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Vidula Kolhatkar et al.
Pharmaceutical research, 32(1), 196-210 (2014-08-06)
An oligonucleotide termed 'T-oligo' having sequence homology with telomere overhang has shown cytotoxicity in multiple cancers. We have demonstrated that T-oligo can induce apoptosis in androgen independent prostate cancer cell line DU-145. In this report, we evaluate the use of
Douglas L Rothman et al.
Neurochemical research, 37(11), 2597-2612 (2012-10-30)
The high in vivo flux of the glutamate/glutamine cycle puts a strong demand on the return of ammonia released by phosphate activated glutaminase from the neurons to the astrocytes in order to maintain nitrogen balance. In this paper we review
Panfeng Yu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 959, 55-61 (2014-04-29)
This paper described a novel application of PEGylated magnetic carbon nanotubes as solid-phase extraction nanosorbents for the determination of puerarin in rat plasma by high performance liquid chromatography (HPLC). A solvothermal method was employed for the synthesis of monodisperse magnetites
Measurement and interpretation of plasma ammonia.
H J Lee et al.
British journal of hospital medicine (London, England : 2005), 75(3), C40-C43 (2014-03-14)
C Esteve et al.
Talanta, 146, 326-334 (2015-12-24)
A rapid and sensitive analytical method for the simultaneous determination of thirteen endocrine disruptors (five phthalates, seven parabens, and bisphenol A) in a single chromatographic run has been developed for the first time. The separation method, based on ultra-high performance
Yu Wan et al.
Environmental monitoring and assessment, 186(10), 6061-6081 (2014-06-19)
The odour emission characteristics of 22 recreational rivers in Nanjing were investigated and analysed. Eight odorous compounds (ammonia (NH₃), hydrogen sulphide (H₂S), sulphur dioxide (SO₂), carbon disulphide (CS₂), nitrobenzene (C₆H₅NO₂), aniline (C₆H₅NH₂), dimethylamine (C₂H₇N), and formaldehyde (HCHO)) were measured in
Gul N Shah et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(18), 7423-7428 (2013-04-17)
Prior studies with carbonic anhydrase (CA) inhibitors implicated mitochondrial CA in ureagenesis and gluconeogenesis. Subsequent studies identified two mitochondrial CAs. To distinguish the contribution of each enzyme, we studied the effects of targeted disruption of the murine CA genes, called
Han Yao et al.
Journal of pharmaceutical and biomedical analysis, 117, 232-239 (2015-09-18)
L-asparaginase is an effective anti-tumor agent for acute lymphoblastic leukemia. This work presents the development of an activity determination of L-ASNase preparations for pharmaceutical quality control purposes, in accordance with analytical Quality by Design principles. Critical method attributes, the absorbance
Andrea Speltini et al.
Journal of chromatography. A, 1379, 9-15 (2015-01-07)
This work presents a novel analytical method based on graphene for the determination of five widely used fluoroquinolones (FQs) in aqueous matrices. The procedure entails solid-phase extraction (SPE) on graphene-derivatized silica (200mg), followed by liquid chromatography with fluorescence detection. Monolayer
Wei Sun et al.
International immunopharmacology, 23(1), 247-253 (2014-09-15)
Resolvin D1 (RvD1), an endogenous lipid mediator derived from docosahexaenoic acid, has been reported to promote a biphasic activity in anti-inflammatory response and regulate inflammatory resolution. The present study aimed to determine the endogenous expression pattern of RvD1 in a
Jamie Jones et al.
The Science of the total environment, 502, 434-447 (2014-10-04)
To support nutrient removal, various stormwater treatment technologies have been developed via the use of green materials, such as sawdust, tire crumbs, sand, clay, sulfur, and limestone, as typical constituents of filter media mixes. These materials aid in the physiochemical
Kåre Nielsen et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 122(12), 1213-1222 (2014-07-24)
Liver collagen proportionate area (CPA) assessed by computer-assisted digital image analysis has been proposed as an accurate and objective histological variable for subclassifying cirrhosis. The study aimed to examine the relationship between CPA and relevant clinical parameters in cirrhotic patients
Niclas Stephanson et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 189-196 (2015-02-18)
A mass spectrometric method for drugs of abuse testing in exhaled breath employing a sampling device collecting aerosol particles was developed and applied in routine use. Analytes covered were amphetamine, methamphetamine, 6-acetylmorphine, morphine, cocaine, benzoylecgonine, diazepam, oxazepam and tetrahydrocannabinol. The
Maria Addolorata Saracino et al.
Journal of pharmaceutical and biomedical analysis, 104, 122-129 (2014-12-17)
A new microextraction by packed sorbent (MEPS) procedure coupled to a high-performance liquid chromatographic method has been developed for quantitation of catecholamines (i.e. norepinephrine, epinephrine and dopamine) in innovative biological samples, namely dried plasma and urine spots. Analyses were carried
Khosro Zangeneh Kamali et al.
TheScientificWorldJournal, 2014, 396135-396135 (2014-08-20)
Hematite (α-Fe2O3) nanoparticles were synthesized by the solid transformation of ferrous hydroxide and ferrihydrite in hydrothermal condition. The as-prepared α-Fe2O3 nanoparticles were characterized by UV-vis, PL, XRD, Raman, TEM, AFM, FESEM, and EDX analysis. The experimental results indicated the formation
Douglas Roberto Monteiro et al.
Medical mycology, 52(6), 627-635 (2014-06-22)
Our aim in this study was to evaluate how the chemical stability of silver nanoparticles (SNs) influences their efficacy against Candida albicans and C. glabrata biofilms. Several parameters of SN stability were tested, namely, temperature (50ºC, 70ºC, and 100ºC), pH
Man-Young Jung et al.
The ISME journal, 8(5), 1115-1125 (2013-11-15)
N2O gas is involved in global warming and ozone depletion. The major sources of N2O are soil microbial processes. Anthropogenic inputs into the nitrogen cycle have exacerbated these microbial processes, including nitrification. Ammonia-oxidizing archaea (AOA) are major members of the
Reassessing the role of astrocytes in ammonia neurotoxicity.
Tore Eid et al.
Nature medicine, 19(12), 1572-1574 (2013-12-07)
Chemistry. New recipe produces ammonia from air, water, and sunlight.
Robert F Service
Science (New York, N.Y.), 345(6197), 610-610 (2014-08-12)
Peter J McGuire et al.
Disease models & mechanisms, 7(2), 205-213 (2013-11-26)
The urea cycle functions to incorporate ammonia, generated by normal metabolism, into urea. Urea cycle disorders (UCDs) are caused by loss of function in any of the enzymes responsible for ureagenesis, and are characterized by life-threatening episodes of acute metabolic
Jun Wang et al.
Environmental science and pollution research international, 22(20), 15976-15984 (2015-06-10)
Ammonia is a common toxicant in aquatic systems; this substance has become a critical threat to fish, especially in early life stages. This study aimed to evaluate the effects of unionized ammonia (NH3-N: 0, 0.068, 0.138, 0.206, 0.275, 0.343, 0.412
Iván Castelló Serrano et al.
Nanoscale, 6(22), 13623-13629 (2014-10-03)
We present herein two colour encoded silica nanospheres (2nanoSi) for the fluorescence quantitative ratiometric determination of trypsin in humans. Current detection methods for cystic fibrosis diagnosis are slow, costly and suffer from false positives. The 2nanoSi proved to be a
Gayong Shim et al.
Journal of controlled release : official journal of the Controlled Release Society, 189, 80-89 (2014-06-29)
Here, we report reduced graphene oxide (rGO) nanosheets coated with an anti-angiogenic anticancer taurocholate derivative of low-molecular-weight heparin (LHT7) as a tumor-targeting nanodelivery platform for anticancer drugs. Surface coating of LHT7 onto rGO was confirmed using fluorescein isothiocyanate-labeled LHT7, monitored
Wenpei Fan et al.
Biomaterials, 35(32), 8992-9002 (2014-08-12)
To achieve the accurate diagnosis and efficient in situ therapy of malignant tumors is encouraging but still remains a big challenge. The integration of upconversion nanoparticles and mesoporous silica that can combine the diagnostic/therapeutic functions within a single platform, may
Dana Hocková et al.
Organic & biomolecular chemistry, 13(15), 4449-4458 (2015-03-15)
Protected N-branched nucleoside phosphonates containing adenine and thymine bases were prepared as the monomers for the introduction of aza-acyclic nucleotide units into modified oligonucleotides. The phosphotriester and phosphoramidite methods were used for the incorporation of modified and natural units, respectively.
Yingying Wen et al.
Journal of chromatography. A, 1368, 18-25 (2014-12-03)
A modified Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) method based on the dispersive solid-phase extraction (dSPE) combined with high performance liquid chromatography (HPLC) was developed for the determination of non-steroidal estrogens in water samples. In this study, graphene
Swen Langer et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 960, 73-81 (2014-05-06)
Water-soluble vitamins are an important class of compounds that require quantification from food sources to monitor nutritional value. In this study we have analysed six water-soluble B vitamins ([thiamine (B1), riboflavin (B2), nicotinic acid (B3, NAc), nicotinamide (B3, NAm), pyridoxal
Freimut Schliess et al.
Hepatology (Baltimore, Md.), 60(6), 2040-2051 (2014-03-29)
The impairment of hepatic metabolism due to liver injury has high systemic relevance. However, it is difficult to calculate the impairment of metabolic capacity from a specific pattern of liver damage with conventional techniques. We established an integrated metabolic spatial-temporal
Krzysztof Helewski et al.
Wiadomosci lekarskie (Warsaw, Poland : 1960), 56(11-12), 560-563 (2004-04-03)
Pathogenesis of hepatic encephalopathy has not been fully revealed and there are many factors which may affect its development. Ammonia and changes in GABA-ergic neurotransmission seem to be the most essential of these factors. Hepatic encephalopathy is frequently, though not
Jacek Wójcikowski et al.
Biochemical pharmacology, 90(2), 188-195 (2014-05-21)
The aim of the present study was to identify cytochrome P450 isoenzymes (CYPs) involved in the 5-sulfoxidation and N-demethylation of the aliphatic-type phenothiazine neuroleptic levomepromazine in human liver. Experiments were performed in vitro using cDNA-expressed human CYP isoforms (Supersomes 1A2
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