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Showing 1-30 of 71 results for "50926" within Papers
Pinar Erkekoglu et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 72, 98-110 (2014-07-12)
Most common alkylanilines in the environment are 2,6-dimethylaniline (2,6-DMA), 3,5-dimethylaniline (3,5-DMA), and 3-ethylaniline (3-EA). 3,5-Dimethylaminophenol (3,5-DMAP), a metabolite of 3,5-DMA, is of particular interest, as it is potentially genotoxic. Supplementation with organic or inorganic forms of selenium (Se) may reduce
C Couteau et al.
International journal of pharmaceutics, 476(1-2), 160-163 (2014-10-01)
Given that previous studies have highlighted the anti-inflammatory nature, which is influenced by UV radiation, of a certain number of ultraviolet filters currently used in Europe, it seemed interesting to evaluate the persistence of this type of effect. The persistence
Alice E McGovern et al.
British journal of pharmacology, 171(15), 3633-3650 (2014-04-26)
Subtypes of the hyperpolarization-activated cyclic nucleotide-gated (HCN) family of cation channels are widely expressed on nerves and smooth muscle cells in many organ systems, where they serve to regulate membrane excitability. Here we have assessed whether HCN channel inhibitors alter
K Korgavkar et al.
The British journal of dermatology, 172(3), 606-615 (2014-09-27)
Striae gravidarum (SG), or stretch marks developing during pregnancy, affect up to 90% of women. While not medically dangerous, SG can be disfiguring, causing emotional and psychological distress. However, studies specifically addressing the prevention of SG, especially during pregnancy, are
Víctor Sanabria-Ayala et al.
Parasitology research, 114(1), 55-64 (2014-10-03)
Previous studies demonstrated that antibodies against triosephosphate isomerase of Taenia solium (TTPI) can alter its enzymatic catalysis. In the present study, we used antibodies produced against the NH2-terminal region of TTPI (1/3NH2TTPI) and the phage display technology to find target
Shinichi Meguro et al.
PloS one, 10(3), e0120142-e0120142 (2015-03-19)
Fat-rich diets not only induce obesity in humans but also make animals obese. Therefore, animals that accumulate body fat in response to a high-fat diet (especially rodents) are commonly used in obesity research. The effect of dietary fat on body
Anna A DePaoli-Roach et al.
The Journal of biological chemistry, 290(2), 841-850 (2014-11-25)
Glycogen is a branched polymer of glucose that acts as an energy reserve in many cell types. Glycogen contains trace amounts of covalent phosphate, in the range of 1 phosphate per 500-2000 glucose residues depending on the source. The function
Jiwei Cui et al.
ACS nano, 9(2), 1571-1580 (2015-02-26)
We report the engineering of poly(ethylene glycol) (PEG) hydrogel particles using a mesoporous silica (MS) templating method via tuning the PEG molecular weight, particle size, and the presence or absence of the template and investigate the cell association and biodistribution
Huan Zhang et al.
Reproduction (Cambridge, England), 148(1), 43-54 (2014-04-02)
In mammals, the primordial follicle pool, providing all oocytes available to a female throughout her reproductive life, is established perinatally. Dysregulation of primordial follicle assembly results in female reproductive diseases, such as premature ovarian insufficiency and infertility. Female mice lacking
Nirupama Ramkumar et al.
American journal of physiology. Renal physiology, 307(8), F931-F938 (2014-08-15)
The physiological and pathophysiological significance of collecting duct (CD)-derived renin, particularly as it relates to blood pressure (BP) regulation, is unknown. To address this question, we generated CD-specific renin knockout (KO) mice and examined BP and renal salt and water
Mervyn G Thomas et al.
Human molecular genetics, 23(15), 4086-4093 (2014-04-02)
Idiopathic infantile nystagmus (IIN) is a genetically heterogeneous disorder, often associated with FRMD7 mutations. As the appearance of the retina is reported to be normal based on conventional fundus photography, IIN is postulated to arise from abnormal cortical development. To
J R Vergara-Salinas et al.
Food chemistry, 171, 62-69 (2014-10-14)
Pressurized hot water extracts obtained at different temperatures possess different compositions and antioxidant activities and, consequently, different bioactivities. We characterized two pressurized hot water extracts from grape pomace obtained at 100°C (GPE100) and 200°C (GPE200) in terms of antioxidant activity
Sabine H van Rijt et al.
ACS nano, 9(3), 2377-2389 (2015-02-24)
Nanoparticles allow for controlled and targeted drug delivery to diseased tissues and therefore bypass systemic side effects. Spatiotemporal control of drug release can be achieved by nanocarriers that respond to elevated levels of disease-specific enzymes. For example, matrix metalloproteinase 9
F Matsuda et al.
Journal of neuroendocrinology, 27(1), 57-65 (2014-11-05)
A luteinising hormone (LH) surge is fundamental to the induction of ovulation in mammalian females. The administration of a preovulatory level of oestrogen evokes an LH surge in ovariectomised females, whereas the response to oestrogen in castrated males differs among
Eva Mihailovska et al.
Molecular biology of the cell, 25(25), 4130-4149 (2014-10-17)
Mutations in the cytolinker protein plectin lead to grossly distorted morphology of neuromuscular junctions (NMJs) in patients suffering from epidermolysis bullosa simplex (EBS)-muscular dystrophy (MS) with myasthenic syndrome (MyS). Here we investigated whether plectin contributes to the structural integrity of
Elena B Lomakina et al.
Biophysical journal, 107(6), 1302-1312 (2014-09-18)
Adhesive interactions between neutrophils and endothelium involve chemokine-induced neutrophil spreading and subsequent crawling on the endothelium to sites of transmigration. We investigated the importance of cell topography in this process using immunofluorescence, scanning electron microscopy, and live-cell imaging using total
Ha-Young Jung et al.
Environmental toxicology and pharmacology, 39(1), 125-136 (2014-12-17)
Cadmium (Cd), an environmental and industrial pollutant, generates free radicals responsible for oxidative stress. Cd can also lead to various renal toxic damage such as the proximal tubules and glomerulus dysfunction. Plantamajoside (PMS), a major compound of Plantago asiatica (PA)
Nora E Szabo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(13), 5233-5246 (2015-04-04)
Spinal cord neurons respond to peripheral noxious stimuli and relay this information to higher brain centers, but the molecules controlling the assembly of such pathways are poorly known. In this study, we use the intersection of Lmx1b and Hoxb8::Cre expression
Dennis R Warner et al.
Development, growth & differentiation, 56(6), 434-447 (2014-05-23)
Clefts of the lip and palate are thought to be caused by genetic and environmental insults but the role of epigenetic mechanisms underlying this common birth defect are unknown. We analyzed the expression of over 600 microRNAs in the murine
Wenpei Fan et al.
Biomaterials, 35(32), 8992-9002 (2014-08-12)
To achieve the accurate diagnosis and efficient in situ therapy of malignant tumors is encouraging but still remains a big challenge. The integration of upconversion nanoparticles and mesoporous silica that can combine the diagnostic/therapeutic functions within a single platform, may
Katerina Bakela et al.
Immunology, 144(1), 158-169 (2014-07-24)
Soluble MHCII (sMHCII) molecules are present in body fluids of healthy individuals and are considered to be involved in the maintenance of self tolerance, and are also related to various diseases. Their concentration increases during in vivo antigen-specific tolerogenic stimulation
Kanako Maki et al.
PloS one, 10(4), e0122986-e0122986 (2015-04-16)
Asthma is a chronic inflammatory disorder of the airways, involving oxidative stress. Upon oxidative stress, glutathione covalently binds to protein thiols to protect them against irreversible oxidation. This posttranslational modification, known as protein S-glutathionylation, can be reversed by glutaredoxin 1
Shishu Goindi et al.
Journal of liposome research, 24(3), 249-257 (2014-03-22)
Levocetirizine, an active enantiomer of cetirizine is third generation antihistaminic agent used for treating various allergies like atopic dermatitis, chronic idiopathic urticaria and allergic rhinitis. Development of novel topical formulation of levocetirizine based on flexible vesicles (FVs) with an aim
Quan Wu et al.
Development (Cambridge, England), 142(3), 575-586 (2015-01-22)
The sex of primordial germ cells (PGCs) is determined in developing gonads on the basis of cues from somatic cells. In XY gonads, sex-determining region Y (SRY) triggers fibroblast growth factor 9 (FGF9) expression in somatic cells. FGF signaling, together
Ahmed Abdeen et al.
American journal of physiology. Renal physiology, 307(11), F1227-F1237 (2014-10-24)
Urinary exosomes are nano-sized vesicles secreted into urine from all types of renal epithelial cells and are known to contain possible biomarker proteins for renal diseases. Gentamicin has been reported to decrease the level of renal aquaporin (AQP)2, which is
Shi Tian et al.
Biochimica et biophysica acta, 1850(4), 708-721 (2014-12-09)
To study the role of miR-143 during embryo implantation in rat. MiR-143 expression in rat early pregnancy was detected by Northern blot. The relation between miR-143 and Lifr predicted and confirmed by bioinformatics method, dual-luciferase activity assay, Western blot and
Yufei Teng et al.
Functional & integrative genomics, 15(3), 277-294 (2014-12-10)
This study was aimed to identify the signature microRNAs, which regulate the biological processes of corneal epithelial progenitor cell (CEPC) homeostasis and regulation through characterizing the differential expression profile of microRNAs in human limbal epithelium containing adult CEPC versus central
Heidi I Chen et al.
Development (Cambridge, England), 141(23), 4500-4512 (2014-11-08)
Identifying coronary artery progenitors and their developmental pathways could inspire novel regenerative treatments for heart disease. Multiple sources of coronary vessels have been proposed, including the sinus venosus (SV), endocardium and proepicardium, but their relative contributions to the coronary circulation
Cemil Aydoğan
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 976-977, 27-32 (2014-12-09)
This study describes the preparation and electrochromatographic application of a new open-tubular capillary column with triethanolamine functionalized stationary phase. The stationary phase was synthesized by in situ grafting polymerization with 3-chloro-2-hydroxypropylmethacrylate based reactive monomer, and followed triethanolamine functionalization. The different
Carlos A Toro et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(2), 571-582 (2015-01-16)
The spatial and temporal distribution of receptors constitutes an important mechanism for controlling the magnitude of cellular responses. Several members of the transient receptor potential (TRP) ion channel family can regulate their function by modulating their expression at the plasma
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