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Yang Xu et al.
Experimental and therapeutic medicine, 11(5), 1812-1818 (2016-05-12)
Bone loss is caused by occlusal hypofunction and is a serious health concern. This is particularly true of tooth loss, which is common in the elderly. However, the cellular and molecular mechanisms underlying bone loss have yet to be fully
Ingrid Nyhus Moen et al.
Cell death discovery, 7(1), 36-36 (2021-02-21)
Elevated activity of bone-degrading osteoclasts (OC) contributes to pathological bone degradation in diseases such as multiple myeloma. Several proinflammatory cytokines, including TNF, contribute to osteoclastogenesis. The receptor-interacting protein kinase 1 (RIPK1) regulates inflammation and cell death. It is recruited to
Layla Panahipour et al.
International journal of molecular sciences, 21(22) (2020-11-19)
Osteoclastogenesis required for bone remodeling is also a key pathologic mechanism of inflammatory osteolysis being controlled by paracrine factors released from dying cells. The secretome of irradiated, dying peripheral blood mononuclear cells (PBMCs) has a major impact on the differentiation
Jiali Wang et al.
Biomaterials, 268, 120576-120576 (2020-12-04)
Periosteum can improve tendon-bone healing when applied to wrap the tendon graft in both animal studies and clinical trials. As magnesium (Mg) ions can significantly elevate the levels of relevant cytokines involving in the osteogenic differentiation of periosteum-derived stem cells
Rafael Scaf de Molon et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 31(8), 1596-1607 (2016-03-08)
Rheumatoid arthritis (RA), an autoimmune inflammatory disorder, results in persistent synovitis with severe bone and cartilage destruction. Bisphosphonates (BPs) are often utilized in RA patients to reduce bone destruction and manage osteoporosis. However, BPs, especially at high doses, are associated
Nicole A Kohart et al.
Leukemia & lymphoma, 61(2), 409-419 (2019-10-09)
Parathyroid hormone-related protein (PTHrP) and macrophage inflammatory protein-1α (MIP-1α) are important factors that increase bone resorption and hypercalcemia in adult T-cell leukemia (ATL). We investigated the role of PTHrP and MIP-1α in the development of local osteolytic lesions in T-cell
Elena Orecchini et al.
Frontiers in pharmacology, 11, 593829-593829 (2021-02-09)
Artocarpus tonkinensis (At) leaf decoction, a traditional remedy prepared in North Vietnam by the Hmong ethnic group, is a tea extract rich in bioactive compounds that may have therapeutic effects in arthritis and backache. Indeed, it has been demonstrated that
B S Margulies et al.
Bone, 79, 121-130 (2015-06-09)
Ewing's sarcoma of bone is a primary childhood malignancy of bone that is treated with X-radiation therapy in combination with surgical excision and chemotherapy. To better study Ewing's sarcoma of bone we developed a novel model of primary Ewing's sarcoma
T cells participate in bone remodeling during the rapid palatal expansion.
Li, et al.
Faseb Journal, 34, 15327-15337 (2021)
Yukiko Kuroda et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 36(8), 1535-1547 (2021-04-28)
Auditory ossicles in the middle ear and bony labyrinth of the inner ear are highly mineralized in adult mammals. Cellular mechanisms underlying formation of dense bone during development are unknown. Here, we found that osteoblast-like cells synthesizing highly mineralized hearing-related
Elizabeth Rendina-Ruedy et al.
Journal of bone and mineral metabolism, 34(4), 380-394 (2015-06-11)
Skeletal fractures are considered a chronic complication of type 2 diabetes mellitus (T2DM), but the etiology of compromised bone quality that develops over time remains uncertain. This study investigated the concurrent alterations in metabolic and skeletal changes in two mouse
Ssu-Yi Lu et al.
Experimental cell research, 328(1), 32-43 (2014-08-26)
Transcription factors Mitf and NFATc1 share many downstream targets that are critical for osteoclastogenesis. Since RANKL signals induce/activate both NFATc1 and Mitf isoform-E (Mitf-E), a tissue-restricted Mitf isoform in osteoclasts, it is plausible that the two factors work together to
Anita Ignatius et al.
Journal of cellular biochemistry, 112(9), 2594-2605 (2011-05-21)
There is a tight interaction of the bone and the immune system. However, little is known about the relevance of the complement system, an important part of innate immunity and a crucial trigger for inflammation. The aim of this study
Sofia Movérare-Skrtic et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(10), 11163-11179 (2019-07-17)
Osteoporosis is a common skeletal disease, affecting millions of individuals worldwide. Currently used osteoporosis treatments substantially reduce vertebral fracture risk, whereas nonvertebral fracture risk, mainly caused by reduced cortical bone mass, has only moderately been improved by the osteoporosis drugs
Li Liu et al.
Acta biomaterialia, 103, 281-292 (2019-12-24)
Iron oxide nanoparticles (IONPs) have been widely used as contrast agents for magnetic resonance imaging (MRI) and other biomedical applications in both clinical and preclinical cases. In the present study, we show that two clinically used IONPs, ferumoxytol and ferucarbotran
Eugene Cho et al.
International journal of molecular sciences, 19(11) (2018-11-06)
Osteoporosis is caused by an imbalance of osteoclast and osteoblast activities and it is characterized by enhanced osteoclast formation and function. Peptidyl-prolyl cis-trans isomerase never in mitosis A (NIMA)-interacting 1 (Pin1) is a key mediator of osteoclast cell-cell fusion via
Jie Zhu et al.
Journal of cellular physiology, 234(11), 21182-21192 (2019-04-30)
Osteocytes, entrapped within the mineralized bone matrix, has been found to have numerous functions such as acting as an orchestrator of bone remodeling through regulation of both osteoclast and osteoblast activity and also functioning as an endocrine cell. Due to
Lubinda Mbundi et al.
Nanomaterials (Basel, Switzerland), 8(6) (2018-06-06)
The control of osteoblast/osteoclast cross-talk is crucial in the bone remodelling process and provides a target mechanism in the development of drugs for bone metabolic diseases. Osteoprotegerin is a key molecule in this biosignalling pathway as it inhibits osteoclastogenesis and
Bing Han et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 128, 110305-110305 (2020-06-03)
Osteoclasts are capable of adhering the bone matrix, then secrete acid and lytic enzymes to resorb it. Reactive oxygen species (ROS), as a signaling messenger, plays an important role in the receptor activator nuclear factor κB ligand (RANKL) signal pathway
Manoj K Pandey et al.
Experimental hematology, 53, 31-42 (2017-06-26)
Bruton's tyrosine kinase (BTK) regulates many vital signaling pathways and plays a critical role in cell proliferation, survival, migration, and resistance. Previously, we reported that a small molecule, KS99, is an inhibitor of tubulin polymerization. In the present study, we
Zhenheng Wang et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 35(4), 752-759 (2015-09-26)
Wear particle-induced osteolysis is a major cause of aseptic loosening, which is one of the most common reasons for total hip arthroplasty (THA) failure. Previous studies have shown that the expression of Receptor activation of nuclear factor (NF)-kB (RANKL) by
Lijun Dong et al.
Frontiers in immunology, 10, 1239-1239 (2019-06-20)
Mannan-binding lectin (MBL) is a vital element in the host innate immune system, which is primarily produced by the liver and secreted into the circulation. Low serum level of MBL is reported to be associated with an increased risk of
Xingtao Ge et al.
Experimental biology and medicine (Maywood, N.J.), 243(8), 715-724 (2018-05-16)
Bone loss is one of the important extra-intestinal manifestations in patients with inflammatory bowel diseases (IBDs). Compounds derived from natural products have been used to treat IBDs. However, the role of natural products on IBD-induced bone loss is not completely
Ke Ren et al.
Molecular pharmaceutics, 8(4), 1043-1051 (2011-03-29)
Wear particle-induced inflammation is considered to be the major cause of aseptic implant loosening and clinical failure after total joint replacement. Due to the frequent absence of symptoms, early detection and intervention prior to implant failure presents a significant challenge.
Xiaoying Zhao et al.
Journal of molecular cell biology, 12(1), 55-70 (2019-04-16)
PIP5k1β is crucial to the generation of phosphotidylinosotol (4, 5)P2. PIP5k1β participates in numerous cellular activities, such as B cell and platelet activation, cell phagocytosis and endocytosis, cell apoptosis, and cytoskeletal organization. In the present work, we aimed to examine
Eva-Lena Stattin et al.
Scientific reports, 7(1), 3012-3012 (2017-06-09)
Autosomal recessive osteopetrosis (ARO) is a heterogeneous disorder, characterized by defective osteoclastic resorption of bone that results in increased bone density. We have studied nine individuals with an intermediate form of ARO, from the county of Västerbotten in Northern Sweden.
Meng Li et al.
Frontiers in pharmacology, 11, 1023-1023 (2020-08-06)
Osteoporosis (OP) is one of the common bone metabolic diseases that endangers postmenopausal women and the elders. Both excessive bone resorption caused by osteoclast over-activation and increased oxidative stress are associated with osteoporosis. Cinnamtannin B-1 (CB-1) is considered as a
Boxi Yan et al.
American journal of translational research, 10(12), 4107-4118 (2019-01-22)
Increasing number of patients with high body-mass index (BMI) are encountered in the orthodontic clinic with the growing prevalence of obesity and overweight worldwide. Some clinical studies found that the rate of orthodontic tooth movement (OTM) in obese patients decreased.
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