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Michael J M Fischer et al.
Pflugers Archiv : European journal of physiology, 466(12), 2229-2241 (2014-03-20)
Transient receptor potential cation channel, subfamily V, member 1 (TRPV1) plays a key role in sensing environmental hazards and in enhanced pain sensation following inflammation. A considerable proportion of TRPV1-expressing cells also express transient receptor potential cation channel, subfamily A...
Alec R Nickolls et al.
Cell reports, 30(3), 932-946 (2020-01-23)
Efficient and homogeneous in vitro generation of peripheral sensory neurons may provide a framework for novel drug screening platforms and disease models of touch and pain. We discover that, by overexpressing NGN2 and BRN3A, human pluripotent stem cells can be transcriptionally...
Juan Yun et al.
Journal of food science, 78(3), M458-M464 (2013-02-13)
The antimicrobial activity of the essential oils (EOs) from cinnamon bark, oregano, mustard, and of their major components cinnamaldehyde, carvacrol, and allyl isothiocyanate (AIT) was evaluated as a gaseous treatment to reduce Salmonella enterica serovar Typhimurium in vitro and on...
Allyl isothiocyanate.
IARC monographs on the evaluation of carcinogenic risks to humans, 73, 37-48 (2000-05-11)
Katrien De Clercq et al.
Human reproduction (Oxford, England), 30(6), 1421-1436 (2015-03-31)
Are members of the transient receptor potential (TRP) channel superfamily functionally expressed in the human endometrial stroma? The Ca(2+)-permeable ion channels TRPV2, TRPV4, TRPC6 and TRPM7 are functionally expressed in primary endometrial stromal cells. Intercellular communication between epithelial and stromal...
Anabela Borges et al.
Journal of food science and technology, 52(8), 4737-4748 (2015-08-06)
Plants contain numerous components that are important sources of new bioactive molecules with antimicrobial properties. Isothiocyanates (ITCs) are plant secondary metabolites found in cruciferous vegetables that are arising as promising antimicrobial agents in food industry. The aim of this study...
Yuesheng Zhang
Molecular nutrition & food research, 54(1), 127-135 (2009-12-05)
Allyl isothiocyanate (AITC), which occurs in many common cruciferous vegetables, is widely and often frequently consumed by humans. Besides antimicrobial activity against a wide spectrum of pathogens, it showed anticancer activity in both cultured cancer cells and animal models, although...
L Manyes et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 83, 293-299 (2015-07-05)
Isothiocyanates (ITCs) are natural compounds derived from cruciferous vegetables produced by enzymatic conversion of metabolites called glucosinolates. They are potentially useful antimicrobial compounds for food applications have been shown to be promising agents against cancer in human cell culture, animal...
Enrico Morera et al.
Bioorganic & medicinal chemistry letters, 22(4), 1674-1677 (2012-01-20)
In order to explore the structural determinants for the TRPV1 and TRPA1 agonist properties of gingerols, a series of nineteen analogues (1b-5) of racemic [6]-gingerol (1a) was synthesized and tested on TRPV1 and TRPA1 channels. The exploration of the structure-activity...
Takuya Kameda et al.
International journal of molecular sciences, 20(7) (2019-04-13)
Transient receptor potential (TRP) channels have emerged as potential sensors and transducers of inflammatory pain. The aims of this study were to investigate (1) the expression of TRP channels in intervertebral disc (IVD) cells in normal and inflammatory conditions and...
Juan M Quiles et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 83, 222-228 (2015-07-07)
Aflatoxins (AFs) are secondary metabolites produced by different species of Aspergillus, such as Aspergillus flavus and Aspergillus parasiticus, which possess mutagenic, teratogenic and carcinogenic activities in humans. In this study, active packaging devices containing allyl isothiocyanate (AITC) or oriental mustard...
Judit Újhelyi et al.
Regulatory peptides, 194-195, 23-29 (2014-09-18)
To validate the potential anti-inflammatory and analgesic role of sita- and vildagliptin, five different experimental models were used in mice: i) mustard oil-induced ear edema, ii) neutrophil accumulation, iii) mechanical and iv) thermal touch sensitivity in complete Freund's adjuvant-induced arthritis...
Harrie J M Gijsen et al.
Journal of medicinal chemistry, 53(19), 7011-7020 (2010-09-03)
The TRPA1 channel can be considered as a key biological sensor to irritant chemicals. In this paper, the discovery of 11H-dibenz[b,e]azepines (morphanthridines) and dibenz[b,f][1,4]oxazepines is described as extremely potent agonists of the TRPA1 receptor. This has led to the discovery...
Ruo-Xiao Cheng et al.
Theranostics, 9(15), 4287-4307 (2019-07-10)
Methylglyoxal (MGO), an endogenous reactive carbonyl compound, plays a key role in the pathogenesis of diabetic neuropathy. The aim of this study is to investigate the role of MGO in diabetic itch and hypoalgesia, two common symptoms associated with diabetic...
Yong-Soo Seo et al.
Bioresource technology, 121, 475-479 (2012-07-31)
This study was conducted to reduce off-flavors from sea tangle (Laminaria japonica) extract since the typical odor of seaweed is an impediment to consumption of seaweed products. Fifty-six odor compounds emitted from the extract were identified using a thermal desorbor...
Catherine E Sansom et al.
Journal of agricultural and food chemistry, 63(6), 1833-1838 (2015-01-28)
The traditionally consumed New Zealand native plant nau, Cook's scurvy grass, Lepidium oleraceum, has a pungent wasabi-like taste, with potential for development as a flavor ingredient. The main glucosinolate in this Brassicaceae was identified by LC-MS and NMR spectroscopy as...
S R Musk et al.
Carcinogenesis, 14(10), 2079-2083 (1993-10-01)
Allyl isothiocyanate, a constituent of mustard and certain vegetables found in the human diet, was tested for cytotoxic and cytostatic effects in HT29 human colon carcinoma cells in vitro. For an exposure time of 24 h, allyl isothiocyanate exhibited a...
Yuka Kimura et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(6), 2451-2457 (2013-02-16)
Accumulating evidence shows that hydrogen sulfide (H2S) has a variety of physiological functions. H2S is produced from cysteine by 3 sulfurtransferases. H2S, in turn, generates polysulfides, the functions of which are not well understood. H2S induces Ca(2+) influx in astrocytes...
J R Daller et al.
Journal of pharmacological and toxicological methods, 66(3), 232-237 (2012-07-17)
Commercial whole-body plethysmography systems used to evaluate the anti-tussive potential of drugs employ sophisticated technology, but these systems may be cost prohibitive for some laboratories. The present study describes an alternative, inexpensive system for evaluating the tussive and anti-tussive potential...
Anne Lerbaek et al.
Contact dermatitis, 51(2), 79-83 (2004-09-18)
Allyl isothiocyanate is present in many plants. Allergic contact dermatitis from allyl isothiocyanate is well known but infrequently reported. The aim of this study was to investigate the prevalence of contact allergy to allyl isothiocyanate in patients with suspected contact...
Katsunari Ippoushi et al.
Food chemistry, 141(2), 1192-1195 (2013-06-26)
Allyl isothiocyanate, a chief component of mustard oil, exhibits anticancer effects in both cultured cancer cells and animal models. The accumulation of the N-acetylcysteine conjugate of allyl isothiocyanate, the final metabolite of allyl isothiocyanate, in urine was evaluated in rats...
Eliziane S Patricio et al.
The Journal of investigative dermatology, 135(10), 2484-2491 (2015-05-09)
A role for proteinase-activated receptor-4 (PAR-4) was recently suggested in itch sensation. Here, we investigated the mechanisms underlying the pruriceptive actions of the selective PAR-4 agonist AYPGKF-NH2 (AYP) in mice. Dorsal intradermal (i.d.) administration of AYP elicited intense scratching behavior...
F Mushantaf et al.
Environmental technology, 33(19-21), 2461-2465 (2013-02-12)
This study investigated the potential application of allyl isothiocyanate (AITC) for the disinfection of water by examining the bactericidal effects of this compound against inoculated Escherichia coli in autoclaved, de-chlorinated tap water and against the natural microbiota (heterotrophic plate count...
Mohammad F Hassan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 153, 510-516 (2015-09-29)
A facile and convenient synthesis of a series of fatty acid derivatives of 1,3,4-oxadiazole and 1,3,4-thiadiazole has been described. The key step of this protocol is the cyclization of acyl thiosemicarbazides via iodobenzene diacetate and methanesulfonic acid under mild conditions....
I Azaiez et al.
Toxicon : official journal of the International Society on Toxinology, 63, 137-146 (2013-01-02)
Fumonisins (FBs) are bioactive compounds produced by several strains of Fusarium spp. which contain a polyketide structure similar to sphinganine. These mycotoxins contain a free amino group that could work as an electron donor and react with the electrophile carbon...
M Carmen Acosta et al.
Investigative ophthalmology & visual science, 55(6), 3403-3412 (2014-05-03)
To produce in guinea pigs a UV-induced keratitis, to analyze the effects of this pathology on corneal nerve activity. In anesthetized animals, one eye was exposed to 254 nm UV-C radiation (500-1000 mJ/cm(2)), excised 24 to 48 hours later and...
Manahito Aoki et al.
European journal of pharmacology, 696(1-3), 62-69 (2012-09-25)
Oxaliplatin and paclitaxel are commonly used anti-cancer drugs, but they frequently cause peripheral neuropathic pain. In this study, we investigated the effect of elcatonin, a synthetic eel calcitonin, on oxaliplatin- and paclitaxel-induced neuropathy in rats. The rats were treated with...
Thomas Voets et al.
Nature chemical biology, 1(2), 85-92 (2006-01-13)
Drosophila melanogaster flies carrying the trp (transient receptor potential) mutation are rapidly blinded by bright light, because of the absence of a Ca2+-permeable ion channel in their photoreceptors. The identification of the trp gene and the search for homologs in...
Qingli Meng et al.
American journal of physiology. Cell physiology, 309(1), C1-10 (2015-04-24)
To address mechanoreceptive roles of trigeminal ganglion (TG) nerve endings in the inner walls of rat anterior eye chambers, we investigated the mechanotransduction process and mechanosensitive (MS) channel on somata of TG neurons innervating this area in vitro. Rat TG...
Eyal Halon et al.
Scientific reports, 5, 17975-17975 (2015-12-15)
Generalist insect can utilize two different modes for regulating their detoxification genes, the constitutive mode and the induced mode. Here, we used the Bemisia tabaci sibling species MEAM1 and MED, as a model system for studying constitutive and induced detoxification...
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