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S J Lee et al.
British journal of cancer, 111(3), 497-505 (2014-06-20)
Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are commonly prescribed because of their therapeutic and preventive effects on cardiovascular diseases. Even though they have been occasionally reported to have antitumour activity, it is unknown whether statins have anti-angiogenic effect in human
Monica N Schointuch et al.
Gynecologic oncology, 134(2), 346-355 (2014-06-01)
Our goal was to evaluate the effects of simvastatin on endometrial cancer cell lines and primary cultures of endometrial cancer cells. Cell proliferation in the ECC-1 and Ishikawa endometrial cancer cell lines and primary cultures of endometrial cancer cells was
Jennifer G Robinson et al.
JAMA, 311(18), 1870-1882 (2014-05-16)
In phase 2 studies, evolocumab, a fully human monoclonal antibody to PCSK9, reduced LDL-C levels in patients receiving statin therapy. To evaluate the efficacy and tolerability of evolocumab when used in combination with a moderate- vs high-intensity statin. Phase 3
Marius Costel Alupei et al.
Cancer letters, 356(2 Pt B), 946-952 (2014-12-03)
Statins possess antitumor actions at doses 100- to 500-fold higher than those needed to lower cholesterol levels. Thus, the antitumor efficacy of statins could be improved greatly by using tumor-targeted delivery systems. Therefore the present work aims to investigate the
Gerardo Leyva-Gómez et al.
Journal of pharmaceutical sciences, 103(8), 2509-2519 (2014-06-12)
To document the efficacy of clonazepam (CLZ) either free as a solution or loaded in solid lipid nanoparticles (CLZ-SLN) or mixed micelles (CLZ-MM), the in vitro blood-brain barrier permeability of the formulations was determined. Behavior and/or electroencephalograms (EEGs) of rodents
Tae Ik Chang et al.
PloS one, 9(10), e109628-e109628 (2014-10-03)
Statins have recently been highlighted for their pleiotropic actions distinct from cholesterol-lowering effects. Despite this interest, it is currently unknown whether statin therapy inhibits peritoneal dialysis (PD)-related epithelial-mesenchymal transition (EMT). In vitro, human peritoneal mesothelial cells (HPMCs) were exposed to
Eric J Niesor et al.
Lipids, 49(12), 1233-1243 (2014-10-11)
The antioxidant xanthophylls lutein and zeaxanthin are absorbed from the diet in a process involving lipoprotein formation. Selective mechanisms exist for their intestinal uptake and tissue-selective distribution, but these are poorly understood. We investigated the role of high-density lipoprotein (HDL)
Yayun Liang et al.
Breast cancer research and treatment, 146(1), 51-62 (2014-06-01)
In most human breast cancers, tumor cell proliferation is estrogen dependent. Although hormone-responsive tumors initially respond to anti-estrogen therapies, most of them eventually develop resistance. Our goal was to identify alternative targets that might be regulated to control breast cancer
Nikolaos Manitsopoulos et al.
Respiratory research, 16, 24-24 (2015-04-08)
Mortality from severe acute respiratory distress syndrome exceeds 40% and there is no available pharmacologic treatment. Mechanical ventilation contributes to lung dysfunction and mortality by causing ventilator-induced lung injury. We explored the utility of simvastatin in a mouse model of
Digvijay G Rana et al.
Canadian journal of physiology and pharmacology, 92(12), 985-992 (2014-11-13)
We have investigated the influence of dopaminergic agents on the expression of brain-derived neurotrophic factor (BDNF) gene in relation with lipid levels in chronic mild stress (CMS). Mice subjected to CMS were treated with simvastatin (10 mg/kg, per os (orally))
Yifeng Xia et al.
Science translational medicine, 6(263), 263ra161-263ra161 (2014-11-21)
Lung cancer is the most common human malignancy and leads to about one-third of all cancer-related deaths. Lung adenocarcinomas harboring KRAS mutations, in contrast to those with EGFR and EML4-ALK mutations, have not been successfully targeted. We describe a combination
Chia-Hsuin Chang et al.
Journal of gastroenterology and hepatology, 30(1), 155-162 (2014-07-22)
The hepatotoxicity of statins in patients with chronic liver diseases remains unclear. In this study, we aimed to estimate the risk of severe hepatic injury associated with different statins in patients with chronic liver disease. A nationwide population-based cohort study
Parvaneh Mehrbod et al.
International journal of molecular medicine, 34(1), 61-73 (2014-05-03)
Influenza A virus is one of the most important health risks that lead to significant respiratory infections. Continuous antigenic changes and lack of promising vaccines are the reasons for the unsuccessful treatment of influenza. Statins are pleiotropic drugs that have
Kirsten E Austad et al.
JAMA internal medicine, 174(8), 1283-1290 (2014-06-10)
In recent years, numerous US medical schools and academic medical centers have enacted policies preventing pharmaceutical sales representatives from interacting directly with students. Little is known about how pharmaceutical sales representatives affect trainees' knowledge about pharmaceutical prescribing. To determine whether
Zeljko Vojvodić et al.
Collegium antropologicum, 38 Suppl 2, 73-78 (2015-02-04)
Prescribing of statins showed an increasing trend in all developed countries, during the last two decades. The aim of this study was to research the trends in statin consumption in the period from 2004 to 2012 as well as trends
Yun Xia et al.
Cell, 175(4), 1059-1073 (2018-10-03)
Motivated by the clinical observation that interruption of the mevalonate pathway stimulates immune responses, we hypothesized that this pathway may function as a druggable target for vaccine adjuvant discovery. We found that lipophilic statin drugs and rationally designed bisphosphonates that
Xin Yang et al.
Clinical and experimental pharmacology & physiology, 41(12), 950-955 (2014-08-15)
The 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) pathway is an important metabolic route that is present in almost every organism. However, whether HMGCR affects the expression of interferon (IFN)-responsive genes is unclear. In the present study, expression levels of IFN-responsive genes were
Laura Marin et al.
Expert opinion on drug delivery, 8(9), 1205-1220 (2011-05-28)
Chronic Obstructive Pulmonary Disease (COPD) is a severe disease that leads to a non-reversible obstruction of the small airways. The prevalence of this disease is rapidly increasing in developed countries, and in 2020 it has been predicted that this disease
Jaewang Lee et al.
Theriogenology, 83(2), 285-293 (2014-12-03)
After the ovarian tissue (OT) transplantation, the ischemia-reperfusion injury causes depletion and apoptosis of follicle. Recent reports stated that simvastatin reduces ischemic damage. Therefore, we used the mouse whole ovarian vitrification and autotransplantation models to investigate the effects of simvastatin.
Simvastatin in moderate-to-severe COPD.
Emmanuel E Egom
The New England journal of medicine, 371(10), 969-969 (2014-09-04)
Dana Cramariuc et al.
Heart (British Cardiac Society), 101(3), 209-214 (2014-10-11)
Women with severe aortic valve stenosis (AS) have better LV systolic function and more concentric LV geometry than their male counterparts. However, sex differences in cardiovascular (CV) outcome during progression of AS have not been reported from a longitudinal prospective
O Gottschalk et al.
Scandinavian journal of rheumatology, 43(5), 356-363 (2014-05-16)
The use of statins in the prevention and treatment of cardiovascular diseases is well established. Their use as anti-inflammatory and immunomodulatory agents in the treatment of rheumatoid arthritis (RA) has also been investigated, with several clinical and experimental studies indicating
Sheila A Doggrell
Expert opinion on pharmacotherapy, 13(10), 1469-1480 (2012-06-26)
The primary target in the treatment of hypercholesterolemia is often to lower low-density lipoprotein (LDL) cholesterol, rather than improve clinical outcomes. Despite the wide use of lipid-modifying drugs, considerable cardiovascular mortality and morbidity remains with this disease. Hypercholesterolemia plays a
Teresa Neuparth et al.
Aquatic toxicology (Amsterdam, Netherlands), 155, 337-347 (2014-08-05)
Simvastatin (SIM), a hypocholesterolaemic drug, is among the most widely used pharmaceuticals worldwide and is therefore of emerging environmental concern. Despite the ubiquitous nature of SIM in the aquatic ecosystems, significant uncertainties exist about sublethal effects of the drug in
Mais Absi et al.
American journal of physiology. Cell physiology, 306(7), C679-C686 (2014-01-31)
Statins and aspirin deliver well-established cardiovascular benefits resulting in their increased use as combined polypills to decrease risk of stroke and heart disease. However, the direct endothelial effect of combined statin/aspirin cotreatment remains unclear. Histamine is an inflammatory mediator that
Mailien Rogers et al.
Anticancer research, 35(4), 1851-1859 (2015-04-12)
The mevalonate pathway plays an important role in cancer biology and has been targeted with farnesyl transferase inhibitors, although their efficacy is limited due to significant adverse effects. Statins and bisphosphonates inhibit the mevalonate pathway at different steps, thus having
Ki-Eun Hwang et al.
Experimental cell research, 323(2), 288-296 (2014-03-19)
Although non-small cell lung cancer (NSCLC) tumors with activating mutations in the epidermal growth factor receptor (EGFR) are highly responsive to EGFR tyrosine kinase inhibitors (TKIs) including gefitinib and erlotinib, development of acquired resistance is almost inevitable. Statins show antitumor
L B Ramsey et al.
Clinical pharmacology and therapeutics, 96(4), 423-428 (2014-06-12)
Simvastatin is among the most commonly used prescription medications for cholesterol reduction. A single coding single-nucleotide polymorphism, rs4149056T>C, in SLCO1B1 increases systemic exposure to simvastatin and the risk of muscle toxicity. We summarize evidence from the literature supporting this association
Simvastatin in moderate-to-severe COPD.
Gerard J Criner et al.
The New England journal of medicine, 371(10), 970-971 (2014-09-04)
Theodosios D Filippatos et al.
Expert opinion on pharmacotherapy, 12(12), 1945-1958 (2011-07-09)
Statin use results in a significant reduction of cardiovascular disease (CVD) risk. However, patients still have residual CVD risk, even if they are receiving optimal statin treatment. This review, based on a Pubmed/Scopus search, discusses the available evidence regarding the
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