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Neha Kaushik et al.
Scientific reports, 5, 8587-8587 (2015-02-27)
In this study, we assessed the role of different reactive oxygen species (ROS) generated by soft jet plasma and chemical-induced ROS systems with regard to cell death in T98G, A549, HEK293 and MRC5 cell lines. For a comparison with plasma
Kannika Adthapanyawanich et al.
Archives of oral biology, 60(2), 320-332 (2014-12-02)
In the submandibular gland (SMG) of mice, the granular convoluted tubule (GCT) develops preferentially in males dependent on androgens. To clarify the molecular mechanism of androgen action in SMG, we examined the SMG of mice deficient for the androgen receptor
Rania Gaber et al.
Diagnostic pathology, 9, 165-165 (2014-09-18)
Epidermal Growth Factor Receptor (EGFR) targeting therapies are currently of great relevance for the treatment of lung cancer. For this reason, in addition to mutational analysis immunohistochemistry (IHC) of EGFR in lung cancer has been discussed for the decision making
Richie Khanna et al.
PloS one, 9(7), e102092-e102092 (2014-07-19)
Pompe disease is an inherited lysosomal storage disorder that results from a deficiency in acid α-glucosidase (GAA) activity due to mutations in the GAA gene. Pompe disease is characterized by accumulation of lysosomal glycogen primarily in heart and skeletal muscles
Karima Bekir et al.
Environmental science and pollution research international, 22(20), 15796-15803 (2015-06-04)
In this work, we report the adaptation of bacteria to stress conditions that induce instability of their cultural, morphological, and enzymatic characters, on which the identification of pathogenic bacteria is based. These can raise serious issues during the characterization of
Sam Chen et al.
Journal of controlled release : official journal of the Controlled Release Society, 196, 106-112 (2014-10-07)
Recently developed lipid nanoparticle (LNP) formulations of siRNA have proven to be effective agents for hepatocyte gene silencing following intravenous administration with at least three LNP-siRNA formulations in clinical trials. The aim of this work was to develop LNP-siRNA systems
R V D'Elia et al.
International journal of immunopathology and pharmacology, 27(4), 585-595 (2015-01-13)
Francisella tularensis is a Gram-negative intracellular bacterium that can cause acute disease in mouse models of infection when administered via the inhalational route. The immune response to a pulmonary infection is typified by an initial lack of pro-inflammatory cytokines, followed
Yuqing Liu et al.
Scientific reports, 5, 17045-17045 (2015-11-21)
Although great attention has been paid to wearable electronic devices in recent years, flexible lightweight batteries or supercapacitors with high performance are still not readily available due to the limitations of the flexible electrode inventory. In this work, highly flexible
Char-Hong Ng et al.
Asian Pacific journal of cancer prevention : APJCP, 15(18), 7959-7964 (2014-10-09)
The significance of the single hormone receptor positive phenotype of breast cancer is still poorly understood. The use of hormone therapy has been found to be less effective for this type, which has a survival outcome midway between double positive
Iwao Ohtsu et al.
PloS one, 10(3), e0120619-e0120619 (2015-04-04)
Intracellular thiols like L-cystine and L-cystine play a critical role in the regulation of cellular processes. Here we show that Escherichia coli has two L-cystine transporters, the symporter YdjN and the ATP-binding cassette importer FliY-YecSC. These proteins import L-cystine, an
Minmin Zhang et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(12), 2569-2574 (2014-05-23)
Liquid-crystal (LC) droplet patterns are formed on a glass slide by evaporating a solution of nematic LC dissolved in heptane. In the presence of an anionic phospholipid, 1,2-dioleoyl-sn-glycero-3-phospho-rac-(1-glycerol) (DOPG), the LCs display a dark cross pattern, indicating a homeotropic orientation.
Ahmed Abdeen et al.
American journal of physiology. Renal physiology, 307(11), F1227-F1237 (2014-10-24)
Urinary exosomes are nano-sized vesicles secreted into urine from all types of renal epithelial cells and are known to contain possible biomarker proteins for renal diseases. Gentamicin has been reported to decrease the level of renal aquaporin (AQP)2, which is
Xiangjiang Liu et al.
Scientific reports, 5, 17167-17167 (2015-12-01)
Surface-enhanced Raman scattering (SERS) can significantly boost the inherently weak Raman scattering signal and provide detailed structural information and binding nature of the molecules on the surface. Despite the long history of this technology, SERS has yet to become a
Martina Sutovska et al.
General physiology and biophysics, 34(2), 167-176 (2015-03-03)
Previously, therapeutic potency of CRAC channels blocker was evidenced as a significant decrease in airway smooth muscle hyperreactivity, antitussive and anti-inflammatory effects. The major role of the respiratory epithelium in asthma pathogenesis was highlighted only recently and CRAC channels were
Aaron Goldman et al.
Nature communications, 6, 6139-6139 (2015-02-12)
Understanding the emerging models of adaptive resistance is key to overcoming cancer chemotherapy failure. Using human breast cancer explants, in vitro cell lines, mouse in vivo studies and mathematical modelling, here we show that exposure to a taxane induces phenotypic
Carolyn J P Jones et al.
Placenta, 36(10), 1130-1137 (2015-08-13)
This study examines the glucose metabolism and glycosylation of villous macrophages (Hofbauer cells) over the course of pregnancy. Sections of placentae from 6 weeks to term were stained with antibodies to α-amylase, glycogen synthase, glycogen phosphorylase and glucose transporters 1
Jang Ho Joo et al.
Physical chemistry chemical physics : PCCP, 17(45), 30292-30299 (2015-10-27)
Despite the critical functions of divalent metal ions (M(2+)s) in association with duplex DNA, fundamental and general interactions of M(2+)s with spherical nucleic acids (SNAs) composed of single-stranded DNA have rarely been investigated. We have explored that the coordinative nature
Carolin Lübker et al.
Biochemical pharmacology, 93(2), 196-209 (2014-12-03)
Membranous adenylyl cyclase 1 (AC1) is associated with memory and learning. AC1 is activated by the eukaryotic Ca(2+)-sensor calmodulin (CaM), which contains nine methionine residues (Met) important for CaM-target interactions. During ageing, Met residues are oxidized to (S)- and (R)-methionine
Y Hassona et al.
British journal of cancer, 111(6), 1230-1237 (2014-08-15)
Previous studies have demonstrated that senescent cancer-associated fibroblasts (CAFs) derived from genetically unstable oral squamous cell carcinomas (GU-OSCC), unlike non-senescent CAFs from genetically stable carcinomas (GS-OSCC), promoted keratinocyte invasion in vitro in a paracrine manner. The mechanism by which this
Mohamad Alaa Terkawi et al.
Malaria journal, 13, 426-426 (2014-11-07)
The design and development of an effective malaria vaccine against the pre-erythrocytic and erythrocytic-stages of infection present a great challenge. In the present study, protective efficacy of oligomannose-coated liposome (OML)-entrapped merozoite and sporozoite antigens against Plasmodium berghei challenge infection in
Ramona Galatola et al.
European journal of medicinal chemistry, 86, 589-604 (2014-09-15)
The development of peptide fusion inhibitors based on short synthetic peptides represents a promising option in the fight against HIV-1 infection, especially in individuals infected with multiresistant HIV-1 strains. GBV-C has the beneficial effect of retarding the progression of AIDS
John-Max Mongkhon et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 63(8), 691-701 (2014-05-27)
Our study was designed to elucidate the precise molecular mechanisms by which sorbitol-modified hyaluronic acid (HA/sorbitol) exerts beneficial effects in osteoarthritis (OA). Human OA chondrocytes were treated with increasing doses of HA/sorbitol ± anti-CD44 antibody or with sorbitol alone and thereafter with
Allan F Pagano et al.
PloS one, 10(12), e0144230-e0144230 (2015-12-03)
Sports trauma are able to induce muscle injury with fibrosis and accumulation of intermuscular adipose tissue (IMAT), which affect muscle function. This study was designed to investigate whether hypoactivity would influence IMAT accumulation in regenerating mouse skeletal muscle using the
Peng-Fei Qiao et al.
World journal of gastroenterology, 21(45), 12822-12834 (2015-12-17)
To investigate whether heat shock pretreatment (HSP) improves mesenchymal stem cell (MSC) repair via autophagy following hepatic ischemia-reperfusion injury (HIRI). Apoptosis of MSCs was induced by 250 mM hydrogen peroxide (H2O2) for 6 h. HSP was carried out using a
Michel Guillon et al.
Contact lens & anterior eye : the journal of the British Contact Lens Association, 38(6), 435-441 (2015-07-21)
The purpose was to compare the effect of the repeated usage of two care systems (one hydrogen peroxide cleaning and disinfecting system and one polyaminopropyl biguanide (PHMB) containing multi-purpose system) with silicone hydrogel contact lenses worn for three months on
Marjan Tavakkoli et al.
Pharmaceutical biology, 52(12), 1550-1557 (2014-09-23)
Finding effective therapies for neurodegenerative diseases is of utmost importance for the aging population. Plants growing in Iran are rich sources of antioxidants and active phytochemicals. The protective capacity of plants, with a special focus on those with reported antioxidant
Sharif Sakr et al.
Endocrinology, 155(4), 1489-1497 (2014-02-04)
Endometriosis is a disease defined by the ectopic growth of uterine endometrium. Stem cells contribute to the generation of endometriosis as well as to repair and regeneration of normal endometrium. Here we demonstrate that the selective estrogen receptor modulator bazedoxifene
Kyo Kobayashi et al.
Pharmaceutical development and technology, 20(2), 219-226 (2013-11-30)
Medical-grade collagen peptide is used as an additive agent in pharmaceutical formulations; however, it is unknown as to whether the compound exerts antioxidant effects in vitro. In this study, we evaluated the antioxidant effects of medical-grade collagen peptide on reactive
Mariana Leão et al.
Experimental cell research, 330(1), 164-177 (2014-09-30)
In this work, the yeast Saccharomyces cerevisiae was used to individually study human p53, p63 (full length and truncated forms) and p73. Using this cell system, the effect of these proteins on cell proliferation and death, and the influence of
Kyoung A Kim et al.
Journal of cellular biochemistry, 115(11), 1877-1887 (2014-06-07)
Because irradiation may cause osteoradionecrosis, antioxidant supplementation is often used to suppress irradiation-mediated injury. This study examined whether a synthetic phenethyl urea compound, (E)-1-(3,4-dihydroxyphenethyl)-3-(3,4-dihydroxystyryl)urea (DPDS-U), prevents irradiation-mediated cellular damage in MC3T3-E1 osteoblastic cells. A relatively high dose of irradiation (>4 Gy)
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