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Katsuyoshi Horibata et al.
Environmental and molecular mutagenesis, 54(9), 747-754 (2013-10-10)
The recently developed Pig-a mutation assay is based on flow cytometric enumeration of glycosylphosphatidylinositol (GPI) anchor-deficient red blood cells caused by a forward mutation in the Pig-a gene. Because the assay can be conducted in nontransgenic animals and the mutations
Tianshun Zhang et al.
Mutation research, 752(1-2), 34-41 (2013-02-02)
Black soybean seed coat is a rich source of polyphenols that have been reported to have various physiological functions. The present study investigated the potential protective effects of polyphenolic extracts from black soybean seed coat on DNA damage in human
Heloísa H P Oliveira et al.
Ecotoxicology and environmental safety, 96, 67-74 (2013-07-23)
In an attempt to explore complex metabolic interactions between toxicants present in polluted freshwater, hepatic metabolism of benzo(a)pyrene (BaP) and tributyltin (TBT) in fish was investigated when these compounds were administrated alone, mixed together and along with dichlorodiphenyltrichloroethane (DDT). Ten
Axelle Chiffre et al.
Environmental science and pollution research international, 22(22), 17486-17498 (2015-07-04)
This study investigates the variations of polycyclic aromatic hydrocarbon (PAH) levels in surface water, suspended particulate matter (SPM) and sediment upstream and downstream of the discharges of two wastewater treatment plant (WWTP) effluents. Relationships between the levels of PAHs in
Yu Bon Man et al.
Mutation research, 752(1-2), 47-56 (2013-02-09)
The aim of this study was to evaluate mutagenicity and genotoxicity of soils from 12 different land use types such as electronic waste dismantling workshop, open burning site and car dismantling workshop (CDW), based on soil concentrations of polycyclic aromatic
Gunnar Boysen et al.
Mutation research, 543(1), 17-30 (2003-01-03)
We review studies which investigate the presence, using structure-specific analytical methods, of DNA or protein adducts of the carcinogen benzo[a]pyrene (BaP) in human tissues. The analytical methods include high performance liquid chromatography with fluorescence detection and gas chromatography-mass spectrometry. Although
H Fromme et al.
Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)), 55(4), 195-205 (1993-04-01)
Polycyclic aromatic hydrocarbons (PAH) have become an ubiquitous upper soil component in consequence of industrialisation involving a multitude of combustion processes. Meaningful contaminations can be found on child playgrounds, for example. These may enter into the organism of small children
Yizhi Song et al.
Environmental pollution (Barking, Essex : 1987), 195, 178-184 (2014-09-23)
A whole-cell bacterial bioreporter Acinetobacter baylyi strain ADP1_recA_lux that responds to genotoxins was employed to directly assess the adverse effects of the bioavailable fraction of mitomycin C (MMC), benzo[a]pyrene (BaP), chromium (VI) and lead (II) in amended soils and soil
Ying Pang et al.
Toxicology letters, 218(2), 105-117 (2013-01-22)
Both arsenite and benzo(a)pyrene (BaP) are known human carcinogens. Studies on the mode-of-action of arsenite indicate that it can also act as co-carcinogen or as a cancer promoter, and that it can facilitate progression of cancers. Some studies on development
[Information on a new occupational disease: "Lung cancer caused by polycyclic aromatic hydrocarbons with evidence of the effect of a cumulative dose of at least 100 benzo(a)pyrene years ([microgram/m3] * years)].
G Praml et al.
Pneumologie (Stuttgart, Germany), 52(12), 684-686 (1999-02-24)
Larisa Ilijin et al.
Environmental toxicology and chemistry, 34(11), 2618-2624 (2015-06-17)
Increased presence of benzo[a]pyrene in the environment underlines the need for development of sensitive biomarkers for monitoring. Antioxidative enzymes could be used as early-warning signals because of their sensitivity and applicability. The activity of 2 antioxidative enzymes, superoxide dismutase (SOD)
Wei Zhao et al.
Toxicology, 309, 73-80 (2013-05-09)
To explore the relationship between DNA polymerase β (pol β) overexpression and benzo[a]pyrene (BaP) carcinogenesis. Firstly, mouse embryonic fibroblasts that express wild-type level of DNA polymerase β (pol β cell) and high level of pol β (pol β oe cell)
Rapid determination of benzo(a)pyrene in olive oil samples with solid-phase extraction and low-pressure, wide-bore gas chromatography-mass spectrometry and fast liquid chromatography with fluorescence detection
Bogusz MJ, et al.
Journal of Chromatography A, 1026(1-2), 1-7 (2004)
Rajesh Mandarapu et al.
Journal of immunotoxicology, 12(1), 48-55 (2014-02-07)
In the past two decades, hematologic and immunologic disorders in humans have been increasingly reported as a result of pesticide exposures. Therefore, safety assessment is required to assess the effects on hematopoiesis and thus on the immune system in addition
Tong Liu et al.
Gene, 555(2), 108-118 (2014-12-03)
HSP70 and HSP90 are the most important heat shock proteins (HSPs), which play the key roles in the cell as molecular chaperones and may involve in metabolic detoxification. The present research has obtained full-length cDNAs of genes HSP70 and HSP90
Claudia Luckert et al.
Toxicology letters, 222(2), 180-188 (2013-07-13)
Metabolic activation of polycyclic aromatic hydrocarbons (PAH) is mediated mainly by cytochrome P₄₅₀ monooxygenases (CYP) CYP1A1, 1A2 and 1B1. Several PAH are known to induce these CYP via aryl hydrocarbon receptor (AhR) signaling. Recently, it was shown that the PAH
Marlon J A Jetten et al.
Toxicology, 323, 61-69 (2014-06-21)
Large differences in toxicity responses occur within the human population. In this study we evaluate whether interindividual variation in baseline enzyme activity (EA)/gene expression (GE) levels in liver predispose for the variation in toxicity responses by assessing dose-response relationships for
Diane Benford et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 48 Suppl 1, S42-S48 (2009-10-13)
Benzo[a]pyrene (BaP) and a number of other polycyclic aromatic hydrocarbons (PAH) are mutagenic and are also carcinogenic in rodent bioassays. Oral carcinogenicity data are not available for individual PAH other than BaP, and so BaP has been used as a
Lenka Smerdová et al.
Toxicology, 314(1), 30-38 (2013-09-13)
Long-term deregulated inflammation represents one of the key factors contributing to lung cancer etiology. Previously, we have observed that tumor necrosis factor-α (TNF-α), a major pro-inflammatory cytokine, enhances genotoxicity of benzo[a]pyrene (B[a]P), a highly carcinogenic polycyclic aromatic hydrocarbon, in rat
Liyun Gao et al.
Toxicology letters, 223(2), 205-210 (2013-10-03)
It has recently been found that the new class of transcripts, long non-coding RNAs (lncRNAs), are pervasively transcribed in the genome. LncRNAs are a large family of non-coding RNAs and regulate many protein-coding genes. Growing evidence indicates that lncRNAs may
Seema Bansal et al.
The Journal of biological chemistry, 289(14), 9936-9951 (2014-02-06)
We report that polycyclic aromatic hydrocarbon (PAH)-inducible CYP1B1 is targeted to mitochondria by sequence-specific cleavage at the N terminus by a cytosolic Ser protease (polyserase 1) to activate the cryptic internal signal. Site-directed mutagenesis, COS-7 cell transfection, and in vitro
Juan Du et al.
Archives of environmental contamination and toxicology, 66(3), 370-378 (2014-02-21)
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in aquatic ecosystems and have been shown to be one of the causes of sediment toxicity to benthic invertebrates. Benzo[a]pyrene (BaP) was selected as a representative for the PAH family of compounds for developing
Hui Chang et al.
Carcinogenesis, 35(8), 1847-1854 (2014-05-28)
The mammalian target of rapamycin (mTOR), which is a master regulator of cellular catabolism and anabolism, plays an important role in tumourigenesis and progression. In this study, we report the chemopreventive effect of the dietary compound ampelopsin (AMP) on breast
Haixia Lin et al.
Toxicological sciences : an official journal of the Society of Toxicology, 139(2), 338-349 (2014-03-07)
Ginkgo biloba has been used for many thousand years as a traditional herbal remedy and its extract has been consumed for many decades as a dietary supplement. Ginkgo biloba leaf extract is a complex mixture with many constituents, including flavonol
S R Crowell et al.
Toxicology letters, 228(1), 48-55 (2014-04-29)
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous and often carcinogenic contaminants released into the environment during natural and anthropogenic combustion processes. Benzo[a]pyrene (B[a]P) is the prototypical carcinogenic PAH, and dibenzo[def,p]chrysene (DBC) is a less prevalent, but highly potent transplacental carcinogenic PAH.
Samuel Obiri et al.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 48(4), 408-416 (2013-02-06)
This study is part of a broader initiative to characterize, quantify and assess the human health risk associated with exposure to polycyclic aromatic hydrocarbons (PAHs) in street dust along the Trans-ECOWAS highway in West Africa. In the first part, PAHs
H A Hattemer-Frey et al.
Toxicology and industrial health, 7(3), 141-157 (1991-05-01)
A multimedia transport model was used to evaluate the environmental partitioning of benzo-a-pyrene (BaP). Measured and predicted environmental concentrations were used to estimate the accumulation of BaP in the food chain and the subsequent extent of human exposure from inhalation
Bioaccumulation in Marine Organisms: Effect of Contaminants from Oil Well Produced Water (2002)
Rapid determination of benzo [a] pyrene in roasted coffee and coffee brew by high-performance liquid chromatography with fluorescence detection
De Kruijf N, et al.
Journal of Agricultural and Food Chemistry, 35(4), 545-549 (1987)
Susanna Sforzini et al.
Chemosphere, 107, 282-289 (2014-01-15)
An immunohistochemical method using antibodies against polycyclic aromatic hydrocarbons (PAHs) and dioxins was developed on frozen tissue sections of the earthworm Eisenia andrei exposed to environmentally relevant concentrations of benzo[a]pyrene (B[a]P) (0.1, 10, 50 ppm) and 2,3,7,8-tetrachloro-dibenzo-para-dioxin (TCDD) (0.01, 0.1
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