Showing 1-30 of 195 results for "

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Zhiyong Shen et al.
Oncotarget, 6(24), 20672-20684 (2015-05-27)
Elevated expression of S100P has been detected in several tumor types and suggested to be responsible for tumor metastasis and invasion, but the upstream regulatory mechanisms promoting S100P overexpression are largely unknown. Here, we report that SOX9 was predicted and...
Gabriela Hernandez-Molina et al.
Clinical and experimental rheumatology, 33(4), 503-508 (2015-07-24)
To assess the presence of acute thrombotic microangiopathy (aTMA) and chronic vascular lesions (cTMA) in lupus nephropathy, and to evaluate their association with extrarrenal lupus features, aPL positivity, antiphospholipid syndrome (APS) and renal survival. We studied lupus patients with renal...
Chien-Feng Li et al.
Oncotarget, 5(22), 11588-11603 (2014-12-05)
Non-random gains of chromosome 5p have been observed in clinically aggressive gastrointestinal stromal tumors, whereas the driving oncogenes on 5p remain to be characterized. We used an integrative genomic and functional approach to identify amplified oncogenes on 5p and to...
Hyein Ahn et al.
Journal of Korean medical science, 30(4), 390-397 (2015-04-02)
Fox transcription factors play a critical role in the regulation of a variety of biological processes. While FoxM1 behaves like the oncogenic transcription factor, FoxO3a is known as a tumor suppressor by inhibiting FoxM1. This study aimed to investigate the...
Charles Robb Flynn et al.
Nature communications, 6, 7715-7715 (2015-07-22)
Roux-en-Y gastric bypass (RYGB) is highly effective in reversing obesity and associated diabetes. Recent observations in humans suggest a contributing role of increased circulating bile acids in mediating such effects. Here we use a diet-induced obesity (DIO) mouse model and...
Maja Ølholm Vase et al.
Leukemia & lymphoma, 56(6), 1677-1685 (2014-09-25)
Post-transplant lymphoproliferative disorders (PTLDs) are potentially fatal, often Epstein-Barr virus (EBV)-driven neoplasias developing in immunocompromised hosts. Initial treatment usually consists of a reduction in immunosuppressive therapy and/or rituximab with or without chemotherapy. However, patients who relapse do poorly, and new...
Tahar Aboulkassim et al.
Human vaccines & immunotherapeutics, 11(4), 951-955 (2015-05-02)
Epstein-Barr virus (EBV) has been recently shown to be present in human breast cancer worldwide, which could play an important role in the initiation and progression of this cancer. In this regard, we aimed to explore the prevalence of EBV...
Yang Shen et al.
mAbs, 7(5), 931-945 (2015-06-16)
Bi-specific antibodies (BsAbs), which can simultaneously block 2 tumor targets, have emerged as promising therapeutic alternatives to combinations of individual monoclonal antibodies. Here, we describe the engineering and development of a novel, human bi-functional antibody-receptor domain fusion molecule with ligand...
Karunakar Saamarthy et al.
BMC cancer, 15, 341-341 (2015-05-02)
B-cell leukemia 3 (Bcl-3) is a member of the inhibitor of κB family, which regulates a wide range of biological processes by functioning as a transcriptional activator or as a repressor of target genes. Elevated expression, sustained nuclear accumulation, and...
Dimitrios Pectasides et al.
BMC cancer, 15, 384-384 (2015-05-10)
The aim of the trial was to compare two active adjuvant chemotherapy regimens in patients with early stage colorectal cancer (CRC). Patients were assigned to oxaliplatin, leucovorin and 5-FU for 12 cycles (group A, FOLFOX6) or oxaliplatin and capecitabine for...
Lili Yu et al.
Nano letters, 15(8), 4928-4934 (2015-07-21)
Because of their extraordinary structural and electrical properties, two-dimensional materials are currently being pursued for applications such as thin-film transistors and integrated circuit. One of the main challenges that still needs to be overcome for these applications is the fabrication...
Shengdong Wang et al.
ChemistryOpen, 4(3), 328-334 (2015-08-08)
Nickel(II) complexes have attracted much attention as a new generation of olefin catalysts since the α-diiminonickel complex was discovered as a highly efficient procatalyst for ethylene polymerization. A series of novel 4-arylimino-1,2,3-trihydroacridylnickel(II) dihalide complexes was synthesized in a one-pot reaction...
Joohoon Kang et al.
ACS nano, 9(4), 3596-3604 (2015-03-19)
Solution dispersions of two-dimensional (2D) black phosphorus (BP)--often referred to as phosphorene--are achieved by solvent exfoliation. These pristine, electronic-grade BP dispersions are produced with anhydrous organic solvents in a sealed-tip ultrasonication system, which circumvents BP degradation that would otherwise occur...
Patricia A Mote et al.
Breast cancer research and treatment, 151(2), 309-318 (2015-04-29)
Progesterone receptor (PR) function, while essential in normal human breast, is also implicated in breast cancer risk. The two progesterone receptors, PRA and PRB, are co-expressed at equivalent levels in normal breast, but early in carcinogenesis normal levels of PRA:PRB...
Ferenc Sipos et al.
World journal of gastroenterology, 21(28), 8569-8579 (2015-08-01)
To characterize the regeneration-associated stem cell-related phenotype of hepatocyte-derived growth factor receptor (HGFR)-expressing cells in active ulcerative colitis (UC). On the whole 38 peripheral blood samples and 38 colonic biopsy samples from 18 patients with histologically proven active UC and...
Mark J Mentrikoski et al.
American journal of clinical pathology, 143(3), 430-436 (2015-02-20)
Even with adequate history, the distinction of cutaneous metastatic breast carcinoma from primary sweat gland carcinoma can be difficult. Although previous studies have attempted to separate these tumors with various immunohistochemical panels, those series have been limited by small numbers...
Francesco Grossi et al.
Disease markers, 2015, 302649-302649 (2015-12-15)
Biomarkers can help to identify patients with early-stages or locally advanced non-small cell lung cancer (NSCLC) who have high risk of relapse and poor prognosis. To correlate the expression of seven biomarkers involved in DNA synthesis and repair and in...
Niklas Gebauer et al.
Leukemia & lymphoma, 56(4), 1100-1106 (2014-07-18)
Epstein-Barr virus (EBV)-associated diffuse large B-cell lymphoma (DLBCL) of the elderly constitutes a provisional clinicopathological entity in the current World Health Organization (WHO) classification and its genomic features remain sparsely characterized. We investigated a cohort of 26 cases of untreated...
Iwona Malicka et al.
Experimental biology and medicine (Maywood, N.J.), 240(11), 1408-1415 (2015-05-21)
The impact of physical activity on carcinogenesis has been demonstrated in many studies. Taking into account the discrepant results of physical exercise on the cell proliferation and apoptosis of breast cancer, we aimed to examine the impact of physical training...
Helena Linardou et al.
Anticancer research, 35(7), 4023-4036 (2015-07-01)
Vascular endothelial growth factor C (VEGFC) and vascular endothelial growth factor receptor 1 (VEGFR1) mRNA overexpression has recently been shown to have strong predictive and prognostic value in patients with high-risk early breast cancer undergoing adjuvant chemotherapy. The present study...
Qian Wang et al.
The Journal of pathology, 236(3), 278-289 (2015-02-20)
Glutamine is conditionally essential in cancer cells, being utilized as a carbon and nitrogen source for macromolecule production, as well as for anaplerotic reactions fuelling the tricarboxylic acid (TCA) cycle. In this study, we demonstrated that the glutamine transporter ASCT2...
Diego Iglesias-Gato et al.
Molecular cancer, 14, 8-8 (2015-01-28)
Ubiquitination is a highly dynamic and reversible process with a central role in cell homeostasis. Deregulation of several deubiquitinating enzymes has been linked to tumor development but their specific role in prostate cancer progression remains unexplored. RNAi screening was used...
Xinying Mu et al.
The Analyst, 140(7), 2449-2464 (2015-02-11)
We report results on a statistical analysis of an infrared spectral dataset comprising a total of 388 lung biopsies from 374 patients. The method of correlating classical and spectral results and analyzing the resulting data has been referred to as...
Guillaume E Courtoy et al.
Fertility and sterility, 104(2), 426-434 (2015-05-25)
To study the in vivo mechanisms of action of ulipristal acetate (UPA) on uterine myomas. Retrospective histologic and immunohistochemical (IHC) study of myomas. Academic research unit. Among 59 women with symptomatic myomas who underwent myomectomy, 42 were treated preoperatively with...
David Casadevall et al.
Oncotarget, 6(18), 16215-16226 (2015-06-05)
We aimed to assess MET intratumoral heterogeneity and its potential impact on biomarker-based patient selection as well as potential surrogate biomarkers of MET activation. Our study included 120 patients with non-squamous Non-small-cell Lung Cancer (nsNSCLC), of which 47 were incorporated...
Maribel D Lacambra et al.
Annals of surgical oncology, 22(11), 3489-3496 (2015-02-11)
Recent data have shown anterior gradient 2 (AGR2) to be a novel oncogene overexpressed in luminal breast cancers. However, many studies only focused on its relationship with treatment resistance, and the clinical relevance of AGR2 has not been widely evaluated....
Nadia Nabil Haj-Yasein et al.
Brain structure & function, 220(4), 2469-2474 (2014-04-20)
The coupling between the water channel aquaporin-4 (AQP4) and K(+) transport has attracted much interest. In this study, we assessed the effect of Aqp4 deletion on activity-induced [K(+)]o changes in acute slices from hippocampus and corpus callosum of adult mice....
Vassiliki Kotoula et al.
PloS one, 10(6), e0128818-e0128818 (2015-06-04)
Massively parallel sequencing (MPS) holds promise for expanding cancer translational research and diagnostics. As yet, it has been applied on paraffin DNA (FFPE) with commercially available highly multiplexed gene panels (100s of DNA targets), while custom panels of low multiplexing...
Arvind Nishtala et al.
Journal of Alzheimer's disease : JAD, 47(1), 197-204 (2015-09-25)
Midlife cardiovascular risk, hypertension (HTN) in particular, has been related cross-sectionally to poorer neuropsychological (NP) performance in middle age and older adults. This study investigated whether a similar relationship persists between midlife HTN or systolic blood pressure (SBP) and NP...
Todd A MacKenzie et al.
The American journal of pathology, 184(12), 3217-3225 (2014-12-03)
Triple-negative breast cancer (TNBC) is an aggressive subtype defined by the lack of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression. Expression of miR-21, an oncomiR, is frequently altered and may be distinctly expressed in the...