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Amphiphilic Polypeptoids Rupture Vesicle Bilayers To Form Peptoid-Lipid Fragments Effective in Enhancing Hydrophobic Drug Delivery.

Yueheng Zhang et al.

Langmuir : the ACS journal of surfaces and colloids, 35(47), 15335-15343 (2019-11-07)

Peptoids are highly biocompatible pseudopeptidic polyglycines with designable substituents on the nitrogen atoms. The therapeutic and drug-carrying potential of these materials requires a fundamental understanding of their interactions with lipid bilayers. In this work, we use amphiphilic polypeptoids with up

Does the Solvent in a Dispersant Impact the Efficiency of Crude-Oil Dispersion?

Jay C Fernandes et al.

Langmuir : the ACS journal of surfaces and colloids, 35(50), 16630-16639 (2019-12-06)

Dispersants, used in the mitigation of oil spills, are mixtures of amphiphilic molecules (surfactants) dissolved in a solvent. The recent large-scale use of dispersants has raised environmental concerns regarding the safety of these materials. In response to these concerns, our

Partitioning of an anchor dipeptide in a phospholipid membrane

Volkov VV and Righini R

The Journal of Physical Chemistry B, 113(50), 16246-16250 (2009)

Combining Cell Surface Display and DNA-Shuffling Technology for Directed Evolution of Streptomyces Phospholipase D and Synthesis of Phosphatidylserine.

Haiyang Zhang et al.

Journal of agricultural and food chemistry, 67(47), 13119-13126 (2019-11-07)

Phospholipids have been widely used in food, medicine, cosmetics, and other fields because of their unique chemical structure and healthcare functions. Phospholipase D (PLD) is a key biocatalyst for the biotransformation of phospholipids. Here, an autodisplay expression system was constructed

Development of rosuvastatin flexible lipid-based nanoparticles: promising nanocarriers for improving intestinal cells cytotoxicity.

Tarek A Ahmed

BMC pharmacology & toxicology, 21(1), 14-14 (2020-02-23)

Rosuvastatin (RSV) is a poorly water-soluble drug that has an absolute oral bioavailability of only 20%. The aim of this work was to prepare a positively charged chitosan coated flexible lipid-based vesicles (chitosomes) and compare their characteristics to the corresponding

Synthesis, structure-activity relationship and biological evaluation of tetracationic gemini Dabco-surfactants for transdermal liposomal formulations.

T N Pashirova et al.

International journal of pharmaceutics, 575, 118953-118953 (2019-12-18)

In this study, we report the relationship between structure, self-assembly behavior and antimicrobial activity of multicationic gemini surfactants and their successful use as stabilizers of a new liposomal formulation for transdermal drug delivery. New surfactants containing natural moiety 1,4-diazabicyclo[2.2.2]octane with

Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy

Fledrich R, et al.

Nature Communications, 9(1), 3025-3025 (2018)

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