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Renata Solarska et al.
Nanoscale, 4(5), 1553-1556 (2012-02-01)
Nanostructuring of semiconductor films offers the potential means for producing photoelectrodes with improved minority charge carrier collection. Crucial to the effective operation of the photoelectrode is also the choice of a suitable electrolyte. The behaviour of the nanostructured WO(3) photoanodes...
Xian Fu et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(38), 13357-13363 (2015-07-28)
A novel metal-doping strategy was developed for the construction of iron-decorated microporous aromatic polymers with high small-gas-uptake capacities. Cost-effective ferrocene-functionalized microporous aromatic polymers (FMAPs) were constructed by a one-step Friedel-Crafts reaction of ferrocene and s-triazine monomers. The introduction of ferrocene...
Bas Vriens et al.
PloS one, 9(7), e102906-e102906 (2014-07-23)
Biomethylation and volatilization of trace elements may contribute to their redistribution in the environment. However, quantification of volatile, methylated species in the environment is complicated by a lack of straightforward and field-deployable air sampling methods that preserve element speciation. This...
Fernanda Crunfli et al.
Clinical and experimental pharmacology & physiology, 42(3), 246-255 (2014-11-29)
Dipyrone is a non-steroidal anti-inflammatory drug used primarily as an analgesic and antipyretic. Some hypothesize that dipyrone activity can modulate other pathways, including endocannabinoid signalling. Thus, the aim of the present study was to evaluate the possible role of endocannabinoids...
Cassandra J Gaston et al.
Environmental science & technology, 44(5), 1566-1572 (2010-02-04)
Dimethyl sulfide (DMS), produced by oceanic phytoplankton, is oxidized to form methanesulfonic acid (MSA) and sulfate, which influence particle chemistry and hygroscopicity. Unlike sulfate, MSA has no known anthropogenic source making it a useful tracer for ocean-derived biogenic sulfur. Despite...
Junna Song et al.
Metabolism: clinical and experimental, 64(3), 428-437 (2014-12-17)
Endothelial dysfunction is tightly associated with cardiovascular complications in diabetic patients. This study aims to investigate the effects of mangiferin on the regulation of endothelial homeostasis under endoplasmic reticulum stress (ER stress) conditions. High glucose (25 mmol/L) exposure induced ER...
Yi-Ling Hsieh et al.
Pharmaceutical research, 32(9), 3110-3118 (2015-04-16)
The aim of this study was to investigate how the disproportionation process can be impacted by the properties of the salt, specifically pHmax. Five miconazole salts and four sertraline salts were selected for this study. The extent of conversion was...
L E Vanatta et al.
Journal of chromatographic science, 49(8), 610-611 (2011-08-24)
A statistical procedure is presented for calibrating chromatographic methods that generate negative chromatographic peaks. The technique is illustrated via data collected during the ion-chromatographic analysis of the ammonium ion in methansulfonic-acid solutions. A peak-integration protocol is explained and subsequent regression...
Yajun Yang et al.
Marine drugs, 12(7), 4086-4095 (2014-07-09)
Enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. No vaccine or antiviral therapy is currently available. In this work, we found that the number of B...
Aki Kijima et al.
Toxicology, 331, 125-135 (2015-03-17)
Nitrofurans are antimicrobial compounds containing a nitro group at the 5-position of the furan ring and an amine or hydrazide side chain derivative. One member of the nitrofurans, nitrofurantoin (NFT), is a renal carcinogen in male rats despite its still...
Zimeng Wang et al.
Environmental science & technology, 49(12), 7236-7244 (2015-05-13)
Ligand-promoted dissolution and reductive dissolution of iron (hydr)oxide minerals control the bioavailability of iron in many environmental systems and have been recognized as biological iron acquisition strategies. This study investigated the potential synergism between ligands (desferrioxamine B (DFOB) or N,N'-Di(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic...
Xian-Zhe Dong et al.
Anti-cancer drugs, 26(3), 331-342 (2014-12-19)
3β-O-{α-L-Pyran rhamnose-(1→3)-[β-D-xylopyranose-(1→2)]-β-D-glucopyranose-(1→4)-[β-D-lucopyranose-(1→2)]-α-L-pyran arabinose}-cyclamiretin A (AG4) is a saponin component obtained from the Giantleaf Ardisia Rhizome (Rhizoma Ardisiae Gigantifoliae). The present study aimed to investigate the antitumor potential of AG4 and its possible mechanisms in human nasopharyngeal carcinoma cells (CNE). We...
Sunitha Rangaraju et al.
eLife, 4, e08833-e08833 (2015-12-02)
Longevity mechanisms increase lifespan by counteracting the effects of aging. However, whether longevity mechanisms counteract the effects of aging continually throughout life, or whether they act during specific periods of life, preventing changes that precede mortality is unclear. Here, we...
Véronique Gilard et al.
Journal of pharmaceutical and biomedical analysis, 102, 476-493 (2014-12-03)
One hundred and fifty dietary supplements (DS) marketed to increase sexual performance were analyzed. All these formulations were claimed to contain only natural compounds, plant extracts and/or vitamins. (1)H NMR spectroscopy was used for detecting the presence of adulterants and...
Nina Bertaux-Skeirik et al.
PLoS pathogens, 11(2), e1004663-e1004663 (2015-02-07)
The cytotoxin-associated gene (Cag) pathogenicity island is a strain-specific constituent of Helicobacter pylori (H. pylori) that augments cancer risk. CagA translocates into the cytoplasm where it stimulates cell signaling through the interaction with tyrosine kinase c-Met receptor, leading cellular proliferation....
Julia E Martin et al.
PLoS genetics, 11(3), e1004977-e1004977 (2015-03-17)
Escherichia coli does not routinely import manganese, but it will do so when iron is unavailable, so that manganese can substitute for iron as an enzyme cofactor. When intracellular manganese levels are low, the cell induces the MntH manganese importer...
Jae Hong Seo et al.
Drug design, development and therapy, 9, 3961-3968 (2015-08-08)
Cilostazol is a Biopharmaceutical Classification System class II drug with low solubility and high permeability, so its oral absorption is variable and incomplete. The aim of this study was to prepare two sulfonate salts of cilostazol to increase the dissolution...
Xuan Zhao et al.
Oncotarget, 6(8), 5582-5596 (2015-02-26)
Anti-apoptotic protein Mcl-1 plays an important role in protecting cell from death in acute myeloid leukemia (AML). The apoptosis blocking activity of Mcl-1 is inhibited by BH3-only protein Noxa. We found that dihydroartemisinin (DHA) and its derivative X-11 are potent...
Tsung-Ming Shih et al.
Chemico-biological interactions, 187(1-3), 207-214 (2010-03-13)
This study compared the ability of nine oximes (HI-6, HLö7, MMB-4, TMB-4, carboxime, ICD585, ICD692, ICD3805, and 2-PAM) to reactivate in vivo cholinesterase (ChE) in blood, brain, and peripheral tissues in guinea pigs intoxicated by one of four organophosphorus nerve...
Mirelle Garcia Silva-Bailão et al.
PloS one, 9(8), e105805-e105805 (2014-08-27)
Iron is a micronutrient required by almost all living organisms, including fungi. Although this metal is abundant, its bioavailability is low either in aerobic environments or within mammalian hosts. As a consequence, pathogenic microorganisms evolved high affinity iron acquisition mechanisms...
Jared M Fine et al.
Neuroscience letters, 584, 362-367 (2014-12-03)
In addition to the hallmark accumulation of amyloid and hyper-phosphorylation of tau, brain changes in Alzheimer's disease are multifactorial including inflammation, oxidative stress, and metal dysregulation. Metal chelators have been explored as a less well known approach to treatment. One...
Qianwen Zhao et al.
Journal of diabetes, 6(4), 304-315 (2013-11-20)
Anemarrhena asphodeloides Bunge is widely used in China for the treatment of diabetes and the polyphenol components are responsible for its anti-diabetic action. This study aimed to investigate the effect of total polyphenol of Anemarrhena asphodeloides (TPAA) on endothelial dysfunction and...
Methane Sulphonic Acid is Green Catalyst in Organic Synthesis.
Kulkarni P.
Orient. J. Chem., 31(1), 447-451 (2015)
M Emmy M Dolman et al.
Journal of pharmaceutical and biomedical analysis, 107, 403-408 (2015-02-11)
A quantitative bioanalytical liquid chromatography-tandem mass spectrometric (LC-MS/MS) assay for GSK2126458, a dual PI3K/mTOR inhibitor, was developed and validated. Plasma and tumor homogenate samples were pre-treated using protein precipitation with acetonitrile containing dabrafenib as internal standard. After dilution with water...
D Nagasamy Venkatesh et al.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 23(6), 667-674 (2015-12-25)
Nelfinavir mesylate (NFV) is an anti-viral drug, used in the treatment of Acquired Immunodeficiency Syndrome (AIDS). Poor oral bioavailability and shorter half-life (3.5-5 h) remain a major clinical limitation of NFV leading to unpredictable drug bioavailability and frequent dosing. In this...
Wei Zhang et al.
Drug development and industrial pharmacy, 40(8), 1101-1111 (2013-07-12)
4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) is a novel nucleoside analog of great interest because of its superior activity against wild-type and multidrug-resistant HIV-1 strains, and favorable safety profiles in vitro and in vivo. The aim of this work was to provide preformulation information...
Facile in-situ preparation of polyaniline/graphene nanocomposites using methanesulfonic acid.
Kim DH and Park SY.
Polymer, 55(12), 2928-2935 (2014)
Valery Radchenko et al.
Nuclear medicine and biology, 41(9), 721-727 (2014-08-05)
The niobium-90 radioisotope ((90)Nb) holds considerable promise for use in immuno-PET, due to its decay parameters (t½ = 14.6h, positron yield=53%, Eß(+)(mean) = 0.35 MeV and Eß(+)(max) = 1.5 MeV). In particular, (90)Nb appears well suited to detect in vivo...
Environmental benefits of methanesulfonic acid. Comparative properties and advantages.
Gernon MD.
Green Chemistry, 1(3), 127-140 (1999)
Wenyuan Liu et al.
Journal of pharmaceutical and biomedical analysis, 52(4), 603-608 (2010-02-09)
10-O-(N,N-dimethylaminoethyl)-ginkgolide B methanesulfonate (XQ-1H), a novel active derivative of ginkgolide B, is a platelet-activating factor antagonist which is being under clinical trial. Two unknown related impurities were observed in analysis of XQ-1H bulk drug. A scaling up preparative liquid chromatography...
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