Showing 1-30 of 195 results for "597775"
Diana M Shih et al.
Journal of lipid research, 56(1), 22-37 (2014-11-08)
We performed silencing and overexpression studies of flavin containing monooxygenase (FMO) 3 in hyperlipidemic mouse models to examine its effects on trimethylamine N-oxide (TMAO) levels and atherosclerosis. Knockdown of hepatic FMO3 in LDL receptor knockout mice using an antisense oligonucleotide...
Song Nie et al.
Journal of proteome research, 14(2), 814-822 (2014-12-04)
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor, with dismal survival outcomes. Recently, cancer stem cells (CSCs) have been demonstrated to play a role in therapeutic resistance and are considered to be the most likely cause of cancer relapse....
Younghoon Kim et al.
PloS one, 10(4), e0122183-e0122183 (2015-04-16)
To find useful tools to evaluate the prognosis in colorectal carcinoma (CRC) patients, we investigated the prognostic values of tumor-infiltrating T lymphocyte subsets according to intratumoral subsites as well as clinical or molecular characteristics. Immunohistochemistry for CD8, CD45RO, and FOXP3...
L Tomiyama et al.
Oncogene, 34(9), 1141-1149 (2014-03-26)
Dlg5 has been reported to participate in cancer progression; however, its role in prostate cancer still remains poorly understood. In this study, we demonstrate that Dlg5 is frequently downregulated in prostate cancer. We show here that Dlg5 is involved in...
T T Seppälä et al.
British journal of cancer, 112(12), 1966-1975 (2015-05-15)
The objective of the study was to examine the role of microsatellite instability (MSI) and BRAF(V600E)mutation in colorectal cancer (CRC) by categorising patients into more detailed subtypes based on tumour characteristics. Tumour samples from 762 population-based patients with sporadic CRC...
Wies van Roosmalen et al.
The Journal of clinical investigation, 125(4), 1648-1664 (2015-03-17)
Tumor cell migration is a key process for cancer cell dissemination and metastasis that is controlled by signal-mediated cytoskeletal and cell matrix adhesion remodeling. Using a phagokinetic track assay with migratory H1299 cells, we performed an siRNA screen of almost...
Christian Schafroth et al.
Oncotarget, 6(39), 41453-41463 (2015-10-27)
VE1 is a monoclonal antibody detecting mutant BRAFV(600E) protein by immunohistochemistry. Here we aim to determine the inter-observer agreement and concordance of VE1 with mutational status, investigate heterogeneity in colorectal cancers and metastases and determine the prognostic effect of VE1...
S Busch et al.
Oncogene, 34(1), 27-38 (2013-12-18)
Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine with the capability to act as tumour suppressor or tumour promoter depending on the cellular context. TGF-beta receptor type-2 (TGFBR2) is the ligand-binding receptor for all members of the TGF-β family. Data...
Roshan Sriram et al.
Breast cancer research : BCR, 17, 7-7 (2015-01-17)
Periostin (Postn) is a secreted cell adhesion protein that activates signaling pathways to promote cancer cell survival, angiogenesis, invasion, and metastasis. Interestingly, Postn is frequently overexpressed in numerous human cancers, including breast, lung, colon, pancreatic, and ovarian cancer. Using transgenic...
Philipp Jurmeister et al.
Lung cancer (Amsterdam, Netherlands), 87(2), 122-129 (2014-12-24)
ALK, MET and ROS1 are prognostic and predictive markers in NSCLC, which need to be implemented in daily routine. To evaluate different detection approaches and scoring systems for optimal stratification of patients eligible for mutation testing in the future, we...
Neerja Vajpayee et al.
Clinical lymphoma, myeloma & leukemia, 15(3), 159-163 (2014-12-03)
The mammalian target of rapamycin (mTOR) pathway regulates many major cellular processes and is implicated in an increasing number of neoplasms, including lymphoma. We correlated immunohistochemical expression of mTOR with germinal center and nongerminal center phenotype, B cell lymphoma-2 (bcl-2)...
J M S Bartlett et al.
British journal of cancer, 113(5), 722-728 (2015-08-19)
TLE3, a nuclear transcriptional repressor downstream of WNT signalling pathways, has been hypothesised as predictive of benefit from adjuvant taxane. MA.21 tissue microarrays were constructed from 1097 out of 2104 (52%) patients. TLE3 staining by immunohistochemistry used validated methodology. Continuous...
Andrea Lunardi et al.
Cancer discovery, 5(5), 550-563 (2015-02-06)
The ETS family of transcription factors has been repeatedly implicated in tumorigenesis. In prostate cancer, ETS family members, such as ERG, ETV1, ETV4, and ETV5, are frequently overexpressed due to chromosomal translocations, but the molecular mechanisms by which they promote...
Timothy D Rohrbach et al.
International journal of oncology, 46(3), 1079-1088 (2014-12-20)
Lung cancer is the leading cause of cancer related deaths. Common molecular drivers of lung cancer are mutations in receptor tyrosine kinases (RTKs) leading to activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pro-growth, pro-survival signaling pathways. Myristoylated alanine rich C-kinase substrate...
Ion Cristóbal et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(2), 347-356 (2014-11-13)
SET is an endogenous PP2A inhibitor that might represent a novel molecular target for antitumor therapy. The aim of this study was to evaluate the molecular effects of SET deregulation and its potential clinical significance in metastatic colorectal cancer (mCRC)....
Jia-Ray Yu et al.
Genes & development, 29(3), 250-261 (2015-02-04)
The mechanisms by which TGF-β promotes lung adenocarcinoma (ADC) metastasis are largely unknown. Here, we report that in lung ADC cells, TGF-β potently induces expression of DOCK4, but not other DOCK family members, via the Smad pathway and that DOCK4...
Qi Fei et al.
Nature communications, 6, 8651-8651 (2015-10-17)
SETDB1 is a histone H3K9 methyltransferase that has a critical role in early development. It is located within a melanoma susceptibility locus and facilitates melanoma formation. However, the mechanism by which SETDB1 regulates tumorigenesis remains unknown. Here we report the...
Bo Gun Jang et al.
Virchows Archiv : an international journal of pathology, 467(3), 285-294 (2015-06-14)
Olfactomedin 4 (OLFM4) has been demonstrated to be upregulated in various cancers and involved in many cellular processes such as cell adhesion, apoptosis, and cell proliferation. In gastric cancer, clinicopathological relevance of OLFM4 expression has been reported. However, there are...
Stephanie H Gold et al.
Clinical psychology & psychotherapy, 22(4), 304-316 (2014-02-20)
This is the first study to explore the relationship between aspects of a therapists' personal therapy and the subsequent psychotherapy process and outcome they perform. The participants were 14 graduate clinicians with various experiences in personal therapy, who treated 54...
Xin-Ke Zhang et al.
International journal of clinical and experimental pathology, 8(5), 5035-5043 (2015-07-21)
BRCA1-associated protein-1 (BAP1) has been investigated the prognostic value for some carcinomas, including mammary carcinoma, pulmonary carcinoma and mesothelioma and so on. However, the status of BAP1 expression and the relationship of that with overall survival were not still estimated...
Sarah L Larsen et al.
PloS one, 10(2), e0118346-e0118346 (2015-02-24)
The underlying mechanisms leading to antiestrogen resistance in estrogen-receptor α (ER)-positive breast cancer is still poorly understood. The aim of this study was therefore to identify biomarkers and novel treatments for antiestrogen resistant breast cancer. We performed a kinase inhibitor...
Jin Zhou et al.
Carcinogenesis, 36(4), 441-451 (2015-03-07)
Gastric cancer (GC) is the second leading cause of global cancer mortality worldwide. However, the molecular mechanism underlying its carcinogenesis and drug resistance is not well understood. To identify novel functionally important genes that were differentially expressed due to combinations...
Shafei Wu et al.
Thoracic cancer, 6(4), 413-420 (2015-08-15)
c-ros oncogene 1 (ROS1) rearrangement presents one of the newest molecular targets in non-small cell lung cancer (NSCLC). ROS1 rearrangement is predominantly found in adenocarcinoma cases and is exclusive to other oncogenes, such as epidermal growth factor receptor (EGFR), Kirsten...
Vita Golubovskaya et al.
Journal of cancer research and clinical oncology, 141(9), 1613-1631 (2015-02-07)
Focal adhesion kinase is an important survival signal in cancer. Recently, we demonstrated that the autophosphorylation inhibitor of FAK, Y15, effectively inhibited cancer cell growth. We detected many cancer cell lines sensitive to Y15 and also detected several cell lines...
Anna Bergamaschi et al.
Breast cancer research : BCR, 16(5), 436-436 (2014-09-13)
The forkhead transcription factor FOXM1 coordinates expression of cell cycle-related genes and plays a pivotal role in tumorigenesis and cancer progression. We previously showed that FOXM1 acts downstream of 14-3-3ζ signaling, the elevation of which correlates with a more aggressive...
Wanming Hu et al.
Medicine, 94(27), e979-e979 (2015-07-15)
CPEB4 plays an important role in cancer progression. However, the clinicopathological significance of CPEB4 expression to glioma and its expression levels in glioma tissues and cell lines are unknown. The present study investigated the potential prognostic value of CPEB4 for...
J Cheng et al.
Prostate cancer and prostatic diseases, 18(2), 182-189 (2015-04-15)
Fatty-acid synthase (FASN), selectively overexpressed in prostate cancer (PCa) cells, has been described as linked to the aggressiveness of PCa. Constitutional genetic variation of the FASN gene and the expression levels of FASN protein in cancer cells could thus be...
Nicolas A Giraldo et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(13), 3031-3040 (2015-02-18)
Clear cell renal cell carcinoma (ccRCC) has shown durable responses to checkpoint blockade therapies. However, important gaps persist in the understanding of its immune microenvironment. This study aims to investigate the expression and prognostic significance of immune checkpoints in primary...
Kitty Pavlakis et al.
Pathology oncology research : POR, 21(2), 273-282 (2014-08-08)
To investigate the immunohistochemical expression of p85 in a cohort of trastuzumab-treated HER2-positive and HER2-negative metastatic breast cancer patients. The medical records of all patients with metastatic breast cancer treated with trastuzumab-based regimens between 1998 and 2010 were reviewed and...
Catherine A Powell et al.
Oncotarget, 6(8), 6373-6385 (2015-03-18)
Fatty acid binding protein 5 (FABP5), an intracellular lipid binding protein, has been shown to play a role in various cancers, including breast cancer. However, FABP5 and its role in triple negative breast cancer (TNBC) have not been studied. We...

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