473790

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Showing 1-12 of 12 results for "473790" within Papers

Diastereoselective synthesis of tetrahydroquinolines via a palladium-catalyzed Heck-Suzuki cascade reaction

Wilson, J. E.

Tetrahedron Letters, 53, 2308-2311 (2012)

Palladium-catalyzed cascade cyclization of ynamides to azabicycles.

Rebecca L Greenaway et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 17(51), 14366-14370 (2011-11-25)

Cascade reactions: A modular assembly of azabicycles by using a cascade cyclization/Suzuki coupling/6π-electrocyclization of bromoenynamides is reported. The reaction offers a wide substituent scope on the bicyclic aminodiene products, which can be selectively oxidized as a general approach to aromatic

Ameliorative Properties of Boronic Compounds in In Vitro and In Vivo Models of Alzheimer's Disease.

Panchanan Maiti et al.

International journal of molecular sciences, 21(18) (2020-09-17)

Alzheimer's disease (AD) is characterized by amyloid (Aβ) aggregation, hyperphosphorylated tau, neuroinflammation, and severe memory deficits. Reports that certain boronic compounds can reduce amyloid accumulation and neuroinflammation prompted us to compare trans-2-phenyl-vinyl-boronic-acid-MIDA-ester (TPVA) and trans-beta-styryl-boronic-acid (TBSA) as treatments of deficits

Build/couple/pair strategy combining the Petasis 3-component reaction with Ru-catalyzed ring-closing metathesis and isomerization.

Erhad Ascic et al.

ACS combinatorial science, 14(4), 253-257 (2012-02-24)

A "build/couple/pair" pathway for the systematic synthesis of structurally diverse small molecules is presented. The Petasis 3-component reaction was used to synthesize anti-amino alcohols displaying pairwise reactive combinations of alkene moieties. Upon treatment with a ruthenium alkylidene-catalyst, these dienes selectively

Rh(I)-catalyzed asymmetric 1,2-addition to α-diketones with chiral sulfur-alkene hybrid ligands.

Xiangqing Feng et al.

Organic letters, 14(2), 624-627 (2012-01-12)

This paper describes a Rh(I)-catalyzed highly efficient and enantioselective 1,2-addition of arylboronic acids to α-diketones with the use of a simple sulfur-alkene hybrid ligand. With as low as a 0.1 mol % catalyst loading, a variety of optically active α-hydroxyketones

Iridium-catalyzed addition of aroyl chlorides and aliphatic acid chlorides to terminal alkynes.

Tomohiro Iwai et al.

Journal of the American Chemical Society, 134(2), 1268-1274 (2011-12-14)

Iridium complexes show high catalytic activity in intermolecular additions of acid chlorides to terminal alkynes to afford valuable (Z)-β-chloro-α,β-unsaturated ketones. Ligands in the catalytic system play a crucial role in this reaction. An N-heterocyclic carbene (NHC) is an efficient ligand

Lewis acid promoted highly diastereoselective Petasis Borono-Mannich reaction: efficient synthesis of optically active β,γ-unsaturated α-amino acids.

Yi Li et al.

Organic letters, 14(8), 2062-2065 (2012-04-07)

An efficient and straightforward method for the preparation of highly enantiomerically enriched β,γ-unsaturated α-amino acid derivatives by a Lewis acid promoted diastereoselective Petasis reaction of vinylboronic acid, N-tert-butanesulfinamide, and glyoxylic acid has been developed. The synthetic utilities of the approach

Ambient temperature synthesis of high enantiopurity N-protected peptidyl ketones by peptidyl thiol ester-boronic acid cross-coupling.

Hao Yang et al.

Journal of the American Chemical Society, 129(5), 1132-1140 (2007-02-01)

alpha-Amino acid thiol esters derived from N-protected mono-, di-, and tripeptides couple with aryl, pi-electron-rich heteroaryl, or alkenyl boronic acids in the presence of stoichiometric Cu(I) thiophene-2-carboxylate and catalytic Pd(2)(dba)(3)/triethylphosphite to generate the corresponding N-protected peptidyl ketones in good-to-excellent yields

Palladium(0)-catalyzed direct cross-coupling reaction of allyl alcohols with aryl- and vinyl-boronic acids

Hirokazu Tsukamoto, et al.

Chemical Communications (Cambridge, England), 1200-1201 (2004)

Copper-mediated sequential cyanation of aryl C-B and arene C-H bonds using ammonium iodide and DMF.

Jinho Kim et al.

Journal of the American Chemical Society, 134(5), 2528-2531 (2012-01-28)

The cyanation of aromatic boronic acids, boronate esters, and borate salts was developed under copper-mediated oxidative conditions using ammonium iodide and DMF as the source of nitrogen and carbon atom of the cyano unit, respectively. The procedure was successfully extended

Rh2(II)-catalyzed intramolecular aliphatic C-H bond amination reactions using aryl azides as the N-atom source.

Quyen Nguyen et al.

Journal of the American Chemical Society, 134(17), 7262-7265 (2012-04-24)

Rhodium(II) dicarboxylate complexes were discovered to catalyze the intramolecular amination of unactivated primary, secondary, or tertiary aliphatic C-H bonds using aryl azides as the N-atom precursor. While a strong electron-withdrawing group on the nitrogen atom is typically required to achieve

Ligand Effects on the Stereochemical Outcome of Suzuki-Miyaura Couplings

Lu, G-P.; et al.

The Journal of Organic Chemistry, 77, 370-3703 (2012)

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