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Eduardo J M Paiva et al.
Ultrasonics sonochemistry, 20(3), 833-838 (2012-12-05)
Ethyl esters of babassu oil were synthesized by alkaline catalysis to make the green production of biodiesel feasible with simple methods and available technology. Babassu oil is a transparent, light yellow oil extracted from the seeds of the babassu palm
Heng-guo Wang et al.
ChemSusChem, 6(1), 56-60 (2012-12-12)
Between the sheets: Sodium-ion batteries are an attractive, low-cost alternative to lithium-ion batteries. Nitrogen-doped porous carbon sheets are prepared by chemical activation of polypyrrole-functionalized graphene sheets. When using the sheets as anode material in sodium-ion batteries, their unique compositional and
A Potasiewicz et al.
British journal of pharmacology, 172(21), 5123-5135 (2015-08-16)
α7 nicotinic acetylcholine receptors (α7 nAChRs) may represent useful targets for cognitive improvement. The aim of this study is to compare the pro-cognitive activity of selective α7-nAChR ligands, including the partial agonists, DMXBA and A-582941, as well as the positive
Yomi Watanabe et al.
Journal of oleo science, 64(11), 1193-1205 (2015-11-03)
The positional distributions of fatty acids (FAs) in fats and oils are principally analyzed by selectively transesterifying the target triacylglycerols (TAGs) at the 1(3) position using Pseudozyma (Candida) antarctica lipase, followed by recovering the resulting 2-monoacylglycerols (MAGs) by chromatography. FA
Bogdan K Ostafiychuk et al.
Nanoscale research letters, 10, 65-65 (2015-04-09)
The results of electrochemical studies of nanoporous carbon as electrode material for electrochemical capacitors (EC) are presented in this work. Nanoporous carbon material (NCM) was obtained from the raw materials of plant origin by carbonization and subsequent activation in potassium
Carlos H Niño et al.
Memorias do Instituto Oswaldo Cruz, 110(7), 890-897 (2015-11-13)
The intracellular parasite Trypanosoma cruzi is the aetiological agent of Chagas disease, a public health concern with an increasing incidence rate. This increase is due, among other reasons, to the parasite's drug resistance mechanisms, which require nicotinamide adenine dinucleotide (NAD+).
Anna A DePaoli-Roach et al.
The Journal of biological chemistry, 290(2), 841-850 (2014-11-25)
Glycogen is a branched polymer of glucose that acts as an energy reserve in many cell types. Glycogen contains trace amounts of covalent phosphate, in the range of 1 phosphate per 500-2000 glucose residues depending on the source. The function
Peng Li et al.
Angewandte Chemie (International ed. in English), 54(2), 574-577 (2014-11-15)
Self-assembly of a trigonal building subunit with diaminotriazines (DAT) functional groups leads to a unique rod-packing 3D microporous hydrogen-bonded organic framework (HOF-3). This material shows permanent porosity and demonstrates highly selective separation of C2H2/CO2 at ambient temperature and pressure.
Taeko Kubo et al.
Journal of pharmacological sciences, 127(1), 127-134 (2015-02-24)
The human ether-a-go-go-related gene (HERG) potassium current (IHERG) has been shown to decrease in amplitude following stimulation with Gq protein-coupled receptors (GqRs), such as α1-adrenergic and M1-muscarinic receptors (α1R and M1R, respectively), at least partly via the reduction of membrane
Hong-Min Kim et al.
PloS one, 10(3), e0120711-e0120711 (2015-03-31)
Hepatic steatosis is the accumulation of excess fat in the liver. Recently, hepatic steatosis has become more important because it occurs in the patients with obesity, type 2 diabetes, and hyperlipidemia and is associated with endoplasmic reticulum (ER) stress and
Kun Qi et al.
Nanoscale, 6(24), 15090-15097 (2014-11-06)
Palladium porous single-crystalline nanoflowers (PSNFs) with enriched high catalytic activity {100} facets were synthesized using a mild and controllable seed mediated growth method. The growth mechanism of the Pd PSNFs was investigated using time dependent morphology evolution through TEM imaging.
Yoshinori Minami et al.
International journal of oncology, 46(2), 548-554 (2014-12-02)
Prostaglandin I2 (PGI2) agonist has been reported to reduce tumor metastasis by modifying tumor angiogenesis; however, the mechanisms of how PGI2 affects the endothelial cells or pericytes in tumor vessel maturation are still unclear. The purpose of this study was
Wei Wang et al.
PloS one, 10(4), e0119005-e0119005 (2015-04-24)
Conjugated linoleic acid (CLA) reduces adiposity in human and mouse adipocytes. This outcome is achieved through a variety of biological responses including increased energy expenditure and fatty acid oxidation, increased inflammation, repression of fatty acid biosynthesis, attenuated glucose transport, and
Luís G Dias et al.
Analytica chimica acta, 900, 36-45 (2015-11-18)
Nowadays the main honey producing countries require accurate labeling of honey before commercialization, including floral classification. Traditionally, this classification is made by melissopalynology analysis, an accurate but time-consuming task requiring laborious sample pre-treatment and high-skilled technicians. In this work the
John D Howa et al.
Forensic science international, 244, 152-157 (2014-09-23)
Isotope ratio analysis allows forensic investigators to discriminate materials that are chemically identical but differ in their isotope ratios. Here we focused on the discrimination of pentaerythritol tetranitrate (PETN), an explosive with military and civilian applications, using carbon (δ(13)C) and
Neil E Hill et al.
Critical care medicine, 43(3), e84-e96 (2015-02-24)
To characterize a long-term model of recovery from critical illness, with particular emphasis on cardiorespiratory, metabolic, and muscle function. Randomized controlled animal study. University research laboratory. Male Wistar rats. Intraperitoneal injection of the fungal cell wall constituent, zymosan or n-saline.
Sahar Mohammad Bagheri et al.
Chemical biology & drug design, 86(5), 1215-1220 (2015-05-27)
A series of 4-hydroxycoumarin-derived compounds 8a-p containing N-benzyl-1,2,3-triazole motif were designed as AChE inhibitors. The title compounds were obtained conveniently using multicomponent click reaction. The in vitro anticholinesterase evaluation of synthesized compounds against AChE and BuChE showed that some of them
Fanny Coumes et al.
Biomacromolecules, 16(11), 3666-3673 (2015-10-17)
Cancer vaccines are considered to be a promising tool for cancer immunotherapy. However, a well-designed cancer vaccine should combine a tumor-associated antigen (TAA) with the most effective immunomodulatory agents and/or delivery system to provoke intense immune responses against the TAA.
Vitor H Teixeira et al.
Molecular pharmaceutics, 12(3), 898-909 (2015-01-16)
Isoniazid (INH) is still one of the two most effective antitubercular drugs and is included in all recommended multitherapeutic regimens. Because of the increasing resistance of Mycobacterium tuberculosis to INH, mainly associated with mutations in the katG gene, new INH-based
Farhad Handjani et al.
The Journal of dermatological treatment, 25(3), 249-250 (2013-08-09)
Molluscum contagiosum (MC) is a common cutaneous viral infection. Potassium hydroxide (KOH), as a strong alkali, and cryotherapy have been used for its treatment. The objective of this study was to compare these two treatment modalities. 30 patients, aged between
Navamoney Arulsamy et al.
The Journal of organic chemistry, 77(17), 7313-7318 (2012-08-03)
Nitric oxide adds to methyl acetoacetate in the presence of KOH in methanol at room temperature to form potassium acetylsydnonate N-oxide (K1) with an (E)-diazeniumdiolation and potassium acetate diazenium diolate (K(2)2) from a (Z)-diazeniumdiolation. A study of the reaction with
Kazuya Mizukami et al.
American journal of physiology. Heart and circulatory physiology, 309(6), H1066-H1074 (2015-08-25)
Left ventricular hypertrophy is associated with an increased risk of ventricular arrhythmias. However, the underlying molecular basis is poorly understood. It has been reported that small-conductance Ca(2+)-activated K(+) (SK) channels are involved in the pathogenesis of ventricular arrhythmias in heart
Rahul Nagar et al.
Indian journal of dermatology, venereology and leprology, 78(5), 620-624 (2012-09-11)
Onychomycosis is one of the most common nail disorders. Mycological examination by potassium hydroxide (KOH) mount and fungal culture is the most commonly used diagnostic method. However, it is associated with a low sensitivity. To evaluate the technique of subungual
Kurian A Kuttiyiel et al.
Nature communications, 5, 5185-5185 (2014-11-07)
Considerable efforts to make palladium and palladium alloys active catalysts and a possible replacement for platinum have had a marginal success. Here we report on a structurally ordered Au10Pd₄₀Co₅₀ catalyst that exhibits comparable activity to conventional platinum catalysts in both
Ute Armbruster et al.
Nature communications, 5, 5439-5439 (2014-12-03)
Many photosynthetic organisms globally, including crops, forests and algae, must grow in environments where the availability of light energy fluctuates dramatically. How photosynthesis maintains high efficiency despite such fluctuations in its energy source remains poorly understood. Here we show that
Espérance Moine et al.
European journal of medicinal chemistry, 105, 80-105 (2015-10-20)
Using a structure-based design approach, we have developed a new series of imidazo[1,2-b]pyridazines, targeting the calcium-dependent protein kinase-1 (CDPK1) from Toxoplasma gondii. Twenty derivatives were thus synthesized. Structure-activity relationships and docking studies confirmed the binding mode of these inhibitors within
Mohammad Hosein Farzaei et al.
Pharmaceutical biology, 53(3), 429-436 (2014-12-05)
Tragopogon graminifolius DC. (Compositae) (TG) has been proposed as an efficacious remedy for gastrointestinal ulcers in Iranian traditional medicine. The present study evaluates the efficacy of TG on experimental colitis and the responsible mechanisms. After induction of IBD by 2,4,6-trinitrobenzenesulfonic
Benoît Chatin et al.
The Biochemical journal, 463(3), 339-349 (2014-08-05)
The major cardiac voltage-gated sodium channel Nav1.5 associates with proteins that regulate its biosynthesis, localization, activity and degradation. Identification of partner proteins is crucial for a better understanding of the channel regulation. Using a yeast two-hybrid screen, we identified dynamitin
Anas Al-Hussein et al.
Pharmaceutical development and technology, 20(1), 50-59 (2013-11-30)
The objective of this study was to investigate both the cryoprotective and lyoprotective effects of the polymer hydroxyethyl cellulose (HEC) on the model protein lactate dehydrogenase (LDH) during freeze thawing and freeze drying cycles. The effect of annealing on both
Patrick Forny et al.
Human mutation, 35(12), 1449-1458 (2014-08-16)
Methylmalonyl-CoA mutase (MUT) is an essential enzyme in propionate catabolism that requires adenosylcobalamin as a cofactor. Almost 250 inherited mutations in the MUT gene are known to cause the devastating disorder methylmalonic aciduria; however, the mechanism of dysfunction of these
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