Showing 1-30 of 170 results for "368407"
Rune Gangsøy Kristiansen et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(10), G1024-G1031 (2014-09-27)
Glycine is an important ammoniagenic amino acid, which is increased in acute liver failure (ALF). We have previously shown that L-ornithine phenylacetate (OP) attenuates ammonia rise and intracranial pressure in pigs suffering from ALF but failed to demonstrate a stoichiometric...
Anthony W Friedline et al.
The journal of physical chemistry. B, 119(44), 14033-14044 (2015-10-06)
Bacterial spores can survive for long periods without nutrients and in harsh environmental conditions. This survival is influenced by the structure of the spore, the presence of protective compounds, and water retention. These compounds, and the physical state of water...
Eric D Packard et al.
Health physics, 104(6), 633-640 (2013-05-01)
Lawrence Livermore National Laboratory must control potentially activated materials and equipment in accordance with U.S. Department of Energy (DOE) Order 458.1, Radiation Protection of the Public and the Environment, which requires DOE approval of the process used to release volumetrically...
Tivadar Orban et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(11), 4579-4588 (2015-07-19)
Age-related macular degeneration (AMD) is a neurodegenerative disease that causes adult-onset blindness. There are 2 forms of this progressive disease: wet and dry. Currently there is no cure for AMD, but several treatment options have started to emerge making early...
Indu Kheterpal et al.
Accounts of chemical research, 39(9), 584-593 (2006-09-20)
The beta-sheet network of the amyloid fibril is a dominant structural feature of this class of protein structures. An attractive way to view the protein misfolding events that lead to the formation of fibrils and other aggregates is to consider...
José C Rodríguez-Pérez et al.
Physical chemistry chemical physics : PCCP, 15(33), 13940-13950 (2013-07-16)
In this paper we describe a novel combination of Raman spectroscopy, isotope editing and X-ray scattering as a powerful approach to give detailed structural information on aromatic side chains in peptide fibrils. The orientation of the tyrosine residues in fibrils...
Jae-Min Ha et al.
Soft matter, 11(29), 5821-5827 (2015-06-11)
We have investigated the distributions of individually isolated and hydrophilically functionalized single-walled carbon nanotubes (p-SWNTs) in the Pluronic L121-water system at the reverse hexagonal phase using small-angle X-ray scattering (SAXS) and contrast-matched small-angle neutron scattering (SANS) measurements. As the p-SWNT-L121-water...
Nguyen Minh Duc et al.
Journal of the American Society for Mass Spectrometry, 26(5), 808-817 (2015-03-06)
G protein-coupled receptors (GPCRs) have important roles in physiology and pathology, and 40% of drugs currently on the market target GPCRs for the treatment of various diseases. Because of their therapeutic importance, the structural mechanism of GPCR signaling is of...
J Bluett et al.
The Analyst, 140(6), 1981-1987 (2015-02-12)
Rheumatoid arthritis (RA) is a common autoimmune disease that causes significant disability and reduced life expectancy. The folate antagonist methotrexate (MTX) is first-line therapy for RA when used weekly at low doses (5-25 mg). However, the true rate of adherence...
Hongsik Shin et al.
Journal of nanoscience and nanotechnology, 13(11), 7444-7447 (2013-11-20)
Carborane powders (C2B10H12) were deposited on silicon substrates and the physical properties of the films were investigated as functions of the distance of the sample from the electrode, the carborane mass, and the plasma-pulse. To obtain the optimum thickness of...
Jörg Ziegler et al.
Amino acids, 46(12), 2799-2808 (2014-09-15)
A new method for the determination of amino acids is presented. It combines established methods for the derivatization of primary and secondary amino groups with 9-fluorenylmethoxycarbonyl chloride (Fmoc-Cl) with the subsequent amino acid specific detection of the derivatives by LC-ESI-MS/MS...
P M Macdonald et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 76(2-3), 452-464 (1999-01-29)
Domain formation in lipid bilayer membranes can occur through electrostatic interactions between charged lipids and oppositely charged polyelectrolytes, such as proteins or polynucleic acids. This review describes a novel method for examining such domains in lipid bilayers, based on 2H...
Michal Szostak et al.
Organic letters, 16(19), 5052-5055 (2014-09-24)
The first general method for the chemoselective synthesis of α,α-dideuterio alcohols directly from feedstock carboxylic acids under single electron transfer conditions using SmI2 is reported. This reaction proceeds after the activation of Sm(II) with a Lewis base, results in excellent...
Askin Birgul et al.
Archives of environmental contamination and toxicology, 68(1), 46-63 (2014-12-07)
Ambient air polycyclic aromatic hydrocarbon (PAH) samples were collected at traffic, residential, coastal, and semiurban sites in Bursa, Turkey, between June 2008 and June 2009. For the traffic, residential, coastal, and semiurban sites, the average gas phase total PAH (∑12PAH)...
Brandon K Tate et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(28), 10160-10169 (2015-06-11)
Alkoxide-bridged disilver cations react with dihydrogen to form hydride-bridged cations, releasing free alcohol. Hydrogenolysis of neutral silver fluorides affords hydride-bridged disilver cations as their bifluoride salts. These reactions proceed most efficiently when the supporting ligands are expanded N-heterocyclic carbenes (NHCs)...
Jose Luis Muñoz-Muñoz et al.
IUBMB life, 65(9), 793-799 (2013-07-31)
A solvent deuterium isotope effect on the inactivation suicide of tyrosinase in its action on o-diphenols (catechol, 4-methylcatechol, and 4-tert-butylcatechol) was observed. This isotope effect, observed during kinetic studies in the transition phase, was higher than that described previously in...
Ana Y Mercedes-Camacho et al.
Biochemistry, 52(44), 7707-7713 (2013-10-15)
The Pin1 peptidyl-prolyl isomerase catalyzes isomerization of pSer/pThr-Pro motifs in regulating the cell cycle. Peptide substrates, Ac-Phe-Phe-phosphoSer-Pro-Arg-p-nitroaniline, were synthesized in unlabeled form, and with deuterium-labeled Ser-d3 and Pro-d7 amino acids. Kinetic data were collected as a function of Pin1 concentration...
Russell J Chedgy et al.
Phytochemistry, 113, 149-159 (2015-01-07)
Salicinoids are phenolic glycosides (PGs) characteristic of the Salicaceae and are known defenses against insect herbivory. Common examples are salicin, salicortin, tremuloidin, and tremulacin, which accumulate to high concentrations in the leaves and bark of willows and poplars. Although their...
Alberto Sánchez-Guijo et al.
Journal of lipid research, 56(9), 1843-1851 (2015-08-05)
Steroids are primarily present in human fluids in their sulfated forms. Profiling of these compounds is important from both diagnostic and physiological points of view. Here, we present a novel method for the quantification of 11 intact steroid sulfates in...
Hongqiang Wang et al.
Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 32(10), 1454-1456 (2012-10-19)
Deuterium is an important predisposing factor for cancer. Deuterium-depleted Water, also known as low deuterium water, ultra-light water or no deuterium water, can be obtained by removing deuterium from natural water. Studies have shown that water with a low deuterium...
Jingping Liu et al.
Analytical and bioanalytical chemistry, 407(9), 2569-2579 (2015-02-01)
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus (DM), which is a major public health problem in the world. To reveal the metabolic changes associated with DN, we analyzed the serum, urine, and renal extracts obtained from control...
Luh P E K Yuni et al.
Journal of thermal biology, 52, 208-216 (2015-08-13)
The study of energy expenditure between populations of a wide ranging ectothermic species may provide an insight into how organisms respond to variation in environmental conditions. In this study, the energy expenditure of male spotted snow skinks, Niveoscincus ocellatus, living...
Thomas Berg et al.
Journal of chromatography. A, 1344, 83-90 (2014-05-02)
Stable isotope-labeled internal standards (SIL-ISs) are often used when applying liquid chromatography-tandem mass spectrometry (LC-MS/MS) to analyze for legal and illegal drugs. ISs labeled with (13)C, (15)N, and (18)O are expected to behave more closely to their corresponding unlabeled analytes...
Andrew C Singer et al.
PloS one, 9(9), e108621-e108621 (2014-09-26)
The concentration of eleven antibiotics (trimethoprim, oxytetracycline, ciprofloxacin, azithromycin, cefotaxime, doxycycline, sulfamethoxazole, erythromycin, clarithromycin, ofloxacin, norfloxacin), three decongestants (naphazoline, oxymetazoline, xylometazoline) and the antiviral drug oseltamivir's active metabolite, oseltamivir carboxylate (OC), were measured weekly at 21 locations within the River...
Demidmaa Tuvdendorj et al.
American journal of physiology. Endocrinology and metabolism, 305(8), E999-E1006 (2013-08-29)
The purpose of this study was to evaluate the variability of subcutaneous abdominal adipose tissue (AT) dynamics in obese subjects with a wide range of insulin sensitivity (IS) and the correlation between these two metabolic measures. Ten obese (BMI 30-40...
Seung Bin Baek et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(46), 14156-14161 (2015-11-19)
Crystallographic observation of adsorbed gas molecules is a highly difficult task due to their rapid motion. Here, we report the in situ single-crystal and synchrotron powder X-ray observations of reversible CO2 sorption processes in an apparently nonporous organic crystal under...
Erik Rytting et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1773-1779 (2014-08-07)
Recent in vitro data obtained in our laboratory revealed similarities between baboons and humans in the biotransformation of bupropion (BUP) by both hepatic and placental microsomes. These data supported the use of baboons to study BUP biotransformation during pregnancy. The...
Jacob J Kinnun et al.
Biochimica et biophysica acta, 1848(1 Pt B), 246-259 (2014-06-20)
This article reviews the application of solid-state ²H nuclear magnetic resonance (NMR) spectroscopy for investigating the deformation of lipid bilayers at the atomistic level. For liquid-crystalline membranes, the average structure is manifested by the segmental order parameters (SCD) of the...
Shaogang Chu et al.
Analytica chimica acta, 885, 183-190 (2015-08-02)
A fast, robust and highly sensitive analysis method for determination of trace levels of organophosphate ester (OPE) flame retardants and plasticizers in lipid-rich samples was presently developed, and based on ultra-high performance liquid chromatography-tandem mass spectrometry coupled to a positive...
Lauren E Bortolotti et al.
Ecological applications : a publication of the Ecological Society of America, 23(1), 110-121 (2013-03-19)
Hydrogen isotopes (delta2H) are often used to infer the origins of migratory animals based on the strong correlation between deuterium content of tissues and long-term patterns of precipitation. However, the extreme flood and drought dynamics of surface waters in prairie...

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