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Showing 1-30 of 147 results for "51-21-8" within Papers
Lanny L Johnson et al.
Cartilage, 3(1), 86-99 (2012-01-01)
This report focuses on the biological events occurring at various intervals following autogenous bone grafting of large-volume defects of the knee joint's femoral condyle secondary to osteochondritis dissecans (OCD) or osteonecrosis (ON). It was hypothesized that the autogenous bone graft
Kirandeep Kaur et al.
Bioorganic & medicinal chemistry, 15(2), 915-930 (2006-11-07)
We report the synthesis, in vitro antiprotozoal (against Plasmodium and Leishmania), antimicrobial, cytotoxicity (Vero and MetHb-producing properties), and in vivo antimalarial activities of two series of 8-quinolinamines. N1-{4-[2-(tert-Butyl)-6-methoxy-8-quinolylamino]pentyl}-(2S/2R)-2-aminosubstitutedamides (21-33) and N1-[4-(4-ethyl-6-methoxy-5-pentyloxy-8-quinolylamino)pentyl]-(2S/2R)-2-aminosubstitutedamides (51-63) were synthesized in six steps from 6-methoxy-8-nitroquinoline and
G L Maxwell et al.
Cancer research, 58(12), 2500-2503 (1998-07-04)
Mutation and deletion of the PTEN tumor suppressor gene occurs in about 40% of endometrial carcinomas. The purpose of this study was to determine whether PTEN mutations also are present in endometrial hyperplasias, which are premalignant precursors of invasive endometrial
Roland Kruse et al.
Folia histochemica et cytobiologica, 47(1), 127-130 (2009-05-08)
Although multiple interactions of seminiferous tubules and the interstitial testicular tissue are known, correlation of cytokeratin 18 expressing Sertoli cells with interstitial changes has still not yet been reported. Considering this fact, we focused our investigation on changes of the
Giuseppina Avantaggiato et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 42(5), 817-824 (2004-03-30)
In vitro screening of 14 adsorbent materials, including some commercial products used to detoxify Fusarium-mycotoxins, were tested in the pH range of 3-8 for deoxynivalenol (DON)- and nivalenol (NIV)-binding ability. Only activated carbon showed to be effective with binding capacities
Rajaian Pushpabai Rajesh et al.
Anticancer research, 35(1), 283-293 (2015-01-01)
Marine invertebrates called ascidians are prolific producers of bioactive substances. The ascidian Eudistoma viride, distributed along the Southeast coast of India, was investigated for its in vitro cytotoxic activity against human cervical carcinoma (HeLa) cells by the MTT assay. The
Dengfeng Cao et al.
International journal of gastrointestinal cancer, 36(1), 39-46 (2005-10-18)
Maspin is both overexpressed in tumors and inflammation, implicating a possible role in bridging inflammation and neoplasia. Idiopathic inflammatory bowel disease (IBD) and IBD-associated dysplasias and carcinomas represent a prototype for studying the relationship between chronic inflammatory states and neoplasia.
Alisa P Alker et al.
Tropical medicine & international health : TM & IH, 13(11), 1384-1391 (2008-12-06)
To determine the relationship between mutations in dhfr and dhps and SP treatment failure in Plasmodium falciparum malaria in the Democratic Republic of the Congo (DRC). Therapeutic efficacy trial was conducted in Rutshuru, Eastern DRC, between June and September 2002
Katja Dressen et al.
Anticancer research, 37(5), 2477-2486 (2017-05-10)
We evaluated the diagnostic performance of a newly-launched magnetic bead-based multiplex immunoassay panel including cancer, apoptotic, immunological and angiogenesis biomarkers for differential diagnosis of colorectal cancer (CRC). Serum samples of 106 individuals comprising of 35 patients with CRC (23 colon
Giovanna Castoldi et al.
Clinical biochemistry, 43(18), 1387-1392 (2010-09-14)
To evaluate oxidative stress in uremia and dialysis and chromogranin A, a stress hormone that could be related to oxidative processes. Plasma oxidative stress biomarkers (-SH, 8-OHdG, and ox-LDL) and chromogranin A were measured in 89 outpatients (21 uremic patients
Glaucia L Veiga et al.
Autonomic neuroscience : basic & clinical, 204, 81-87 (2016-12-10)
It is known that increased sympathetic nerve activity in chronic kidney disease (CKD) progressively worsens kidney function and hypertension. We tested the hypothesis that total renal denervation contributes to reduce sympathetic activation to different beds and improves renal function in
Laura Lavefve et al.
Foods (Basel, Switzerland), 9(4) (2020-04-15)
Wild blueberry (WBB) powder can be added to the formulation of foods to encourage consumption of health-promoting polyphenolics, but the stability of polyphenolics throughout storage is important. We determined the stability of polyphenolics in five products (ice pop, oatmeal bar
F Puglisi et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 19(9), 1541-1546 (2008-04-29)
Preclinical data have indicated a synergistic interaction between docetaxel and capecitabine by means of taxane-induced up-regulation of thymidine phosphorylase (TP). On the basis of such premises, we conducted a phase II trial to determine the activity and tolerability of weekly
Yun Zhang et al.
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery, 13(10), 762-765 (2010-10-26)
To evaluate the impact of loss of heterozygosity (LOH) at chromosome 9p21 and P16(INK4A)(CDKN2A) expression on the prognosis of gastrointestinal stromal tumor (GIST). A total of 51 cases with GISTs were characterized by immunohistochemistry and evaluated for LOH at 9p21
Maher Kharrat et al.
The Journal of clinical endocrinology and metabolism, 89(1), 368-374 (2004-01-13)
Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders mainly due to defects in the steroid 21-hydroxylase (CYP21) gene. To determine the mutational spectrum in the Tunisian CAH population, the CYP21 active gene was analyzed in 51 unrelated
Xueqiong Zhu et al.
Early human development, 86(10), 657-663 (2010-08-25)
Aquaporins are a family of membrane-bound water channel proteins that regulate the flow of water across a variety of biological membranes. The expression of aquaporin 8 and aquaporin 9 has been demonstrated in human chorioamniotic membrane and placenta. But their
Katherine Tarlock et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(16), 5038-5048 (2019-06-12)
KIT mutations (KIT+) are common in core binding factor (CBF) AML and have been associated with varying prognostic significance. We sought to define the functional and clinical significance of distinct KIT mutations in CBF pediatric AML. Following transfection of exon
Daniela Fenoglio et al.
Cancer immunology, immunotherapy : CII, 62(6), 1041-1052 (2013-04-18)
Anti-tumor vaccination is a new frontier in cancer treatment applicable to immunogenic neoplasms such as prostate and renal cancers. GX301 is a vaccine constituted by four telomerase peptides and two adjuvants, Montanide ISA-51 and Imiquimod. The aim of this study
Harry M Lightfoot et al.
Breast cancer research and treatment, 88(2), 109-116 (2004-11-27)
Focal adhesion kinase (FAK) is a protein tyrosine kinase that is overexpressed in a subset of invasive breast cancers. FAK transmits signals that mediate several functions including tumor cell proliferation, migration, adhesion and survival. We used immunohistochemical techniques to assess
Jessica S Fortin et al.
Bioorganic & medicinal chemistry, 16(15), 7477-7488 (2008-06-27)
Recently, a subset of N-phenyl-N'-(2-chloroethyl)ureas (CEU) was found abrogating the nuclear translocation of thioredoxin-1 and arresting the cell cycle in G(0)/G(1) phase. Several derivatives were prepared to assess their effect on cell cycle progression and on the intracellular location of
M Tariq Javed et al.
Tuberculosis (Edinburgh, Scotland), 87(5), 437-445 (2007-06-16)
Spoligotyping is a typing tool used worldwide for epidemiological studies on Mycobacterium tuberculosis complex organisms; however it has received little attention regarding improvement of its discriminatory power (DP). In this study, we have evaluated a spoligotyping membrane prepared with 25
Jasper Trevelyan et al.
The American journal of cardiology, 94(5), 564-569 (2004-09-03)
Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may have anti-inflammatory actions, an effect that could explain some of their beneficial effects on cardiovascular events in clinical trials. Coronary artery bypass grafting (CABG) is associated with a systemic inflammatory response and
Miroslav Merta et al.
Renal failure, 24(5), 585-593 (2002-10-17)
The reason of variability of clinical course and progression to end-stage renal failure (ESRF) of two widespread chronic nephropathies--autosomal dominant polycystic kidney disease (ADPKD) and IgA nephropathy (IGAN) is not clear. The endothelial dysfunction is considered in the number of
M Kieć-Swierczyńska
Medycyna pracy, 45(4), 303-309 (1994-01-01)
During the period between January 1989 and 15 April 1994 allergy to chemical compounds present in rubber was found in 51 (15%) out of 339 patients with occupational dermatitis. In this group (20 workers of the metallurgical industry, 15 health
Nirmala A Jambhekar et al.
Archives of pathology & laboratory medicine, 134(8), 1181-1187 (2010-07-31)
Chordoma is a rare, notochordal tumor with a characteristic histomorphology and immunohistochemical profile. At times, it presents a diagnostic challenge, especially in small biopsies. Brachyury, a nuclear transcription factor, is a recently described immunohistochemical marker for diagnosing chordomas. To study
Hisayuki Shigematsu et al.
Journal of the National Cancer Institute, 97(5), 339-346 (2005-03-03)
Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers are associated with increased sensitivity of these cancers to drugs that inhibit EGFR kinase activity. However, the role of such mutations in
Grazyna Chłoń-Rzepa et al.
Bioorganic & medicinal chemistry, 15(15), 5239-5250 (2007-05-23)
On the basis of our earlier studies with the serotonin receptor ligands in the group of 1,3-dimethyl-3,7-dihydropurine-2,6-dione derivatives, a series of new arylpiperazinylalkyl and tetrahydroisoquinolinylalkyl analogs of 8-alkoxy-1,3-dimethyl-3,7-dihydropurine-2,6-dione (10-25) and 1,3-dimethyl-7,9-dihydro-3H-purine-2,6,8-trione (26-30) were synthesized and their 5-HT(1A), 5-HT(2A), and 5-HT(7)
A M M Baylis et al.
Oecologia, 179(4), 1053-1065 (2015-09-02)
Despite global declines in the abundance of marine predators, knowledge of foraging ecology, necessary to predict the ecological consequences of large changes in marine predator abundance, remains enigmatic for many species. Given that populations suffering severe declines are of conservation
San-quan Zhang et al.
Zhonghua yi xue za zhi, 90(18), 1243-1246 (2010-07-22)
To clone, prepare probe for and explore the expression levels of KIAA1173 gene in skin squamous cell carcinoma (SSCC) and investigate its expression, clinical and pathological significance. KIAA1173 gene fragment (354 bp) was cloned and its cDNA probe prepared. The
Alice Y Ho et al.
International journal of radiation oncology, biology, physics, 69(3), 677-684 (2007-05-23)
The ATM gene product is a central component of cell cycle regulation and genomic surveillance. We hypothesized that DNA sequence alterations in ATM predict for adverse effects after external beam radiotherapy for early breast cancer. A total of 131 patients
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