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Matilde A Cordeiro et al.
American journal of botany, 101(3), 488-498 (2014-03-19)
Seedling establishment and survival are highly sensitive to soil salinity and plants that evolved in saline environments are likely to express traits that increase fitness in those environments. Such traits are of ecological interest and they may have practical value
Pietro Fagiolino et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 140-146 (2014-07-23)
The aim of this work was to study the effect of the sex and the smoking status on the pharmacokinetics and the bioequivalence assessment of a branded and a generic cyclosporine A microemulsion formulation in soft-gelatin capsule. Sixteen healthy volunteers
Ziqing Qian et al.
Biochemistry, 53(24), 4034-4046 (2014-06-05)
Cyclic heptapeptide cyclo(FΦRRRRQ) (cFΦR4, where Φ is l-2-naphthylalanine) was recently found to be efficiently internalized by mammalian cells. In this study, its mechanism of internalization was investigated by perturbing various endocytic events through the introduction of pharmacologic agents and genetic
Matthew F Rouhier et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(7), R850-R861 (2014-07-25)
The effect of two small molecules VU342 and VU573 on renal functions in the yellow fever mosquito Aedes aegypti was investigated in vitro and in vivo. In isolated Malpighian tubules, VU342 (10 μM) had no effect on the transepithelial secretion
D Draganescu et al.
International journal of biological macromolecules, 72, 614-623 (2014-09-23)
Flaxseed lignans are a natural source of useful biologically active components that show a diverse spectrum of health-promoting properties. The valuable effects of the phenolic molecules are mainly due to their antioxidant activity by preventing oxidative stress and stimulate collagen
Izabela Tuleta et al.
Atherosclerosis, 236(2), 400-410 (2014-08-26)
Obstructive sleep apnoea (OSA) has been implicated as a risk factor for atherosclerosis. The aim of our study was to examine the effects of chronic intermittent hypoxia in apoE-/- mice serving as model of OSA on endothelial dysfunction and oxidative
Marit Gjerde Tellevik et al.
Acta tropica, 137, 99-104 (2014-05-27)
Leishmaniasis is one of the world's most neglected infectious diseases, affecting around 12 million people and more than 350 million at risk of infection. The clinical picture varies from self-healing cutaneous lesions to severe visceral infections, but still no commercial
Common sense medicine and cerebrospinal lavage.
B C Tsui
Anaesthesia, 69(8), 936-937 (2014-07-22)
Xiaoning Li et al.
Bioconjugate chemistry, 26(3), 520-528 (2015-02-26)
Subcutaneous delivery is one of the preferred administration routes for therapeutic monoclonal antibodies (mAbs). High antibody dosing requirements and small injection volumes necessitate formulation and delivery of highly concentrated mAb solutions. Such elevated antibody concentrations can lead to undesirable solution
Jerald S Goldstein et al.
Obstetrics and gynecology, 107(2 Pt 2), 506-508 (2006-02-02)
Spontaneous heterotopic pregnancies are rare, but with assisted reproductive techniques the incidence may approach 1:100. With the widespread use of transvaginal ultrasonography, physicians have attempted treatment of heterotopic pregnancies with minimally invasive procedures such as transvaginal guided potassium chloride (KCl)
Pierre-André Billat et al.
Analytical and bioanalytical chemistry, 407(12), 3449-3456 (2015-02-24)
Ganciclovir (GCV) is prescribed for cytomegalovirus infection which is a major issue in immunodepressed patients. It is however characterized by hematological toxicity. A better understanding of GCV concentration-effects relationships implies the measurement of intracellular forms. The objective of this study
Algis Grybauskas et al.
Molecular vision, 21, 201-212 (2015-03-25)
The aqueous humor nourishes the avascular tissues of the anterior segment, and the trabecular meshwork (TM) plays a role in the efflux of endogenous substances and xenobiotics from the aqueous humor. ATP (ATP)-binding cassette (ABC) transporter superfamily members respond to
Kamal Shaik Fakiruddin et al.
Cancer cell international, 14(1), 122-122 (2014-12-04)
Tumour homing capacity of engineered human adipose-derived mesenchymal stromal cells (ADMSCs) expressing anti-tumour agents might be the key for a much safer and yet efficient targeted tumour therapy. However, ADMSCs exhibit resistant to most gene transfection techniques and the use
Fanrong Zeng et al.
Planta, 240(2), 291-308 (2014-05-14)
Rice plants employ two strategies to cope with Cr toxicity: immobilizing Cr ions into cell walls to reduce its translocation and activating antioxidant defense to mitigate Cr-induced oxidative stress. The investigation aimed at understanding the physiological and proteomic responses of
Knut Fredrik Seip et al.
Journal of chromatography. A, 1347, 1-7 (2014-05-06)
Electromembrane extraction (EME) was performed on samples containing substantial amounts of NaCl to investigate how the presence of salts affected the recovery, repeatability, and membrane current in the extraction system. A group of 17 non-polar basic drugs with various physical
Amber Hanif Palla et al.
Journal of ethnopharmacology, 160, 61-68 (2014-11-30)
Linum usitatissimum, commonly known as Flaxseed has traditionally been used for the management of diarrhea and gastrointestinal infections. This study was planned to assess pharmacological basis for the medicinal use of Flaxseed in infectious and non-infectious diarrhea. The crude aqueous-methanolic
Merve Bacanlı et al.
Environmental toxicology and pharmacology, 38(3), 774-782 (2014-10-13)
Oxidative stress has an important role in the development of sepsis-induced multiorgan failure. Ferulic acid (FA), a well-established natural antioxidant, has several pharmacological activities including anti-inflammatory, anticancer and hepatoprotective. This study aimed to investigate the effects of FA on sepsis-induced
Zhenchang Liang et al.
PloS one, 9(8), e105146-e105146 (2014-08-19)
Grapes are rich in phytochemicals with many proven health benefits. Phenolic profiles, antioxidant and antiproliferative activities of twenty-four selected Vitis vinifera grape cultivars were investigated in this study. Large ranges of variation were found in these cultivars for the contents
Shuai Qian et al.
International journal of pharmaceutics, 468(1-2), 272-282 (2014-04-09)
The present study aimed to develop an in situ gel formulation for intranasal delivery of tacrine (THA), an anti-Alzheimer's drug. Thermosensitive polymer Pluronic F-127 was used to prepare THA in situ gels. Sol-gel transition temperature (Tsol-gel), rheological properties, in vitro
Paolo Massobrio et al.
BMC neuroscience, 14, 22-22 (2013-02-28)
A large number of invertebrate models, including the snail Helix, emerged as particularly suitable tools for investigating the formation of synapses and the specificity of neuronal connectivity. Helix neurons can be individually identified and isolated in cell culture, showing well-conserved
Blair K Gage et al.
Islets, 6(2), e29236-e29236 (2014-12-09)
Human embryonic stem cells (hESCs) are pluripotent and capable of generating new β-cells, but current in vitro differentiation protocols generally fail to produce mature, glucose-responsive, unihormonal β-cells. Instead, these methods tend to produce immature polyhormonal endocrine cells which mature in
Francisco E Martín-Cano et al.
American journal of physiology. Gastrointestinal and liver physiology, 306(7), G614-G621 (2014-02-15)
The main roles of the colonic mucosa are the absorption of water and electrolytes and the barrier function that preserves the integrity of the colonic wall. The mediators and mechanisms to accomplish these functions are under continuous investigation, but little
Frida Loría et al.
Neurobiology of disease, 76, 1-12 (2015-01-03)
Friedreich's ataxia (FA) is a recessive, predominantly neurodegenerative disorder caused in most cases by mutations in the first intron of the frataxin (FXN) gene. This mutation drives the expansion of a homozygous GAA repeat that results in decreased levels of
Maiko Kunii et al.
FEMS microbiology letters, 356(1), 45-52 (2014-05-28)
Osmoadaptation may be an important trait for the pathogenicity of Streptococcus mutans. However, how this organism adapts to changes in osmolality in the oral cavity remains unclear. In this study, we showed that S. mutans utilizes K(+) for osmoadaptation, in
P A Léon Bouyou et al.
Analytical and bioanalytical chemistry, 406(20), 5019-5030 (2014-06-11)
Trace levels of the veterinary antibiotic compound sulfadiazine (SDZ) can be determined in agricultural drainage water samples with this new method. Optimized sample pretreatment and solid-phase extraction was combined with liquid chromatography coupled to tandem mass spectrometry (SPE LC-MS/MS) using
Christoph Haller et al.
Nucleic acid therapeutics, 25(1), 20-26 (2014-12-11)
A multitude of stem cell types has been extensively studied and used for myocardial regenerative therapy. Amongst these endothelial progenitor cells form a promising source. In our present study, we investigated a one-staged approach for isolation and application of autologous
Panpan Yan et al.
The Analyst, 139(17), 4365-4372 (2014-07-12)
This study reports the development of an electrochemiluminescent (ECL) immunosensor for ultrasensitive detection of phenylethanolamine A (PA) based on CdSe quantum dots (QDs) and gold nanoparticles (GNPs). The GNPs/ovalbumin-PA/anti-PA-QD immunosensor was fabricated layer by layer using GNPs as substrates and
Gregory Saia et al.
Journal of neurochemistry, 129(4), 743-752 (2014-01-31)
The regulation of transcription factor function in response to neuronal activity is important for development and function of the nervous system. The transcription factor Sp4 regulates the developmental patterning of dendrites, contributes to complex processes including learning and memory, and
Jérémy Carlier et al.
Journal of analytical toxicology, 38(9), 619-627 (2014-07-06)
Atractyloside (ATR) and carboxyatractyloside (CATR) are diterpene glycosides that are responsible for the toxicity of several Asteraceae plants around the world. Mediterranean gum thistle (Atractylis gummifera L.) and Zulu impila (Callilepis laureola DC.), in particular, are notoriously poisonous and the
Shiow-Fern Ng et al.
Drug development and industrial pharmacy, 40(11), 1538-1546 (2013-09-13)
Topical emollients are known to provide symptomatic relief for atopic dermatitis. In hospitals, wet-wrap therapy has been shown to benefit children with moderate-to-severe atopic dermatitis (AD), but the application of wet-wraps is tedious and time-consuming. Topical emollients have low residence
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