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Pankaj Kumar et al.
Biochimica et biophysica acta. Molecular cell research, 1867(8), 118728-118728 (2020-04-29)
Acquired multidrug resistance of cancer cells challenges the chemotherapeutic interventions. To understand the role of molecular chaperone, Hsp90 in drug adapted tumor cells, we have used in vitro drug adapted epidermoid tumor cells as a model system. We found that
Hongwei Ma et al.
Cell death & disease, 11(1), 24-24 (2020-01-15)
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. Dry AMD is characterized by a progressive macular degeneration of the retinal pigment epithelium (RPE) and photoreceptors, and the RPE oxidative damage/dystrophy is at the core of
Abhijnya Vijayavittal Kanugovi et al.
Journal of cellular biochemistry, 121(4), 2770-2781 (2019-11-07)
The Hsp90 chaperone has become the attractive pharmacological target to inhibit tumor cell proliferation. However, tumor cells can evolve with mechanisms to overcome Hsp90 inhibition. Using human neuroblastoma, we have investigated one such limitation. Here, we demonstrate that neuroblastoma cells
Jyoti B Kaushal et al.
Cancers, 13(13) (2021-07-03)
Niclosamide (Nic), an FDA-approved anthelmintic drug, is reported to have anti-cancer efficacy and is being assessed in clinical trials for various solid tumors. Based on its ability to target multiple signaling pathways, in the present study, we evaluated the therapeutic
Pankaj Kumar et al.
Cancer reports (Hoboken, N.J.), e1261-e1261 (2020-08-08)
Cancer emergence is associated with a series of cellular transformations that include acquired drug resistance followed by tumor metastasis. Matrix metalloproteinases (MMPs) and Hsp90 chaperone are implicated in tumor progression, however, they are not studied in the context of drug
Paula Szalai et al.
Bio-protocol, 8(9), e2835-e2835 (2018-05-05)
In this protocol, we describe a method to monitor cell proliferation and death by live-cell imaging of propidium iodide (PI)-stained adherent mammalian cells. PI is widely used to assess cell death. However, it is usually used in end-point assays. Recently
Naga Gowthami Vykuntham et al.
Toxicology in vitro : an international journal published in association with BIBRA, 65, 104828-104828 (2020-03-19)
The altered molecular pathways in response to chemotherapeutic interventions impose limitations on breast cancer treatments. Therefore, understanding the outcome of these alternative pathways may help in improving the chemotherapy. In this study, using hormone responsive and hormone independent breast cancer
Yujin Jin et al.
International journal of molecular sciences, 22(19) (2021-10-14)
Breast cancer (BC) a very common cancer in women worldwide. Triple negative breast cancer (TNBC) has been shown to have a poor prognosis with a high level of tumor metastatic spread. Here, the inhibitory effects of ginsenoside-Rh1 (Rh1) on BC
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