Showing 1-30 of 51 results for "40003"
Karoline Trescher et al.
Clinical hemorheology and microcirculation, 52(2-4), 391-401 (2012-09-15)
As shown in several studies, various properties of biomaterials such as stiffness, surface roughness, chemical composition or the amount of functional groups at the surface can influence adhesion, viability, proliferation and functionalities of cells. The aim of this work was...
K Hashimoto
Sangyo igaku. Japanese journal of industrial health, 22(5), 327-347 (1980-09-01)
Acrylonitrile (AN, CH2 = CH CN), a highly reactive compound having an active vinyl and cyanide group, has been widely used in various synthetic chemical industries. AN is known to produce toxic actions to human beings as well as experimental...
J Whysner et al.
Regulatory toxicology and pharmacology : RTP, 27(3), 217-239 (1998-08-07)
Acrylonitrile (ACN) exposure is associated with tumors in rat brain, Zymbal gland, and mammary gland. Adducts affecting base pairing were formed in isolated DNA exposed in vitro to the ACN metabolite cyanoethylene oxide (CNEO). DNA from liver, which is not...
[Hematological indicators after exposure to acrylonitrile (review of the literature)].
P P Kuznetsov et al.
Gigiena truda i professional'nye zabolevaniia, (7)(7), 41-43 (1986-07-01)
T De Smedt et al.
Toxicology letters, 231(3), 344-351 (2014-09-17)
On Saturday May 4, 2013, a train transporting chemicals derailed in the village of Wetteren (Belgium) and caused a leak of acrylonitrile (ACN). To assess the human exposure to acrylonitrile in the local population with the highest suspected exposure. Between...
Masaki Ohata et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 28(11), 1105-1108 (2012-11-15)
The stability of Hg in an acrylonitrile-butadiene-styrene disk certified reference material (ABS disk CRM, NMIJ CRM 8116-a) during measurements by wavelength dispersion X-ray fluorescence (WD-XRF) analysis was evaluated in this study. The XRF intensities of Hg (L(α)) and Pb (L(α))...
A Léonard et al.
Mutation research, 436(3), 263-283 (1999-06-04)
Acrylonitrile (AN) is an important intermediary for the synthesis of a variety of organic products, such as artificial fibres, household articles and resins. Although acute effects are the primary concern for an exposure to AN, potential genotoxic, carcinogenic and teratogenic...
N Scharnagl et al.
Clinical hemorheology and microcirculation, 52(2-4), 295-311 (2012-09-15)
The chemical composition of a substrate can influence the adhesion, viability and proliferation of cells seeded on the substrate. The aim of this work was to investigate the influence of different cationic or anionic moieties in acrylonitrile-based copolymers on the...
Shaoxia Lin et al.
Organic & biomolecular chemistry, 10(23), 4571-4576 (2012-05-10)
A highly efficient multi-component anion relay cascade reaction based on 1-acetylcyclopropanecarboxamides, aldehydes and acrylonitrile has been developed, which provides strategically novel and atom-economic access to biologically important biscyanoethylated furo[3,2-c]pyridinones. In this one-pot transformation, up to five bonds (one C-N, one...
National Toxicology Program technical report series, (573)(573), 1-155 (2012-07-28)
Styrene-acrylonitrile trimer (SAN Trimer) is a mixture of isomers formed by the condensation of two moles of acrylonitrile and one mole of styrene and has a molecular weight of 210. The mixture is composed of two structural forms: 4-cyano-1,2,3,4-tetrahydro-a-methyl-1-naphthaleneacetonitrile (THNA...
Philip Cole et al.
Regulatory toxicology and pharmacology : RTP, 52(3), 342-351 (2008-10-18)
Several retrospective cohort epidemiology studies evaluated a number of health outcomes in workers exposed to acrylonitrile (AN). The epidemiology studies included in this review have been published since 1970 and were identified through Ovid and MEDLINE retrieval services using search...
Acrylonitrile and human cancer--an overview.
D Coggon et al.
Scandinavian journal of work, environment & health, 24 Suppl 2, 81-82 (1998-08-26)
D Zhang et al.
Clinical radiology, 70(1), 74-80 (2014-12-03)
To detect the β-amyloid plaques (Aβ) in a rat model of Alzheimer's disease (AD) using superparamagnetic iron oxide nanoparticles coated with 1,1-dicyano-2-[6-(dimethylamino)-naphthalene-2-yl] propene carboxyl derivative (DDNP-SPIO). DDNP-SPIO was prepared in a previous trial. The binding affinity of DDNP-SPIO to Aβ...
N A Esmen
Scandinavian journal of work, environment & health, 24 Suppl 2, 63-70 (1998-08-26)
The reconstruction of worker exposures has been the mainstay of modem industrial epidemiologic studies. In most cases, the researchers are faced with the difficult dilemma created by the scarcity of the exposure measurement data vis-à-vis the demands for refined quantification....
M Duverger et al.
Toxicological European research. Recherche europeenne en toxicologie, 3(3), 131-140 (1981-05-01)
The mutagenic activity and the metabolism of four vinylic monomers; vinyl chloride, styrene, acrylonitrile and butadiene are reviewed. Those chemicals are converted by the mixed function oxidases system of the endoplasmic reticulum into reactive intermediates which can interact with macromolecules...
Mamta Behl et al.
Toxicology, 314(1), 84-94 (2013-09-26)
Styrene acrylonitrile (SAN) trimer is a by-product in the production of acrylonitrile styrene plastics. Following a report of a childhood cancer cluster in the Toms River section of Dover Township, New Jersey, SAN Trimer was identified as one of the...
Acrylonitrile, acrylic and modacrylic fibres, and acrylonitrile-butadiene-styrene and styrene-acrylonitrile copolymers.
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 19, 73-113 (1979-02-01)
H Sakurai
Industrial health, 38(2), 165-180 (2000-05-17)
The occupational exposure limit for acrylonitrile (AN) has been set by many organizations on the basis of its carcinogenicity. However, recent epidemiological studies do not afford evidence supporting the hypothesis that AN is carcinogenic to humans. Review of the 18...
M M Tarskikh et al.
Vestnik Rossiiskoi akademii meditsinskikh nauk, (2)(2), 63-66 (2013-07-04)
Statistical analysis within the 20-year period showed that approximately 49% of workers who were exposed to widespread industrial poison acrylonitrile subsequently died from malignancy of different localization. The conducted experimental investigations demonstrated that acrylonitrile with the subacute intoxication of animals...
Daan Huizer et al.
Toxicology letters, 231(3), 337-343 (2014-07-23)
The application of human physiologically based pharmacokinetic (PBPK) modeling combined with measured biomonitoring data, has a great potential to backtrack external exposure to chemicals during chemical incidents. So far, an important shortcoming of 'reversed dosimetry' is that uncertainty and variability...
Andrej Petric et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(41), 16492-16497 (2012-09-27)
The positron-emission tomography (PET) probe 2-(1-[6-[(2-fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene) (FDDNP) is used for the noninvasive brain imaging of amyloid-β (Aβ) and other amyloid aggregates present in Alzheimer's disease and other neurodegenerative diseases. A series of FDDNP analogs has been synthesized and characterized using...
Holly Meredith Kolenda-Roberts et al.
Toxicologic pathology, 41(1), 98-108 (2012-07-24)
Twenty-eight spontaneously occurring glial tumors (previously diagnosed as astrocytomas, oligodendrogliomas, and gliomas) and eleven granular cell tumors (GCTs) were selected for evaluation using a panel of immunohistochemistry (IHC) stains (Ricinus communis agglutinin type 1 [RCA-1], ionized calcium-binding adapter molecule 1...
Danish J Malik et al.
PloS one, 7(8), e43354-e43354 (2012-08-24)
Novel carbon materials have been prepared by the carbonization of acrylonitrile (AN)/divinylbenzene (DVB) suspension porous copolymers having nominal crosslinking degrees in the range of 30-70% and obtained in the presence of various amounts of porogens. The carbons were obtained by...
A Van Nieuwenhuyse et al.
Toxicology letters, 231(3), 352-359 (2014-08-17)
On May 4, 2013, a train transporting chemicals derailed in Wetteren, Belgium. Several tanks loaded with acrylonitrile (ACN) exploded, resulting in a fire and a leakage of ACN. To determine exposure to ACN and to assess discriminating factors for ACN...
Takashi Tomioka et al.
Organic & biomolecular chemistry, 10(26), 5113-5118 (2012-05-24)
α-Diaminoboryl carbanions, readily prepared from acetonitrile, stereoselectively convert 2-nitrobenzaldehydes into nitrophenyl (Z)-acrylonitriles. Subsequent reductive cyclization leads to a series of 2-aminoquinoline derivatives. The entire procedure is practically operated in a single flask.
Gabriele Leng et al.
Toxicology letters, 231(3), 360-364 (2014-06-25)
The analytical determination of hemoglobin adducts was used as an effective biomonitoring tool after a fire outbrake at a chemical plant close to Cologne/Germany in 2008. More than 1000 people (e.g. fire-men, police officers, and workers) were potentially exposed to...
Barbara H Neal et al.
Critical reviews in toxicology, 39(7), 589-612 (2009-08-05)
Risk assessment of acrylonitrile (AN) toxicity to humans has focused on potential carcinogenicity and acute toxicity. Epidemiological studies from China reported reproductive and developmental effects in AN workers, including infertility, birth defects, and spontaneous abortions. A weight-of-the-evidence (WoE) evaluation of...
Jinqing Zhou et al.
Organic & biomolecular chemistry, 10(21), 4179-4185 (2012-05-02)
In the current study, a convenient and simple way is presented to synthesize a novel type of supported heterogeneous organocatalyst in 21-81% yield by the copolymerization of 9-amino-9-deoxy-epi-cinchonine organocatalyst with acrylonitrile using AIBN as radical initiator. The chemical compositions (x/y)...
Hongwei Hou et al.
Analytical biochemistry, 430(1), 75-82 (2012-08-08)
The acrylonitrile metabolites 2-cyanoethylmercapturic acid (CEMA) and 2-hydroxyethylmercapturic acid (HEMA) have been determined in human urine using an automated column-switching procedure. A diluted sample was centrifuged just prior to being injected into a reusable precolumn packed with a restricted access...
S Guedidi et al.
Enzyme and microbial technology, 51(6-7), 325-333 (2012-10-09)
A combined fluorescence analysis, involving the use of steady-state fluorescence and fluorescence anisotropy was used, allowing eliciting information about the structural changes induced on trypsin after exposure to membrane surfaces with diverse chemistry, designed through a layer-by-layer methodology. Using this...

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