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Francisca O Peixoto et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(1), 104-115 (2014-12-31)
BACKGROUND/ AIMS: The knowledge of the molecular network that governs fetal lung branching is an essential step towards the discovery of novel therapeutic targets against pulmonary pathologies. Lung consists of two highly branched systems: airways and vasculature. Ephrins and its
Yuan He et al.
Investigative ophthalmology & visual science, 55(10), 6742-6755 (2014-09-13)
Oxidative stress plays an important role in health and aging. We have shown that oxidative stress impairs mitochondrial function and promotes RPE cell death in an age-dependent manner. This study investigates the role of pigment epithelium-derived factor (PEDF) in limiting
Chi Keung Lam et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(47), E6466-E6475 (2015-11-11)
The major underpinning of massive cell death associated with myocardial infarction involves opening of the mitochondrial permeability transition pore (mPTP), resulting in disruption of mitochondria membrane integrity and programmed necrosis. Studies in human lymphocytes suggested that the hematopoietic-substrate-1 associated protein
Grazielle V B Huguenin et al.
Microcirculation (New York, N.Y. : 1994), 22(8), 687-699 (2015-07-28)
To investigate the effects of dietary supplementation with GBNs on microvascular endothelial function in hypertensive and dyslipidemic patients. Ninety-one patients of both sexes aged 62.1 ± 9.3 years received 13 g/day of GBNs or a placebo for three months with
Sveta Chakrabarti et al.
PLoS genetics, 10(9), e1004659-e1004659 (2014-09-26)
The p38 mitogen-activated protein (MAP) kinase signaling cassette has been implicated in stress and immunity in evolutionarily diverse species. In response to a wide variety of physical, chemical and biological stresses p38 kinases phosphorylate various substrates, transcription factors of the
Roman Davydov et al.
Biochemistry, 53(30), 4894-4903 (2014-07-22)
The fleeting ferric peroxo and hydroperoxo intermediates of dioxygen activation by hemoproteins can be readily trapped and characterized during cryoradiolytic reduction of ferrous hemoprotein-O2 complexes at 77 K. Previous cryoannealing studies suggested that the relaxation of cryogenerated hydroperoxoferric intermediates of
Michael R Kierny et al.
PloS one, 10(4), e0124492-e0124492 (2015-04-23)
Candidate biomarkers, indicative of disease or injury, are beginning to overwhelm the process of validation through immunological means. Recombinant antibodies developed through phage-display offer an alternative means of generating monoclonal antibodies faster than traditional immunization of animals. Peptide segments of
Jixiang Zhang et al.
Medical oncology (Northwood, London, England), 32(4), 101-101 (2015-03-05)
Hesperetin, a flavonoid from citrus fruits, has been proved to possess biological activity on various types of human cancers. However, few related studies on hepatocellular carcinoma are available. In this study, we aimed to investigate the effect of hesperetin on
Pascale Perret et al.
International journal of molecular sciences, 16(11), 27730-27740 (2015-11-28)
Maurocalcine (MCa) is the first natural cell penetrating peptide to be discovered in animal venom. In addition to the fact that it represents a potent vector for the cell penetration of structurally diverse therapeutic compounds, MCa also displays several distinguishing
Wen-Qing Li et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 23(8), 1579-1588 (2014-05-29)
Germline genetic variants in PLCE1 (10q23) have demonstrated consistent associations with risk of esophageal squamous cell carcinoma (ESCC) and gastric cancer among Chinese. We evaluated PLCE1 mRNA and protein expression in paired tumor-normal tissues, and their relationship with survival. PLCE1
Kelly K Arthur et al.
Journal of pharmaceutical sciences, 104(4), 1548-1554 (2015-01-07)
Differential scanning calorimetry (DSC) is a useful tool for monitoring thermal stability of the molecular conformation of proteins. Here, we present an example of the sensitivity of DSC to changes in stability arising from a common chemical degradation pathway, oxidation.
Erik Berglund et al.
Experimental cell research, 326(2), 315-325 (2014-05-16)
DOG1, a Ca(2+)-activated Cl(-) channel (CaCC), was identified in 2004 to be robustly expressed in gastrointestinal stromal tumors (GIST). It was rapidly included as a tumor marker in routine diagnostics, but the functional role remained unknown. CaCCs are important regulators
Justin E Mirus et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(7), 1764-1771 (2015-01-16)
Pancreatic ductal adenocarcinoma (PDA) is the fourth leading cause of cancer-related death in the United States, and its incidence is on the rise. Advanced disease is nearly uniformly lethal, emphasizing the need to identify PDA at its earliest stages. To
Seydou Sylla et al.
Microbiology and immunology, 58(7), 398-408 (2014-05-23)
Post-weaning multisystemic wasting syndrome (PMWS) associated with porcine circovirus type 2 (PCV2) has caused the swine industry significant health challenges and economic damage. Although inactivated and subunit vaccines against PMWS have been used widely, so far no DNA vaccine is
Jian Chen et al.
International journal of food microbiology, 193, 152-158 (2014-12-03)
The use of antagonistic yeasts to control postharvest pathogens is a promising alternative to fungicides. The effectiveness of the antagonists against fungal pathogens is greatly dependent on their viability, which is usually mediated by reactive oxygen species (ROS). Here, we
Eva Cuypers et al.
Forensic science international, 242, 103-110 (2014-07-23)
Today, forensic hair analysis is considered to be a standard method for identifying chronic drug users since information about drug use stored and located in hair can cover several months to even years. When interpreting these results, one should be
Aksorntong Chooruk et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 96(5), 519-522 (2013-06-12)
To study the prevalence and the number of lactobacilli in normal subjects and in women with bacterial vaginosis (BV). The studied subjects consisted of 60 normal and 60 BV women. The diagnosis of BV was based on at least three
Hildegunn Iversen et al.
PloS one, 10(2), e0118140-e0118140 (2015-02-27)
Enterohemorrhagic E. coli (EHEC) is associated with severe gastrointestinal disease. Upon entering the gastrointestinal tract, EHEC is exposed to a fluctuating environment and a myriad of other bacterial species. To establish an infection, EHEC strains have to modulate their gene
Ravi Kumar et al.
Archives of microbiology, 196(4), 295-305 (2014-02-27)
Calcium/calmodulin-dependent kinases (Ca(2+)/CaMKs) are Ser/Thr protein kinases that respond to change in cytosolic free Ca(2+) ([Ca(2+)]c) and play multiple cellular roles in organisms ranging from fungi to humans. In the filamentous fungus Neurospora crassa, four Ca(2+)/CaM-dependent kinases, Ca(2+)/CaMK-1 to 4
Yusuke Ohara et al.
Cancer science, 104(8), 1127-1134 (2013-05-18)
CD44(+) /CD24(+) /EpCAM(+) cells have been reported to be cancer stem cells in pancreatic cancer; however, the histological and clinical importance of these cells has not yet been investigated. Here we clarified the characteristics of CD44(+) /CD24(+) /EpCAM(+) cells in
Jian Xie et al.
Zhongguo gu shang = China journal of orthopaedics and traumatology, 26(4), 332-335 (2013-07-13)
To study the effect of H2O2 on the morphological pattern,vitality,proliferation,cycle period of rabbit intervertebral disc nucleus pulposus cells. Ten New Zealand white rabbits (2 to 3 kg, female) were used for isolating nucleus pulposus cells under sterilized condition. The culture
Kristin J Adolfsen et al.
PLoS computational biology, 11(11), e1004562-e1004562 (2015-11-07)
Hydrogen peroxide (H2O2) is used by phagocytic cells of the innate immune response to kill engulfed bacteria. H2O2 diffuses freely into bacteria, where it can wreak havoc on sensitive biomolecules if it is not rapidly detoxified. Accordingly, bacteria have evolved
Oscar G Vidaurre et al.
Brain : a journal of neurology, 137(Pt 8), 2271-2286 (2014-06-05)
Axonal damage is a prominent cause of disability and yet its pathogenesis is incompletely understood. Using a xenogeneic system, here we define the bioenergetic changes induced in rat neurons by exposure to cerebrospinal fluid samples from patients with multiple sclerosis
H Lee et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(6), 786-793 (2014-03-08)
Although there is growing evidence that an increase in mucosal mast cells (MMCs) in the small and large intestine is associated with visceral hypersensitivity, few studies have evaluated MMCs in humans with esophageal symptoms. The aim of this study was
Sridhar Chinthakindi et al.
Journal of chromatography. A, 1423, 54-62 (2015-11-12)
Present study aimed at graphene surface modification to achieve selective analyte binding in dispersive solid phase extraction. Magnetic graphene - polystyrene sulfonic acid (MG-PSS) cation exchange nano-composite was prepared by non-covalent wrapping method. Composite was characterized by FT-IR and zeta
Liang Li et al.
BMC plant biology, 14, 381-381 (2014-12-31)
Recently we showed that de novo expression of a turtle riboflavin-binding protein (RfBP) in transgenic Arabidopsis increased H2O2 concentrations inside leaf cells, enhanced the expression of floral regulatory gene FD and floral meristem identity gene AP1 at the shoot apex
Roselind S Lam et al.
Journal of immunology (Baltimore, Md. : 1950), 193(5), 2349-2362 (2014-07-30)
The role of the macrophage in the immunopathology of periodontitis has not been well defined. In this study, we show that intraoral inoculation of mice with Porphyromonas gingivalis resulted in infection, alveolar bone resorption, and a significant increase in F4/80(+)
H Ghebeh et al.
British journal of cancer, 111(8), 1552-1561 (2014-08-15)
A major therapeutic challenge for breast cancer is the ability of cancer cells to evade killing of conventional chemotherapeutic agents. We have recently reported the actin-bundling protein (fascin) as a major regulator of breast cancer metastasis and survival. Survival of
Veronika Sele et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 30, 171-179 (2015-01-27)
In the present study liver samples (n=26) of Northeast Arctic cod (Gadus morhua), ranging in total arsenic concentrations from 2.1 to 240mg/kg liver wet weight (ww), were analysed for their content of total arsenic and arsenic species in the lipid-soluble
Ilse S Pienaar et al.
Neurobiology of disease, 74, 392-405 (2014-12-24)
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become an accepted treatment for motor symptoms in a subset of Parkinson's disease (PD) patients. The mechanisms why DBS is effective are incompletely understood, but previous studies show that DBS
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