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Estella Rao et al.
Biochimica et biophysica acta. General subjects, 1863(5), 784-794 (2019-02-12)
The interaction between proteins and membranes is of great interest in biomedical and biotechnological research for its implication in many functional and dysfunctional processes. We present an experimental study on the interaction between model membranes and alpha-lactalbumin (α-La). α-La is
Arthur Sletten et al.
Biochemical and biophysical research communications, 452(3), 422-427 (2014-08-31)
All eukaryotic organisms store excess lipid in intracellular lipid droplets. These dynamic structures are associated with and regulated by numerous proteins. Perilipin 2, an abundant protein on most lipid droplets, promotes neutral lipid accumulation in lipid droplets. However, the mechanism
Alessandra Luchini et al.
Colloids and surfaces. B, Biointerfaces, 168, 2-9 (2018-05-08)
Gold nanoparticles (AuNPs) are considered suitable systems for drug delivery and diagnostics with several applications in biomedicine. Size, shape and surface functionalization of these nanoparticles are important parameters influencing their behavior in a biological environment. This study describes the preparation
Magali Deleu et al.
Biochimica et biophysica acta, 1828(2), 801-815 (2012-11-20)
Surfactin, a bacterial amphiphilic lipopeptide is attracting more and more attention in view of its bioactive properties which are in relation with its ability to interact with lipids of biological membranes. In this work, we investigated the effect of surfactin
Arianna Ceccarelli et al.
Biochimica et biophysica acta, 1862(9), 813-822 (2017-05-14)
In this study we provide the first evidence of the interaction of a truncated-TRAF2 with lipid raft microdomains. We have analyzed this interaction by measuring the diffusion coefficient of the protein in large and giant unilamellar vesicles (LUVs and GUVs
N S Ríos Colombo et al.
Biochimie, 165, 183-195 (2019-08-06)
Class II bacteriocins are unmodified membrane-active peptides that act over a narrow spectrum of target bacteria. They bind a specific receptor protein on the membrane to form a pore, leading to membrane permeabilization and cell death. However, little is known
Justyna Barucha-Kraszewska et al.
Langmuir : the ACS journal of surfaces and colloids, 29(4), 1174-1182 (2013-01-15)
Development of fluorescence methods involves the necessity of understanding the fluorescent probes behavior in their ground and excited states. In the case of biological membranes, the position of the dyes in the lipid bilayer and their response after excitation are
Seiichi Morita et al.
Journal of bioscience and bioengineering, 125(4), 457-463 (2017-11-28)
The effect of the saturation of fatty acid (FA) in 1,2-dimyristoyl-sn-glycero-3-phosphocoline (DMPC)/FA membrane on the interaction between lipid membrane and amyloid β monomer was investigated by using the Langmuir monolayer technique. The surface pressure (Π)-mean molecular area (A) isotherms and
Johannes Franz et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 23(40), 9690-9697 (2017-05-16)
Nitrated fatty acids (NO
Ludmila Michaylovna Lukyanenko et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 27(2), 160-167 (2012-12-04)
Aluminum belongs to a group of potential toxic elements capable of penetrating the human body. In this paper, the effect of aluminum concentrations on red blood cell membranes using different fluorescent probes able to localize in various parts of the
Keita Hayashi et al.
Colloids and surfaces. B, Biointerfaces, 87(1), 28-35 (2011-05-31)
The surface properties of Span 80 vesicles at various cholesterol contents, together with those of various liposomes, were characterized by using fluorescence probes. The membrane fluidity of the Span 80 vesicles was measured by 1,6-diphenyl-1.3.5-hexatriene (DPH) and trimethlyammonium-DPH (TMA-DPH), and
Hugo A Pérez et al.
Colloids and surfaces. B, Biointerfaces, 178, 346-351 (2019-03-23)
Comparison of the behavior of Laurdan in gel and in the liquid crystalline DPPC bilayers with that observed in chloroform and OctOH allow concluding that changes in the membrane lipid order cannot be ascribed to changes in viscosity of the
Dylan M Owen et al.
Nature communications, 3, 1256-1256 (2012-12-06)
Lipid microdomains are postulated to regulate many membrane-associated processes but have remained highly controversial. Here we provide the first direct evidence that the plasma membrane of intact, live cells is comprised of a sub-resolution mixture of approximately 76% ordered and
Patrycja Zawilska et al.
Biophysical chemistry, 221, 1-9 (2016-11-20)
Long-chain alkylresorcinols (ARs) are commonly found in plant and bacteria cells, and they exhibit a wide variety of biological effects, including antifungal, antitumor, and antiphrastic activities. The cholesterol (Chol)-like effect of ARs with hydrocarbon side-chain lengths ranging from C15 to
Adéla Melcrová et al.
Langmuir : the ACS journal of surfaces and colloids, 35(35), 11358-11368 (2019-08-09)
Regulation of cell metabolism, membrane fusion, association of proteins with cellular membranes, and cellular signaling altogether would not be possible without Ca2+ ions. The distribution of calcium within the cell is uneven with the negatively charged inner leaflet of the
Nozomi Watanabe et al.
The journal of physical chemistry. B, 121(39), 9213-9222 (2017-08-19)
Bilayer vesicles have garnered considerable research attention as molecular vehicles capable of noncovalent interaction with biomolecules via electrostatic and hydrophobic bonds and van der Waals interactions. Guanidinium strongly interacts with phosphate groups. Thus, guanidinium modification of vesicles helps intensify the
S Hofstetter et al.
Applied and environmental microbiology, 79(6), 2103-2106 (2013-01-22)
This study determined the membrane fluidity of clostridial endospores during treatment with heat and pressure with nisin or reutericyclin. Heating (90°C) reduced laurdan (6-dodecanoyl-2-dimethylaminonaphthalene) general polarization, corresponding to membrane fluidization. Pressure (200 MPa) stabilized membrane order. Reutericyclin and nisin exhibit
Erdinc Sezgin et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 16(7), 1387-1394 (2015-03-11)
Physicochemical properties of the plasma membrane have been shown to play an important role in cellular functionality. Among those properties, the molecular order of the lipids, or the lipid packing, is of high importance. Changes in lipid packing are believed
Ayaka Ito et al.
eLife, 4, e08009-e08009 (2015-07-15)
The liver X receptors (LXRs) are transcriptional regulators of lipid homeostasis that also have potent anti-inflammatory effects. The molecular basis for their anti-inflammatory effects is incompletely understood, but has been proposed to involve the indirect tethering of LXRs to inflammatory
Jian Peng et al.
Antibiotics (Basel, Switzerland), 10(1) (2021-01-07)
Increasing microbial resistance, coupled with a lack of new antimicrobial discovery, has led researchers to refocus on antimicrobial peptides (AMPs) as novel therapeutic candidates. Significantly, the less toxic cecropins have gained widespread attention for potential antibacterial agent development. However, the
Martín M Dodes Traian et al.
Journal of lipid research, 53(3), 609-616 (2011-12-21)
Lateral organization of biological membranes is frequently studied using fluorescence microscopy. One of the most widely used probes for these studies is 2-dimethylamino-6-lauroylnaphthalene (laurdan). The fluorescence of this probe is sensitive to the environment polarity, and thus laurdan reports the
Nicolas Puff et al.
Biochimica et biophysica acta, 1838(8), 2105-2114 (2014-05-20)
Lipid rafts are assumed to undergo biologically important size-modulations from nanorafts to microrafts. Due to the complexity of cellular membranes, model systems become important tools, especially for the investigation of the factors affecting "raft-like" Lo domain size and the search
Ioan Tivig et al.
European biophysics journal : EBJ, 49(1), 105-111 (2019-12-25)
The electroporation of cells is nowadays used for a large variety of purposes, from basic research to cancer therapy and food processing. Understanding molecular mechanisms of the main processes involved in electroporation is thus of significant interest. In the present
Laura Bordoni et al.
Antioxidants (Basel, Switzerland), 9(1) (2019-12-28)
Extra virgin olive (EVO) oil and Nigella sativa (NG) oil are two well-known Mediterranean foods whose consumption has been associated with beneficial effects on human health. This study investigates the nutrigenomic properties of two high quality EVO and NG oils
M A Soto-Arriaza et al.
Journal of colloid and interface science, 385(1), 48-57 (2012-08-15)
In the present work, we analyze the effect of incorporation of the nonanol family (e.g., 1-Nonanol (1-N), 5-Nonanol (5-N), and 2,6-Dimethyl-4-Heptanol (2,6-DH)) into DPPC LUVs in the presence of different gramicidin concentrations. The principal aim of this work is to
Cristiana Angelucci et al.
PloS one, 7(12), e50804-e50804 (2012-12-20)
Interactions occurring between malignant cells and the stromal microenvironment heavily influence tumor progression. We investigated whether this cross-talk affects some molecular and functional aspects specifically correlated with the invasive phenotype of breast tumor cells (i.e. adhesion molecule expression, membrane fluidity
Lakshmi N M Suri et al.
Biochimica et biophysica acta, 1818(7), 1581-1589 (2012-03-06)
The interfacial surface tension of the lung is regulated by phospholipid-rich pulmonary surfactant films. Small changes in temperature affect surfactant structure and function in vitro. We compared the compositional, thermodynamic and functional properties of surfactant from hibernating and summer-active 13-lined
Bao Zhu et al.
Chemosphere, 247, 125876-125876 (2020-01-25)
Aluminium oxide nanoparticles (Al2O3 NPs) potentially cause health hazards after their release into the environment. The crystalline phase of Al2O3 NPs determines their surface structure and the number of functional groups. The adsorption of natural organic matter (NOM) or biomolecules
Aaron Peng et al.
Chemistry and physics of lipids, 165(1), 15-22 (2011-10-26)
Liposomes consisted of phosphatidylinositol (PI) and phosphatidylcholine (PC) have been utilized as delivery vehicle for drugs and proteins. In the present work, we studied the effect of soy PI on physical properties of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) liposomes such as phase state
Beatriz Apellániz et al.
Journal of virology, 88(22), 13367-13377 (2014-09-12)
The HIV-1 glycoprotein 41 promotes fusion of the viral membrane with that of the target cell. Structural, biochemical, and biophysical studies suggest that its membrane-proximal external region (MPER) may interact with the HIV-1 membrane and induce its disruption and/or deformation
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