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534064

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Ilona Olędzka et al.
Journal of pharmaceutical and biomedical analysis, 102, 45-53 (2014-09-23)
The purpose of this work is the evaluation of the nutritional status of patients with cystic fibrosis (CF), based on the level of vitamin C in urine and vitamins A and E in serum, using the fast, selective and fully...
Yunqing Zhu et al.
ACS nano, 8(7), 6644-6654 (2014-06-17)
The facile loading of sensitive and fragile biomacromolecules, such as glucose oxidase, hemoglobin, and ribonucleic acid (RNA), via synthetic vehicles directly in pure aqueous media is an important technical challenge. Inspired by the nucleus pore complex that connects the cell...
Janet van Eersel et al.
Neuropathology and applied neurobiology, 41(7), 906-925 (2015-03-13)
Tau becomes hyperphosphorylated in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD-tau), resulting in functional deficits of neurones, neurofibrillary tangle (NFT) formation and eventually dementia. Expression of mutant human tau in the brains of transgenic mice has produced different lines...
Piers R Boshier et al.
The Journal of surgical research, 193(2), 704-712 (2014-10-06)
Esophagectomy and gastrectomy are associated with profound metabolic changes and significant postoperative morbidity. The aim of this prospective clinical study was to determine whether breath analysis can offer novel insight into the surgical metabolic response and identify biomarkers of postoperative...
Chihiro Shimizuhira et al.
The Journal of investigative dermatology, 134(11), 2709-2718 (2014-04-24)
Contact hypersensitivity (CHS) has been widely used to study cutaneous immune responses, as a prototype of delayed-type hypersensitivity. Although natural killer T (NKT) cells have been assumed to have an important role in CHS, their role is controversial. Here, we...
Timothy R DeGrado et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(8), 1348-1354 (2014-07-23)
Abnormalities of zinc homeostasis are indicated in many human diseases. A noninvasive imaging method for monitoring zinc in the body would be useful to understand zinc dynamics in health and disease. To provide a PET imaging agent for zinc, we...
Anna H Le et al.
PloS one, 9(8), e106013-e106013 (2014-08-26)
Angiogenesis, the formation of new blood vessels, is important for the survival of ovarian transplants and the restoration of ovarian functions. Without angiogenesis, transplanted ovarian tissue becomes more susceptible to tissue damage and necrosis. Administration of analgesics for pain management...
Julia M Lewis et al.
The Journal of investigative dermatology, 135(5), 1405-1414 (2014-09-19)
Cutaneous squamous cell carcinoma (SCC) is the most prevalent invasive malignancy with metastatic potential. The epidermis is exposed to a variety of environmental DNA-damaging chemicals, principal among which are polyaromatic hydrocarbons (PAHs) ubiquitous in the environment, tobacco smoke, and broiled...
Petr Tůma et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 821(1), 53-59 (2005-05-19)
Capillary electrophoretic (CE) method was developed for the determination of urinary 3-methylhistidine (3MH) and 1-methylhistidine (1MH) indicating the extent of degradation of skeletal muscle proteins and thereby the state of human health. 3MH, 1MH and histidine can be separated in...
Manouela V Valtcheva et al.
The journal of pain : official journal of the American Pain Society, 16(4), 346-356 (2015-02-03)
Chronic pruritic conditions are often associated with dry skin and loss of epidermal barrier integrity. In this study, repeated application of acetone and ether followed by water (AEW) to the cheek skin of mice produced persistent scratching behavior with no...
Elisabeth Lenz et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 96, 44-52 (2015-07-22)
Co-amorphous drug formulations provide the possibility to stabilize a drug in its amorphous form by interactions with low molecular weight compounds, e.g. amino acids. Recent studies have shown the feasibility of spray drying as a technique to manufacture co-amorphous indomethacin-arginine...
Tahseen H Nasti et al.
Journal of immunology (Baltimore, Md. : 1950), 194(6), 2683-2695 (2015-02-20)
Prevention of tumors induced by environmental carcinogens has not been achieved. Skin tumors produced by polyaromatic hydrocarbons, such as 7,12-dimethylbenz(a)anthracene (DMBA), often harbor an H-ras point mutation, suggesting that it is a poor target for early immunosurveillance. The application of...
Maria Margalef et al.
Journal of agricultural and food chemistry, 63(45), 9996-10003 (2015-10-27)
After ingestion flavanols are metabolized by phase-II enzymes and the microbiota and are distributed throughout the body depending on several factors. Herein we aim to evaluate whether flavanols are tissue-accumulated after the long-term administration of a grape seed polyphenol extract...
Sapan Kumar Sharma et al.
International journal of medicinal mushrooms, 17(7), 661-669 (2015-11-13)
In this study, using standard methods, mycelial nutrients, bioactive compounds, and antioxidants were analyzed for the first time for five fungal species: Isaria sinclairii (Berk.) Lloyd, I. tenuipes Peck, I. japonica Yasuda, I. farinosa (Holmsk) Fr. and Cordyceps tuberculata (Lebert)...
Emma Kettle et al.
Traffic (Copenhagen, Denmark), 16(11), 1174-1192 (2015-09-25)
Cytokinesis is the final stage of cell division and produces two independent daughter cells. Vesicles derived from internal membrane stores, such as the Golgi, lysosomes, and early and recycling endosomes accumulate at the intracellular bridge (ICB) during cytokinesis. Here, we...
M Y Khuhawar et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 873(1), 15-19 (2008-09-02)
Capillary gas chromatographic (GC) determination of methylglyoxal (MGo) was developed on the basis of precolumn derivatization with 1,2-diaminopropane (DAP) at pH 3. The elution was carried out on an HP-5 (30 m x 0.32 mm i.d.) connected with FID. The...
Waziha Farha et al.
Biomedical chromatography : BMC, 29(12), 1932-1936 (2015-06-03)
Perilla leaves contain many interfering substances; thus, it is difficult to protect the analytes during identification and integration. Furthermore, increasing the amount of sample to lower the detection limit worsens the situation. To overcome this problem, we established a new...
Zohreh Majidnia et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 105, 105-113 (2015-08-16)
In this paper, both maghemite (γ-Fe2O3) and titanium oxide (TiO2) nanoparticles were synthesized and mixed in various ratios and embedded in PVA and alginate beads. Batch sorption experiments were applied for removal of barium ions from aqueous solution under sunlight...
Marta Maciejewska et al.
Antonie van Leeuwenhoek, 107(2), 519-531 (2014-12-11)
A novel actinobacterium, designated MM109(T), was isolated from a moonmilk deposit collected from the cave 'Grotte des Collemboles' located in Comblain-au-Pont, Belgium. Based on a polyphasic taxonomic approach comprising chemotaxonomic, phylogenetic, morphological, and physiological characterization, the isolate has been affiliated...
Valentina Di Felice et al.
Journal of tissue engineering and regenerative medicine, 9(11), E51-E64 (2013-04-18)
The use of three-dimensional (3D) cultures may induce cardiac progenitor cells to synthesize their own extracellular matrix (ECM) and sarcomeric proteins to initiate cardiac differentiation. 3D cultures grown on synthetic scaffolds may favour the implantation and survival of stem cells...
Volodymyr Kuzmenko et al.
Materials science & engineering. C, Materials for biological applications, 58, 14-23 (2015-10-20)
The problem of recovery from neurodegeneration needs new effective solutions. Tissue engineering is viewed as a prospective approach for solving this problem since it can help to develop healthy neural tissue using supportive scaffolds. This study presents effective and sustainable...
Juan Carlos Ledesma et al.
Neuropharmacology, 85, 36-44 (2014-05-28)
In the central nervous system ethanol (EtOH) is metabolized into acetaldehyde by different enzymes. Brain catalase accounts for 60% of the total production of EtOH-derived acetaldehyde, whereas cerebral cytochrome P450 2E1 (CYP 2E1) produces 20% of this metabolite. Acetaldehyde formed...
Abdulreza Mashroofeh et al.
Chemosphere, 120, 575-583 (2014-12-03)
The levels of 16 polycyclic aromatic hydrocarbons (PAHs) were determined in the liver, kidney, gills and muscle tissues of Persian sturgeon (Acipenser persicus; n=16), and Stellate sturgeon (Acipenser stellatus; n=7) collected from coastal waters of the South Caspian Sea from...
Darina Očadlíková et al.
Experimental hematology, 43(4), 268-276 (2015-01-15)
Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunosuppressive molecule expressed in some subsets of normal and neoplastic cells. Mature human dendritic cells (DCs) have been shown to express IDO1, but little is known about its expression and function during DC differentiation...
Xiao Hu et al.
The Analyst, 140(24), 8118-8126 (2015-11-04)
In the cell, protein-ligand recognition involves association and dissociation processes controlled by the affinity of the two binding partners and chemical harvesting of adenosine triphosphate energy. Fundamental knowledge of selected recognition events is currently translated in a synthetic environment for...
Feng-Ming Ding et al.
Experimental lung research, 41(1), 44-55 (2014-11-15)
We aimed to investigate the activity of regulatory T (Treg) cells in chronic Pseudomonas aeruginosa (PA) lung infection and its influence on effector T-cell responses. C57BL/6 mice were randomly inoculated with PA-laden agarose beads (1 × 10(5) CFU/50 μL) or...
Konrad Kleszczyński et al.
Journal of pineal research, 58(1), 117-126 (2014-11-27)
Melatonin, a lipophilic compound synthesized and released from the pineal gland, effectively acts against ultraviolet radiation (UVR), one of the main inducers of epidermal damage, skin cancer, inflammation, and DNA photo damage. One of the common known stress protein induced...
Tiina Kelkka et al.
Antioxidants & redox signaling, 21(16), 2231-2245 (2014-05-03)
Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by mutations in the phagocyte reactive oxygen species (ROS)-producing NOX2 enzyme complex and characterized by recurrent infections associated with hyperinflammatory and autoimmune manifestations. A translational, comparative analysis of CGD patients and...
T Satoh et al.
International archives of occupational and environmental health, 67(2), 131-134 (1995-01-01)
To develop a proper protocol for biological exposure monitoring of acetone, we evaluated whether exposure to acetone on the previous day affects the biological monitoring value at the end of a work day. One hundred and ten male workers exposed...
Donatella Tesei et al.
Journal of proteomics, 128, 39-57 (2015-07-21)
The black yeast Exophiala dermatitidis is a worldwide distributed agent of primary and secondary diseases in both immunocompromised and healthy humans, with a high prevalence in human-made environments. Since thermo-tolerance has a crucial role in the fungus persistence in man-dominated...
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