Search Within
Applied Filters:
Keyword:'563110'
Showing 1-30 of 765 results for "

563110

" within Papers
Yaíma L Lightfoot et al.
The EMBO journal, 34(7), 881-895 (2015-02-11)
Intestinal immune regulatory signals govern gut homeostasis. Breakdown of such regulatory mechanisms may result in inflammatory bowel disease (IBD). Lactobacillus acidophilus contains unique surface layer proteins (Slps), including SlpA, SlpB, SlpX, and lipoteichoic acid (LTA), which interact with pattern recognition...
Johan van der Stok et al.
Tissue engineering. Part A, 21(9-10), 1495-1506 (2015-01-30)
A promising bone graft substitute is porous titanium. Porous titanium, produced by selective laser melting (SLM), can be made as a completely open porous and load-bearing scaffold that facilitates bone regeneration through osteoconduction. In this study, the bone regenerative capacity...
Yu-Ting Xu et al.
Archives of oral biology, 60(7), 1059-1065 (2015-05-08)
The objective of this study was to investigate the antibacterial effects on a cariogenic biofilm of a bioactive glass (BAG) combined with either sodium fluoride (NaF) or triclosan (TCS). According to minimal bactericidal concentrations, 37.5mg/ml of BAG, 4.69 mg/ml of...
Kirsten A Fairfax et al.
Journal of leukocyte biology, 97(1), 71-78 (2014-11-09)
Aicda is a critical component of antibody class-switching in B cells. In this work, we study the impact of TLR4 activation and IL-10 stimulation on Aicda expression in B cells. Through the global analysis of miRNAs in response to TLR4...
Diana Gaspar et al.
Biochimica et biophysica acta, 1853(2), 308-316 (2014-12-03)
Cancer remains a major cause of morbidity and mortality worldwide. Although progress has been made regarding chemotherapeutic agents, new therapies that combine increased selectivity and efficacy with low resistance are still needed. In the search for new anticancer agents, therapies...
Shan Feng et al.
Immunology, 145(3), 367-379 (2015-02-17)
Osteoclasts reside on bone and are the main bone resorbing cells playing an important role in bone homeostasis, while natural killer (NK) cells are bone-marrow-derived cells known to play a crucial role in immune defence against viral infections. Although mature...
Hong-guang Xu et al.
Bone, 66, 232-239 (2014-06-28)
Calcification of end plate chondrocytes is a major cause of intervertebral disc (IVD) degeneration. However, the underlying molecular mechanism of end plate chondrocyte calcification is still unclear. The aim of this study was to clarify whether autophagy in end plate...
Nicholas A Spidale et al.
Journal of immunology (Baltimore, Md. : 1950), 193(1), 21-25 (2014-06-04)
Thymic dendritic cells (DC) mediate self-tolerance by presenting self-peptides to and depleting autoreactive thymocytes. Despite a significant role in negative selection, the events regulating thymic DC maturation and function under steady-state conditions are poorly understood. We report that cross-talk with...
Burcu Temizoz et al.
European journal of immunology, 45(4), 1159-1169 (2014-12-23)
Agonists for TLR9 and Stimulator of IFN Gene (STING) act as vaccine adjuvants that induce type-1 immune responses. However, currently available CpG oligodeoxynucleotide (ODN) (K-type) induces IFNs only weakly and STING ligands rather induce type-2 immune responses, limiting their potential...
Melanie Piédavent-Salomon et al.
Brain : a journal of neurology, 138(Pt 11), 3263-3274 (2015-09-12)
Recent association studies have linked numerous genetic variants with an increased risk for multiple sclerosis, although their functional relevance remains largely unknown. Here we investigated phenotypical and functional consequences of a genetic variant in the CD226 gene that, among other...
David E Sanin et al.
PLoS pathogens, 11(5), e1004841-e1004841 (2015-05-15)
The skin provides an important first line of defence and immunological barrier to invasive pathogens, but immune responses must also be regulated to maintain barrier function and ensure tolerance of skin surface commensal organisms. In schistosomiasis-endemic regions, populations can experience...
Lizette Utomo et al.
Biomedical materials (Bristol, England), 10(1), 015010-015010 (2015-01-15)
Scaffolds are widely used to reconstruct cartilage. Yet, the fabrication of a scaffold with a highly organized microenvironment that closely resembles native cartilage remains a major challenge. Scaffolds derived from acellular extracellular matrices are able to provide such a microenvironment....
Jennifer J Heller et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 3934-3946 (2014-09-07)
Proper immune responses are needed to control pathogen infection at mucosal surfaces. IL-22-producing CD4(+) T cells play an important role in controlling bacterial infection in the gut; however, transcriptional regulation of these cells remains elusive. In this study, we show...
Betty Revon Liu et al.
The Journal of membrane biology, 248(2), 355-368 (2015-02-07)
Bacterial and archaeal cell envelopes are complex multilayered barriers that serve to protect these microorganisms from their extremely harsh and often hostile environments. Import of exogenous proteins and nanoparticles into cells is important for biotechnological applications in prokaryotes. In this...
Chiew Xsia Tay et al.
Journal of endodontics, 41(6), 858-863 (2015-03-31)
Successful endodontic treatment outcomes require new strategies for the complete eradication of microbial biofilms in the root canal system. Matrix metalloproteinases (MMPs) are essential enzymes in microbial cell growth and homeostasis, and they require transition metal ion cofactors to function....
Annapoorna Mohandas et al.
Colloids and surfaces. B, Biointerfaces, 127, 105-113 (2015-02-11)
Reduced levels of endogenous growth factors and diminished angiogenesis are contributory factors for impaired wound healing in diabetic patients. Vascular endothelial growth factor (VEGF) is the most potent angiogenic growth factor which stimulates multiple phases of wound healing angiogenesis and...
Ting Liu et al.
Biotechnology and bioengineering, 112(10), 2051-2059 (2015-04-23)
Electroactive biofilms play essential roles in determining the power output of microbial fuel cells (MFCs). To engineer the electroactive biofilm formation of Shewanella oneidensis MR-1, a model exoelectrogen, we herein heterologously overexpressed a c-di-GMP biosynthesis gene ydeH in S. oneidensis...
Debargh K Dutta et al.
PloS one, 10(4), e0124389-e0124389 (2015-04-22)
Multinucleate giant cells (MGCs) are formed by the fusion of 5 to 15 monocytes or macrophages. MGCs can be generated by hip implants at the site where the metal surface of the device is in close contact with tissue. MGCs...
Silvia García-Cobos et al.
The Journal of antimicrobial chemotherapy, 69(9), 2394-2399 (2014-06-04)
Non-typeable Haemophilus influenzae are a major cause of acute otitis media (AOM), including chronic and recurrent otitis in young children. The objective of this study was to determine whether non-typeable H. influenzae isolates causing these infections produce biofilms and carry...
Li Xiao et al.
Biology of the cell, 106(12), 405-419 (2014-09-02)
During embryonic development, cell death transforms the solid embryonic cell mass into a hollow structure (cavitation), which allows the surviving cells to differentiate into varied tissues and organs around the cavity. This process can be partly reproduced with embryonic stem...
Jason K F Wong et al.
PloS one, 9(11), e112672-e112672 (2014-11-11)
Repaired tendons may be complicated by progressive fibrosis, causing adhesion formation or tendon softening leading to tendon rupture and subsequent reduced range of motion. There are few therapies available which improve the gliding of damaged tendons in the hand. We...
Zhejun Wang et al.
PloS one, 10(7), e0132512-e0132512 (2015-07-15)
Human oral biofilms are multispecies microbial communities that exhibit high resistance to antimicrobial agents. Dental plaque gives rise to highly prevalent and costly biofilm-related oral infections, which lead to caries or other types of oral infections. We investigated the ability...
YanFen Meng et al.
Science China. Life sciences, 58(3), 287-296 (2014-10-02)
Rickettsia heilongjiangensis is an obligate intracellular bacterium that causes Far-Eastern tick-borne spotted fever. Outer membrane protein B (OmpB) is an important surface protein antigen of rickettsiae. In the present study, the ompB gene of R. heilongjiangensis was divided into four...
Marco Giannelli et al.
Photomedicine and laser surgery, 33(9), 473-480 (2015-08-04)
We previously showed that photoablative laser therapy followed by multiple photodynamic cycles (PAPD) after scaling/root planing (SRP) improved healing of periodontitis patients as compared with conventional SRP after 1-year follow-up. This study reports the favorable results of PAPD plus SRP...
Megan J Farrell et al.
Journal of biomechanics, 47(9), 2173-2182 (2013-11-19)
The success of stem cell-based cartilage repair requires that the regenerate tissue reach a stable state. To investigate the long-term stability of tissue engineered cartilage constructs, we assessed the development of compressive mechanical properties of chondrocyte and mesenchymal stem cell...
Jetze Visser et al.
Nature communications, 6, 6933-6933 (2015-04-29)
Despite intensive research, hydrogels currently available for tissue repair in the musculoskeletal system are unable to meet the mechanical, as well as the biological, requirements for successful outcomes. Here we reinforce soft hydrogels with highly organized, high-porosity microfibre networks that...
Tiffany Bouchery et al.
Nature communications, 6, 6970-6970 (2015-04-29)
Defining the immune mechanisms underlying protective immunity to helminth infection remains an important challenge. Here we report that lung CD4(+) T cells and Group 2 innate lymphoid cells (ILC2s) work in concert to block Nippostrongylus brasiliensis (Nb) development in the...
Prabhat K Sharma et al.
Immunology, 145(3), 443-453 (2015-03-11)
Mucosa-associated invariant T (MAIT) cells express the semi-invariant T-cell receptor TRAV1-2 and detect a range of bacteria and fungi through the MHC-like molecule MR1. However, knowledge of the function and phenotype of bacteria-reactive MR1-restricted TRAV1-2(+) MAIT cells from human blood...
Claire D Bourke et al.
International journal for parasitology, 45(4), 215-224 (2015-01-13)
Keratinocytes constitute the majority of cells in the skin's epidermis, the first line of defence against percutaneous pathogens. Schistosome larvae (cercariae) actively penetrate the epidermis to establish infection, however the response of keratinocytes to invading cercariae has not been investigated....
Henrike Veninga et al.
European journal of immunology, 45(3), 747-757 (2014-12-10)
Ag delivery to specific APCs is an attractive approach in developing strategies for vaccination. CD169(+) macrophages in the marginal zone of the spleen represent a suitable target for delivery of Ag because of their strategic location, which is optimal for...
Page 1 of 26
Page 1 of 26