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Ines Höfig et al.
The journal of gene medicine, 14(8), 549-560 (2012-08-14)
Although lentiviral transduction methods are widely used, their broader application is dependent upon the optimization of lentiviral transduction efficiency for a broad range of cell types. In the present study, we focus on the evaluation of two chemical classes with...
Pau Loke Show et al.
Bioresource technology, 116, 226-233 (2011-11-09)
An extractive fermentation technique was developed using a thermoseparating reagent to form a two-phase system for simultaneous cell cultivation and downstream processing of extracellular Burkholderia cepacia lipase. A 10% (w/w) solution of ethylene oxide-propylene oxide (EOPO) with a molecular mass...
Anne Bee Hegge et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47(1), 65-74 (2012-05-23)
Solubilization and stabilization from rapid degradation by the use of nanocarriers are necessary to exploit curcumin's phototoxic potential towards pathogenic bacteria. However, maintenance of the phototoxicity requires a careful selection of type and amount of nanocarrier. The phototoxicity of an...
Marcilio S S Cunha-Filho et al.
TheScientificWorldJournal, 2012, 126723-126723 (2012-05-26)
This work evaluated the potential of Pluronics (varieties F127 and P123) in combination with solubilizing agents to be used as syringeable in situ gelling depots of intratumoral β-lapachone (βLAP). Pluronic dispersions prepared at various concentrations in the absence and the...
Wei Zhang et al.
Biomaterials, 32(11), 2894-2906 (2011-01-25)
The aim of this study was to exploit the possibility of combination of active targeting function of folic acid by folate receptor-mediated endocytosis and overcoming multidrug resistance (MDR) by Pluronic block copolymers to promote drug delivery to MDR tumor following...
Céline Durand-Gasselin et al.
Langmuir : the ACS journal of surfaces and colloids, 26(14), 12321-12329 (2010-06-10)
Two amino-terminated amphiphilic copolymers, M600 and M1000, with different ethylene oxide to propylene oxide EO/PO ratios, 1/9 and 19/3, respectively, were coupled by thioctic acid, which allows an excellent affinity with gold surface. Then, amphiphilic thermally responsive gold nanoparticles (AuNPs)...
Juan Ramón Avendaño-Gómez et al.
Journal of colloid and interface science, 380(1), 75-82 (2012-06-02)
The aim of this works is to study an oil-in-water emulsion stabilized with a triblock copolymer Synperonic F127 which presents a double size distribution of oil droplets. The emulsions were studied experimentally by means of differential scanning calorimetry (DSC) and...
Véronique Wintgens et al.
Biomacromolecules, 13(2), 528-534 (2012-01-13)
The main goal of this work was to develop two strategies for stabilization of nanoassemblies made of β-cyclodextrin polymer and amphiphilic dextran associated through host-guest complexes. The first strategy was to coat the nanoassemblies with a dextran derivative bearing adamantyl...
S Kehoe et al.
Journal of the mechanical behavior of biomedical materials, 14, 180-185 (2012-10-03)
PLGA/pluronic F127 based nerve guidance conduits (NGCs) for peripheral nerve regeneration offer excellent potential for clinical use. To date, little emphasis has been directed towards the effect of pluronic F127 on their subsequent mechanical properties as a function of degradation...
Yun-Chao Chen et al.
Cell biochemistry and biophysics, 60(3), 267-273 (2011-01-22)
The pluronic block copolymers are able to enhance the ultrasound-induced gene delivery in vitro. In the present study, the effects of pluronics on the efficiency of gene transfer into skeletal muscle in vivo under sonoporation were investigated. Plasmid DNA encoding...
Jörg Fiedler et al.
International journal of molecular medicine, 27(1), 139-145 (2010-11-12)
We have previously reported that star shaped poly(ethylene oxide-stat-propylene oxide) macromers with 80% EO content and isocyanate functional groups at the distal ends [NCO-sP(EO-stat-PO)] can be used to generate coatings that are non-adhesive but easily functionalized for specific cell adhesion....
S B Rizwan et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 79(1), 15-22 (2011-01-18)
Different delivery strategies to improve the immunogenicity of peptide/protein-based vaccines are currently under investigation. In this study, the preparation and physicochemical characterisation of cubosomes, a novel lipid-based particulate system currently being explored for vaccine delivery, was investigated. Cubosomes were prepared...
Shi-Hui Wei et al.
Huan jing ke xue= Huanjing kexue, 31(6), 1537-1541 (2010-08-12)
A series of functionalized SBA-16 were synthesized and subsequently oxidized into sulfonic functionalized mesoporous silica mixing tetraethyl orthosilicate (TEOS) and 3-mercaptopropyltriethoxysilane (TMMPS), with triblock copolymers pluronic (F127) and cetyltrimethyl ammonium bromide (CTMABr) served as the mixing template by combination of...
Bahareh Yahyaei et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 101, 343-348 (2012-11-06)
Ag nanoparticles have been synthesized via UV irradiation of ethanolic solution of AgNO3 in presence of pluronic F127 surfactant. This study is aimed at developing a rapid, simple and green method to prepare Ag nanoparticles and understanding its generation kinetics....
J Araújo et al.
International journal of pharmaceutics, 393(1-2), 167-175 (2010-04-07)
The purpose of this study was to develop a novel nanostructured lipid carrier (NLC) for the intravitreal-targeting delivery of triamcinolone acetonide (TA) by direct ocular instillation. A five-level central composite rotable design was used to study the influence of four...
Luis Nogueiras-Nieto et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 80(3), 585-595 (2011-12-21)
The competitive interactions between the poly-[propylene oxide] (POO)-poly-[ethylene oxide] (PEO) block copolymer poloxamer 407 (Pluronic F127) and two drugs, triamcinolone acetonide and ciclopirox olamine, by the formation of inclusion complexes with two cyclodextrin hydrophilic derivatives, hydroxypropyl-β-cyclodextrin (HPβCD; molar substitution (MS)...
Hong Ding et al.
Nanoscale, 3(4), 1813-1822 (2011-03-03)
In this study QDs were encapsulated in carboxylated PluronicF127 (F127COOH) triblock polymeric micelles and conjugated with anti-mesothelin antibody for the purpose of alleviating potential toxicity, enhancing the stability and improving targeting efficiency of CdTe/ZnS quantum dots (QDs) in tumors. The...
Jordi Esquena et al.
Langmuir : the ACS journal of surfaces and colloids, 28(33), 12334-12340 (2012-06-28)
A novel and simple single-step method for the preparation of meso/macroporous silica materials is described, which consists in templating in highly concentrated emulsions with a cubic liquid crystal in the continuous phase. Tetraethyl orthosilicate (TEOS) was solubilized in the aqueous...
Chong Sun et al.
Journal of biomedical nanotechnology, 9(5), 825-832 (2013-06-28)
Quantification of the blood glucose concentration in the whole blood was not easy to achieve because the detection process was affected by many factors, such as glucose metabolism and biofouling. In this paper, we established an amperometric glucose biosensor applied...
Ram Malal et al.
Journal of tissue engineering and regenerative medicine, 5(5), 394-401 (2010-10-12)
The objective of this study was to engineer surfaces comprising covalently bound polyethylene oxide-polypropylene oxide-polyethylene oxide (PEO-PPO-PEO) chains, able to coil and uncoil in aqueous media, as a function of temperature. Thermoresponsive surfaces can be used in diverse areas, such...
Tran Huu Dung et al.
Journal of biomedical nanotechnology, 9(7), 1286-1292 (2013-08-06)
A series of dendrimer G5-pluronic F127 nanofilms (at 1:10, 1:20 and 1:30 mole ratios), loaded with various percent of metronidazole hydrochloride, were prepared by the drug deposition with/without gelatin coating. The nanostructural feature of dendrimer G5-pluronic F127 as a matrix...
Diego A Chiappetta et al.
Nanomedicine (London, England), 8(2), 223-237 (2012-11-24)
To investigate the intranasal administration of poly(ethylene oxide)-poly(propylene oxide) polymeric micelles loaded with high payloads of the first-line antiretroviral drug efavirenz for targeting to the CNS. The effect of micellar size and composition and drug payload was assessed, employing simple...
Supramolecular assembly of cyclodextrin-based nanospheres for gene delivery.
Min-min Fan et al.
Journal of controlled release : official journal of the Controlled Release Society, 152 Suppl 1, e141-e142 (2011-12-27)
Tarek A Ahmed et al.
Pharmaceutical development and technology, 16(5), 497-510 (2010-06-17)
A suitable topical formulation of mefenamic acid was developed in order to eliminate the gastrointestinal disorders associated with its oral administration. Drug coprecipitates prepared with different polymers at various drug-to-polymer ratios improved drug solubility and dissolution compared to pure drug...
Na Li et al.
Journal of colloid and interface science, 350(1), 117-125 (2010-07-06)
Nanoparticles consisting of a cross-linked cationic polymer network were prepared using Pluronic F127 and poly(ethylenimine) (PEI) and suggested as a drug delivery system for the anticancer drug Paclitaxel (PTX). In order to further improve the targeting capability of nanoparticles, folic...
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