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Showing 1-30 of 283 results for "59-14-3" within Papers
Lukás Cermák et al.
The Journal of biological chemistry, 277(10), 7955-7961 (2002-01-05)
CD43 (leukosialin, sialophorin), an abundant leukocyte surface sialoglycoprotein, regulates leukocyte adhesion and transmits activating signals in T cells and dendritic cells. Immobilized anti-CD43 monoclonal antibody (mAb) MEM-59 has been previously shown to induce apoptosis of hematopoietic progenitors. In this study
Ellen Smid-Koopman et al.
Journal of the Society for Gynecologic Investigation, 10(1), 49-57 (2003-01-09)
To study the functional differences between the two progesterone receptor isoforms (hPRA and hPRB) in human endometrial cancer, two new endometrial carcinoma cell lines were created-one expressing hPRA and one expressing hPRB.A well-differentiated, hPR-negative Ishikawa cell line was stably transfected
E Perzborn et al.
Journal of thrombosis and haemostasis : JTH, 3(3), 514-521 (2005-03-08)
BAY 59-7939 is an oral, direct Factor Xa (FXa) inhibitor in development for the prevention and treatment of arterial and venous thrombosis. BAY 59-7939 competitively inhibits human FXa (K(i) 0.4 nm) with > 10 000-fold greater selectivity than for other
Fenghua Wang et al.
The American journal of surgical pathology, 33(10), 1529-1539 (2009-07-04)
Extragonadal yolk sac tumors (YSTs; primary and metastatic) are rare but are malignant germ cell tumors. Pathologic diagnosis of extragonadal YSTs can be challenging without immunohistochemical markers but markers used for diagnosing these tumors such as placental-like alkaline phosphatase (PLAP)
Fenghua Wang et al.
The American journal of surgical pathology, 33(10), 1529-1539 (2009-07-04)
Extragonadal yolk sac tumors (YSTs; primary and metastatic) are rare but are malignant germ cell tumors. Pathologic diagnosis of extragonadal YSTs can be challenging without immunohistochemical markers but markers used for diagnosing these tumors such as placental-like alkaline phosphatase (PLAP)
Zhihui Wang et al.
BMC cancer, 8, 308-308 (2008-10-28)
14-3-3 sigma promotes G2/M cell cycle arrest by sequestering cyclin B1-CDC2 complex in cytoplasm. Down-regulation of 14-3-3sigma, which has been demonstrated in various carcinomas, may contribute to malignant transformation. However, the exact role of 14-3-3sigma in the pathogenesis of vulvar
Pritsana Raungrut et al.
Anticancer research, 38(6), 3507-3514 (2018-06-01)
14-3-3γ is involved in the metastasis of lung cancer cells. However, its functional roles in tumor cell invasion and the underlying mechanisms are still not understood. In this study, the roles and molecular mechanisms of 14-3-3γ in epithelial-mesenchymal transition (EMT)
Walter L Murfee et al.
Microcirculation (New York, N.Y. : 1994), 13(3), 261-273 (2006-04-22)
Recently the authors have shown that neuron-glial antigen 2 (NG2) is expressed by perivascular cells along arterioles and capillaries, but not along venules in quiescent rat mesenteric microvascular networks. To investigate how the spatial distribution of this proteoglycan changes during
O A Akinyemi et al.
African journal of medicine and medical sciences, 42(1), 73-79 (2013-08-06)
Caudal block is a commonly performed day case anaesthetic procedure in children for most infraumbilical surgeries worldwide [1] as it provides good analgesia in the perioperative period. In Nigeria there is paucity of data on caudal block hence the justification
D C Calverley et al.
Blood, 91(4), 1295-1303 (1998-03-07)
The initiation of primary hemostasis is mediated by interaction of the platelet glycoprotein Ib (GPIb) surface receptor and its arterial subendothelial von Willebrand factor (vWF) ligand. The intracellular signaling immediately following GPIb receptor occupancy connecting the adhesive event to platelet
H Kaya et al.
European journal of gynaecological oncology, 29(4), 350-356 (2008-08-22)
The purpose of this study was to investigate the frequency of expression of the erbB/HER family of growth factor receptors, their ligand neuregulinalpha (NRGalpha) and the most important pathways activated by HER receptors that are mitogen-activated protein kinase (MAPK) and
Erika De León Vázquez et al.
Virology, 448, 344-355 (2013-12-10)
Kaposi's sarcoma-associated herpesvirus LANA (1162 residues) mediates episomal persistence of viral genomes during latency. LANA mediates viral DNA replication and segregates episomes to daughter nuclei. A 59 residue deletion immediately upstream of the internal repeat elements rendered LANA highly deficient
Elisabeth Burnor et al.
Neurology, 90(1), e31-e38 (2017-12-01)
To measure the frequency, persistence, isoform specificity, and clinical correlates of neurofascin antibodies in patients with peripheral neuropathies. We studied cohorts of patients with Guillain-Barre syndrome (GBS) or chronic inflammatory demyelinating polyneuropathy (CIDP) (n = 59), genetic neuropathy (n =
Noureddine Mazoir et al.
Chemistry & biodiversity, 17(9), e2000287-e2000287 (2020-07-10)
Semisynthetic functionalized triterpenes (4α,14-dimethyl-5α,8α-8,9-epoxycholestan-3β-yl acetate; 4α,14-dimethyl-5α-cholest-8-ene-3,7,11-trione; 4α,14-dimethyl-5α-cholesta-7,9(11)-dien-3-one and 4α,14-dimethyl-5α-cholest-8-en-3β-yl acetate), previously prepared from 31-norlanostenol, a natural insecticide isolated from the latex of Euphorbia officinarum, have been subjected to oxidation with hydrogen peroxide (H2 O2 ) and iodosobenzene (PhIO) catalyzed by
Apurva R Patel et al.
Journal of controlled release : official journal of the Controlled Release Society, 213, 18-26 (2015-06-17)
3, 3-Diindolylmethane-14 (DIM-14), a novel lipophilic derivative of DIM, has demonstrated anticancer activity in different types of cancers. However, poor solubility and low oral bioavailability of DIM-14 limit its translational benefits in vivo. This study was carried out to improve
S Abromson-Leeman et al.
Journal of immunology (Baltimore, Md. : 1950), 154(1), 388-398 (1995-01-01)
BALB/c mice are resistant to disease induction when experimental protocols that induce experimental autoimmune encephalomyelitis (EAE) in susceptible strains of animals are used. We have previously described a panel of myelin basic protein (MBP)-specific CD4+ T cell clones from BALB/c
E Garza González et al.
Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva, 99(2), 71-75 (2007-04-10)
to assess the efficacy of rabeprazole (RPZ), amoxicillin (Am), and clarithromycin (Cla) (7 vs. 14 days) in the eradication of H. pylori, and to determine the effect of strain-specific antibiotic resistance and host CYP2C19 status. first, we determined the CYP2C19
John M Miles et al.
Diabetes, 53(3), 521-527 (2004-02-28)
Little is known about the fate of the lipolytic products produced by the action of lipoprotein lipase (LPL) on circulating triglyceride-rich lipoproteins in humans. We studied eight lean, healthy male subjects after an overnight fast. Subjects received infusions of lipid
Jialu Xu et al.
Neuro endocrinology letters, 31(6), 848-851 (2011-01-05)
The expression of iNOS mRNA and protein levels was studied in hypothyroid rat cerebral cortex during early days after postnatal life. The homogenate of the cerebral cortex was examined using Real-time reverse transcription polymerase chain reaction (real-time RT PCR) and
Toshihiro Shiozawa et al.
Pathology international, 63(2), 77-84 (2013-03-08)
Adenosquamous carcinoma of the lung (Ad-Sq) is an uncommon subtype with poor prognosis. We analyzed the clinicopathological characteristics of Ad-Sq, focusing the correlation between Epidermal Growth Factor Receptor (EGFR) mutation and clinicopathological factors. A total of 67 cases were selected
C De Simone et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 29(9), 1786-1790 (2015-03-03)
Genetic factors might have a role for lack of therapeutic response to anti-TNF-alpha agents, as previously suggested in patients with rheumatoid arthritis and inflammatory bowel disease. We evaluated the role of the main TNF-alpha polymorphisms (-238G>A, -308G>A, -857C>T) in predicting
Yanjun Zhang et al.
The Lancet. Infectious diseases, 21(2), 181-192 (2020-11-21)
With the unprecedented morbidity and mortality associated with the COVID-19 pandemic, a vaccine against COVID-19 is urgently needed. We investigated CoronaVac (Sinovac Life Sciences, Beijing, China), an inactivated vaccine candidate against COVID-19, containing inactivated severe acute respiratory syndrome coronavirus 2
Annemiek Broyl et al.
The Lancet. Oncology, 11(11), 1057-1065 (2010-09-25)
Bortezomib-induced peripheral neuropathy is a dose-limiting toxicity in patients with multiple myeloma, often requiring adjustment of treatment and affecting quality of life. We investigated the molecular profiles of early-onset (within one treatment cycle) versus late-onset (after two or three treatment
Serhii Holota et al.
Bioorganic chemistry, 86, 126-136 (2019-01-29)
A series of novel 2-(5-aminomethylene-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropionic acid ethyl esters has been synthesized. Target compounds were evaluated for their trypanocidal activity towards Trypanosoma brucei brucei and Trypanosoma brucei gambiense. Several hit-compounds (8, 10, 12) inhibited growth of the parasites at sub-micromolar concentrations
Wenjie Tang et al.
Life sciences, 84(13-14), 421-427 (2009-03-24)
The identification of transcription factors that regulate the transcription of the fibroblast growth factor-2 (FGF-2) gene has facilitated the understanding of the etiology of cardiovascular diseases. The purpose of this study was to determine the molecular mechanism underlying the activation
Giuseppe Rovere et al.
Investigative ophthalmology & visual science, 57(15), 6652-6661 (2016-12-09)
To analyze the responses of different retinal ganglion cell (RGC) types to acute ocular hypertension (AOH) and intravitreal administration of brain-derived neurotrophic factor (BDNF). In adult albino rats, the anterior chamber of the left eye was cannulated with a needle
L M Oliveira et al.
The Journal of clinical endocrinology and metabolism, 86(4), 1532-1538 (2001-04-12)
Kallmann syndrome (KS) consists of congenital, isolated, idiopathic hypogonadotropic hypogonadism (IHH) and anosmia. The gene responsible for the X-linked form of KS, KAL, encodes a protein, anosmin, that plays a key role in the migration of GnRH neurons and olfactory
Chanika Sritara et al.
Asian Pacific journal of cancer prevention : APJCP, 13(8), 4203-4208 (2012-10-27)
This study assessed if onfFN mRNA in the peripheral blood of patients with DTC can identify individuals with metastatic disease. Comparison of onfFN mRNA was made among 3 groups: disease-free, lymph node metastasis, and distant metastasis using real-time RT-PCR on
M Callander et al.
Multiple sclerosis (Houndmills, Basingstoke, England), 13(4), 441-445 (2007-04-28)
We analysed HLA haplotypes in pairs of 78 sporadic multiple sclerosis (MS) patients and 78 healthy siblings. The presence of 2 oligoclonal IgG bands, detected by immunoblotting of the cerebrospinal fluid in healthy siblings, has previously been defined as MS
A S Kamiguti et al.
Toxicon : official journal of the International Society on Toxinology, 29(8), 961-972 (1991-01-01)
Thirty-four patients envenomed by Bothrops jararaca in Brazil were studied. Of these, 20 (59%) had incoagulable blood associated with local and/or systemic bleeding and 10 of the 20 were thrombocytopenic. Among 14 patients with coagulable blood, 6 (43%) had bleeding
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