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Megan L Killian et al.
BMC musculoskeletal disorders, 15, 297-297 (2014-09-07)
Traumatic impaction is known to cause acute cell death and macroscopic damage to cartilage and menisci in vitro. The purpose of this study was to investigate cell viability and macroscopic damage of the medial and lateral menisci using an in
Sonthaya Umsumarng et al.
Basic & clinical pharmacology & toxicology, 116(5), 390-397 (2014-09-30)
Our previous study reported multi-drug resistance (MDR) reversing properties of synthetic stemofoline derivatives (STFD), OH-A1, NH-B6 and NH-D6 on P-glycoprotein (P-gp) overexpressing leukaemic cells (K562/Adr); however, the mechanism was unclear. In this study, we further investigated whether the STFD reverse
Shakila Tobwala et al.
Experimental biology and medicine (Maywood, N.J.), 240(2), 261-272 (2014-09-24)
Acetaminophen (N-acetyl-p-aminophenol, APAP) is one of the most widely used over-the-counter antipyretic analgesic medications. Despite being safe at therapeutic doses, an accidental or intentional overdose can result in severe hepatotoxicity; a leading cause of drug-induced liver failure in the U.S.
Monika Praschberger et al.
Pharmaceutical development and technology, 20(2), 176-182 (2013-11-14)
Severe iron deficiency requires intravenous iron supplementation to replenish iron stores. Intravenous iron sucrose has been used for decades for the treatment of anemia. New generic iron sucrose products are now marketed for the use in several countries and there
Dolly Holt-Casper et al.
Journal of translational medicine, 13, 194-194 (2015-06-19)
Myocardial infarction (MI) results in damaged heart tissue which can progress to severely reduce cardiac function, leading to death. Recent studies have injected dissociated, suspended cardiac cells into coronary arteries to restore function with limited results attributed to poor cell
Margarete K Akens et al.
Photodiagnosis and photodynamic therapy, 11(3), 426-433 (2014-09-02)
Photodynamic therapy (PDT), a non-ionizing, minimally invasive drug-light treatment, has recently been shown to successfully ablate tumor within rat vertebrae with concurrent improvements in bone strength and architecture. The bisphosphonate zoledronic acid (zol), a current drug for patients with skeletal
Leonel A Cortes et al.
PloS one, 10(8), e0136852-e0136852 (2015-09-01)
disease is one of the most neglected tropical diseases in the world, affecting nearly 15 million people, primarily in Latin America. Only two drugs are used for the treatment of this disease, nifurtimox and benznidazole. These drugs have limited efficacy
Verena Rickert et al.
Pulmonary pharmacology & therapeutics, 28(2), 130-137 (2014-03-25)
Riociguat is a new soluble guanylate cyclase stimulator under development for pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. So far, the interaction potential of riociguat with other drugs is nearly unknown. Therefore, we assessed in vitro the potency of riociguat
Michael O Schär et al.
Clinical orthopaedics and related research, 473(5), 1635-1643 (2015-02-19)
Platelet-rich concentrates are used as a source of growth factors to improve the healing process. The diverse preparation protocols and the gaps in knowledge of their biological properties complicate the interpretation of clinical results. In this study we aimed to
Lachlan M Moldenhauer et al.
Stem cell research, 14(3), 380-395 (2015-04-23)
Circulating endothelial progenitor cells (EPCs) provide revascularisation for cardiovascular disease and the expansion of these cells opens up the possibility of their use as a cell therapy. Herein we show that interleukin-3 (IL3) strongly expands a population of human non-adherent
Jae Y Lee et al.
Journal of biomedical materials research. Part A, 103(6), 2126-2132 (2014-10-09)
Electrically conducting polymers (CPs) have been recognized as novel biomaterials that can electrically communicate with biological systems. For their tissue engineering applications, CPs have been modified to promote cell adhesion for improved interactions between biomaterials and cells/tissues. Conventional approaches to
Shang-Hsun Tsou et al.
PloS one, 10(1), e0116747-e0116747 (2015-01-31)
Cellular mechanisms of multidrug resistance (MDR) are related to ABC transporters, apoptosis, antioxidation, drug metabolism, DNA repair and cell proliferation. It remains unclear whether the process of resistance development is programmable. We aimed to study gene expression profiling circumstances in
A Retamales et al.
Biochemical and biophysical research communications, 464(2), 596-602 (2015-07-08)
Myogenic differentiation is a complex and well-coordinated process for generating mature skeletal muscle fibers. This event is autocrine/paracrine regulated by growth factors, principally Myostatin (MSTN) and Insulin-like Growth Factor-1 (IGF-1). Myostatin, a member of the transforming growth factor-β superfamily, is
S Pretor et al.
Molecular pharmaceutics, 12(1), 34-45 (2014-11-21)
In vitro studies of ocular bioavailability of active pharmaceutical ingredients (API) from colloidal drug delivery systems do not consider physiological shear stress generated by eyelid wiping and tear flow. The present study introduces a live cell imaging approach which enables
Philippe Beauchamp et al.
Tissue engineering. Part C, Methods, 21(8), 852-861 (2015-02-06)
Cardiomyocytes (CMs) are terminally differentiated cells in the adult heart, and ischemia and cardiotoxic compounds can lead to cell death and irreversible decline of cardiac function. As testing platforms, isolated organs and primary cells from rodents have been the standard
Alison E Wallace et al.
Journal of leukocyte biology, 97(1), 79-86 (2014-11-09)
During pregnancy, a specialized type of NK cell accumulates in the lining of the uterus (decidua) and interacts with semiallogeneic fetal trophoblast cells. dNK cells are functionally and phenotypically distinct from PB NK and are implicated in regulation of trophoblast
Ge Zhang et al.
BMC cancer, 14, 310-310 (2014-06-03)
Cancer invasion and metastasis develops through a series of steps that involve the loss of cell to cell and cell to matrix adhesion, degradation of extracellular matrix and induction of angiogenesis. Different protease systems (e.g., matrix metalloproteinases, MMPs) are involved
Nadir Abuzeid et al.
Journal of ethnopharmacology, 157, 134-139 (2014-09-28)
The emergence of multidrug-resistant strains of Mycobacterium tuberculosis underscores the need for continuous development of new and efficient methods to determine the susceptibility of isolates of Mycobacterium tuberculosis in the search for novel antimycobacterial agents. Natural products constitute an important
Haibin Tong et al.
Pharmaceutical biology, 53(3), 345-349 (2014-10-22)
P-selectin is a promising target for inflammatory-related diseases. Polysaccharides are the active ingredients of Sanguisorba officinalis L. (Rosaceae) responsible for its anti-inflammatory activities; however, the molecular mechanism is not clear yet. This study evaluates the effects of polysaccharides (SOPs) from
Yuhuan Wang et al.
Blood, 125(23), 3627-3636 (2015-04-09)
Thrombopoiesis is the process by which megakaryocytes release platelets that circulate as uniform small, disc-shaped anucleate cytoplasmic fragments with critical roles in hemostasis and related biology. The exact mechanism of thrombopoiesis and the maturation pathways of platelets released into the
Kathleen M McAndrews et al.
ACS chemical biology, 10(8), 1932-1938 (2015-06-06)
Cancer-associated fibroblasts (CAFs) are known to promote tumor growth and metastasis; however their differential accumulation in invasive and noninvasive tumors is not fully understood. We hypothesized that differences in cell adhesion may contribute to this phenomenon. To test this, we
Angela Burleigh et al.
Breast cancer research : BCR, 17, 4-4 (2015-01-13)
The extracellular signals regulating mammary epithelial cell growth are of relevance to understanding the pathophysiology of mammary epithelia, yet they remain poorly characterized. In this study, we applied an unbiased approach to understanding the functional role of signalling molecules in
Shaowei Li et al.
Stem cells translational medicine, 4(4), 359-368 (2015-03-07)
Postnatal tissue-specific stem/progenitor cells hold great promise to enhance repair of damaged tissues. Many of these cells are retrieved from bone marrow or adipose tissue via invasive procedures. Peripheral blood is an ideal alternative source for the stem/progenitor cells because
Rong Huang et al.
Scientific reports, 5, 17768-17768 (2015-12-04)
The extravasation of tumor cells is a key event in tumor metastasis. However, the mechanism underlying tumor cell extravasation remains unknown, mainly hindered by obstacles from the lack of complexity of biological tissues in conventional cell culture, and the costliness
Xiao-Cong Huang et al.
Biochemical pharmacology, 85(9), 1257-1268 (2013-02-19)
High intrinsic or acquired expression of membrane spanning, adenosine triphosphate binding cassette (ABC) transporter proteins, such as P-glycoprotein (P-gp), in cancers represents a major impediment to chemotherapy, with accelerated drug efflux leading to multi-drug resistance (MDR). Although ABC transporter inhibitors
Yoshiyuki Tsukamoto et al.
American journal of cancer research, 5(10), 2998-3014 (2015-12-23)
Previously, we have reported that gain at chromosome 20q13 is the most common genomic copy number aberration in gastric cancer (GC) (29/30 cases), and that among the genes located in this region, we have identified DDX27, whose expression level shows
Yu-Hui Lee et al.
Cellular & molecular immunology, 12(2), 231-242 (2014-06-03)
Spontaneous term labour is associated with amplified inflammatory events in the myometrium including cytokine production and leukocyte infiltration; however, potential mechanisms regulating such events are not fully understood. We hypothesized that mechanical stretch of the uterine wall by the growing
Manohar C Dange et al.
Clinical & experimental metastasis, 31(6), 661-673 (2014-06-22)
Interactions between molecules on the surface of tumor cells and those on the target organ endothelium play an important role in their arrest in an organ. Galectin-3 on the lung endothelium and high affinity ligands poly-N-acetyllactosamine (polyLacNAc) on N-oligosaccharides on
Himali Somaweera et al.
The Analyst, 140(15), 5029-5038 (2015-06-09)
A microfluidic diffusion diluter was used to create a stable concentration gradient for dose response studies. The microfluidic diffusion diluter used in this study consisted of 128 culture chambers on each side of the main fluidic channel. A calibration method
T Nakama et al.
Gene therapy, 22(2), 127-137 (2014-12-17)
Age-related macular degeneration (AMD) is a vision-threatening disease characterized by choroidal fibrovascular membrane (FVM) formation, choroidal neovascularization (CNV) and choroidal fibrosis. No safe and effective therapeutic method has been developed for the choroidal fibrosis, although anti-vascular endothelial growth factor therapy
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