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Jennifer C Ryan et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(12), R1488-R1492 (2014-10-24)
Clinical studies indicate that hepatic drug transport may be altered in chronic kidney disease (CKD). Uremic solutes associated with CKD have been found to alter the expression and/or activity of hepatocyte transporters in experimental animals and in cultured cells. However
Samantha Herretes et al.
Investigative ophthalmology & visual science, 56(4), 2348-2357 (2015-02-07)
The primary objective of the present study was to identify the kinetics and origin of ocular infiltrating T cells in a preclinical model of graft-versus-host disease (GVHD) that induces eye tissue damage. Graft-versus-host disease was induced using an major histocompatibility
Pam Satjawatcharaphong et al.
Optometry and vision science : official publication of the American Academy of Optometry, 92(9), e334-e341 (2015-07-21)
To identify patient characteristics at a baseline ocular surface evaluation that correlate with improvement in dry eye symptoms at a follow-up visit after treatment with the LipiFlow Thermal Pulsation System. Thirty-two patients completed a comprehensive baseline ocular surface evaluation and
Kibaek Choe et al.
The Journal of clinical investigation, 125(11), 4042-4052 (2015-10-06)
Lacteals are lymphatic vessels located at the center of each intestinal villus and provide essential transport routes for lipids and other lipophilic molecules. However, it is unclear how absorbed molecules are transported through the lacteal. Here, we used reporter mice
Christopher Kesten et al.
The EMBO journal, 38(24), e101822-e101822 (2019-11-19)
Environmental adaptation of organisms relies on fast perception and response to external signals, which lead to developmental changes. Plant cell growth is strongly dependent on cell wall remodeling. However, little is known about cell wall-related sensing of biotic stimuli and
Kristin M Fischer et al.
Journal of glaucoma, 23(9), 613-615 (2013-02-23)
To establish the validity of a fluorophotometric protocol based on 2 time points to facilitate aqueous humor flow rate calculations in minimally cooperative species. A standard canine fluorophotometry protocol was followed in 6 dogs. Fluorescein concentrations were obtained at 4
Timothy C Chang et al.
Journal of visualized experiments : JoVE, (71)(71), e4409-e4409 (2013-01-29)
Probe-based confocal laser endomicroscopy (CLE) is an emerging optical imaging technology that enables real-time in vivo microscopy of mucosal surfaces during standard endoscopy. With applications currently in the respiratory and gastrointestinal tracts, CLE has also been explored in the urinary
Maria M Shchepinova et al.
Biochimica et biophysica acta, 1837(1), 149-158 (2013-10-01)
In our search for fluorescent uncouplers of oxidative phosphorylation, three esters of fluorescein, n-butyl-, n-octyl-, and n-dodecyl-oxycarbonyl-fluorescein (C4-FL, C8-FL, C12-FL) were synthesized and characterized. With increasing liposomal lipid content, the long-chain alkyl derivatives of fluorescein (C8-FL, C12-FL and commercially available
Marta P Pereira Morais et al.
Scientific reports, 3, 1437-1437 (2013-03-28)
Glycated proteins are important biomarkers for age-related disorders, however their analysis is challenging because of the complexity of the protein-carbohydrate adducts. Here we report a method that enables the detection and identification of individual glycated proteins in complex samples using
Beau J Fenner et al.
Investigative ophthalmology & visual science, 54(13), 8013-8019 (2013-11-14)
To determine the reliability of single- and double-zone corneal fluorescent staining compared with five-zone analysis for the prediction of dry eye disease. Prospective study of 510 subjects with dry eye disease characterized using corneal fluorescein staining, Schirmer scores, and tear
Simon Cheong et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 72(12), 2461-2468 (2014-09-30)
Bisphosphonates (BPs) are widely used for the management of bone diseases such as osteoporosis and bone malignancy. However, osteonecrosis of the jaws (ONJ) is a serious complication of BP treatment. ONJ lesions mainly occur after extraction of teeth deemed unrestorable
Jorawer S Singh et al.
Experimental eye research, 115, 239-245 (2013-07-09)
Corneal endothelial cells form a leaky barrier on the posterior surface of the cornea, allowing influx of nutrient-carrying aqueous humor through the paracellular space and efflux of excess fluid. Corneal edema arises when the density of these non-proliferative endothelial cells
Si Hyung Jin et al.
Lab on a chip, 15(18), 3677-3686 (2015-08-08)
We present a programmable microfluidic static droplet array (SDA) device that can perform user-defined multistep combinatorial protocols. It combines the passive storage of aqueous droplets without any external control with integrated microvalves for discrete sample dispensing and dispersion-free unit operation.
Chie Sotozono et al.
American journal of ophthalmology, 158(5), 983-993 (2014-07-19)
To evaluate the therapeutic benefits of tear-exchangeable, limbal, rigid contact lenses (limbal CLs) in patients with Stevens-Johnson syndrome- or toxic epidermal necrolysis-associated ocular sequelae. Noncomparative, retrospective, interventional case series. We enrolled 53 eyes of 42 patients (mean age, 51.8 ±
Luis Solorio et al.
Journal of pharmaceutical sciences, 104(10), 3471-3480 (2015-07-16)
Phase-sensitive in situ forming implants (ISFI) are a promising platform for the controlled release of therapeutic agents. The simple manufacturing, ease of placement, and diverse payload capacity make these implants an appealing delivery system for a wide range of applications.
Haitham Askar et al.
Journal of dentistry, 43(7), 832-838 (2015-03-15)
Infiltrants are non-filled low-viscosity resins that have been developed to arrest lesion progression by penetrating into the porosities of non-cavitated lesions where they are hardened and arrest lesion progression. The addition of fillers to infiltrant resin might combine the high
Bin-wu Lin et al.
Investigative ophthalmology & visual science, 56(1), 45-53 (2014-12-11)
To investigate the effect of FK-506 eye drops on Botulinum toxin B (BTX-B)-induced mouse dry eye. Forty-five CBA/J mice were followed up for 4 weeks after treatment with 0.025% FK-506, vehicle or 0.9% saline eye drops 3 days after intralacrimal
P Quin et al.
Scientific reports, 5, 16773-16773 (2015-12-01)
Agricultural soils are the primary anthropogenic source of atmospheric nitrous oxide (N2O), contributing to global warming and depletion of stratospheric ozone. Biochar addition has shown potential to lower soil N2O emission, with the mechanisms remaining unclear. We incubated eucalypt biochar
Xian-Fu Zhang et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 113, 92-99 (2013-05-30)
The fluorescence and absorption properties of several xanthene and phthalocyanine dyes were measured in the presence and absence of chemically derived graphene (CDG) sheets. The interaction of pyronine Y (PYY) with graphene sheets was compared with that of rhodamine 6G
Beata Kolesinska et al.
Chemistry & biodiversity, 10(1), 1-38 (2013-01-24)
After a survey of the special role, which the amino acid proline plays in the chemistry of life, the cell-penetrating properties of polycationic proline-containing peptides are discussed, and the widely unknown discovery by the Giralt group (J. Am. Chem. Soc.
Fuyuko Takata et al.
Biochemical and biophysical research communications, 433(4), 586-590 (2013-03-26)
Blood-brain barrier (BBB) disruption occurs frequently in CNS diseases and injuries. Few drugs have been developed as therapeutic candidates for facilitating BBB functions. Here, we examined whether metformin up-regulates BBB functions using rat brain microvascular endothelial cells (RBECs). Metformin, concentration-
Flavia Laffleur et al.
Journal of pharmaceutical sciences, 104(7), 2153-2160 (2015-04-23)
It was the aim of this study to evaluate the permeation-enhancing effect of synthesized thiolated hyaluronic acid (HA). HA, a naturally found polysaccharide, was chemically modified with l-cysteine ethyl ether (C) via amide bond formation. In vitro permeation enhancement was
Up-to-date expert opinion referencing the best evidence available on intraoperative cerebrospinal fluid leak during endoscopic sinus surgery.
H Al-Reefy et al.
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 38(1), 48-53 (2013-02-20)
Brandon C Lane et al.
Current drug discovery technologies, 10(2), 160-169 (2013-02-01)
The use of fluorescent technologies in neurosurgery has a substantial history with applications to vascular and tumor surgery dating back to the 1940s. This review focuses on the applications of fluorescence imaging to intracranial vascular and neoplastic lesions using sodium
J Chhablani et al.
Eye (London, England), 29(4), 519-524 (2015-01-24)
To assess intra/inter-observer agreement, and diagnostic capabilities of a color fundus photograph, fundus fluorescein angiography (FFA), and spectral domain optical coherence tomography (SD-OCT) in making a diagnosis of myopic choroidal neovascularization (CNV). Two masked observers evaluated FFA and SD-OCT images
Shan Zong et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 93, 127-135 (2015-04-07)
Polymer-based local drug delivery system may be suitable for the treatment of cervix cancer. A pilot study was carried out to examine the efficacy of cisplatin-loaded poly(ethylene oxide)/polylactide composite electrospun nanofibers as a local chemotherapy system against cervical cancer in
Mami Yokota et al.
Biological & pharmaceutical bulletin, 38(9), 1383-1388 (2015-09-04)
The effects of glycation on skin permeation and accumulation of compounds were evaluated using an in vitro glycated skin model. Glycation of the skin of hairless mice was induced using vertical diffusion cells and incubation with phosphate-buffered saline containing 50 mM
Huihui Yao et al.
The journal of physical chemistry. A, 117(6), 1351-1359 (2013-01-18)
2',7'-Dichloro- and 2',7'-difluorofluoresceins are superior alternatives to underivatized fluorescein. Although several studies characterizing their condensed-phase photophysical properties have been reported, little is known about their intrinsic characteristics. Here, the gas-phase properties of three charge states of each fluorescein are characterized
The value of tear osmolarity as a metric in evaluating the response to dry eye therapy in the clinic and in clinical trials.
Francisco Amparo et al.
American journal of ophthalmology, 157(4), 915-916 (2014-03-19)
Bart Kramer et al.
International journal of molecular sciences, 20(18) (2019-09-25)
Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most lethal cancers due to a high chemoresistance and poor vascularization, which results in an ineffective systemic therapy. PDAC is characterized by a high intratumoral pressure, which is not captured by current
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