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46955

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Christian Kranjec et al.
Journal of virology, 88(13), 7155-7169 (2014-04-04)
The cancer-causing high-risk human papillomavirus (HPV) E6 oncoproteins target a number of cellular proteins that contain PDZ domains. However, the role of many of these interactions in either the HPV life cycle or in HPV-induced malignancy remains to be defined....
Markus Becker et al.
Biochimica et biophysica acta, 1837(6), 888-898 (2014-03-19)
The homotrimeric, secondary active betaine carrier BetP from Corynebacterium glutamicum is a model system for stress-regulated transport in bacteria. Its activity responds to hyperosmotic stress and it harbors two different functions, transport catalysis (betaine uptake) and stimulus sensing, resp. activity...
Katsuyuki Inoue et al.
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 200, 54-65 (2015-03-17)
The thyroid anlage develops in the foramen caecum area of the tongue, and migrates through the anterior neck towards its final position in front of the laryngeal cartilages. During migration, the thyroglossal duct, a temporary structure connecting the thyroid anlage...
Christine Rondanino et al.
Reproductive biomedicine online, 31(1), 89-99 (2015-05-24)
The decapitated sperm defect is a rare type of teratozoospermia responsible for male infertility. Spermatozoa from patients affected by this syndrome are used for intracytoplasmic sperm injection (ICSI) although little is known about their DNA integrity. This study evaluated sperm...
Jung Ryeol Lee et al.
European journal of obstetrics, gynecology, and reproductive biology, 178, 16-20 (2014-06-21)
To investigate the effects of necrostatin-1 (Nec-1) supplementation on vitrification, warming and transplantation of ovarian tissue. Ovaries from 4-week-old ICR mice were vitrified using a two-step procedure; ovaries were suspended in equilibration solution for 10min, and then mixed with vitrification...
Thomas Buus Jensen et al.
PloS one, 10(4), e0124902-e0124902 (2015-04-16)
Albumin has been identified in preparations of renal distal tubules and collecting ducts by mass spectrometry. This study aimed to establish whether albumin was a contaminant in those studies or actually present in the tubular cells, and if so, identify...
Agnieszka Śmieszek et al.
BioMed research international, 2015, 769402-769402 (2015-06-13)
Metformin, a popular drug used to treat diabetes, has recently gained attention as a potentially useful therapeutic agent for treating cancer. In our research metformin was added to in vitro cultures of bone marrow-derived multipotent mesenchymal stromal cells (BMSCs) and...
Kyle D Dukes et al.
Analytical biochemistry, 458, 43-48 (2014-04-24)
Silver nanoparticles have been modified with self-assembled monolayers of hydroxyl-terminated long chain thiols and encapsulated with a silica shell. The resulting core-shell nanoparticles were used as optical labels for cell analysis using flow cytometry and microscopy. The excitation of plasmon...
G R Willis et al.
BJOG : an international journal of obstetrics and gynaecology, 121(13), 1596-1603 (2014-05-13)
To assess circulating biochemical indices of endothelial function and nitro-oxidative stress in women with polycystic ovary syndrome (PCOS). Case-control study. Seventeen women with PCOS and eighteen age- and body mass index-matched healthy volunteers. Nitric oxide (NO) metabolite levels were assessed...
Ji-Young Na et al.
Research in veterinary science, 97(3), 605-610 (2014-12-04)
This study evaluated the effectiveness of irradiated porcine tendon xenografts for lateral collateral ligament (LCL) reconstruction. Twenty healthy adult beagle dogs underwent LCL reconstruction using irradiated porcine tendons treated with poly-gamma-glutamic acid. Serological and histological assessments were performed to evaluate...
Xiang Gao et al.
International journal of nanomedicine, 10, 7109-7128 (2015-11-26)
The construction of functional biomimetic scaffolds that recapitulate the topographical and biochemical features of bone tissue extracellular matrix is now of topical interest in bone tissue engineering. In this study, a novel surface-functionalized electrospun polycaprolactone (PCL) nanofiber scaffold with highly...
Patrick Jenkins et al.
Journal of biophotonics, 8(11-12), 908-917 (2015-03-03)
Flow cytometry is a powerful means for in vitro cellular analyses where multi-fluorescence and multi-angle light scattering can indicate unique biochemical or morphological features of single cells. Yet, to date, flow cytometry systems have lacked the ability to capture complex...
Lei Zou et al.
Biological & pharmaceutical bulletin, 38(7), 1012-1019 (2015-05-08)
Sphingosine-1-phosphate type-1 receptor (S1P1) agonists have the potential to inhibit the egress of lymphocytes, and have been demonstrated to provide protective effects on some acute inflammatory diseases. However, the value of S1P1 agonists on acute pancreatitis (AP) remains unclear. The...
Long Wang et al.
Molecular medicine reports, 11(4), 2711-2716 (2014-12-18)
Glucocorticoid‑induced osteoporosis (GIOP) is a widespread clinical complication following glucocorticoid therapy. This irreversible damage to bone‑forming and ‑resorbing cells is essential in the pathogenesis of osteoporosis. Autophagy is a physiological process involved in the regulation of cells and their responses...
Tongyu Liu et al.
Journal of neuroscience research, 92(9), 1199-1204 (2014-05-09)
Ependymal cells are multiciliated epithelial cells that line the ventricles in the adult brain. Abnormal function or structure of ependymal cilia has been associated with various neurological deficits. For the first time, we report three distinct ependymal cell types, I...
Yuanyuan Cheng et al.
Oxidative medicine and cellular longevity, 2015, 434052-434052 (2015-08-13)
Leukotriene B4 12-hydroxydehydrogenase (LTB4DH) catalyzes the oxidation of proinflammatory LTB4 into less bioactive 12-oxo-LTB4. We recently discovered that LTB4DH was induced by two different natural products in combination. We previously isolated gallic acid from Radix Paeoniae through a bioactivity-guided fractionation...
Maria Spiliotaki et al.
Breast cancer research : BCR, 16(6), 485-485 (2014-11-30)
Clinical dormancy is frequently observed in breast cancer. In the present study, we aimed to characterize circulating tumor cells (CTCs) in dormancy candidates (DC) with early breast cancer in terms of proliferation and apoptosis. Cytospins of peripheral blood mononuclear cells...
Lei Zhong et al.
Molecular medicine reports, 12(1), 119-126 (2015-03-05)
Estrogen receptors (ERs) are important for preventing endotoxin-induced myocardial dysfunction. Therefore, plant-derived phytoestrogens, which target ERs may also affect endotoxin-induced toxicity in cardiomyocytes. Our previous study revealed that notoginsenoside-R1 (NG-R1), a predominant phytoestrogen from Panax notoginseng, protects against cardiac dysfunction....
Jogchum Plat et al.
PloS one, 9(10), e110758-e110758 (2014-10-31)
The inflammatory component of non-alcoholic steatohepatitis (NASH) can lead to irreversible liver damage. Therefore there is an urgent need to identify novel interventions to combat hepatic inflammation. In mice, omitting cholesterol from the diet reduced hepatic inflammation. Considering the effects...
Liping Ma et al.
Journal of ethnopharmacology, 153(3), 864-871 (2014-04-02)
Rhubarb is a well-known traditional Chinese medicine and has been used in China for thousands of years. Anthraquinone derivatives including rhein, emodin, aloe-emodin, chrysophanol and physcion are the important components in rhubarb. Here we studied the interaction of five anthraquinone...
Susan H Roelofs et al.
Lab on a chip, 15(6), 1458-1464 (2015-01-22)
Desalination as a sample preparation step is essential for noise reduction and reproducibility of mass spectrometry measurements. A specific example is the analysis of proteins for medical research and clinical applications. Salts and buffers that are present in samples need...
Di-Fei Wang et al.
Molecular medicine reports, 12(2), 2695-2700 (2015-05-13)
In the present study, a glucosamine-induced model of insulin-resistant skeletal muscle cells was established in order to investigate the effect of inhibition of phosphatase and tensin homolog (PTEN)/5'-adenosine monophosphate-activated protein kinase (AMPK) on these cells. The glucosamine-induced insulin-resistant skeletal muscle...
M Martin et al.
Acta physiologica (Oxford, England), 215(4), 167-176 (2015-08-25)
Angiotensin-converting enzyme inhibitors are treatment of choice in hypertensive patients. Clinically used inhibitors exhibit a structural similarity to naturally occurring peptides. This study evaluated antihypertensive and cardioprotective effects of ACE-inhibiting peptides derived from food proteins in spontaneously hypertensive rats. Isoleucine-tryptophan...
B Li et al.
Free radical research, 48(7), 758-768 (2014-04-12)
Stromal interaction molecule (STIM) proteins are parts of elaborate eukaryotic Ca(2+) signaling systems and are considered to be important players in regulating neuronal Ca(2+) homeostasis under normal ageing and pathological conditions. Here, we investigated the potential role of STIM1 in...
Samaneh Mashaghi et al.
Scientific reports, 5, 11837-11837 (2015-07-03)
Scale reduction of chemical reactions enables novel screening and synthesis approaches that facilitate a highly parallelized and combinatorial exploration of chemical space. Droplet-based microfluidics have evolved as a powerful platform to allow many chemical reactions within small volumes that each...
Liang Zhou et al.
Oncology reports, 32(4), 1734-1740 (2014-08-12)
As a highly aggressive malignant disease, the prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) is poor. Yet, the mechanisms underlying the progression of PDAC remain unclear. MicroRNAs (miRNAs) may be involved in various human cancers as cancer suppressors or...
G Anupa et al.
Reproductive biology and endocrinology : RB&E, 13(1), 121-121 (2015-11-08)
Human placental villous cytotrophoblasts exhibit relative externalization of negatively charged moieties to the outer leaflet of the plasma membrane during the time of syncytialization rendering their reactivity to positively charged cationic antimicrobial peptides (CAMPs) during the window of implantation and...
Yukio Akasaki et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(12), 3349-3358 (2014-09-05)
A major signaling pathway that regulates cellular aging is the insulin/insulin-like growth factor 1 (IGF-1)/phosphatidylinositol 3-kinase (PI3K)/Akt/FoxO transcription factor axis. We previously observed that FoxO transcription factors are dysregulated in aged and OA cartilage. The objective of this study was...
David T Hoang et al.
Molecular cancer therapeutics, 14(3), 713-726 (2015-01-02)
Although poorly understood, androgen receptor (AR) signaling is sustained despite treatment of prostate cancer with antiandrogens and potentially underlies development of incurable castrate-resistant prostate cancer. However, therapies targeting the AR signaling axis eventually fail when prostate cancer progresses to the...
Jessica MacIntyre et al.
European journal of pharmacology, 735, 105-114 (2014-04-23)
The endocannabinoid system plays a role in regulation of vasoactivity in the peripheral vasculature; however, little is known about its role in regulation of the CNS microvasculature. This study investigated the pharmacology of cannabinoids and cannabimimetic lipids in the retinal...
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