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499609

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Stéphanie Chadet et al.
Journal of immunology (Baltimore, Md. : 1950), 195(2), 651-660 (2015-06-17)
High concentrations of extracellular ATP (eATP) resulting from cell damage may be found during an ischemia/reperfusion (I/R) episode at the site of injury. eATP activates purinergic receptors in dendritic cells (DCs) and may inhibit inflammation. This immunosuppressive activity could be...
Rebecca J Taugher et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(31), 10247-10255 (2014-08-01)
Carbon dioxide (CO2) inhalation lowers brain pH and induces anxiety, fear, and panic responses in humans. In mice, CO2 produces freezing and avoidance behavior that has been suggested to depend on the amygdala. However, a recent study in humans with...
Kenta Nakamura et al.
PloS one, 9(10), e109831-e109831 (2014-10-08)
Retinal regeneration in the adult newt is a useful system to uncover essential mechanisms underlying the regeneration of body parts of this animal as well as to find clues to treat retinal disorders such as proliferative vitreoretinopathy. Here, to facilitate...
Tomasz Rusak et al.
Thrombosis research, 134(1), 192-198 (2014-05-16)
Using patients with polycythemia vera (PV) as an experimental model, we evaluated the impact of clot retraction (CR) and architecture of the clot on fibrinolysis. We studied the kinetics of clot retraction and the fibrinolysis rate in whole blood from...
C Arimany-Nardi et al.
British journal of pharmacology, 171(16), 3868-3880 (2014-05-02)
Inhibitors of DNA methyltransferases (DNMTs), such as azacytidine, decitabine and zebularine, are used for the epigenetic treatment of cancer. Their action may depend upon their translocation across the plasma membrane. The aim of this study was to identify transporter proteins...
Takahito Miyake et al.
Glia, 63(10), 1870-1882 (2015-05-27)
Microglia, the resident immune cells in the brain, survey the environment of the healthy brain. Microglial migration is essential for many physiological and pathophysiological processes. Although microglia express some members of the transient receptor potential (TRP) channel family, there is...
Maria M Pérez-Madrigal et al.
ACS applied materials & interfaces, 6(12), 9719-9732 (2014-05-27)
Nanomembranes have been prepared by spin-coating mixtures of a polythiophene (P3TMA) derivative and thermoplastic polyurethane (TPU) using 20:80, 40:60, and 60:40 TPU:P3TMA weight ratios. After structural, topographical, electrochemical, and thermal characterization, properties typically related with biomedical applications have been investigated:...
Sry D Hujaya et al.
Pharmaceutical research, 32(9), 3066-3086 (2015-04-09)
To investigate the properties of phenylboronic acid-functional poly(amido amine) polymers (BA-PAA) in forming multilayered thin films with poly(vinyl alcohol) (PVA) and chondroitin sulfate (ChS), and to evaluate their compatibility with COS-7 cells. Copolymers of phenylboronic acid-functional poly(amido amine)s, differing in...
Priyanka Sinha et al.
International journal of biological macromolecules, 72, 1069-1075 (2014-10-15)
The utility of isolated okra (Hibiscus esculentus) gum (OG) was evaluated as a potential sustained drug release polymer-blends with sodium alginate in the development of controlled glibenclamide release ionically-gelled beads for oral use. OG was isolated from okra fruits and...
Xingsheng Li et al.
Biochimica et biophysica acta, 1852(12), 2700-2705 (2015-10-03)
Primary Hyperoxaluria Type 3 is a recently discovered form of this autosomal recessive disease that results from mutations in the gene coding for 4-hydroxy-2-oxoglutarate aldolase (HOGA1). This enzyme is one of the 2 unique enzymes in the hydroxyproline catabolism pathway....
Abaid Malik et al.
Basic & clinical pharmacology & toxicology, 116(1), 47-52 (2014-06-05)
The antifungal ionophore nystatin dissipates the Na(+) and K(+) gradients across the cell membrane, leading to cellular gain of Na(+) and cellular loss of K(+) . The increase of cellular Na(+) concentration may result in Ca(2+) accumulation in exchange for...
Jinyuan Chen et al.
Bulletin of environmental contamination and toxicology, 95(2), 145-149 (2015-06-21)
The recent increase in nanomaterial usage has led to concerns surrounding its health risks and environmental impact. The food chain is an important pathway for high-trophic-level organisms absorbing and enriching nanomaterials. Our study therefore simulated nanometer titanium dioxide (nano-TiO2) transfer...
Daniela Sieghart et al.
Journal of cellular and molecular medicine, 19(1), 187-197 (2014-10-15)
Balneotherapy employing sulphurous thermal water is still applied to patients suffering from diseases of musculoskeletal system like osteoarthritis (OA) but evidence for its clinical effectiveness is scarce. Since the gasotransmitter hydrogen sulphide (H2 S) seems to affect cells involved in...
Juan Du et al.
Archives of microbiology, 197(7), 883-888 (2015-05-27)
A yellow-colored, Gram-negative, strictly aerobic, non-motile, rod-shaped bacterium, designated THG-MM5(T), was isolated from road soil in Yongin-si, Gyeonggi-do, Republic of Korea. Based on 16S rRNA gene sequence, strain THG-MM5(T) was moderately related to Sphingomonas sediminicola KACC 15039(T) (96.1%), Sphingomonas ginsengisoli...
Gimano D Amatngalim et al.
Journal of immunology (Baltimore, Md. : 1950), 194(7), 3340-3350 (2015-02-26)
Basal cells play a critical role in the response of the airway epithelium to injury and are recently recognized to also contribute to epithelial immunity. Antimicrobial proteins and peptides are essential effector molecules in this airway epithelial innate immunity. However...
Kaitlin C Murphy et al.
Annals of biomedical engineering, 43(8), 2010-2021 (2014-12-21)
Mesenchymal stem/stromal cells (MSCs) are under examination for use in cell therapies to repair bone defects resulting from trauma or disease. MSCs secrete proangiogenic cues and can be induced to differentiate into bone-forming osteoblasts, yet there is limited evidence that...
Temmei Ito et al.
Biomedical materials (Bristol, England), 10(1), 015025-015025 (2015-03-03)
In order to obtain a hydroxyapatite (HAp)-poly(ethylene glycol) (PEG) composite, tetra amine-terminated PEG was crosslinked using disuccinimidyl tartrate to obtain a PEG hydrogel. Using two kinds of chelators with different stability constants for Ca ion (N-(2-hydroxyethyl) ethylenediamine-N,N',N'-triacetic acid (EDTA-OH, 8.14)...
Mara Alaide Guzmán-Ruiz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(46), 15419-15429 (2015-11-21)
In mammals, daily changes in body temperature (Tb) depend on the integrity of the suprachiasmatic nucleus (SCN). Fasting influences the Tb in the resting period and the presence of the SCN is essential for this process. However, the origin of...
Clément Menuet et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(45), 15110-15122 (2014-11-08)
Brainstem catecholaminergic neurons play key roles in the autonomic, neuroendocrine, and behavioral responses to glucoprivation, yet the functions of the individual groups are not fully understood. Adrenergic C3 neurons project widely throughout the brain, including densely to sympathetic preganglionic neurons...
Michael R King et al.
American journal of physiology. Cell physiology, 308(10), C792-C802 (2015-03-20)
Circulating tumor cells (CTC) have been implicated in the hematogenous spread of cancer. To investigate the fluid phase of cancer from a physical sciences perspective, the multi-institutional Physical Sciences-Oncology Center (PS-OC) Network performed multidisciplinary biophysical studies of single CTC and...
Jae Ho Jo et al.
Biomedical materials (Bristol, England), 10(4), 045007-045007 (2015-07-15)
This study was undertaken to evaluate the effects of different rhBMP-2 release profiles in defect areas around dental implants on osseointegration and bone regeneration. Four beagle dogs (13-15 kg) were used. The defect was 3 mm deep and there was a 1 mm...
Corey P Parlet et al.
Journal of leukocyte biology, 97(4), 769-778 (2015-01-22)
Alcoholics are at increased risk of Staphylococcus aureus skin infection and serious sequelae, such as bacteremia and death. Despite the association between alcoholism and severe S. aureus skin infection, the impact of EtOH on anti-S. aureus cutaneous immunity has not...
Kiranj K Chaudagar et al.
Clinical and experimental hypertension (New York, N.Y. : 1993), 36(8), 557-566 (2014-02-05)
Telmisartan possesses endothelial protective effects due to angiotensin II type 1 receptor antagonist, peroxisome proliferator-activated receptor γ (PPARγ) agonist and antioxidant action. Therefore, our objective was to study effect of telmisartan on angiogenic responsiveness of coronary endothelial cells (cECs) of...
Fei Ma et al.
Meat science, 95(1), 22-26 (2013-05-07)
The effects of high pressure processing (HPP) on the water-binding capacity and texture profile (TPA) of salt-soluble meat protein (SSMP) containing 0.2% CaCl2 and 0.6% κ-carrageenan (SSMP-CK) gels were investigated. The results showed that 300-400 MPa improved water-binding capacity and...
Aurélie Ginisty et al.
Stem cells (Dayton, Ohio), 33(2), 515-525 (2014-10-14)
Neural stem cells, whose major reservoir in the adult mammalian brain is the subventricular zone (SVZ), ensure neuropoiesis, a process during which many generated cells die. Removal of dead cells and debris by phagocytes is necessary for tissue homeostasis. Using...
Stefan Spulber et al.
PloS one, 9(4), e94227-e94227 (2014-04-18)
Perfluorooctane sulfonate (PFOS) is a widely spread environmental contaminant. It accumulates in the brain and has potential neurotoxic effects. The exposure to PFOS has been associated with higher impulsivity and increased ADHD prevalence. We investigated the effects of developmental exposure...
Davi A G Mázala et al.
American journal of physiology. Cell physiology, 308(9), C699-C709 (2015-02-06)
Duchenne muscular dystrophy (DMD) is characterized by progressive muscle wasting secondary to repeated muscle damage and inadequate repair. Elevations in intracellular free Ca²⁺ have been implicated in disease progression, and sarcoplasmic/endoplasmic reticulum Ca²⁺-ATPase 1 (SERCA1) overexpression has been shown to...
Tasha M Santiago-Rodriguez et al.
Microbiome, 3, 58-58 (2015-11-10)
Most human microbiota studies focus on bacteria inhabiting body surfaces, but these surfaces also are home to large populations of viruses. Many are bacteriophages, and their role in driving bacterial diversity is difficult to decipher without the use of in...
Kelly B Clancy et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(9), 3946-3958 (2015-03-06)
Layer (L)2 is a major output of primary sensory cortex that exhibits very sparse spiking, but the structure of sensory representation in L2 is not well understood. We combined two-photon calcium imaging with deflection of many whiskers to map whisker...
Andrew T Lucas et al.
PloS one, 9(11), e112823-e112823 (2014-11-15)
The translationally-controlled tumor protein (TCTP) is a highly conserved, ubiquitously expressed, abundant protein that is broadly distributed among eukaryotes. Its biological function spans numerous cellular processes ranging from regulation of the cell cycle and microtubule stabilization to cell growth, transformation...
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