Search Within
Applied Filters:
Keyword:'340855'
Showing 1-30 of 1471 results for "

340855

" within Papers
Wei Shui et al.
Journal of biomedical materials research. Part A, 102(10), 3429-3438 (2013-10-18)
Successful bone tissue engineering at least requires sufficient osteoblast progenitors, efficient osteoinductive factors, and biocompatible scaffolding materials. We have demonstrated that BMP9 is one of the most potent factors in inducing osteogenic differentiation of mesenchymal progenitors. To facilitate the potential...
Mirjam Ketema et al.
Molecular biology of the cell, 26(13), 2402-2417 (2015-05-15)
Epidermolysis bullosa simplex associated with late-onset muscular dystrophy (EBS-MD) is an autosomal recessive disorder resulting from mutations in the plectin gene. The majority of these mutations occur within the large exon 31 encoding the central rod domain and leave the...
Maria C Franco et al.
The Journal of biological chemistry, 290(31), 19055-19066 (2015-06-19)
Peroxynitrite production and tyrosine nitration are present in several pathological conditions, including neurodegeneration, stroke, aging, and cancer. Nitration of the pro-survival chaperone heat shock protein 90 (Hsp90) in position 33 and 56 induces motor neuron death through a toxic gain-of-function....
Sana Thabet et al.
Applied and environmental microbiology, 80(24), 7527-7535 (2014-09-28)
We have investigated the antimicrobial effects of photocatalysis on the yeast model Saccharomyces cerevisiae. To accurately study the antimicrobial mechanisms of the photocatalytic process, we focused our investigations on two questions: the entry of the nanoparticles in treated cells and...
Diana Gabriela Soares et al.
Clinical oral investigations, 19(5), 1013-1020 (2014-09-25)
To evaluate human dental pulp stem cell viability and capacity to recover from experimental dental bleaching techniques. Enamel/dentin disks adapted to trans-wells were positioned on previously cultivated dental pulp stem cells. Bleaching gels containing 35, 17.5, 10, and 8 %...
Heenam Kwon et al.
Journal of biomedical materials research. Part A, 103(2), 534-544 (2014-04-23)
Cartilage tissue engineering has emerged as an attractive therapeutic option for repairing damaged cartilage tissue in the arthritic joint. High levels of proinflammatory cytokines present at arthritic joints can cause cartilage destruction and instability of the engineered cartilage tissue, and...
Shijie He et al.
Biophysical journal, 109(3), 489-500 (2015-08-06)
Pattern-dependent collective behaviors of cells have recently raised intensive attention. However, the underlying mechanisms that regulate these behaviors are largely elusive. Here, we report a quantitative study, combining experiment and modeling, on cell polarization and arrangement on a micropatterned substrate....
Tanira M Bastos et al.
Antimicrobial agents and chemotherapy, 58(10), 6044-6055 (2014-08-06)
cis-[RuCl(NO2)(dppb)(5,5'-mebipy)] (complex 1), cis-[Ru(NO2)2(dppb)(5,5'-mebipy)] (complex 2), ct-[RuCl(NO)(dppb)(5,5'-mebipy)](PF6)2 (complex 3), and cc-[RuCl(NO)(dppb)(5,5'-mebipy)](PF6)2 (complex 4), where 5,5'-mebipy is 5,5'-dimethyl-2,2'-bipyridine and dppb is 1,4-bis(diphenylphosphino)butane, were synthesized and characterized. The structure of complex 2 was determined by X-ray crystallography. These complexes exhibited a higher...
W Mohamed et al.
European cells & materials, 28, 258-268 (2014-10-24)
Staphylococcus aureus is the most clinically relevant pathogen regarding implant-associated bone infection and its capability to invade osteoblasts is well known. The aim of this study was to investigate firstly whether S. aureus is not only able to invade but...
Eun-Joo Shin et al.
Free radical biology & medicine, 84, 355-372 (2015-04-07)
To determine the role of ceruloplasmin (Cp) in epileptic seizures, we used a kainate (KA) seizure animal model and examined hippocampal samples from epileptic patients. Treatment with KA resulted in a time-dependent decrease in Cp protein expression in the hippocampus...
Jie Ji et al.
Oncotarget, 6(19), 17135-17146 (2015-04-29)
Dendritic cell (DC) based vaccines have emerged as a promising immunotherapy for cancers. However, most DC vaccines so far have achieved only limited success in cancer treatment. Photodynamic therapy (PDT), an established cancer treatment strategy, can cause immunogenic apoptosis to...
Andreas O Stucki et al.
Lab on a chip, 15(5), 1302-1310 (2014-12-19)
We report a lung-on-a-chip array that mimics the pulmonary parenchymal environment, including the thin alveolar barrier and the three-dimensional cyclic strain induced by breathing movements. The micro-diaphragm used to stretch the alveolar barrier is inspired by the in vivo diaphragm...
Valentina Di Felice et al.
Journal of tissue engineering and regenerative medicine, 9(11), E51-E64 (2013-04-18)
The use of three-dimensional (3D) cultures may induce cardiac progenitor cells to synthesize their own extracellular matrix (ECM) and sarcomeric proteins to initiate cardiac differentiation. 3D cultures grown on synthetic scaffolds may favour the implantation and survival of stem cells...
Yasong Wu et al.
Nature cell biology, 17(6), 715-725 (2015-05-20)
We describe robust induction of autophagy during the reprogramming of mouse fibroblasts to induced pluripotent stem cells by four reprogramming factors (Sox2, Oct4, Klf4 and c-Myc), henceforth 4F. This process occurs independently of p53 activation, and is mediated by the...
Michela Battistelli et al.
Current pharmaceutical design, 21(25), 3665-3672 (2015-01-24)
Apoptosis is essential for skeletal muscle development and homeostasis. It has been frequently involved in several muscle myopathies and sarcopenia, as well as in denervation, in disuse and acute strenuous or eccentric physical exercise. In this work skeletal muscle cell...
Mojtaba Koosha et al.
Journal of biomedical materials research. Part A, 103(9), 3081-3093 (2015-03-03)
Electrospinning process has been widely used to produce nanofibers from polymer blends. Poly(vinyl alcohol) (PVA) and chitosan (CS) have numerous biomedical applications such as wound healing and tissue engineering. Nanofibers of CS/PVA have been prepared by many works, however, a...
Caiyun Li et al.
Journal of microencapsulation, 31(6), 573-578 (2014-04-05)
Bovine serum albumin (BSA) nanoparticle is a promising drug carrier system. Oridonin (ORI)-loaded galactosylated BSA nanoparticle (ORI-GB-NP) was prepared for liver targeting delivery of ORI. This work was designed to investigate the in vitro release, in vivo pharmacokinetics and tissue...
Sara Pasqualetti et al.
International journal of experimental pathology, 96(1), 11-20 (2015-01-22)
Long-term effects of glucocorticoid treatment in humans induce bone loss and increase the risk of fracture in the skeleton. The pathogenic mechanisms of glucocorticoid-induced osteoporosis (GIOP) are still unclear. The GIOP and its effects have been reproduced in several animal...
Valentina Bravatà et al.
Anticancer research, 35(5), 2577-2591 (2015-05-13)
Intraoperative electron radiation therapy (IOERT) is a therapeutic technique which administers a single high dose of ionizing radiation immediately after surgical tumor removal. IOERT induces a strong stress response: both tumor and normal cells activating pro- and antiproliferative cell signaling...
Ángel E Mercado-Pagán et al.
Journal of biomaterials applications, 29(4), 557-565 (2014-06-11)
One of the main challenges for clinical implementation of small diameter vascular grafts (SDVGs) is their limited hemocompatibility. Important design specifications for such grafts include features that minimize the long-term risks of restenosis, fouling, and thrombus formation. In our lab...
Fatemeh Momen-Heravi et al.
Scientific reports, 5, 9991-9991 (2015-05-15)
Hepatocyte damage and inflammation in monocytes/macrophages are central to the pathogenesis of alcoholic hepatitis (AH). MicroRNAs (miRNAs) regulate all of these processes. MiRNA-122 is abundantly expressed in hepatocytes while monocytes/macrophages have low levels. The role of exosomes in AH and...
Denusa M Veríssimo et al.
Experimental biology and medicine (Maywood, N.J.), 240(2), 175-184 (2014-09-24)
The aim of this study was to evaluate the bone regenerative effect of glutaraldehyde (GA) cross-linking on mineralized polyanionic collagen membranes in critical-sized defects on rat calvarias. Bone calvarial defects were induced in Wistar rats, which were then divided into...
Zu-Quan Hu et al.
Analytica chimica acta, 867, 74-82 (2015-03-31)
Fumonisin B analogs, particularly FB1, FB2, and FB3, are major mycotoxins found in cereals. Single-chain fragment variable (scFv) antibodies represent a promising alternative immunoassay system. A phage-displayed antibody library derived from four monoclonal antibodies (mAbs) generated against FB1 was used...
Diani Meza Casa et al.
Journal of nanoscience and nanotechnology, 15(12), 10183-10188 (2015-12-19)
In this study, nanoparticles based on bovine serum albumin (BSA) containing amphotericin B (AmB) were obtained by the desolvation method and characterized with respect to size, size distribution, AmB encapsulation efficiency, AmB state of aggregation, and AmB in vitro release...
Chun-Shui Pan et al.
PloS one, 10(5), e0126640-e0126640 (2015-05-21)
Lipopolysaccharide (LPS) causes microvascular barrier disruption, leading to albumin leakage from microvessels resulting in a range of disastrous sequels. Salvianolic acid B (SalB) is a major water-soluble component derived from Salvia miltiorrhiza. Previous studies showed its potential to attenuate microvascular...
De Lu Zhang et al.
Aquatic toxicology (Amsterdam, Netherlands), 157, 215-224 (2014-12-03)
Aphanizomenon flos-aquae is a cyanobacterium that produces neurotoxins or paralytic shellfish poisons (PSPs) called aphantoxins, which present threats to environmental safety and human health via eutrophication of water bodies worldwide. Although the molecular mechanisms of this neurotoxin have been studied...
Luana Pereira Borba-Santos et al.
Journal of medical microbiology, 64(Pt 4), 415-422 (2015-02-15)
Sporotrichosis is a common mycosis caused by dimorphic fungi from the Sporothrix schenckii complex. In recent years, sporotrichosis incidence rates have increased in the Brazilian state of Rio de Janeiro, where Sporothrix brasiliensis is the species more frequently isolated from...
Yasuhisa Ishida et al.
The International journal of artificial organs, 37(11), 854-860 (2014-12-03)
Acellular nerves are a reconstruction material and provide scaffolds for nerve regeneration. Numerous methods to develop acellular nerves have been described. However, these methods pose problems that can be attributed to incomplete acellular processing and destruction of the extracellular matrix...
Pamela V Lear et al.
Endocrinology, 156(3), 975-986 (2014-12-30)
Intracellular calcium-permeable channels have been implicated in thermogenic function of murine brown and brite/beige adipocytes, respectively transient receptor potential melastin-8 and transient receptor potential vanilloid-4. Because the endo-lysosomal two-pore channels (TPCs) have also been ascribed with metabolic functionality, we studied...
Tara M Mleynek et al.
Human molecular genetics, 23(23), 6223-6234 (2014-07-06)
Cerebral cavernous malformation (CCM) is a disease of vascular malformations known to be caused by mutations in one of three genes: CCM1, CCM2 or CCM3. Despite several studies, the mechanism of CCM lesion onset remains unclear. Using a Ccm1 knockout...
Page 1 of 50
Page 1 of 50