Showing 1-30 of 48 results for "516155"
Yusha Imtiaz et al.
Nanomaterials (Basel, Switzerland), 10(8) (2020-08-23)
Polysaccharides have been shown to have immunomodulatory properties. Modulation of the immune system plays a crucial role in physiological processes as well as in the treatment and/or prevention of autoimmune and infectious diseases. Cellulose nanocrystals (CNCs) are derived from cellulose...
Marc P Kai et al.
ACS nano, 10(1), 861-870 (2015-11-26)
Long-circulating nanoparticles are essential for increasing tumor accumulation to provide therapeutic efficacy. While it is known that tumor presence can alter the immune system, very few studies have explored this impact on nanoparticle circulation. In this report, we demonstrate how...
Ting-Yu Shih et al.
Advanced healthcare materials, 7(10), e1701469-e1701469 (2018-02-15)
A covalently crosslinked methacrylated (MA)-alginate cryogel vaccine has been previously shown to generate a potent response against murine melanoma, but is not mechanically robust and requires a large 16G needle for delivery. Here, covalent and ionic crosslinking of cryogels are...
Ana Margarida Piloto et al.
Scientific reports, 8(1), 4944-4944 (2018-03-23)
A highly sensitive fluorescence detection probe was developed by tailoring plastic antibodies on the external surface of aqueous soluble quantum dots (QDs). The target was Myoglobin (Myo), a cardiac biomarker that quenched the intrinsic fluorescent emission of cadmium telluride (CdTe)...
Jillian L Perry et al.
ACS nano, 14(6), 7200-7215 (2020-05-29)
CpG oligodeoxynucleotides are potent toll-like receptor (TLR) 9 agonists and have shown promise as anticancer agents in preclinical studies and clinical trials. Binding of CpG to TLR9 initiates a cascade of innate and adaptive immune responses, beginning with activation of...
Sidi A Bencherif et al.
Nature communications, 6, 7556-7556 (2015-08-13)
A biomaterial-based vaccination system that uses minimal extracorporeal manipulation could provide in situ enhancement of dendritic cell (DC) numbers, a physical space where DCs interface with transplanted tumour cells, and an immunogenic context. Here we encapsulate GM-CSF, serving as a...
Johanna Simon et al.
Nanoscale, 10(22), 10731-10739 (2018-05-31)
Formation of the biomolecular corona ultimately determines the successful application of nanoparticles in vivo. Adsorption of biomolecules such as proteins is an inevitable process that takes place instantaneously upon contact with physiological fluid (e.g. blood). Therefore, strategies are needed to...
Jasper Van Hoorick et al.
Advanced healthcare materials, 9(16), e2000760-e2000760 (2020-07-01)
Corneal blindness is the fourth leading cause of visual impairment. Of specific interest is blindness due to a dysfunctional corneal endothelium which can only be treated by transplanting healthy tissue from a deceased donor. Unfortunately, corneal supply does not meet...
Jianping Liu et al.
Small (Weinheim an der Bergstrasse, Germany), 16(31), e2002115-e2002115 (2020-07-02)
Nanotheranostics have been actively sought in precision nanomedicine in recent years. However, insufficient tumor accumulation and limited cell uptake often impede the nanotheranostic efficacy. Herein, pH-sensitive charge-reversible polymer-coated layered double hydroxide (LDH) nanohybrids are devised to possess long circulation in...
Vitalii Rosiuk et al.
Langmuir : the ACS journal of surfaces and colloids, 35(21), 7009-7017 (2019-05-14)
Nanoprecipitation is a straightforward yet powerful technique to synthesize polymer nanoparticles loaded with various biologically active compounds or contrast agents. Particle formation in this approach is kinetically controlled, and various assembly parameters have been used to control the size distribution...
Nicholas Jun-An Chan et al.
Nature communications, 11(1), 1630-1630 (2020-04-04)
The high toughness of natural spider-silk is attributed to their unique β-sheet secondary structures. However, the preparation of mechanically strong β-sheet rich materials remains a significant challenge due to challenges involved in processing the polymers/proteins, and managing the assembly of...
Jacob Brown et al.
Annals of biomedical engineering, 48(3), 1016-1024 (2019-05-28)
Imaging soft biomaterials in vivo is a significant challenge, as most conventional techniques are limited by biomaterial contrast, penetration depth, or spatial resolution. Exogeneous contrast agents used to increase contrast may also alter material properties or exhibit local toxicity. The...
Daniel Breite et al.
Polymers, 11(1) (2019-04-10)
Membrane filters are designed for selective separation of components from a mixture. While separation by size might be the most common approach, other characteristics like charge can also be used for separation as presented in this study. Here, a polyether...
Kazuhiko Ishihara et al.
Polymers, 12(8) (2020-08-13)
Water-soluble and cytocompatible polymers were investigated to enhance a transporting efficiency of biomolecules into cells in vitro. The polymers composed of a 2-methacryloyloxyethyl phosphorylcholine (MPC) unit, a hydrophobic monomer unit, and a cationic monomer unit bearing an amino group were...
Shang-Lin Yeh et al.
ACS omega, 6(5), 3517-3524 (2021-02-16)
Antifouling treatment is critical to certain biomedical devices for their functions and patients' life. Facial, versatile, and universal coating methods to conjugate antifouling materials on a wide variety of biomaterials are beneficial for the fabrication of low-fouling biomedical devices. We...
Shabnam Jafari et al.
Molecules (Basel, Switzerland), 24(9) (2019-05-15)
The United States is currently experiencing an opioid crisis, with more than 47,000 deaths in 2017 due to opioid overdoses. Current approaches for opioid identification and quantification in body fluids include immunoassays and chromatographic methods (e.g., LC-MS, GC-MS), which require...
Mariia Levit et al.
Polymers, 12(1) (2020-04-15)
In this work, a method to prepare hybrid amphiphilic block copolymers consisting of biocompatible synthetic glycopolymer with non-degradable backbone and biodegradable poly(amino acid) (PAA) was developed. The glycopolymer, poly(2-deoxy-2-methacrylamido-D-glucose) (PMAG), was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. Two...
Peng Yang et al.
Advanced healthcare materials, 8(6), e1800854-e1800854 (2018-11-28)
Bacterial infection has evolved into one of the most dangerous global health crises. Designing potent antimicrobial agents that can combat drug-resistant bacteria is essential for treating bacterial infections. In this paper, a strategy to graft metallopolymer-antibiotic bioconjugates on gold nanoparticles...
Jingyun Wang et al.
Journal of colloid and interface science, 551, 1-9 (2019-05-10)
Ultrasound-responsive chemistry was exploited in manufacture of drug delivery nanoparticulates for pursuit of on-demand ultrasound-stimulated drug release function. In principle, the ultrasound-labile oxyl-alkylhydroxylamine (-oa-) linkage was tailored between the segments of amphiphiles. Consequently, the hydrophobic chemotherapeutic doxorubicin could be readily...
Alice E Stanton et al.
ACS applied materials & interfaces, 11(9), 8849-8857 (2019-02-23)
Different tissue types are characterized by varying stiffness and biochemical ligands. Increasing substrate stiffness has been shown to trigger Yes-associated protein (YAP) translocation from the cytoplasm to the nucleus, yet the role of ligand density in modulating mechanotransduction and stem...
Jiae Seo et al.
ACS applied materials & interfaces, 9(23), 19591-19600 (2017-05-24)
The goal of this study is to fabricate a stable plasma filtration membrane with antibiofouling properties via an electrospinning process. To this end, a random-type copolymer consisting of zwitterionic phosphorylcholine (PC) groups and ultraviolet (UV)-cross-linkable phenyl azide groups was synthesized....
Mehdi Mehrali et al.
ACS applied materials & interfaces, 11(13), 12283-12297 (2019-03-14)
The emergence of nontoxic, eco-friendly, and biocompatible polymers derived from natural sources has added a new and exciting dimension to the development of low-cost and scalable biomaterials for tissue engineering applications. Here, we have developed a mechanically strong and durable...
Nisarg J Shah et al.
Nature biomedical engineering, 4(1), 40-51 (2020-01-16)
Acute myeloid leukaemia (AML) is a malignancy of haematopoietic origin that has limited therapeutic options. The standard-of-care cytoreductive chemotherapy depletes AML cells to induce remission, but is infrequently curative. An immunosuppressive AML microenvironment in the bone marrow and the paucity...
Leonor Pérez-Fuentes et al.
Soft matter, 11(25), 5077-5086 (2015-06-02)
Minute concentrations of big hydrophobic ions have the ability to induce substantial effects in soft matter systems, including novel phases in lipid layers, giant charge inversion in colloids and nanostructuration in polymer surfaces in contact with water. The effects are...
Simone Lerch et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(6), 1585-1596 (2015-05-10)
Many nanoparticular drug delivery approaches rely on a detailed knowledge of the acidification process during intracellular trafficking of endocytosed nanoparticles (NPs). Therefore we produced a nanoparticular pH sensor composed of the fluorescent pH-sensitive dual wavelength dye carboxy seminaphthorhodafluor-1 (carboxy SNARF-1)...
Thomas D Michl et al.
Acta biomaterialia, 108, 168-177 (2020-03-18)
Amphiphilic polymers bearing cationic moieties are an emerging alternative to traditional antibiotics given their broad-spectrum activity and low susceptibility to the development of resistance. To date, however, much remains unclear regarding their mechanism of action. Using functional assays (ATP leakage...
Sami I Somo et al.
Acta biomaterialia, 65, 53-65 (2017-11-05)
Alginate hydrogels have been investigated for a broad variety of medical applications. The ability to assemble hydrogels at neutral pH and mild temperatures makes alginate a popular choice for the encapsulation and delivery of cells and proteins. Alginate has been...
Min Sun et al.
Biomaterials, 201, 16-32 (2019-02-21)
Interconnected macroporous hydrogel is hydrophilic; it exhibits soft tissue-like mechanical property and aqueous-stable macroporosity for 3D spheroid culture. There is an unmet need to develop cleavable macroporous hydrogel, for the ease of retrieving functional spheroids for further in vitro and...
Parasmani Pageni et al.
Biomaterials, 178, 363-372 (2018-05-16)
Over-prescription and improper use of antibiotics has led to the emergence of bacterial resistance, posing a major threat to public health. There has been significant interest in the development of alternative therapies and agents to combat antibiotic resistance. We report...
Jiuyang Zhang et al.
Scientific reports, 5, 11914-11914 (2015-07-24)
Metallopolymers combine a processable, versatile organic polymeric skeleton with functional metals, providing multiple functions and methodologies in materials science. Taking advantage of cationic cobaltocenium as the key building block, organogels could be simply switched to hydrogels via a highly efficient...

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