Showing 1-30 of 55 results for "55222"
Sophie Zatta et al.
BMC genomics, 18(1), 757-757 (2017-09-29)
In the domestic dog, corpora lutea (CL) are the only source of progesterone (P4), both in pregnant and non-pregnant cycles because there is no placental steroidogenesis. The absence of an endogenous luteolysin in absence of pregnancy results in long-lasting physiological...
Thaís Pereira de Mello et al.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 51(2), 427-436 (2019-11-19)
Scedosporium spp. and Lomentospora prolificans are filamentous fungi that emerged as human pathogens; however, their mechanisms of virulence/pathogenesis are still largely unknown. In the present work, we have evaluated the interaction of S. apiospermum, S. minutisporum, S. aurantiacum, and L....
Mayra Diosa-Toro et al.
Antiviral research, 161, 90-99 (2018-11-24)
Dengue is the most common arboviral disease worldwide with 96 million symptomatic cases annually. Despite its major impact on global human health and huge economic burden there is no antiviral drug available to treat the disease. The first tetravalent dengue...
Pablo López-Soriano et al.
PloS one, 12(4), e0176201-e0176201 (2017-04-28)
Xanthomonas arboricola pv. pruni is a quarantine pathogen and the causal agent of the bacterial spot disease of stone fruits and almond, a major threat to Prunus species. Rapid and specific detection methods are essential to improve disease management, and...
Adam G Peres et al.
Infection and immunity, 83(4), 1587-1597 (2015-02-04)
Staphylococcus aureus is a Gram-positive bacterium that is carried by a quarter of the healthy human population and that can cause severe infections. This pathobiosis has been linked to a balance between Toll-like receptor 2 (TLR2)-dependent pro- and anti-inflammatory responses....
Kevin J Landmark et al.
ACS nano, 2(4), 773-783 (2009-02-12)
Organic-coated superparamagnetic iron oxide nanoparticles (OC-SPIONs) were synthesized and characterized by transmission electron microscopy and X-ray photoelectron spectroscopy. OC-SPIONs were transferred from organic media into water using poly(amidoamine) dendrimers modified with 6-TAMRA fluorescent dye and folic acid molecules. The saturation...
Han-Gil Cho et al.
Archives of virology, 162(11), 3389-3396 (2017-08-06)
Noroviruses (NoVs) are the major global source of acute gastroenteritis (AGE) outbreaks. To detect NoVs, real-time reverse transcription-quantitative PCR (RT-qPCR) assays have been widely employed since the first decade of the 21
Julita Piasecka et al.
Molecular therapy. Nucleic acids, 19, 627-642 (2020-01-17)
The influenza A virus is a human pathogen that poses a serious public health threat due to rapid antigen changes and emergence of new, highly pathogenic strains with the potential to become easily transmitted in the human population. The viral...
Hugo Brito et al.
PloS one, 10(5), e0126891-e0126891 (2015-05-30)
A guanine-rich strand within the promoter of the KRAS gene can fold into an intra-molecular G-quadruplex structure (G4), which has an important role in the regulation of KRAS transcription. We have previously identified indolo[3,2-b]quinolines with a 7-carboxylate group and three...
Hao Li et al.
PloS one, 10(3), e0120421-e0120421 (2015-03-18)
Hexaploid triticale could be either synthesized by crossing tetraploid wheat with rye, or developed by crossing hexaploid wheat with a hexaploid triticale or an octoploid triticale. Here two hexaploid triticales with great morphologic divergence derived from common wheat cultivar M8003...
Nina T Grossman et al.
Antimicrobial agents and chemotherapy, 59(2), 1030-1037 (2014-12-03)
Candida parapsilosis is the second or third most common cause of candidemia in many countries. The Infectious Diseases Society of America recommends fluconazole as the primary therapy for C. parapsilosis candidemia. Although the rate of fluconazole resistance among C. parapsilosis...
Paula Michalak et al.
Scientific reports, 9(1), 3801-3801 (2019-03-09)
Influenza virus causes seasonal epidemics and dangerous pandemic outbreaks. It is a single stranded (-)RNA virus with a segmented genome. Eight segments of genomic viral RNA (vRNA) form the virion, which are then transcribed and replicated in host cells. The...
Lydia Farack et al.
Developmental cell, 48(1), 115-125 (2018-12-07)
Pancreatic beta cells have been shown to be heterogeneous at multiple levels. However, spatially interrogating transcriptional heterogeneity in the intact tissue has been challenging. Here, we developed an optimized protocol for single-molecule transcript imaging in the intact pancreas and used...
Sukanya Iyer et al.
Nature microbiology, 3(6), 741-748 (2018-05-16)
Bacteria adapt to environmental stress by producing proteins that provide stress protection. However, stress can severely perturb the kinetics of gene expression, disrupting protein production. Here, we characterized how Escherichia coli mitigates such perturbations under nutrient stress through the kinetic...
Jun Yu et al.
Gut, 66(1), 70-78 (2015-09-27)
To evaluate the potential for diagnosing colorectal cancer (CRC) from faecal metagenomes. We performed metagenome-wide association studies on faecal samples from 74 patients with CRC and 54 controls from China, and validated the results in 16 patients and 24 controls...
Rasanthi U Wijesinghe et al.
Applied and environmental microbiology, 81(13), 4306-4315 (2015-04-19)
Clostridium botulinum type E toxin is responsible for extensive mortality of birds and fish in the Great Lakes. The C. botulinum bontE gene that produces the type E toxin was amplified with quantitative PCR from 150 sloughed algal samples (primarily...
Andri T Rachmadi et al.
The Science of the total environment, 542(Pt A), 976-982 (2015-11-13)
We investigated the occurrence and attenuation of several human enteric viruses (i.e., norovirus, adenovirus, Aichi virus 1, polyomaviruses, and enterovirus) as well as a plant virus, pepper mild mottle virus (PMMoV), at two surface flow wetlands in Arizona. The retention...
Mingwei Shao et al.
Communications biology, 3(1), 527-527 (2020-09-25)
Fungal-bacterial associations are present in nature, playing important roles in ecological, evolutionary and medicinal processes. Here we report a fungus-bacterial symbiont from marine sediment. The bacterium lives inside the fungal mycelium yet is robust enough to survive independent of its...
Hongwei Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(11), 5955-5963 (2020-03-04)
In plants, the mechanism for ecological sympatric speciation (SS) is little known. Here, after ruling out the possibility of secondary contact, we show that wild emmer wheat, at the microclimatically divergent microsite of "Evolution Canyon" (EC), Mt. Carmel, Israel, underwent...
Daviel Cardenas et al.
mSphere, 4(2) (2019-03-08)
During their parasitic life cycle, through sandflies and vertebrate hosts, Leishmania parasites confront strikingly different environments, including abrupt changes in pH and temperature, to which they must rapidly adapt. These adaptations include alterations in Leishmania gene expression, metabolism, and morphology...
M P Kowalewski et al.
Theriogenology, 83(6), 1038-1047 (2015-01-18)
The mechanisms governing corpus luteum (CL) function in domestic dogs remain not fully elucidated. The upregulated expression of cyclooxygenase 2 and prostaglandin (PG) E2 synthase (PGES) at the beginning of the canine luteal phase indicated their luteotrophic roles, and the...
Laith Harb et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(41), 25751-25758 (2020-09-30)
Although the F-specific ssRNA phage MS2 has long had paradigm status, little is known about penetration of the genomic RNA (gRNA) into the cell. The phage initially binds to the F-pilus using its maturation protein (Mat), and then the Mat-bound...
Carsten C Mahrenholz et al.
Journal of peptide science : an official publication of the European Peptide Society, 16(6), 297-302 (2010-05-18)
The growing demand for binding assays to study protein-protein interaction can be addressed by peptide array-based methods. The SPOT technique is a widespread peptide-array technology, which is able to distinguish semi-quantitatively the binding affinities of peptides to defined protein targets...
Luciana Richer et al.
Infection and immunity, 83(12), 4693-4700 (2015-09-30)
Although Leptospira can infect a wide range of mammalian species, most studies have been conducted in golden Syrian hamsters, a species particularly sensitive to acute disease. Chronic disease has been well characterized in the rat, one of the natural reservoir...
Redouane Bouchaala et al.
Colloids and surfaces. B, Biointerfaces, 156, 414-421 (2017-05-30)
Light is an attractive trigger for release of active molecules from nanocarriers in biological systems. Here, we describe a phenomenon of light-induced release of a fluorescent dye from lipid nano-droplets under visible light conditions. Using auto-emulsification process we prepared nanoemulsion...
Caroline Marnata et al.
Journal of virology, 89(23), 12131-12144 (2015-09-25)
Hepatitis C virus (HCV) only infects humans and chimpanzees, while GB virus B (GBV-B), another hepatotropic hepacivirus, infects small New World primates (tamarins and marmosets). In an effort to develop an immunocompetent small primate model for HCV infection to study...
Qi-Pin Qin et al.
Scientific reports, 6, 37644-37644 (2016-11-30)
A series of group-10 metal complexes 1-14 of oxoisoaporphine derivatives were designed and synthesized. 1-14 were more selectively cytotoxic to Hep-G2 cells comparing with normal liver cells. In vitro cytotoxicity results showed that complexes 1-6, 7, 8, 10 and 11...
Marta Soszynska-Jozwiak et al.
Scientific reports, 7(1), 15041-15041 (2017-11-10)
Influenza A virus is a threat for humans due to seasonal epidemics and occasional pandemics. This virus can generate new strains that are dangerous through nucleotide/amino acid changes or through segmental recombination of the viral RNA genome. It is important...
Qiang Wang et al.
PloS one, 13(10), e0206609-e0206609 (2018-10-30)
In this study, we describe an inter-laboratory collaborative ring trial validation of species-specific TaqMan real-time PCR assays for the detection of porcine- and chicken-derived materials in meat products. We comprehensively evaluated the performance of these assays in different environments and...
Maria Musarra-Pizzo et al.
Plants (Basel, Switzerland), 9(2) (2020-02-23)
Natural compounds are a prominent source of novel antiviral drugs. Several reports have previously shown the antimicrobial activity of pistachio polyphenol extracts. Therefore, the aim of our research was to investigate the activity of polyphenol-rich extracts of natural shelled (NPRE)...

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