Showing 1-14 of 14 results for "46946"
Haruo Aramoto et al.
American journal of physiology. Heart and circulatory physiology, 287(4), H1590-H1598 (2004-05-25)
Vascular endothelial growth factor (VEGF) induces mild vasodilation and strong increases in microvascular permeability. Using intravital microscopy and digital integrated optical intensity image analysis, we tested, in the hamster cheek pouch microcirculation, the hypothesis that differential signaling pathways in arterioles...
Elena Naumovska et al.
International journal of molecular sciences, 21(14) (2020-07-18)
Intestinal organoids have emerged as the new paradigm for modelling the healthy and diseased intestine with patient-relevant properties. In this study, we show directed differentiation of induced pluripotent stem cells towards intestinal-like phenotype within a microfluidic device. iPSCs are cultured...
Giovanni S Offeddu et al.
Biomaterials, 212, 115-125 (2019-05-22)
Recent therapeutic success of large-molecule biologics has led to intense interest in assays to measure with precision their transport across the vascular endothelium and into the target tissue. Most current in vitro endothelial models show unrealistically large permeability coefficients due...
Julia Rogal et al.
Scientific reports, 10(1), 6666-6666 (2020-04-22)
Obesity and its numerous adverse health consequences have taken on global, pandemic proportions. White adipose tissue (WAT) - a key contributor in many metabolic diseases - contributes about one fourth of a healthy human's body mass. Despite its significance, many...
Sandra Dittmar et al.
Journal of virology, 82(22), 11273-11282 (2008-09-05)
In order to analyze whether measles virus (MV) is transported via transmigrating leukocytes across endothelial barriers or whether virus spreads via infection of endothelial cells and basolateral release, we investigated the migratory behavior of infected human primary T lymphocytes across...
D M Gawlowski et al.
Microvascular research, 37(1), 1-15 (1989-01-01)
Fluorescein-labeled dextran MW 150K (FITC-Dx 150) is commonly utilized as a macromolecular fluorochrome in inflammatory studies. We examined the influence of FITC-Dx 150 on leukocyte activity as assessed by adherence to cheek pouch microvessels. Transcapillary exchange was evaluated as fluorochrome...
Neil Y C Lin et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(12), 5399-5404 (2019-03-06)
Three-dimensional renal tissues that emulate the cellular composition, geometry, and function of native kidney tissue would enable fundamental studies of filtration and reabsorption. Here, we have created 3D vascularized proximal tubule models composed of adjacent conduits that are lined with...
Nikolce Gjorevski et al.
Lab on a chip, 20(18), 3365-3374 (2020-08-08)
The multiphasic etiology of tissue inflammation and the fundamental immunological differences between species render inflammatory pathologies difficult to recapitulate in animal models, and account for the paucity of therapies that are successfully translated from rodents to humans. Here, we present...
A Bollinger et al.
Lymphology, 40(2), 52-62 (2007-09-15)
Fluorescence microlymphography (FML) is an almost atraumatic technique used to visualize the superficial skin network of initial lymphatics through the intact skin of man. Visualization was performed with an incident light fluorescence microscope following subepidermal injection of minute amounts of...
Fátima Z G A Cyrino et al.
Clinical and experimental pharmacology & physiology, 31(3), 159-162 (2004-03-11)
1. The present study was designed to evaluate the effect of micronization on the protective effect of the purified flavonoid fraction (MPFF) on increases in macromolecular permeability induced by ischaemia-reperfusion in the hamster cheek pouch microcirculation. 2. Male hamsters (Mesocricetus...
Takayuki Ishii et al.
Brain research, 1321, 164-168 (2010-01-26)
Ischemia-reperfusion injury is induced by recovery of blood flow after ischemia. This phenomenon is a main cause of ischemic brain injury. The integrity of the blood-brain barrier (BBB) fails after cerebral ischemia and reperfusion. Further elucidation of this phenomenon promotes...
Hu Huang et al.
PloS one, 6(6), e21411-e21411 (2011-07-07)
VEGFR1 and 2 signaling have both been increasingly shown to mediate complications of ischemic retinopathies, including retinopathy of prematurity (ROP), age-related macular degeneration (AMD), and diabetic retinopathy (DR). This study evaluates the effects of blocking VEGFR1 and 2 on pathological...
Gabor Eros et al.
Arthritis research & therapy, 11(2), R43-R43 (2009-03-20)
Phosphatidylcholine and phosphatidylcholine-derived metabolites exhibit anti-inflammatory properties in various stress conditions. We hypothesized that dietary phosphatidylcholine may potentially function as an anti-inflammatory substance and may decrease inflammatory activation in a chronic murine model of rheumatoid arthritis (collagen-induced arthritis). The experiments...

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