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F Chris Bennett et al.
Neuron, 98(6), 1170-1183 (2018-06-05)
Microglia, the brain's resident macrophages, are dynamic CNS custodians with surprising origins in the extra-embryonic yolk sac. The consequences of their distinct ontogeny are unknown but critical to understanding and treating brain diseases. We created a brain macrophage transplantation system
In Bok Paek et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 809(2), 345-350 (2004-08-19)
A rapid, sensitive and selective hydrophilic interaction liquid chromatography-tandem mass spectrometric (HILIC-MS/MS) method for the determination of levosulpiride in human plasma was developed. Levosulpiride and internal standard, tiapride were extracted from human plasma with ethyl acetate at pH 11 and
H Y Cho et al.
Neuroscience, 169(1), 378-387 (2010-05-05)
The purposes of this study were to clarify the involvement of P-glycoprotein in the absorption of levosulpiride in knockout mice that lack the Abcb1a/ 1b gene, and to evaluate the relationship between genetic polymorphisms in ABCB1 (exon 12, 21 and
Pieter Janssen et al.
The American journal of gastroenterology, 108(9), 1382-1391 (2013-09-06)
The relationship between symptom improvement (SI) and acceleration of gastric emptying (GE) for different drugs used in the treatment of idiopathic and diabetic gastroparesis is uncertain. In this paper we examined the study-specific correlations between SI and GE, and we
Hyeo-Il Ma et al.
Journal of the neurological sciences, 284(1-2), 140-143 (2009-05-27)
To investigate if diabetes is more common in drug-induced parkinsonism patients. We performed a hospital-based retrospective case-control study on 44 drug-induced parkinsonism (DIP) patients, 177 Parkinson disease patients, and 176 acute stroke patients matched for age and sex who were
José M Entrena et al.
Psychopharmacology, 205(1), 21-33 (2009-03-28)
We evaluated the effects of haloperidol and its metabolites on capsaicin-induced mechanical hypersensitivity (allodynia) and on nociceptive pain induced by punctate mechanical stimuli in mice. Subcutaneous administration of haloperidol or its metabolites I or II (reduced haloperidol) dose-dependently reversed capsaicin-induced
Jonathan T Perelmuter et al.
Current biology : CB, 29(13), 2190-2198 (2019-06-18)
Dopamine is integral to attentional and motivational processes, but studies are largely restricted to the central nervous system. In mammals [1, 2] and fishes [3, 4], central dopaminergic neurons project to the inner ear and could modulate acoustic signals at
Fermín Mearin et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2(4), 301-308 (2004-04-07)
Levosulpiride is a benzamide derivate D(2) dopamine antagonist with prokinetic activity that can accelerate gastric emptying and reduce discomfort in response to gastric distention. The aim of the study is to compare the clinical efficacy of levosulpiride and cisapride in
Hae-Won Shin et al.
Movement disorders : official journal of the Movement Disorder Society, 24(15), 2249-2253 (2009-10-02)
Levosulpiride is a substituted benzamide that is widely used for the management of dyspepsia and emesis. However, little is known about levosulpiride-induced movement disorders (LIM). The aim of this study was to investigate the clinical characteristics of patients with LIM.
E Distrutti et al.
Alimentary pharmacology & therapeutics, 16(3), 613-622 (2002-03-06)
Altered visceral perception is common in functional dyspepsia (FD). Dopaminergic pathways control gastrointestinal motility, but whether they modulate visceral sensitivity is unknown. To investigate whether levosulpiride, a D2 antagonist, modulates gastric sensitivity and compliance in dyspeptic patients. Eight healthy subjects
Hea-Young Cho et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 796(2), 243-251 (2003-10-29)
A rapid, selective and highly sensitive reversed-phase high-performance liquid chromatography (HPLC) method was developed for the determination of levosulpiride, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy benzamide, in human serum and urine. The method involved the extraction with a dichloromethane followed by back-extraction into 0.025 M
Improvement and validation of a liquid chromatographic method for the determination of levosulpiride in human serum and urine.
Cho Y-H and Lee B-Y
Journal of Chromatography. B, Biomedical Sciences and Applications, 976(2), 243-251 (2003)
Combination therapy of levosulpiride and lamotrigine associated with tardive dyskinesia.
Dattatreya Namdeorao Mendhekar et al.
The Australian and New Zealand journal of psychiatry, 43(2), 178-179 (2009-01-27)
Levosulpiride: a review of its clinical use in psychiatry.
Mucci A, et al.
Pharmacological Research, 31(2), 95-101 (1995)
Type 1 (insulin-dependent) diabetes mellitus and gastric emptying: role of blood glucose concentration and dopamine D2 receptors.
P Melga et al.
Diabetes, nutrition & metabolism, 17(1), 62-65 (2004-05-28)
Hyuk Lee et al.
Journal of gastroenterology and hepatology, 22(11), 1741-1747 (2007-10-05)
This prospective study was conducted to characterize the clinical features of adult rumination syndrome, in the absence of psychiatric illness, by applying newly modified clinical criteria, and to elucidate factors influencing outcomes after treatment. Twenty-one adult patients diagnosed with rumination
M Tonini et al.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 35(4), 244-250 (2003-06-13)
The dopamine D2 receptor antagonist levosulpiride is a substituted benzamide derivative, whose gastrokinetic properties are exploited clinically for the management of functional dyspepsia. However, for other benzamide derivatives, such as cisapride and mosapride, agonism towards serotonin 5-HT4 receptors is considered
Wilda Orisme et al.
Cellular signalling, 22(3), 447-456 (2009-11-06)
Partitioning of cellular components is a critical mechanism by which cells can regulate their activity. In rod photoreceptors, light induces a large-scale translocation of arrestin from the inner segments to the outer segments. The purpose of this project is to
Sergio Agosti et al.
The American journal of emergency medicine, 31(11), 1624-1624 (2013-07-31)
We report the case of an 89-year-old female patient who presented to the emergency department after out-of-hospital cardiac arrest due to polymorphic ventricular tachycardia treated by public access defibrillation. The admission electrocardiogram (ECG) showed extreme QT prolongation (650 milliseconds) with
Vaneeta Jindal et al.
Journal of pharmacology & pharmacotherapeutics, 2(2), 80-84 (2011-07-21)
To investigate the effect of ethanolic extract of fruit pulp of Tamarindus indica Linn. (Family: Caesalpiniaceae) on obesity in rats using cafeteria diet-induced obesity and antipsychotic drug (sulpiride)-induced obesity. Cafeteria dietwas administered for 40 successive days to male Wistar rats
Raúl León-Barúa et al.
Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru, 28(3), 267-269 (2008-10-30)
We expose, this time, our ideas and findings on the etiopathogenesis, diagnosis and treatment of the dyspeptic syndrome.
Levosulpiride: a new solution for premature ejaculation?
E Greco et al.
International journal of impotence research, 14(4), 308-309 (2002-08-02)
Su-Eon Jin et al.
Journal of pharmaceutical and biomedical analysis, 35(4), 929-936 (2004-06-15)
A rapid and simple high performance liquid chromatography (HPLC) method was developed and validated for determination of levosulpiride in human plasma. After extraction with ethylacetate/methylene chloride (5:1, v/v), analysis of levosulpiride in plasma samples was carried out using a reverse
F Demarosi et al.
Minerva stomatologica, 56(1-2), 21-26 (2007-02-09)
This paper evaluated the efficacy of the systemic administration of levosulpiride, an antipsychotic and antidepressant drug, in the management of burning mouth syndrome. Forty-four subjects suffering from idiopathic burning mouth syndrome were enrolled in the study. Patients underwent a thorough
Levosulpiride-induced resting orolingual tremor.
Han-Joon Kim et al.
Movement disorders : official journal of the Movement Disorder Society, 24(11), 1700-1701 (2009-05-20)
D Zanetti et al.
Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 24(2), 49-57 (2004-10-08)
L-sulpiride is the levorotatory enantiomer of sulpiride, a neuroleptic of the family of benzamide derivatives; it has a characteristic antagonist effect on central DA2 dopaminergic receptors and dopamine DA1 "autoreceptors". Its efficacy in the symptomatic control of acute vertigo spells
Syed Javid Hussain et al.
Journal of Ayub Medical College, Abbottabad : JAMC, 22(4), 124-126 (2010-10-01)
Premature ejaculation is one of the most common sexual disorders. A large number of treatment options have been used so far for the treatment of this dysfunction and still a large number of experts are doing research in this field.
Jordi Serra
Gastroenterologia y hepatologia, 33(8), 586-590 (2010-09-21)
Levosulpiride is a sulpiride isomer that exerts its prokinetic action through a dual mechanism: 1) as a D(2) dopamine receptor antagonist and 2) as a serotonin 5HT(4) receptor agonist, conferring this drug with a cholinergic effect. At a dosage of
H Y Cho et al.
International journal of clinical pharmacology and therapeutics, 42(3), 174-180 (2004-03-31)
To evaluate the bioequivalence of a single oral 25 mg dose of 2 levosulpiride preparations in healthy male Korean volunteers. The study was conducted as a randomized, 2-period crossover design in 28 healthy male Korean volunteers who received a single
Eun Hee Ahn et al.
BMB reports, 44(5), 329-334 (2011-05-28)
Many proteins with poor transduction efficiency were reported to be delivered to cells by fusion with protein transduction domains (PTDs). In this study, we investigated the effect of levosulpiride on the transduction of PEP-1 ribosomal protein S3 (PEP-1-rpS3), and examined
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