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Treatment of proton pump inhibitor-resistant patients with gastroesophageal reflux disease.
Yoshikazu Kinoshita et al.
Journal of gastroenterology, 41(3), 286-287 (2006-05-16)
Sung-Kyun Ko et al.
Nature chemistry, 6(10), 885-892 (2014-09-23)
Anion transporters based on small molecules have received attention as therapeutic agents because of their potential to disrupt cellular ion homeostasis. However, a direct correlation between a change in cellular chloride anion concentration and cytotoxicity has not been established for
Ana M Reyes-Ramos et al.
Cancers, 11(10) (2019-10-30)
The paracrine interaction between tumor cells and adjacent stroma has been associated with the oncogenic activity of the Hedgehog (Hh) pathway in triple-negative breast tumors. The present study developed a model of paracrine Hh signaling and examined the impact of
Christopher Howell et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 48(9), 1214-1221 (2018-06-21)
Viral infection of the bronchial epithelium disrupts the barrier properties of the epithelium in healthy individuals and those with lung disease. Repair of the bronchial epithelium is dependent of the formation of a provisional fibrin matrix and migration of epithelial
Magdalena Gorska et al.
Anticancer research, 36(1), 221-229 (2016-01-02)
3D cell cultures have revolutionized the understanding of cell behavior, allowing culture of cells with the possibility of resembling in vivo intercellular signaling and cell-extracellular matrix interaction. The effect of limited oxygen penetration into 3D culture of highly metastatic osteosarcoma
Ramona Emig et al.
Cells, 10(3) (2021-04-04)
The mechanical environment of cardiac cells changes continuously and undergoes major alterations during diseases. Most cardiac diseases, including atrial fibrillation, are accompanied by fibrosis which can impair both electrical and mechanical function of the heart. A key characteristic of fibrotic
Isabelle Hernandez Cantão et al.
Biological procedures online, 19, 9-9 (2017-08-09)
Primordial germ cells (PGC) are the precursors of the gametes. During pre-natal development, PGC undergo an epigenetic reprogramming when bulk DNA demethylation occurs and is followed by sex-specific de novo methylation. The de novo methylation and the maintenance of the
Isolation and characterization of human breast tumor-derived endothelial cells
Cristina Grange
Oncology Reports, 15(12), 381-386 (2006)
Hyun Gyu Lee et al.
PLoS computational biology, 17(9), e1009447-e1009447 (2021-09-24)
The dispersal or mixing of cells within cellular tissue is a crucial property for diverse biological processes, ranging from morphogenesis, immune action, to tumor metastasis. With the phenomenon of 'contact inhibition of locomotion,' it is puzzling how cells achieve such
Rashmi Singh et al.
Aquatic toxicology (Amsterdam, Netherlands), 192, 30-39 (2017-09-18)
The current study was aimed to understand the effects of chronic fluoride exposure on fish immune system. African sharp tooth catfish (Clarias gariepinus) were exposed to 73.45mg/L of fluoride corresponding to 1/10 96h LC
Sara E Jager et al.
Glia, 68(7), 1375-1395 (2020-02-12)
Satellite glial cells (SGCs) are homeostatic cells enveloping the somata of peripheral sensory and autonomic neurons. A wide variety of neuronal stressors trigger activation of SGCs, contributing to, for example, neuropathic pain through modulation of neuronal activity. However, compared to
Zhen Chen et al.
Frontiers in cell and developmental biology, 9, 728352-728352 (2021-10-09)
In the mammalian cochlea, spiral ganglion neurons (SGNs) relay the acoustic information to the central auditory circuits. Degeneration of SGNs is a major cause of sensorineural hearing loss and severely affects the effectiveness of cochlear implant therapy. Cochlear glial cells
Jae Jun Sim et al.
Methods and protocols, 3(2) (2020-05-01)
In this protocol, we introduced a method of measuring mitochondrial dysfunction to confirm the epithelial-mesenchymal transition (EMT) in pancreatic cancer cells under a hypoxic environment. There are many expertized and complicated methods to verify EMT. However, our methods have indicated
Maria Dafne Cardamone et al.
Molecular cell, 69(5), 757-772 (2018-03-03)
As most of the mitochondrial proteome is encoded in the nucleus, mitochondrial functions critically depend on nuclear gene expression and bidirectional mito-nuclear communication. However, mitochondria-to-nucleus communication pathways in mammals are incompletely understood. Here, we identify G-Protein Pathway Suppressor 2 (GPS2) as a
Rashmi Singh et al.
Toxicology research, 5(5), 1477-1489 (2016-07-27)
Fluoride is known to induce apoptosis though the mechanisms remain obscure. The aim of the present study was to understand the underlying molecular mechanisms of fluoride-induced apoptosis using fish headkidney macrophages (HKMs). Exposure to fluoride triggered HKM cell apoptosis as
Robin C Su et al.
Chemosphere, 257, 127111-127111 (2020-06-03)
Microcystin-leucine arginine (MC-LR) is a potent liver toxin produced by freshwater cyanobacteria, also known as blue-green algae. While harmful algal blooms are increasing in frequency and severity worldwide, there is still no established method for the diagnosis and assessment of
Janine J G Arts et al.
Frontiers in immunology, 12, 667213-667213 (2021-06-05)
An inflammatory response requires leukocytes to migrate from the circulation across the vascular lining into the tissue to clear the invading pathogen. Whereas a lot of attention is focused on how leukocytes make their way through the endothelial monolayer, it
Gabriella Marucci et al.
Life sciences, 205, 155-163 (2018-05-16)
A3 adenosine receptor (A3AR) signalling activation seems to mediate anticancer effect, and it has been targeted for drug development. The identification of potent and selective A3AR agonists could be crucial for cancer drug development. In the present study was determined
Maria Pompea Antonia Baldassarre et al.
Nutrients, 13(7) (2021-07-03)
Myo-inositol (Myo) improves insulin resistance, glucose metabolism, and helps gestational diabetes (GDM) management. GDM is associated with a pro-inflammatory state and increased oxidative stress, which are both involved in vascular damage in diabetes. Our aim was to study Myo anti-inflammatory/antioxidant
Marjan Biočanin et al.
Lab on a chip, 19(9), 1610-1620 (2019-03-29)
Single-cell RNA-sequencing (scRNA-seq) has revolutionized biomedical research by enabling the in-depth analysis of cell-to-cell heterogeneity of tissues with unprecedented resolution. One of the catalyzing technologies is single cell droplet microfluidics, which has massively increased the overall cell throughput, routinely allowing
Yuji Naito et al.
Journal of gastroenterology, 41(3), 198-208 (2006-05-16)
Reflux of the duodenal contents with gastric acid has been reported to contribute to the development of esophageal mucosal damage and inflammation. Recent studies show that pancreatic trypsin can stimulate the production of inflammatory mediators, including chemokines and prostaglandins from
Molecular features of the cytotoxicity of an NHE inhibitor: Evidence of mitochondrial alterations, ROS overproduction and DNA damage
Francesca Aredia
BMC Cancer, 16 (2016)
Heizel Rosado-Galindo et al.
Recent progress in materials, 2(2) (2020-01-01)
Cells can respond to different topographical cues in their natural microenvironment. Hence, scientists have employed microfabrication techniques and materials to generate culture substrates containing topographies for cell-based assays. However, one of the limitations of custom topographical platforms is the lack
Mariangela Ucci et al.
Oxidative medicine and cellular longevity, 2019, 8184656-8184656 (2019-03-29)
Diabetes is associated with vascular inflammation, endothelial dysfunction, and oxidative stress, promoting the development of cardiovascular diseases (CVD). Several studies showed that a carotenoid-rich diet is associated to a reduced cardiovascular risk in healthy and diabetic subjects, although the mechanisms
Thomas L Willett et al.
Annals of biomedical engineering, 35(11), 1961-1972 (2007-09-04)
Presently, there is a lack of fundamental understanding regarding changes in collagen's molecular state due to mechanical damage. The bovine tail tendon (BTT; steers approximately 30 months) was characterized and used as an in vitro model for investigating the effect
Sarah Spear et al.
Frontiers in immunology, 10, 542-542 (2019-04-12)
B cells are salient features of pancreatic ductal adenocarcinoma (PDAC) tumors, yet their role in this disease remains controversial. Murine studies have indicated a protumoral role for B cells, whereas clinical data show tumor-infiltrating B cells are a positive prognostic
Liza Meutia Sari et al.
F1000Research, 7, 723-723 (2018-06-11)
Background: Oral squamous cell carcinoma is a neoplasm of keratinocyte cells of oral mucosa epithelium that can potentially spread through lymphatic tissue or blood vessel. Although areca nut is one of the plants with a risk of inducing that cancer
Y Imamura et al.
The Kurume medical journal, 38(4), 251-258 (1991-01-01)
Dilution of viruses, which were previously treated with 10 micrograms acetyltrypsin/ml, in MEM supplemented with 2.5% fetal bovine serum caused little damage of cell monolayers resulting in the formation of discrete plaques. When agar and acetyltrypsin were added to the
Sergio Guerrero-Castillo et al.
The EMBO journal, 40(21), e108648-e108648 (2021-09-21)
So-called ρ0 cells lack mitochondrial DNA and are therefore incapable of aerobic ATP synthesis. How cells adapt to survive ablation of oxidative phosphorylation remains poorly understood. Complexome profiling analysis of ρ0 cells covered 1,002 mitochondrial proteins and revealed changes in
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