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407712

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Frédéric Mercier et al.
Bioorganic & medicinal chemistry, 18(21), 7422-7431 (2010-10-05)
Various peptidoglycan fragments were synthesized from two anhydro-muramic acid derivatives protected with a Bn or a PMB group at the 4th position, in homogenate phase or on a solid support. In order to facilitate HPLC detection, a chromophoric group was
Aditya Kapil Valiveti et al.
Chemico-biological interactions, 237, 125-132 (2015-06-14)
A series of mono pyridinium oximes linked with arenylacetamides as side chains were synthesized and their in vitro reactivation potential was evaluated against human acetylcholinesterase (hAChE) inhibited by organophosphorus inhibitors (OP) such as sarin, VX and tabun. The reactivation data
Kristin Samuelsson et al.
Chemical research in toxicology, 24(1), 35-44 (2010-11-16)
Diphenylthiourea (DPTU) is a known skin sensitizer commonly used as a vulcanization accelerator in the production of synthetic rubber, for example, neoprene. The versatile usage of neoprene is due to the multifaceted properties of the material; for example, it is
A benzylamine oxidase distinct from monoamine oxidase B--widespread distribution in man and rat.
R Lewinsohn et al.
Biochemical pharmacology, 27(14), 1857-1863 (1978-01-01)
Saioa Gomez-Zorita et al.
Journal of physiology and biochemistry, 69(3), 585-593 (2013-01-15)
Resveratrol is a naturally occurring polyphenol found in many dietary sources and red wine. Recognized as a cancer chemoprevention agent, an anti-inflammatory factor and an antioxidant molecule, resveratrol has been proposed as a potential anti-obesity compound and to be beneficial
Hélène Lebel et al.
Chemical communications (Cambridge, England), 48(63), 7799-7801 (2012-07-04)
A novel chiral N-mesyloxycarbamate to perform rhodium-catalyzed stereoselective C-H amination reactions is reported. Chiral benzylic and propargylic amines are produced in good yields and selectivities using ethyl acetate as solvent. The corresponding free amines are easily obtained by cleavage of
Preparation and characterization of azlactone functionalized polymer supports and their application as scavengers.
Guyomard A, et al.
Eur. Polymer J., 40(10), 2343-2348 (2004)
Mahmoud H El-Maghrabey et al.
Analytica chimica acta, 881, 139-147 (2015-06-05)
A fast, simple, and sensitive flow injection analysis method was developed for the measurement of semicarbazide-sensitive amine oxidase (SSAO) activity in human serum. Benzaldehyde, generated by the action of SSAO after incubation of serum with benzylamine, was derivatized with a
Sandra Grès et al.
Journal of physiology and biochemistry, 68(4), 651-662 (2012-05-02)
Semicarbazide-sensitive amine oxidase (SSAO) is a transmembrane enzyme that metabolizes primary amines from endogenous or dietary origin. SSAO is highly expressed in adipose, smooth muscle and endothelial cells. In each of these cell types, SSAO is implicated in different biological
Charlene Galea et al.
Journal of pharmaceutical and biomedical analysis, 111, 333-343 (2015-01-30)
Supercritical fluid chromatography (SFC) is drawing considerable interest as separation technique in the pharmaceutical industry. The technique is already well established in chiral separations both analytically and on a preparative scale. The use of SFC as a technique for drug
Jia Liu et al.
Analytica chimica acta, 689(1), 69-76 (2011-02-23)
(5R)-Hydroxytriptolide, a semisynthetic structural analog of triptolide, exhibits anti-inflammatory and immunosuppressive effect both in vitro and in vivo. The compound is currently undergoing Phase I clinical trials. This work describes the quantification of (5R)-hydroxytriptolide in human plasma based on chemical
Hong Cao et al.
Organic letters, 13(1), 11-13 (2010-12-02)
A versatile synthesis of unsaturated seven-membered ring lactams has been developed. The sequence involves hydroamination of Baylis-Hillman acetate with amines, followed by intramolecular cyclocarbonylation reactions of the resulting allylamines. This process can tolerate a wide array of functional groups, and
Capillary electrophoresis of alkali and alkaline-earth cations with imidazole or benzylamine buffers.
Morin PCF and Dreux M.
Journal of Liquid Chromatography and Related Technologies, 17(18), 3869-3888 (1994)
Ren-Qi Wang et al.
Analytica chimica acta, 853, 608-616 (2014-12-04)
A hydrophilic interaction liquid chromatography (HILIC) method was developed to measure the composition of humic substances from river, reservoir, and treated wastewater based on their physicochemical properties. The current method fractionates the humic substances into four well-defined groups based on
E S Simon et al.
Rapid communications in mass spectrometry : RCM, 26(6), 631-638 (2012-02-14)
Motivated by the need for chemical strategies designed to tune peptide fragmentation to selective cleavage reactions, benzyl ring substituent influence on the relative formation of carbocation elimination (CCE) products from peptides with benzylamine-derivatized lysyl residues has been examined using collision-induced
Liujiao Bian et al.
Journal of chromatography. A, 1401, 42-51 (2015-05-20)
The interactions between angiogenesis inhibitor Kringle 5 and its five specific ligands were investigated by frontal affinity chromatography in combination with fluorescence spectra and site-directed molecular docking. The binding constants of trans-4-(aminomethyl) cyclohexane carboxylic acid (AMCHA), epsilon-aminocaproic acid (EACA), benzylamine
Giulia Caron et al.
Journal of medicinal chemistry, 48(9), 3269-3279 (2005-04-29)
Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm of the partition coefficient of the neutral species in
Chris J Weston et al.
The Journal of clinical investigation, 125(2), 501-520 (2015-01-07)
Nonalcoholic fatty liver disease (NAFLD) encompasses a range of manifestations, including steatosis and cirrhosis. Progressive disease is characterized by hepatic leukocyte accumulation in the form of steatohepatitis. The adhesion molecule vascular adhesion protein-1 (VAP-1) is a membrane-bound amine oxidase that
A Olivieri et al.
Journal of biochemical and molecular toxicology, 25(1), 26-27 (2011-02-16)
Semicarbazide-sensitive amine oxidase (SSAO) is a copper-containing enzyme that catalyzes the oxidative deamination of endogenous and exogenous primary amines. SSAO exists in mammals both as a plasma-soluble and as a membrane-bound form, and its active site is able to come
Valerie J Klema et al.
Biochemistry, 52(13), 2291-2301 (2013-03-05)
Copper amine oxidases (CAOs) are responsible for the oxidative deamination of primary amines to their corresponding aldehydes. The CAO catalytic mechanism can be divided into two half-reactions: a reductive half-reaction in which a primary amine substrate is oxidized to its
Zhiqiang Guo et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 83(1), 344-347 (2011-09-17)
[Ni(CH(3)COO)(2)·(NH(2)CH(2)Ph)(4)] complex was synthesized using benzylamine and nickel acetate. The molecular structure of this complex was obtained by single crystal X-ray diffraction and characterized by elemental analysis, IR spectrometry and thermal analysis. The complex crystallized in the monoclinic space group
C Carpéné et al.
Physiological research, 61(3), 251-257 (2012-04-07)
Uric acid is involved in nitrogenous waste in animals, together with ammonia and urea. Uric acid has also antioxidant properties and is a surrogate marker of metabolic syndrome. We observed that the elevated plasma uric acid of high-fat fed mice
Keiichiro Ohara et al.
Journal of medicinal chemistry, 50(26), 6465-6475 (2007-12-07)
A series of polyaromatic guanidino derivatives was synthesized and evaluated for growth inhibitory properties in several human carcinoma cell lines. The properties of these guanidino compounds were compared to those of their corresponding synthetic amino precursors. The size of the
Tamilselvan Mohan et al.
Biomacromolecules, 16(8), 2403-2411 (2015-07-23)
In this contribution, a hydrophobically modified polysaccharide derivative is synthesized in an eco-friendly solvent water by conjugation of benzylamine with the backbone of the biopolymer. Owing to the presence of aromatic moieties, the resulting water-soluble polysaccharide derivative self-assembles spontaneously and
Eagleson M.
Concise Encyclopedia Chemistry, 125-125 (1994)
Josep Mercader et al.
Future medicinal chemistry, 2(12), 1735-1749 (2011-03-25)
Benzylamine exerts insulin-like effects in adipocytes (e.g., glucose uptake and antilipolysis) and improves glucose handling in rodents. In murine adipocytes, benzylamine mimics another insulin action: it enhances apelin expression in a manner that is blocked by the semicarbazide-sensitive amine oxidase/vascular
Michael L Berger et al.
Bioorganic & medicinal chemistry, 17(9), 3456-3462 (2009-04-07)
We resolved 1,2-diphenylethylamine (DPEA) into its (S)- and (R)-enantiomer and used them as precursors for synthesis of (S)- and (R)-1-(1,2-diphenylethyl)piperidine, flexible homeomorphs of the NMDA channel blocker MK-801. We also describe the synthesis of the dicyclohexyl analogues of DPEA. These
Cécilia Ménard-Moyon et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 17(11), 3222-3227 (2011-02-11)
Carbon nanotubes (CNTs) are very promising as carriers for the delivery of bioactive molecules. The multifunctionalization of CNTs is necessary to impart multimodalities for the development of future CNT-based multipotent therapeutic constructs. In this context, we report the first example
Zi Jun Wang et al.
ChemSusChem, 8(20), 3459-3464 (2015-09-10)
Metal-free visible-light photocatalysts offer a clean, sustainable solution to many pressing environmental issues. Herein, we present a molecular design strategy to fine-tune the valence and conduction band levels of a series of conjugated microporous polymer networks based on poly(benzochalcogenadiazole) for
Fei Mao et al.
Bioorganic & medicinal chemistry, 20(19), 5884-5892 (2012-09-05)
In an effort to identify novel multifunctional drug candidates for the treatment of Alzheimer's disease (AD), a series of hybrid molecules were synthesised by reacting N-(aminoalkyl)tacrine with salicylic aldehyde or derivatives of 2-aminobenzaldehyde. These compounds were then evaluated as multifunctional
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