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Lekha Nair K et al.
Journal of nanobiotechnology, 9(1), 42-42 (2011-09-29)
Specific properties of amphiphilic copolymeric micelles like small size, stability, biodegradability and prolonged biodistribution have projected them as promising vectors for drug delivery. To evaluate the potential of δ-valerolactone based micelles as carriers for drug delivery, a novel triblock amphiphilic
Alice E van der Ende et al.
Journal of the American Chemical Society, 130(27), 8706-8713 (2008-06-12)
We present the synthesis of discrete functionalized polyester nanoparticles in selected nanoscale size dimensions via a controlled intermolecular chain cross-linking process. The novel technique involves the controlled coupling of epoxide functionalized polyesters with 2,2'-(ethylenedioxy)bis(ethylamine) to give well-defined nanoparticles with narrow
Fabian Weber et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 19(4), 1288-1302 (2013-01-09)
The static and dynamic stereochemistry of unsubstituted δ-valerolactone, all monomethylated δ-lactones, and all nongeminally dimethylated δ-lactones was explored with the B3LYP functional and def2-TZVPP basis set. A search strategy was employed which allowed the entire conformational space of any (poly-)substituted
Patricia de Aguiar Amaral et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 8(1), 69-75 (2005-06-11)
A series of delta-valerolactones has been synthesized in good yields, by reaction of ethyl acetoacetate with several aldehydes in presence of LDA. The in vivo analgesic activity of these compounds has been evaluated. The results indicate that the lactones synthesized
Courtney L Millar et al.
Metabolic syndrome and related disorders, 16(9), 464-469 (2018-08-22)
High-density lipoprotein (HDL) particles are protective against atherosclerosis. However, HDL function is impaired in metabolic syndrome (MetS) due to low-grade inflammation and dyslipidemia. Foods containing polyphenols, such as grapes, may prevent HDL dysfunction via antioxidant or anti-inflammatory effects. We evaluated
David Vauzour et al.
Biochimica et biophysica acta, 1864(1), 69-78 (2017-10-08)
Non-alcoholic fatty liver disease (NAFLD) affects 25% of adults and at present no licensed medication has been approved. Despite its complex patho-physiology, dietary strategies aiming at delaying or preventing NAFLD have taken a reductionist approach, examining the impact of single
Ryo Shintani et al.
Organic letters, 11(2), 457-459 (2008-12-17)
A new synthetic method of multisubstituted nipecotic acid (piperidine-3-carboxylic acid) derivatives has been developed by way of palladium-catalyzed decarboxylative cyclization of gamma-methylidene-delta-valerolactones with imines. By employing the diethoxyphosphinoyl group as the N-protecting group for imines, the reaction proceeds smoothly with
Catalina Marín-Echeverri et al.
Antioxidants (Basel, Switzerland), 7(12) (2018-12-14)
Metabolic syndrome (MetS) is associated with low-grade inflammation and high-density lipoprotein (HDL) dysfunction. Polyphenol-rich foods may improve these alterations. Agraz is a fruit rich in polyphenols (mainly anthocyanins); however, there is limited information about its effects on human health. We
Jing Yang et al.
Macromolecular bioscience, 5(9), 896-903 (2005-09-01)
In our previous study [J. Yang, L. Jia, L. Yin, J. Yu, Z. Shi, Q. Fang, A. Cao, Macromol. Biosci. 2004, 4, 1092.], new biodegradable copolymers of diblock methoxy poly(ethylene glycol)-block-poly(epsilon-caprolactone) and methoxy poly(ethylene glycol)-block-poly(delta-valerolactone), and triblock poly(epsilon-caprolactone)-block-poly(ethylene glycol)-block-poly(epsilon-caprolactone) and
Synthesis of thymoquinone-artemisinin hybrids: new potent antileukemia, antiviral, and antimalarial agents
Frohlich T, et al.
ACS Medicinal Chemistry Letters, 9(6), 534-539 (2017)
Direct catalytic asymmetric addition of allylic cyanides to aldehydes for expeditious access to enantioenriched unsaturated δ-valerolactones.
Yasunari Otsuka et al.
Chemistry, an Asian journal, 8(2), 354-358 (2012-12-05)
Artificial molecular clamp: a novel device for synthetic polymerases.
Yoshinori Takashima et al.
Angewandte Chemie (International ed. in English), 50(33), 7524-7528 (2011-07-12)
Ryo Shintani et al.
Organic letters, 11(16), 3754-3756 (2009-07-30)
A new synthetic method of spirooxindole derivatives has been developed by way of a palladium-catalyzed decarboxylative cyclization of gamma-methylidene-delta-valerolactones with isatins. By employing a newly prepared phosphoramidite ligand, the reaction proceeds smoothly with excellent diastereoselectivity. Preliminary results of its application
Hyungjoo Kim et al.
Environmental research, 187, 109667-109667 (2020-05-23)
One-pot conversion of alginic acid, which was derived from brown algae, to furfural was investigated using various solid acid catalysts. Among the solid acid catalysts tested, Amberlyst-15 showed the highest activity in furfural production in aqueous media. When the effect
Hagai Tavori et al.
Bioorganic & medicinal chemistry, 16(15), 7504-7509 (2008-06-24)
Paraoxonase1 (PON1) is a HDL bound enzyme and many of the anti-atherogenic properties of HDL are attributed to PON1. The enzyme precise mechanism of protective action and its endogenous substrate remain elusive. PON1 hydrolyzes organophosphates, arylesters and lactones, whereas the
Jing Yang et al.
Macromolecular bioscience, 4(12), 1092-1104 (2004-12-09)
The chemical preparation of structurally well-defined biodegradable amphiphilic block copolymers is now of great interest for biomedical applications and the fundamental mimetic study of biomacromolecule self-assembly. For this purpose, in this study, (R,R)-N,N'-bis(3-tert-butylsalicylidene)-1,2-cyclohexanediamine 2 as a ligand was first synthesized
Faquan Zeng et al.
Bioconjugate chemistry, 17(2), 399-409 (2006-03-16)
Epidermal growth factor (EGF)-conjugated copolymer micelles were prepared from a mixture of diblock copolymers of methoxy poly(ethylene glycol)-block-poly(delta-valerolactone) (MePEG-b-PVL) and EGF-PEG-b-PVL for targeted delivery to EGF receptor (EGFR)-overexpressing cancers. The block copolymers and functionalized block copolymers were synthesized using PEG
Y Sawada et al.
British journal of plastic surgery, 47(3), 158-161 (1994-04-01)
A new drug delivery system, made of a mixture of DL-lactic acid polymer and a copoly (L-lactic acid/delta-valerolactone) polymer (LAP) containing varying concentrations of Ofloxacin, has been evaluated. Results revealed that a LAP drug delivery system containing 0.03% Ofloxacin inhibited
Total Synthesis of (+)-Guadinomic Acid via Hydroxyl-Directed Guanidylation
Reid BT, et al.
The Journal of Organic Chemistry, 83(16), 9492-9496 (2018)
Antonio Osorio-Lozada et al.
The Journal of organic chemistry, 74(3), 1360-1363 (2008-12-24)
The syntheses of simplactones (3R,4S)-1 and (3R,4R)-2 were achieved in 5 steps from N-acyl thiazolidinethione chiral auxiliaries. The syntheses feature a double diastereoselective acetate aldol reaction solely controlled by the chirality of the auxiliary. Highly diastereoselective aldol reactions with s-trioxane
Motofumi Osaki et al.
The Journal of organic chemistry, 74(5), 1858-1863 (2009-02-03)
BETA-cyclodextrin (beta-CD)-based nanosphere 1 initiated the oligomerization of delta-valerolactone (delta-VL) on the surface of 1 to give oligo(delta-VL)-tethered beta-CD nanosphere 2 in bulk. Atomic force microscopy indicated that the molecular size of 2 is twice that of 1. The addition
Leonid Gaidukov et al.
Biochemistry, 44(35), 11843-11854 (2005-09-01)
Serum paraoxonase (PON1) is a high-density lipoprotein (HDL)-associated enzyme exhibiting antiatherogenic properties. This study examined the interaction of recombinant PON1 with reconstituted HDL comprised of PC, cholesterol, and various apolipoproteins (apoA-I, -II, and -IV). The affinity, stability, and lactonase activity
Ratul Sarkar et al.
The Journal of pharmacy and pharmacology, 67(7), 951-962 (2015-04-02)
This study attempts to investigate the antimicrobial properties of Kalanchoe blossfeldiana with a particular reference to quorum sensing (QS)-mediated biofilm formation. The methanol extract of K. blossfeldiana leaves (MEKB) was evaluated for antimicrobial properties including QS-controlled production of biofilm (including virulence
Bowen Wang et al.
Biomaterials, 178, 293-301 (2018-06-30)
Drug-eluting stents are the most commonly employed method to control post-angioplasty restenosis. Unfortunately, they exacerbate life-threatening stent thrombosis because of endothelium damage caused by both drug and stenting. To solve this major medical problem, an endothelium-protective and stent-free anti-restenotic method
S Y Lin et al.
Journal of microencapsulation, 17(5), 577-586 (2000-10-19)
Three low-molecular weight polyesters, poly(L-lactic acid) (PLA), copoly(lactic acid/glycolic acid) (PLGA) and poly(delta-valerolactone) (PV), were used to prepare water-soluble sodium diclofenac-loaded microspheres by using the oil-in-oil (o/o) emulsification-solvent evaporation method. Their micromeritic and physicochemical properties, and degradation and dissolution behaviours
Helen Lee et al.
Biomacromolecules, 6(6), 3119-3128 (2005-11-15)
Six amphiphilic diblock copolymers based on methoxy poly(ethylene glycol) (MePEG) and poly(delta-valerolactone) (PVL) with varying hydrophilic and hydrophobic block lengths were synthesized via a metal-free cationic polymerization method. MePEG-b-PVL copolymers were synthesized using MePEG with Mn = 2000 or Mn
Ryo Shintani et al.
Organic letters, 11(24), 5642-5645 (2009-11-17)
A palladium-catalyzed decarboxylative [4 + 3] cyclization of gamma-methylidene-delta-valerolactones with 1,1-dicyanocyclopropanes has been developed to produce cycloheptane derivatives in a convergent manner. This method can be applied to the synthesis of azepanes by reacting with aziridines, and their asymmetric variants
Motofumi Osaki et al.
Organic & biomolecular chemistry, 7(8), 1646-1651 (2009-04-04)
Cinnamoyl alpha-cyclodextrin (alpha-CD) has been found to initiate polymerization of delta-valerolactone (delta-VL) to give a polymer in high yield. By the presence of the cinnamoyl group, hydrogen bond was formed between the carbonyl oxygen of delta-VL and the hydroxyl group
Organolanthanide-initiated living polymerizations of ε -caprolactone, δ-valerolactone, and β-propiolactone
Yamashita M, et al.
Macromolecules, 29(5), 1798-1806 (1996)
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