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361798

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Chan Mi Kim et al.
Current Alzheimer research, 12(6), 563-571 (2015-06-02)
Alzheimer's disease (AD) is the most common neurodegenerative disorder pathologically characterized by amyloid-beta (Aβ) plaques and neurofibrillary tangles. The aggregation of Aβ precedes tau pathologies in AD; however, the causal relation between the two pathologies and the mechanisms by which
Shahla Hamza Al-Saqi et al.
Cell and tissue banking, 16(2), 181-193 (2014-08-15)
Mesenchymal stem cells (MSCs) have vast potential in cell therapy, and are experimentally used in the clinic. Therefore, it is critical to find a serum- and xeno-free cryopreservation method. The aim of this study was to compare two serum- and
Koichi Mikami et al.
Chemical record (New York, N.Y.), 6(1), 1-11 (2006-02-14)
The difficulty as well as the significance of the direct generation of metal enolates of alpha-CF(3) ketones cannot be easily understood by chemists unfamiliar with F. In sharp contrast to the sunny side of non-F, hydrocarbon chemistry, F chemistry has
Miren Ettcheto et al.
Experimental gerontology, 65, 69-78 (2015-03-24)
Previous studies suggest that Alzheimer's disease (AD) neurobiology could not be explained solely by an increase in β-amyloid levels. Recently, it has been proposed that alterations in brain cholesterol metabolism may contribute to the pathogenesis of AD. In the present
Hadrien D'inca et al.
The American journal of pathology, 185(7), 1877-1888 (2015-05-17)
The rabbit VX2 tumor is a fast-growing carcinoma model commonly used to study new therapeutic devices, such as catheter-based therapies for patients with inoperable hepatocellular carcinoma. The evaluation of tumor viability after such locoregional therapies is essential to directing hepatocellular
Keum-Shik Hong et al.
Neuroscience letters, 587, 87-92 (2014-12-23)
Functional near-infrared spectroscopy (fNIRS) is an optical imaging method that can be used for a brain-computer interface (BCI). In the present study, we concurrently measure and discriminate fNIRS signals evoked by three different mental activities, that is, mental arithmetic (MA)
Fatemeh Shahbazi et al.
Computer methods and programs in biomedicine, 122(2), 191-198 (2015-09-08)
The aims of this study are summarized in the following items: first, to investigate the class discrimination power of long-term heart rate variability (HRV) features for risk assessment in patients suffering from congestive heart failure (CHF); second, to introduce the
Eleonore Durand et al.
BMC evolutionary biology, 15, 103-103 (2015-06-08)
Long term selection experiments bring unique insights on the genetic architecture of quantitative traits and their evolvability. Indeed, they are utilized to (i) monitor changes in allele frequencies and assess the effects of genomic regions involved traits determinism; (ii) evaluate
Decoupling deprotonation from metalation: Thia-Fries rearrangement.
Alan M Dyke et al.
Angewandte Chemie (International ed. in English), 47(27), 5067-5070 (2008-05-28)
Martin J P Harger
Chemical communications (Cambridge, England), (22)(22), 2863-2865 (2005-06-02)
The reaction of PSCl3 with Pr(i)2NH at 60 degrees C affords the disubstitution product (Pr(i)2N)2P(S)Cl without first forming the monosubstitution product Pr(i)2NP(S)Cl2; a P(III) compound (possibly PCl3) generated in situ seems to be a crucial intermediate.
Zhaobin Wu et al.
Journal of agricultural and food chemistry, 63(22), 5388-5394 (2015-05-21)
The objective of this study is to test the feasibility of multi-isotopic and elemental analyses combined with chemometric techniques for differentiating the botanical origins of major honey products in China. The stable isotope and elemental compositions of 57 honey samples
Sanjeev Ahuja et al.
Biotechnology progress, 31(5), 1370-1380 (2015-06-23)
Characterization of manufacturing processes is key to understanding the effects of process parameters on process performance and product quality. These studies are generally conducted using small-scale model systems. Because of the importance of the results derived from these studies, the
Leandi Liebenberg et al.
Journal of forensic sciences, 60(5), 1277-1282 (2015-03-17)
Historically, population differences were quantified using cranial indices. Even though the application of indices is associated with numerous statistical and methodological problems, the use of cranial indices to estimate ancestry persists as demonstrated by its inclusion in several recent papers
Niels F Andersen et al.
European journal of haematology, 95(3), 211-217 (2014-10-30)
Syndecan-1 (SDC1), hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF) and interleukin-6 (IL6) are expressed by malignant plasma cells and cells in the bone marrow microenvironment and may be involved in the angiogenic process in multiple myeloma (MM). In
Evanly Vo
Journal of occupational and environmental hygiene, 1(12), 799-805 (2005-03-04)
The aim of this study was to assess the use of colorimetric indicator pads and the thermo-hand method for detection of inorganic/organic base permeation of chemical protective gloves under simulated in-use conditions. Breakthrough times for four types of gloves were
Roberta Fusco et al.
BioMed research international, 2015, 237863-237863 (2015-09-05)
The purpose of our study was to evaluate the diagnostic value of an imaging protocol combining dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted MRI (DW-MRI) in patients with suspicious breast lesions. A total of 31 breast lesions (15 malignant and 16
Arjun Mendiratta et al.
Chemical communications (Cambridge, England), (27)(27), 3403-3405 (2005-07-06)
Deprotonation of the titanium formate complex [Ar(t-Bu)N]3TiOC(O)H with LiN(i-Pr)2 resulted in the release of free CO and the formation of a titanium(IV) oxoanion complex, isolated as its lithium salt.
Mogens K Boisen et al.
PloS one, 9(10), e109430-e109430 (2014-10-21)
We tested the hypothesis that expression of microRNAs (miRNAs) in cancer tissue can predict effectiveness of bevacizumab added to capecitabine and oxaliplatin (CAPEOX) in patients with metastatic colorectal cancer (mCRC). Patients with mCRC treated with first line CAPEOX and bevacizumab
Bouclé Sébastien et al.
Molecules (Basel, Switzerland), 15(11), 7742-7749 (2010-11-03)
Treatment of 1,4,4-trimethyl-3,4-dihydroquinolin-2(1H)-one (2) with lithium diisopropylamide (LDA) followed by a wide range of electrophiles give the corresponding 4,4-dimethyl-3-substituted-3,4-dihydroquinolin-2-ones (3-13), providing a very mild electrophilic substitution of the 4,4-dimethyl-1,2,3,4-tetrahydroquinoline core.
Yulia B Monakhova et al.
Talanta, 141, 60-65 (2015-05-13)
Discriminant analysis (DA) methods, such as linear discriminant analysis (LDA) or factorial discriminant analysis (FDA), are well-known chemometric approaches for solving classification problems in chemistry. In most applications, principle components analysis (PCA) is used as the first step to generate
Juan Eugenio Iglesias et al.
NeuroImage, 115, 117-137 (2015-05-06)
Automated analysis of MRI data of the subregions of the hippocampus requires computational atlases built at a higher resolution than those that are typically used in current neuroimaging studies. Here we describe the construction of a statistical atlas of the
Diane N H Kim et al.
Journal of biomedical optics, 20(11), 111211-111211 (2015-08-26)
Standard algorithms for phase unwrapping often fail for interferometric quantitative phase imaging (QPI) of biological samples due to the variable morphology of these samples and the requirement to image at low light intensities to avoid phototoxicity. We describe a new
Levi J Hargrove et al.
JAMA, 313(22), 2244-2252 (2015-06-10)
Some patients with lower leg amputations may be candidates for motorized prosthetic limbs. Optimal control of such devices requires accurate classification of the patient's ambulation mode (eg, on level ground or ascending stairs) and natural transitions between different ambulation modes.
Joshua D Schaefferkoetter et al.
Physics in medicine and biology, 60(14), 5543-5556 (2015-07-03)
In the context of investigating the potential of low-dose PET imaging for screening applications, we developed methods to assess small lesion detectability as a function of the number of counts in the scan. We present here our methods and preliminary
Philip D Harvey et al.
Schizophrenia research, 166(1-3), 334-338 (2015-06-29)
We previously reported that treatment with 160mg/d of lurasidone improved cognitive performance in a manner superior to placebo, quetiapine XR 600mg/d, and lurasidone 80mg/d, based on a 6-week randomized trial of patients with an acute exacerbation of schizophrenia. The objective
Martin E Gosnell et al.
Biochimica et biophysica acta, 1863(1), 56-63 (2015-10-04)
Hyperspectral imaging uses spectral and spatial image information for target detection and classification. In this work hyperspectral autofluorescence imaging was applied to patient olfactory neurosphere-derived cells, a cell model of a human metabolic disease MELAS (mitochondrial myopathy, encephalomyopathy, lactic acidosis
Tetrahedron Letters, 47, 6405-6405 (2006)
Stefano Biffani et al.
Genetics, selection, evolution : GSE, 47, 4-4 (2015-02-06)
SNP (single nucleotide polymorphisms) genotype data are increasingly available in cattle populations and, among other things, can be used to predict carriers of specific haplotypes. It is therefore convenient to have a practical statistical method for the accurate classification of
Lekha Gupta et al.
The Journal of organic chemistry, 74(5), 2231-2233 (2009-02-05)
Ortholithiations of a range of arenes mediated by lithium diisopropylamide (LDA) in THF at -78 degrees C reveal substantial accelerations by as little as 0.5 mol % of LiCl (relative to LDA). Substrate dependencies suggest a specific range of reactivity
Aristea Sideri et al.
American journal of physiology. Gastrointestinal and liver physiology, 308(7), G591-G604 (2015-01-17)
In inflammatory bowel disease (IBD), obesity is associated with worsening of the course of disease. Here, we examined the role of obesity in the development of colitis and studied mesenteric fat-epithelial cell interactions in patients with IBD. We combined the
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