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60142

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Knut Fredrik Seip et al.
Journal of chromatography. A, 1347, 1-7 (2014-05-06)
Electromembrane extraction (EME) was performed on samples containing substantial amounts of NaCl to investigate how the presence of salts affected the recovery, repeatability, and membrane current in the extraction system. A group of 17 non-polar basic drugs with various physical...
Paola Ciceri et al.
Molecular and cellular biochemistry, 410(1-2), 197-206 (2015-09-09)
An increasing amount of patients affected by advanced chronic kidney disease suffer from vascular calcification (VC) that associates with cardiovascular morbidity and mortality. In this study, we created a new experimental in vitro model, trying to better elucidate high phosphate...
Pietro Fagiolino et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 140-146 (2014-07-23)
The aim of this work was to study the effect of the sex and the smoking status on the pharmacokinetics and the bioequivalence assessment of a branded and a generic cyclosporine A microemulsion formulation in soft-gelatin capsule. Sixteen healthy volunteers...
Bing Wu et al.
Environmental science & technology, 49(9), 5760-5770 (2015-04-09)
The ability of engineered nanomaterials (NMs) to act as inhibitors of ATP-binding cassette (ABC) efflux transporters in embryos of white sea urchin (Lytechinus pictus) was studied. Nanocopper oxide (nano-CuO), nanozinc oxide (nano-ZnO), and their corresponding metal ions (CuSO4 and ZnSO4)...
Jafar Abolhasani et al.
Environmental monitoring and assessment, 187(9), 554-554 (2015-08-08)
This work describes a novel Fe3O4@SiO2@polythiophene magnetic nanocomposite and its application in the preconcentration of Hg(II) ions. The parameters affecting the preconcentration procedure were opted by a Box-Behnken design through response surface methodology. Three factors (uptake time, magnetic nanosorbent amount...
Noomi Altgärde et al.
The Journal of biological chemistry, 290(35), 21473-21485 (2015-07-15)
Glycoprotein C (gC) mediates the attachment of HSV-1 to susceptible host cells by interacting with glycosaminoglycans (GAGs) on the cell surface. gC contains a mucin-like region located near the GAG-binding site, which may affect the binding activity. Here, we address...
Shu Rui Ng et al.
The Analyst, 140(12), 4224-4231 (2015-04-29)
pH sensors were fabricated by anodically electrodepositing iridium oxide films (AEIROFs) onto microelectrodes on chips and coated with poly(ethyleneimine) (PEI) for mechanical stability. These demonstrate super-Nernstian response to pH from pH 4.0 to 7.7 in chloride-free phosphate buffer. The surface...
Gabriel E Zentner et al.
Nature communications, 6, 8733-8733 (2015-10-23)
Chromatin endogenous cleavage (ChEC) uses fusion of a protein of interest to micrococcal nuclease (MNase) to target calcium-dependent cleavage to specific genomic loci in vivo. Here we report the combination of ChEC with high-throughput sequencing (ChEC-seq) to map budding yeast...
R Freiry et al.
Bulletin of environmental contamination and toxicology, 93(4), 442-445 (2014-08-30)
The sensitivity of Danio rerio to three chemicals was compared at two growth stages [larval (10 ± 2 after hatching) and post-larval (60 ± 4 days after hatching)] based on acute toxicity tests. Thirty-nine 48 h acute toxicity tests were...
Alec N Salt et al.
The Journal of the Acoustical Society of America, 133(3), 1561-1571 (2013-03-08)
Responses of the ear to low-frequency and infrasonic sounds have not been extensively studied. Understanding how the ear responds to low frequencies is increasingly important as environmental infrasounds are becoming more pervasive from sources such as wind turbines. This study...
Mattias Carlström et al.
Antioxidants & redox signaling, 23(4), 295-306 (2013-11-15)
Inorganic nitrate and nitrite from endogenous and dietary sources have emerged as alternative substrates for nitric oxide (NO) formation in addition to the classic L-arginine NO synthase (NOS)-dependent pathway. Here, we investigated a potential cross-talk between these two pathways in...
M Alsaqati et al.
Purinergic signalling, 10(2), 241-249 (2013-12-07)
Receptors for purines and pyrimidines are expressed throughout the cardiovascular system. This study investigated their functional expression in porcine isolated pancreatic arteries. Pancreatic arteries (endothelium intact or denuded) were prepared for isometric tension recording and preconstricted with U46619, a thromboxane...
Andrey V Belikov et al.
Lasers in surgery and medicine, 47(9), 723-736 (2015-09-27)
Laser radiation is often used to provide micro and nanoparticle delivery into the skin for medical and cosmetic purposes. This technique inherently has limited speed and effective penetration. We proposed and investigated a new method of rapid delivery of solid...
Sônia Pamplona et al.
Molecules (Basel, Switzerland), 20(10), 18777-18788 (2015-10-27)
Swietenia macrophylla (mahogany) is a highly valued timber species, whereas the leaves are considered to be waste product. A total of 27 phenolic compounds were identified in aqueous extracts from mahogany leaves by comparing retention times and mass spectra data...
John O DiRaddo et al.
Molecular pharmacology, 88(3), 450-459 (2015-06-20)
The elemental anion chloride is generally considered a passive participant in neuronal excitability, and has never been shown to function as an agonist in its own right. We show that the antagonist-mediated, glutamate-independent inverse agonism of group II and III...
Qamar Zia et al.
International journal of nanomedicine, 10, 1769-1790 (2015-03-19)
In the present study, we developed a self-assembled biodegradable polyglutamic acid (PGA)-based formulation of amphotericin B (AmB) and evaluated its in vitro antifungal potential against Candida albicans. The AmB-loaded PGA nanoparticles were prepared in-house and had a mean size dimension...
Gerson F Duarte Junior et al.
Electrophoresis, 36(16), 1935-1940 (2015-03-27)
This paper describes the use of ionic solutions as sensing electrodes for capacitively coupled contactless conductivity detection on electrophoresis microchips. Initially, two channels were engraved in a PMMA holder by using a CO2 laser system and sealed with a thin...
Pelin Onsekizoglu Bagci et al.
Journal of food science, 80(9), N2071-N2078 (2015-08-05)
Gold nanoparticles (AuNPs) were synthesized at room temperature following a simple, rapid, and green route using fresh-squeezed apple juice as a reducing reagent. The optimal AuNPs, based on the particle color, stability, and color change suitable for colorimetric detection of...
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D Joon et al.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 19(8), 986-991 (2015-07-15)
The main challenge in combatting extra-pulmonary tuberculosis (EPTB) is the lack of a rapid, reliable and inexpensive diagnostic test for the detection of Mycobacterium tuberculosis. To evaluate the diagnostic potential of an L-serine dehydratase gene (sdaA) loop-mediated isothermal amplification (LAMP)...
Raghuram Dhumpa et al.
Integrative biology : quantitative biosciences from nano to macro, 7(9), 1061-1067 (2015-07-28)
Within single islets of Langerhans, the endocrine portion of the pancreas, intracellular metabolites, as well as insulin secretion, oscillate with a period of ∼5 min. In vivo, pulsatile insulin oscillations are also observed with periods ranging from 5-15 minutes. In...
Tristan H Coady et al.
Genes & development, 29(16), 1696-1706 (2015-08-08)
Amyotrophic lateral sclerosis (ALS) is caused by mutations in a number of genes, including the gene encoding the RNA/DNA-binding protein translocated in liposarcoma or fused in sarcoma (TLS/FUS or FUS). Previously, we identified a number of FUS target genes, among...
Marit Gjerde Tellevik et al.
Acta tropica, 137, 99-104 (2014-05-27)
Leishmaniasis is one of the world's most neglected infectious diseases, affecting around 12 million people and more than 350 million at risk of infection. The clinical picture varies from self-healing cutaneous lesions to severe visceral infections, but still no commercial...
Landi Cheng et al.
Current drug delivery, 12(3), 351-357 (2015-06-10)
The objective of this research project was to develop a nanoparticle drug delivery system using the biopolymer chitosan as the base component. The nanoparticles were produced through ionotropic gelation by flush mixing chitosan with counterions carrageenan and alginate. The nanoparticles...
Maritza Padrón-Nieves et al.
Parasitology research, 113(6), 2121-2128 (2014-03-29)
Besides infection with drug-resistant parasites, therapeutic failure in leishmaniasis may be caused by altered drug pharmacokinetics, re-infection, and host immunologic compromise. Our aim has been to evaluate if relapses that occur in patients suffering from diffuse cutaneous leishmaniasis (DCL) associate...
Bita Bayatsarmadi et al.
Chemistry, an Asian journal, 10(7), 1546-1553 (2015-04-22)
The development of ordered mesoporous carbon materials with controllable structures and improved physicochemical properties by doping heteroatoms such as nitrogen into the carbon framework has attracted a lot of attention, especially in relation to energy storage and conversion. Herein, a...
Chunfeng Wang et al.
Pharmaceutical biology, 53(3), 451-456 (2014-12-05)
Given that Pinus massoniana Lamb (Pinaceae) bark extract (PMBE) is a safe and non-toxic flavonoid found abundantly in nature, it was considered a promising novel candidate agent in the treatment of virus infection. Experiments were conducted to assay the antiviral...
Mehdi Vafaye Valleh et al.
Zygote (Cambridge, England), 23(5), 712-721 (2014-09-03)
The effects of the paternal breed on early embryo and later pre- and postnatal development are well documented. Several recent studies have suggested that such paternal effects may be mediated by the paternally induced epigenetic modifications during early embryogenesis. The...
Matthew F Rouhier et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(7), R850-R861 (2014-07-25)
The effect of two small molecules VU342 and VU573 on renal functions in the yellow fever mosquito Aedes aegypti was investigated in vitro and in vivo. In isolated Malpighian tubules, VU342 (10 μM) had no effect on the transepithelial secretion...
Jingyi Chen et al.
The Analyst, 140(16), 5578-5584 (2015-06-27)
A novel glucose biosensor was developed by immobilizing glucose oxidase (GOD) on a three-dimensional (3D) porous kenaf stem-derived carbon (3D-KSC) which was firstly proposed as a novel supporting material to load biomolecules for electrochemical biosensing. Here, an integrated 3D-KSC electrode...
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