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Aghil Sharifzadeh et al.
Mycoses, 58(8), 478-484 (2015-07-15)
The purposes of this study were to investigate the enzymatic activity of different Candida species and their antifungal susceptibility patterns. The study involved a total of 83 isolates of Candida from the genital tract of the female Camelus dromedarius. After
Yiying Liu et al.
PloS one, 10(8), e0136241-e0136241 (2015-09-01)
Emerging fungal and oomycete pathogens are increasingly threatening animals and plants globally. Amongst oomycetes, Saprolegnia species adversely affect wild and cultivated populations of amphibians and fish, leading to substantial reductions in biodiversity and food productivity. With the ban of several
Brian M Zid et al.
Nature, 514(7520), 117-121 (2014-08-15)
A universal feature of the response to stress and nutrient limitation is transcriptional upregulation of genes that encode proteins important for survival. Under many such conditions, the overall protein synthesis level is reduced, thereby dampening the stress response at the
Marta Pokrywczynska et al.
Pancreas, 43(5), 801-808 (2014-04-18)
This study was designed to evaluate the impact of fructose-rich diet and chronic kidney disease (CKD) on the in vitro function of pancreatic islets. Fifty-four rats were divided into 3 equal groups as follows: control, rats with CKD 1/2 that
Archana Kumari et al.
Journal of neurophysiology, 113(3), 1034-1040 (2014-11-14)
Taste sensation on the anterior tongue requires chorda tympani nerve function and connections with continuously renewing taste receptor cells. However, it is unclear which signaling pathways regulate the receptor cells to maintain chorda tympani sensation. Hedgehog (HH) signaling controls cell
Hibah O Awwad et al.
Frontiers in neurology, 6, 132-132 (2015-07-03)
Physiological alterations, anxiety, and cognitive disorders are strongly associated with blast-induced traumatic brain injury (blast TBI), and are common symptoms in service personnel exposed to blasts. Since 2006, 25,000-30,000 new TBI cases are diagnosed annually in U.S. Service members; increasing
Xinchun Lin et al.
Critical care medicine, 43(6), e160-e169 (2015-03-19)
Administration of NaHCO3 does not improve cellular function or reduce the mortality of acute lactic acidosis. This might be related to aggravation of intracellular acidosis, but it could also be due to activation of Na+/H+ exchanger with a deleterious increment
Benjamin D Korman et al.
Arthritis research & therapy, 16(4), R147-R147 (2014-07-12)
Our objectives were to examine mononuclear cell gene expression profiles in patients with systemic lupus erythematosus (SLE) and healthy controls and to compare subsets with and without atherosclerosis to determine which genes' expression is related to atherosclerosis in SLE. Monocytes
Christian Willrodt et al.
Biotechnology and bioengineering, 112(9), 1738-1750 (2015-03-20)
Metabolic engineering strategies mark a milestone for the fermentative production of bulk and fine chemicals. Yet, toxic products and volatile reaction intermediates with low solubilities remain challenging. Prominent examples are artificial multistep pathways like the production of perillyl acetate (POHAc)
Zi Li Lin et al.
The Journal of reproduction and development, 61(5), 361-367 (2015-06-09)
Junction-mediating and regulatory protein (JMY) is a regulator of both transcription and actin filament assembly. JMY is a critical nucleation-promoting factor (NPF); however, its role in the development of mammalian embryos is poorly understood. In the current study, we investigated
Ippei Shimizu et al.
The Journal of clinical investigation, 124(5), 2099-2112 (2014-04-10)
Brown adipose tissue (BAT) is a highly vascularized organ with abundant mitochondria that produce heat through uncoupled respiration. Obesity is associated with a reduction of BAT function; however, it is unknown how obesity promotes dysfunctional BAT. Here, using a murine
Hongtao Dou et al.
Mycoses, 58(3), 149-159 (2015-01-16)
Two strains of Cryptococcus neoformans (PU 66 and PU112) were simultaneously isolated from a patient with systemic lupus erythematosus. We aimed to trace the source of the mixed infections. Multi-locus sequence typing (MLST) and the DiversiLab system analyses were performed
Carlos A Saura et al.
PloS one, 6(4), e19430-e19430 (2011-05-12)
Neurexins are a large family of neuronal plasma membrane proteins, which function as trans-synaptic receptors during synaptic differentiation. The binding of presynaptic neurexins to postsynaptic partners, such as neuroligins, has been proposed to participate in a signaling pathway that regulates
Yang Zhou et al.
Journal of molecular neuroscience : MN, 55(4), 941-950 (2014-11-20)
Sulfiredoxin-1 (Srxn1), an endogenous antioxidant protein, is involved in keeping the balance of the cell's oxidation/reduction and can resist oxidative stress. However, the exact antioxidant effects of Srxn1 remain fully unclear. The study aims to examine the effects of Srxn1
O Carolina Rojas et al.
Mycoses, 58(5), 267-272 (2015-03-03)
Chromoblastomycosis is a chronic granulomatous disease caused frequently by fungi of the Fonsecaea genus. The objective of this study was the phenotypic and molecular identification of F. pedrosoi strains isolated from chromoblastomycosis patients in Mexico and Venezuela. Ten strains were included
Haijiang Wu et al.
Molecular and cellular endocrinology, 417, 27-35 (2015-09-13)
Renal tubular epithelial cells (RTEC) apoptosis, which plays a key role in the pathogenesis and progression of diabetic nephropathy (DN), is believed to be contributive to the hyperglycemia-induced kidney failure, though the exact mechanisms remain elusive. In this study, we
Joanne Packer et al.
BMC research notes, 8, 276-276 (2015-07-01)
This study is a collaboration between Macquarie University researchers and the Yaegl Aboriginal Community of northern NSW, Australia to investigate the antimicrobial potential of plants used in the topical treatment of wounds, sores and skin infections. Based on previously documented
Ying-ying Gong et al.
PloS one, 9(12), e113784-e113784 (2014-12-02)
High-fat diet (HFD) is an environmental factor that contributes to the pathogenesis of obesity and type 2 diabetes. A number of genes influencing oxidative phosphorylation (OXPHOS) were found to be downregulated in skeletal muscle of humans and rats treated with
S Doyon et al.
Emergency medicine clinics of North America, 12(2), 301-316 (1994-05-01)
Flumazenil is an important adjunct to the diagnosis and treatment of benzodiazepine toxicity. It must be used cautiously with attention to a number of clinical caveats. Currently it is advised that flumazenil should not be used routinely in all patients
Jianhua Li et al.
Chembiochem : a European journal of chemical biology, 15(11), 1673-1681 (2014-07-22)
GuA6DT, a flavonoid prenyltransferase, was identified from Glycyrrhiza uralensis, and it was found that this enzyme regiospecifically transfers a dimethylallyl moiety to apigenin at the C-6 position. A further substrate specificity investigation indicated that the existence of hydroxyls at both
Mofoluwake M Ishola et al.
Bioresource technology, 165, 9-12 (2014-03-19)
Oil palm empty fruit bunches (OPEFB), a lignocellulosic residue of palm oil industries was examined for ethanol production. Milled OPEFB exposed to simultaneous saccharification and fermentation (SSF) with enzymes and Saccharomyces cerevisiae resulted just in 14.5% ethanol yield compared to
Erin M Kropp et al.
Stem cells translational medicine, 4(5), 483-493 (2015-04-03)
The tumorigenic potential of human pluripotent stem cells (hPSCs) is a major limitation to the widespread use of hPSC derivatives in the clinic. Here, we demonstrate that the small molecule STF-31 is effective at eliminating undifferentiated hPSCs across a broad
Michael A Pfaller et al.
Journal of clinical microbiology, 52(9), 3223-3229 (2014-06-22)
This study addressed the application of anidulafungin as a surrogate marker to predict the susceptibility of Candida to caspofungin due to unacceptably high interlaboratory variation of caspofungin MIC values. CLSI reference broth microdilution methods and species-specific interpretive criteria were used
N V Batista et al.
Clinical and experimental immunology, 178(3), 416-427 (2014-08-13)
The prevalence of food allergy is rising in the western world. Allergen restriction is the chosen treatment in this condition, but continuous ingestion of the antigen has shown positive results in clinical trials. In a previous study, we have shown
Shefeeq M Theparambil et al.
Glia, 63(9), 1581-1594 (2015-03-31)
Cytosolic H(+) buffering plays a major role for shaping intracellular H(+) shifts and hence for the availability of H(+) for biochemical reactions and acid/base-coupled transport processes. H(+) buffering is one of the prime means to protect the cell from large
Saleh Al-Quraishy et al.
International journal of nanomedicine, 10, 6741-6756 (2015-11-26)
The study was designed to investigate the anti-hyperglycemic activity of selenium nanoparticles (SeNPs) in streptozotocin-induced diabetic rats. Fifty-five mg/kg of streptozotocin was injected in rats to induce diabetes. Animals either treated with SeNPs alone or with insulin (6 U/kg) showed
Benoît Chatin et al.
Molecular therapy. Nucleic acids, 4, e244-e244 (2015-06-24)
The intracellular delivery of biologically active protein represents an important emerging strategy for both fundamental and therapeutic applications. Here, we optimized in vitro delivery of two functional proteins, the β-galactosidase (β-gal) enzyme and the anti-cytokeratin8 (K8) antibody, using liposome-based formulation.
C Ekman et al.
Journal of applied physiology (Bethesda, Md. : 1985), 119(9), 953-960 (2015-09-05)
Healthy first-degree relatives with heredity of type 2 diabetes (FH+) are known to have metabolic inflexibility compared with subjects without heredity for diabetes (FH-). In this study, we aimed to test the hypothesis that FH+ individuals have an impaired response
Clara Iannuzzi et al.
Journal of cellular physiology, 230(11), 2807-2820 (2015-04-08)
Protein glycation is a non-enzymatic, irreversible modification of protein amino groups by reactive carbonyl species leading to the formation of advanced glycation end products (AGEs). Several proteins implicated in neurodegenerative diseases have been found to be glycated in vivo and
Hakan Ciftci et al.
Colloids and surfaces. B, Biointerfaces, 123, 685-691 (2014-12-03)
This study is focused on the investigation of electrocatalytic effect of glucose oxidase (GOx) immobilized on the graphite rod (GR) electrode. The enzyme modified electrode was prepared by encapsulation of immobilized GOx within enzymatically formed poly(1,10-phenanthroline-5,6-dione) (pPD) film. The electrochemical
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