Showing 1-30 of 33 results for "


Tao Chen et al.
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 41(4), 700-702 (2010-09-21)
To design and synthesize novel peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. A series of novel PPARgamma agonists were designed based on the binding character of PPARgamma agonists and the distribution of pharmacophore. The target compounds were synthesized using p-hydroxybenzaldehyde, 1...
Ethylene dibromide (1,2-dibromoethane).
IARC monographs on the evaluation of carcinogenic risks to humans, 71 Pt 2, 641-669 (1999-09-07)
Biao Gu et al.
The Analyst, 140(8), 2778-2784 (2015-02-27)
A novel ratiometric fluorescent Hg(2+) detecting system was rationally developed based on the typical excited state intramolecular proton transfer (ESIPT) characteristic of the latent fluorophore, 2-(1-(p-tolyl)-1H-phenanthro[9,10-d]imidazol-2-yl)phenol (Pol) and the Hg(2+)-mediated cleavage of the vinyl group. The probe responds selectively to...
Elisabeth M Loecken et al.
Chemical research in toxicology, 21(2), 453-458 (2008-01-01)
The environmental contaminant 1,2-dibromoethane and diepoxybutane, an oxidation product of the important industrial chemical butadiene, are bis-functional electrophiles and are known to be mutagenic and carcinogenic. One mechanism by which bis-electrophiles can exert their toxic effects is through the induction...
Yoen Jung Lee et al.
Molecules and cells, 33(3), 309-316 (2012-03-22)
To identify specific biomarkers generated upon exposure of L5178Y mouse lymphoma cells to carcinogens, 2-DE and MALDI-TOF MS analysis were conducted using the cellular proteome of L5178Y cells that had been treated with the known carcinogens, 1,2-dibromoethane and O-nitrotoluene and...
Kengo Watanabe et al.
Chemical research in toxicology, 20(11), 1594-1600 (2007-10-03)
Dihaloalkanes are of toxicological interest because of their high-volume use in industry and their abilities to cause tumors in rodents, particularly dichloromethane and 1,2-dichloroethane. The brominated analogues are not used as extensively but are known to produce more toxicity in...
Katerina Papezová et al.
Journal of chromatography. A, 1150(1-2), 327-331 (2006-10-03)
Substrate inhibition is a common phenomenon in enzyme kinetics. We report here for the first time its study by a combination of the electrophoretically mediated microanalysis (EMMA) methodology with a partial filling technique. In this setup, the part of capillary...
Yoen Jung Lee et al.
Molecules and cells, 33(2), 203-210 (2012-02-24)
1,2-Dibromoethane and glycidol are well known genotoxic carcinogens, which have been widely used in industry. To identify a specific biomarker for these carcinogens in cells, the cellular proteome of L5178Y mouse lymphoma cells treated with these compounds was analyzed by...
Annamaria Colacci et al.
Toxicology in vitro : an international journal published in association with BIBRA, 25(6), 1183-1190 (2011-06-16)
Cell transformation assays (CTAs) are currently regarded as the only possible in vitro alternative to animal testing for carcinogenesis studies. CTAs have been proposed as screening tests for the carcinogenic potential of compounds that have no evidence of genotoxicity but...
Frida Jonsson et al.
Human mutation, 36(4), 463-473 (2015-02-14)
Corneal dystrophies are a clinically and genetically heterogeneous group of inherited disorders that bilaterally affect corneal transparency. They are defined according to the corneal layer affected and by their genetic cause. In this study, we identified a dominantly inherited epithelial...
Genotoxic effects of 1,2-dibromoethane and 1,2-dichloroethane.
U Rannug
Mutation research, 76(3), 269-295 (1980-11-01)
Report on carcinogens : carcinogen profiles, 12, 135-138 (2011-08-20)
Ngoc-Duc Doan et al.
Biopolymers, 104(5), 629-635 (2015-03-20)
The conformation of the N-amino-imidazolidin-2-one (Aid) peptidomimetic was investigated using NMR spectroscopy and X-ray crystallography. In solution, the tetrapeptide model p-bromobenzoyl-Aid-l-Phe-N'-iso-propylamide (1) exhibited shielded and solvent exposed amide protons indicative of a turn conformation. In the crystal lattice of 1...
James K Henderson et al.
Environmental science & technology, 42(3), 864-870 (2008-03-08)
Field evidence from underground storage tank sites where leaded gasoline leaked indicates the lead scavengers 1,2-dibromoethane (ethylene dibromide, or EDB) and 1,2-dichloroethane (1,2-DCA) may be present in groundwater at levels that pose unacceptable risk. These compounds are seldom tested for...
James K Henderson et al.
Journal of contaminant hydrology, 108(1-2), 29-45 (2009-06-19)
An analytical model is used to simulate the effects of partial source removal and plume remediation on ethylene dibromide (EDB) and 1,2-dichloroethane (1,2-DCA) plumes at contaminated underground storage tank (UST) sites. The risk posed by EDB, 1,2-DCA, and commingled gasoline...
Anthony S Danko et al.
New biotechnology, 30(1), 39-43 (2012-05-23)
The ability of pentane, benzene, and toluene to support aerobic cometabolism of ethylene dibromide (1,2-dibromoethane, EDB) was evaluated. A pentane enrichment culture cometabolized EDB, with a transformation capacity of 0.35 μmol EDB/mg biomass (66.2 μg EDB/mg biomass) in the absence...
S D Humphreys et al.
Adverse drug reactions and toxicological reviews, 18(3), 125-148 (1999-12-11)
DBE is transported in the UK in road tankers and there is always the possibility of an accident. The consequences could be serious, since this chemical is absorbed by all routes, rapidly penetrates clothing and there is no effective antidote....
Maryam Ebrahimi et al.
Journal of the American Chemical Society, 133(41), 16560-16565 (2011-09-02)
Adsorbates on metals, but not previously on semiconductors, have been observed to display long-range repulsive interactions. On metals, due to efficient dissipation, the repulsions are weak, typically on the order of 5 meV at 10 Å. On the 7×7 reconstruction...
Oksana Degtjarik et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 69(Pt 3), 284-287 (2013-03-23)
Haloalkane dehalogenases are microbial enzymes that convert a broad range of halogenated aliphatic compounds to their corresponding alcohols by the hydrolytic mechanism. These enzymes play an important role in the biodegradation of various environmental pollutants. Haloalkane dehalogenase LinB isolated from...
Emmy De Buck et al.
PloS one, 10(4), e0122523-e0122523 (2015-04-16)
Although increased prevalence of transfusion transmissible infections (TTI) among "men who have sex with men" (MSM) has been well documented, the exclusion of MSM as blood donors is contested. The aim of this systematic review is to find studies that...
Robert McKeever et al.
Journal of hazardous materials, 209-210, 92-98 (2012-02-04)
Although 1,2-dibromoethane (EDB) is a common groundwater contaminant, there is the lack of knowledge surrounding EDB biodegradation, especially under aerobic conditions. We have performed an extensive microcosm study to investigate the biodegradation of EDB under simulated in situ and biostimulated...
Rong Yu et al.
Applied and environmental microbiology, 79(4), 1359-1367 (2012-12-25)
1,2-Dichloroethane (1,2-DCA) and 1,2-dibromoethane (ethylene dibromide [EDB]) contaminate groundwater at many hazardous waste sites. The objectives of this study were to measure yields, maximum specific growth rates (μ), and half-saturation coefficients (K(S)) in enrichment cultures that use 1,2-DCA and EDB...
Tomasz Kuder et al.
Environmental science & technology, 46(14), 7495-7502 (2012-06-09)
EDB (1,2-dibromoethane) is frequently detected at sites impacted by leaded gasoline. In reducing environments, EDB is highly susceptible to abiotic degradation. A study was conducted to evaluate the potential of compound-specific isotope analysis (CSIA) in assessing abiotic degradation of EDB...
Neelima Singh et al.
The Journal of the Association of Physicians of India, 55, 842-845 (2008-04-15)
In view of high incidence and mortality due to ethylene dibromide poisoning, a prospective study was planned to assess demographic, toxicological, clinical profile and outcome. Prospectively collected data of sixty four patients with ethylene dibromide poisoning were reviewed. All the...
Monique T Binet et al.
Environmental toxicology and chemistry, 29(9), 1984-1993 (2010-09-08)
As part of a larger study investigating the fate and effects of brominated volatile organic compounds (VOCs) in contaminated groundwaters discharging to surface waters, the toxicity of 1,2 dibromoethene (DBE) and 1,1,2-tribromoethene (TriBE) to freshwater aquatic biota was investigated. Their...
Liping Liu et al.
Chemical research in toxicology, 20(1), 155-163 (2007-01-18)
The production of mutations and the reduction in survival of cells treated with alpha,omega-dihaloalkanes is greatly enhanced by the presence of O6-alkylguanine-DNA alkyltransferase (AGT), a DNA repair protein that removes O6-alkylguanine adducts from DNA [Liu, L., Hachey, D. L., Valadez...
A Ch Mitropoulos
Journal of colloid and interface science, 336(2), 679-690 (2009-06-09)
Porous Vycor is examined by measuring CH(2)Br(2) adsorption in situ with small-angle X-ray scattering. When a class of pores fills with condensed vapors of this particular adsorbate it ceases to act as scatterer and only the remaining empty pores produce...
Jin-Ling Song et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 74(5), 1084-1089 (2009-10-24)
The quaterisation process of 1,2-dibromoethane and pyridine is in situ traced by electronic absorption spectrum. Two absorption peaks, induced by mono- and bis-pyridinium salt of 1,2-dibromoethane, appear at 429 nm and 313 nm, respectively. To explain the phenomena, several kinds...
J A Hoppin et al.
The European respiratory journal, 34(6), 1296-1303 (2009-06-23)
Although specific pesticides have been associated with wheeze in farmers, little is known about pesticides and asthma. Data from 19,704 male farmers in the Agricultural Health Study were used to evaluate lifetime use of 48 pesticides and prevalent adult-onset asthma...
Mir Ali Farajzadeh et al.
Biomedical chromatography : BMC, 29(12), 1921-1931 (2015-05-28)
In present study, a simultaneous derivatization and air-assisted liquid-liquid microextraction method combined with gas chromatography-nitrogen phosphorous detection has been developed for the determination of some phenolic compounds in biological samples. The analytes are derivatized and extracted simultaneously by a fast...