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Rui-Xiang Wang et al.
Nanoscale, 6(24), 14999-15007 (2014-11-05)
A novel nanostructured catalyst of platinum nanoparticles supported on 5,10,15,20-tetrakis(1-methyl-4-pyridinio)porphyrin tetra(p-toluenesulfonate) (TMPyP) functionalized graphene (TMPyP-graphene) is synthesized by the hydrothermal polyol process. The as-synthesized nanocomposites are characterized by Fourier transform infrared (FTIR) spectroscopy, UV-vis absorption spectroscopy, Raman spectroscopy, X-ray diffraction...
Ganna Fedorova et al.
Chemosphere, 111, 55-60 (2014-07-07)
In this study, the stability of 124 target analytes in influent and effluent wastewater samples during short-term (4°C) and long-term (-18°C) storage was assessed. The most common storage scenario was considered, in which samples were frozen immediately after sampling without...
Austin Pantel et al.
PLoS biology, 12(1), e1001759-e1001759 (2014-01-11)
Type I interferons (IFNs) play an important role in direct antiviral defense as well as linking the innate and adaptive immune responses. On dendritic cells (DCs), IFNs facilitate their activation and contribute to CD8(+) and CD4(+) T cell priming. However...
Dong-Xia Zhao et al.
Journal of separation science, 38(4), 571-575 (2014-12-11)
We established a qualitative method to analyze the main chemical compositions of the root of Aster tataricus. Most of the peaks were separated on a C(18) column packed with 5.0 μm particles, and 28 compounds were identified, including 11 chlorogenic...
Han Lin et al.
Biology of reproduction, 92(3), 77-77 (2015-01-23)
Cyclin-dependent kinase inhibitors p21(Cip1) (CDKN1A) and p27(Kip1) (CDKN1B) are expressed in Leydig cells. Previously, we reported that Cdkn1b knockout in the mouse led to increased Leydig cell proliferative capacity and lower steroidogenesis. However, the relative importance of CDKN1A and CDKN1B...
Siddharth Jambhrunkar et al.
Molecular pharmaceutics, 11(10), 3642-3655 (2014-08-29)
Mesoporous silica nanoparticles (MCM-41) with different surface chemistry were used as carrier system to study its influence on drug delivery and anticancer activity of curcumin (CUR). CUR was encapsulated in pristine MCM-41 (hydrophilic and negatively charged), amino functionalized MCM-41 (MCM-41-NH2...
Cheng-Feng Zhang et al.
The Journal of investigative dermatology, 135(5), 1348-1357 (2014-10-08)
Autophagy is the central cellular mechanism for delivering organelles and cytoplasm to lysosomes for degradation and recycling of their molecular components. To determine the contribution of autophagy to melanocyte (MC) biology, we inactivated the essential autophagy gene Atg7 specifically in...
Radha Karki et al.
European journal of medicinal chemistry, 84, 555-565 (2014-07-26)
A series of eighteen trihydroxylated 2,4,6-triphenyl pyridines were designed and synthesized which contain hydroxyl groups at ortho, meta or para position of each phenyl rings attached to the central pyridine. They were evaluated for topoisomerase I and II inhibitory activity...
Adrian Weisz et al.
Journal of chromatography. A, 1380, 120-129 (2015-01-17)
Three low-level subsidiary color impurities (A, B, and C) often present in batches of the color additive D&C Red No. 33 (R33, Acid Red 33, Colour Index No. 17200) were separated from a portion of R33 by spiral high-speed counter-current...
Swati Singh et al.
Applied and environmental microbiology, 81(2), 754-764 (2014-11-16)
Xenorhabdus nematophila engages in a mutualistic partnership with the nematode Steinernema carpocapsae, which invades insects, migrates through the gut, and penetrates into the hemocoel (body cavity). We showed previously that during invasion of Manduca sexta, the gut microbe Staphylococcus saprophyticus...
Matthew Di Rago et al.
Forensic science international, 243, 35-43 (2014-05-06)
The aim of this study was to develop an LC-MS/MS based screening technique that covers a broad range of acidic and neutral drugs and poisons by combining a small sample volume and efficient extraction technique with simple automated data processing....
Hua Tian et al.
Journal of lipid research, 55(9), 1970-1980 (2014-05-24)
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) imaging has been used for the direct analysis of single intact Xenopus laevis embryo surfaces, locating multiple lipids during fertilization and the early embryo development stages with subcellular lateral resolution (∼4 μm). The method...
Mohamed Dawoud
Drug development and industrial pharmacy, 41(1), 156-162 (2013-10-30)
Due to their small particle size, colloidal fat emulsions are suitable for intravenous administration. In order to obtain information on their potential in vivo performance, it is important to find a simple and effective in vitro assay to evaluate the...
Xiaohui Xu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 33(5), 1272-1282 (2014-05-08)
In Chinese culture, the roots of Averrhoa carambola L. have long been used for medical purposes due to their potent pharmaceutical activities, such as improving digestive function and treating diabetes. Recently, we prepared extracts of Averrhoa carambola L. root (EACR)...
Chester E Chamberlain et al.
The Journal of clinical investigation, 124(9), 4093-4101 (2014-08-19)
Endocrine cell proliferation fluctuates dramatically in response to signals that communicate hormone demand. The genetic alterations that override these controls in endocrine tumors often are not associated with oncogenes common to other tumor types, suggesting that unique pathways govern endocrine...
Rosalind M K Stewart et al.
Investigative ophthalmology & visual science, 56(3), 2021-2030 (2015-02-28)
The conjunctiva plays a key role in ocular surface defence and maintenance of the tear film. Ex vivo expansion of conjunctival epithelial cells offers potential to reconstruct the ocular surface in cases of severe cicatrising disease, but requires initial biopsies...
D K Dastur et al.
The British journal of nutrition, 36(2), 143-159 (1976-09-01)
1. The B-vitamin status of fifty-nine patients, mainly from the lower socio-economic classes in Bombay, with a history of chronic malnutrition, and of alcoholism of 1-5-20 years' duration, was studied before and during treatment, and in relation to their clinical...
Leslie A Mitchell et al.
The American journal of pathology, 185(2), 372-386 (2014-12-02)
Epithelial barrier function is maintained by tight junction proteins that control paracellular fluid flux. Among these proteins is junctional adhesion molecule A (JAM-A), an Ig fold transmembrane protein. To assess JAM-A function in the lung, we depleted JAM-A in primary...
Wan Cao et al.
Journal of chromatography. A, 1390, 13-21 (2015-03-10)
This report describes the use of trace-chitosan-wrapped multi-walled carbon nanotubes (CS-MWCNTs) as a sorbent material in dispersive micro solid-phase extraction (DMSPE), which was combined with ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry to analyze phenolic compounds in...
Lisa M Parsons et al.
PloS one, 9(10), e107250-e107250 (2014-10-09)
Caenorabditis elegans bus-4 glycosyltransferase mutants are resistant to infection by Microbacterium nematophilum, Yersinia pestis and Yersinia pseudotuberculosis and have altered susceptibility to two Leucobacter species Verde1 and Verde2. Our objective in this study was to define the glycosylation changes leading...
Qingmeng Zhang et al.
Disease markers, 2015, 684794-684794 (2015-04-11)
Knee osteoarthritis (OA) is a highly prevalent chronic degenerative joint disease that mainly affects the elderly population. The aim of this study was to investigate serum signature metabolites as potential biomarkers for early diagnosis of knee OA. Global serum metabolic...
Rajaian Pushpabai Rajesh et al.
Anticancer research, 35(1), 283-293 (2015-01-01)
Marine invertebrates called ascidians are prolific producers of bioactive substances. The ascidian Eudistoma viride, distributed along the Southeast coast of India, was investigated for its in vitro cytotoxic activity against human cervical carcinoma (HeLa) cells by the MTT assay. The...
Ning Wang et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(1), 194-206 (2014-04-29)
To develop convenient, effective cold chain-free subunit vaccines, a mannose-PEG-cholesterol conjugate (MPC) was synthesized as a lectin binding molecule and anchored onto liposomes which entrapped lipid A and model antigen to form a vaccine adjuvant-delivery system targeting antigen presenting cells....
Sarah Afshordel et al.
Prostaglandins, leukotrienes, and essential fatty acids, 92, 23-31 (2014-06-29)
The present study investigated the effects of orally administered long chain omega-3 polyunsaturated fatty acids (PUFA) on mitochondrial function and processing of the amyloid precursor protein (APP) in brains of young (3 months old) and aged (24 months old) NMRI-mice....
Amber Farooqui et al.
PloS one, 10(2), e0118431-e0118431 (2015-02-27)
Synergistic combinations of antimicrobial agents with different mechanisms of action have been introduced as more successful strategies to combat infections involving multidrug resistant (MDR) bacteria. In this study, we investigated synergistic antimicrobial activity of Camellia sinensis and Juglans regia which...
U Shah et al.
Indian journal of pharmaceutical sciences, 76(3), 198-202 (2014-07-19)
The present study depicts the development of a validated RP-HPLC method for the determination of the pamabrom in presence of degradation products or other pharmaceutical excipients. Stress study was performed on pamabrom and it was found that it degrade sufficiently...
Gwen B Effgen et al.
Journal of neurotrauma, 31(13), 1202-1210 (2014-02-25)
An increasing number of U.S. soldiers are diagnosed with traumatic brain injury (TBI) subsequent to exposure to blast. In the field, blast injury biomechanics are highly complex and multi-phasic. The pathobiology caused by exposure to some of these phases in...
Paul R S Baker et al.
Journal of lipid research, 55(11), 2432-2442 (2014-09-17)
Phospholipids serve as central structural components in cellular membranes and as potent mediators in numerous signaling pathways. There are six main classes of naturally occurring phospholipids distinguished by their distinct polar head groups that contain many unique molecular species with...
YuTian Miao et al.
Journal of food science and technology, 51(12), 4005-4011 (2014-12-06)
In our present paper, the effect of water activity and processing conditions in reconstituted potato chips was considered as a model to investigate the changes of acrylamide (AA) and 5-hydroxymethylfurfural (HMF). The results suggested that the formation of AA and...
Robert Shrake et al.
Journal of colloid and interface science, 437, 140-146 (2014-10-15)
Zwitterionic quantum dots prepared through incorporated zwitterionic ligands on quantum dot surfaces, are being paid significant attention in biomedical applications because of their excellent colloidal stability across a wide pH and ionic strength range, antifouling surface, good biocompatibility, etc. In...