used to diagnose...
Pablo Power et al.
The Journal of antimicrobial chemotherapy, 67(10), 2379-2387 (2012-07-10)
Our aim was to unravel the inactivation pathway of the class A β-lactamase produced by Bacillus licheniformis BS3 (BS3) by clavulanate. The interaction between clavulanate and BS3 was studied by X-ray crystallography, pre-steady-state kinetics and mass spectrometry. The analysis of...
[Inhibitors of the New Delhi-Metallolactamase].
Ulrike Holzgrabe
Pharmazie in unserer Zeit, 41(4), 270-270 (2012-07-06)

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