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Lubinda Mbundi et al.
Nanomaterials (Basel, Switzerland), 8(6) (2018-06-06)
The control of osteoblast/osteoclast cross-talk is crucial in the bone remodelling process and provides a target mechanism in the development of drugs for bone metabolic diseases. Osteoprotegerin is a key molecule in this biosignalling pathway as it inhibits osteoclastogenesis and...
Thomas H Craven et al.
Scientific reports, 8(1), 13490-13490 (2018-09-12)
Serine proteases are released by neutrophils to act primarily as antimicrobial proteins but excessive and unbalanced serine protease activity results in serious host tissue damage. Here the synthesis of a novel chemical sensor based on a multi-branched fluorescence quencher is...
Hiroshi Hinou et al.
Bioorganic & medicinal chemistry, 27(13), 2822-2831 (2019-05-14)
Structural and functional effects of core M1 type glycan modification catalyzed by protein O-linked mannose β1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) were investigated using a core M1 glycoform focused library of an α-dystroglycan fragment, 372TRGAIIQTPTLGPIQPTRV390. Evanescent-field fluorescence-assisted microarray system illuminated the specific binding...
Alessandra Soriente et al.
Journal of materials science. Materials in medicine, 29(5), 62-62 (2018-05-08)
The present work is focused on the design of a bioactive chitosan-based scaffold functionalized with organic and inorganic signals to provide the biochemical cues for promoting stem cell osteogenic commitment. The first approach is based on the use of a...
Valeria Perugini et al.
Journal of materials science. Materials in medicine, 31(4), 37-37 (2020-03-25)
The in vitro study of the properties of the human mesenchymal stem cells as well as their manipulation in culture for clinical purposes depends on the elimination of artefacts caused by the lack of their natural environment. It is now...
Benjamin L Lu et al.
Journal of labelled compounds & radiopharmaceuticals (2020-03-27)
α-Calcitonin gene related peptide (αCGRP) inhibitors are important medicinal targets due to their ability to produce antimigraine effects, thus, the discovery of long-acting αCGRP inhibitors is of significant interest. Herein we report the synthesis of an isotopically labelled version of...
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