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F Wang et al.
Journal of chromatography. A, 883(1-2), 113-118 (2000-07-26)
A rapid and simple method is presented for determining neuro-excitatory nonprotein amino acid 3-N-oxalyl-2,3-diaminopropionic acid (beta-ODAP) and non-protein amino acids in Lathyrus sativus. Seed and foliage extracts of Lathyrus sativus were treated with 1-fluoro-2,4-dinitrobenzene (FDNB) and a reversed-phase high-performance liquid...
Wen Yu et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 17(3), 1253-1270 (2020-04-17)
The balance of major excitatory (glutamate, Glu) and inhibitory (γ-aminobutyric acid, GABA), named as E/I neurotransmission, is critical for proper information processing. Anxiety-like responses upon stress are accompanied by abnormal alterations in the formation and function of synapses, resulting in...
Mingcan Xia et al.
The Journal of allergy and clinical immunology, 134(3), 634-644 (2014-04-29)
CCR10 and CCL27 make up the most skin-specific chemokine receptor/ligand pair implicated in skin allergy and inflammatory diseases, including atopic dermatitis and psoriasis. This pair is thought to regulate the migration, maintenance, or both of skin T cells and is...
Xiang-Dong Zhang et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(6), 949-952 (2012-12-15)
To study the immune activity of polysaccharide extracted from root of Salvia miltiorrhiza. Investigated the effects of polysaccharide extracted from root of Salvia miltiorrhiza on lymphocyte proliferation response of mouse induced by LPS (the lipopolysaccharide LPS), phagocytosis of the peritoneal...
Laura H Eaton et al.
Immunology, 144(1), 139-148 (2014-07-22)
Upon antigen/allergen recognition, epidermal Langerhans' cells (LC) are mobilized and migrate to the local lymph node where they play a major role in initiating or regulating immune responses. It had been proposed that all chemical allergens induce LC migration via...
Feng Qu et al.
PloS one, 7(12), e52454-e52454 (2013-01-10)
Hypersensitivity diseases are associated with many severe human illnesses, including leprosy and tuberculosis. Emerging evidence suggests that the pathogenesis and pathological mechanisms of treating these diseases may be attributable to sphingolipid metabolism. High performance liquid chromatography-tandem mass spectrometry was employed...
Qian Zhang et al.
The Journal of experimental medicine, 211(13), 2549-2566 (2014-11-26)
DOCK8 mutations result in an inherited combined immunodeficiency characterized by increased susceptibility to skin and other infections. We show that when DOCK8-deficient T and NK cells migrate through confined spaces, they develop cell shape and nuclear deformation abnormalities that do...
A D Christensen et al.
Clinical and experimental immunology, 171(2), 220-230 (2013-01-05)
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4)-immunoglobulin (Ig) has immunosuppressive properties both in vivo and in vitro, but much is still unknown about the mechanisms by which CTLA-4-Ig exerts its immunosuppressive activities in vivo. The aim of this study was to investigate...
Topical tacrolimus treatment does not facilitate photocarcinogenesis in cancer-prone mice.
Takeo Shiga et al.
Journal of dermatological science, 68(2), 112-115 (2012-09-18)
Sandrine Jacquoilleot et al.
Toxicology letters, 237(1), 11-20 (2015-05-30)
Glutathione (GSH) is the most prominent antioxidant in cells and the co-factor of an important set of enzymes involved in the skin metabolic clearance system, glutathione S-transferases (GST). Here, we describe an LC-MS (liquid chromatography-mass spectroscopy) method to measure GSH...
Hiraku Suga et al.
Journal of immunology (Baltimore, Md. : 1950), 190(12), 6059-6070 (2013-05-10)
Sensitization and challenge using dinitrofluorobenzene (DNFB) induce contact hypersensitivity (CHS) with Th1 cell infiltration, whereas those using FITC generate CHS with Th2 cell infiltration. In this study, we attempted to determine the role of CXCR3, a chemokine receptor, in Th1-...
Weiya Liu et al.
Protein science : a publication of the Protein Society, 22(4), 444-454 (2013-01-30)
For over four decades free Mg(2+) ions, that is, those in excess of MgATP, have been reported to affect a wide variety of properties of phosphorylase kinase (PhK), including its affinity for other molecules, proteolysis, chemical crosslinking, phosphorylation, binding to...
Magdalena Zemelka-Wiącek et al.
Journal of immunological methods, 387(1-2), 270-275 (2012-11-28)
Contact hypersensitivity (CHS) is an experimental model of allergic contact dermatitis (ACD) that can be studied in mice. For CHS responses, mice are immunized by painting with a reactive hapten, such as 1-fluoro-4,6-dinitrobenzene (DNFB), on the shaved abdominal and chest...
Shiow-Fern Ng et al.
AAPS PharmSciTech, 16(3), 656-663 (2014-12-17)
Hydrocortisone cream intended for atopic eczema often produces unwanted side effects after long-term use. These side effects are essentially due to repeated percutaneous administration of the medication for skin dermatitis, as atopic eczema is a relapsing disorder. Hence, there is...
G Paraskevas et al.
Journal of pharmaceutical and biomedical analysis, 29(5), 865-872 (2002-07-03)
A spectrophotometric method for the determination of lisinopril (LN) in single and multicomponent tablets also containing hydrochlorothiazide (HCT), based on the derivatization reaction with 1-fluoro-2,4-dinitrobenzene (FDNB, Sanger reagent) is described. Aqueous solutions of LN (4.5-27.2 x 10(-5) M) react with...
Ming-Feng Chiang et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6476-6481 (2013-04-12)
B lymphocyte-induced maturation protein-1 (Blimp-1) is a transcriptional repressor important for the differentiation and function of several types of immune cells. Because skin serves as a physical barrier and acts as an immune sentinel, we investigated whether Blimp-1 is involved...
Helena Shifrin et al.
PloS one, 8(2), e57668-e57668 (2013-03-08)
The cholinergic anti-inflammatory system and α7 nicotinic receptors in macrophages have been proposed to play a role in neuroimmunomodulation and in the etiology of ulcerative colitis. We investigated the ability of a cholinesterase (ChE) inhibitor rivastigmine, to improve the pathology...
Tae-Ho Kim et al.
Life sciences, 93(15), 516-524 (2013-08-13)
Atopic dermatitis (AD) is a chronic and relapsing inflammatory dermatitis characterized by pruritic and eczematous skin lesions. Here, we investigated the therapeutic effect of the fruit flavonoid naringenin on DNFB induced atopic dermatitis mice model. AD-like skin lesion was induced...
Karl J Okolotowicz et al.
Bioorganic & medicinal chemistry, 23(17), 5282-5292 (2015-08-19)
Cardiomyopathy is the leading cause of death worldwide. Despite progress in medical treatments, heart transplantation is one of the only current options for those with infarcted heart muscle. Stem cell differentiation technology may afford cell-based therapeutics that may lead to...
Deolinda R Santinha et al.
Archives of biochemistry and biophysics, 533(1-2), 33-41 (2013-03-12)
Prevalence of skin inflammatory disorders has increased in recent years being estimated that 15-20% of the general population suffers from allergic contact dermatitis (ACD). Currently, the sensitizing potential of chemicals is assessed through animal tests; however growing ethical concerns and...
Hyungwoo Kim et al.
Molecular medicine reports, 12(3), 3632-3638 (2015-06-06)
Astaxanthin (AST) is known to exhibit antioxidative and antitumor properties, therefore, the present study investigated its other potential medical applications. AST was observed to exhibit anti‑allergic and anti‑inflammatory effects in a dinitrofluorobenzene (DNFB)‑induced contact dermatitis (CD) mouse model and RBL‑2H3...
Mudit Vaid et al.
Biochemical pharmacology, 85(8), 1066-1076 (2013-02-12)
Silymarin inhibits UVB-induced immunosuppression in mouse skin. To identify the molecular mechanisms underlying this effect, we used an adoptive transfer approach in which dendritic cells (DCs) from the draining lymph nodes of donor mice that had been UVB-exposed and sensitized...
Jin-Hee Kim et al.
Immunology, 142(3), 506-516 (2014-03-19)
Transglutaminase 2 (TG2) has been reported to play a role in dendritic cell activation and B-cell differentiation after immunization. Its presence and role in T cells, however, has not been explored. In the present study, we determined the expression of...
Morten M Nielsen et al.
The Journal of investigative dermatology, 135(5), 1311-1319 (2015-01-31)
The interaction between keratinocytes (KCs) and skin-resident immune cells has an important role in induction of contact hypersensitivity. A specific subset of γδ T cells termed dendritic epidermal T cells (DETCs) are located in mouse epidermis, and we have recently...
Chihiro Shimizuhira et al.
The Journal of investigative dermatology, 134(11), 2709-2718 (2014-04-24)
Contact hypersensitivity (CHS) has been widely used to study cutaneous immune responses, as a prototype of delayed-type hypersensitivity. Although natural killer T (NKT) cells have been assumed to have an important role in CHS, their role is controversial. Here, we...
Rao Fu et al.
Journal of ethnopharmacology, 162, 176-180 (2015-01-13)
The leaves of Sapium sebiferum (L.) Roxb. have long been used in Traditional Chinese Medicine (TCM) for the treatment of eczema, shingles, edema, swelling, ascites, scabs, and snakebites, among other maladies. The present study was an outreach research behind our...
Szymon Dziomba et al.
Analytical and bioanalytical chemistry, 406(26), 6713-6721 (2014-08-26)
Derivatization is a frequently used sample preparation procedure applicable to the enhancement of analyte detection sensitivity. Amino acids mostly require derivatization prior to electrophoretic or chromatographic analysis, especially if spectrophotometric detection is used. This study presents an on-line preconcentration technique...
Daiki Nakagomi et al.
The Journal of investigative dermatology, 133(3), 702-711 (2012-11-30)
In the past decade, mechanisms underlying allergic contact dermatitis have been intensively investigated by using contact hypersensitivity (CHS) models in mice. However, the regulatory mechanisms, which could be applicable for the treatment of allergic contact dermatitis, are still largely unknown....
Jie Wu et al.
International journal of clinical and experimental medicine, 8(2), 2128-2137 (2015-05-02)
Scutellaria baicalensis is a Chinese herbal medicine that has been used for centuries to treat psoriasis. Baicalin is one of the major flavonoids and bioactive components of S. baicalensis and is responsible for the pharmacologic actions of the plant. This...
Jin-Chul Heo et al.
Bioscience, biotechnology, and biochemistry, 76(11), 2021-2025 (2012-11-08)
LX519290, a synthetic derivative from a combinatorial chemistry library, has been screened for anti-atopic activity, but its biological activities have not yet been elucidated. To assess whether LX519290 has the potential to lessen 2,4-dinitrofluorobenzene-induced atopic dermatitis symptoms in mice, first...
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