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Aydın Güçlü et al.
Renal failure, 37(2), 192-197 (2015-01-08)
Diabetic nephropathy is the most common cause of end-stage renal disease. Emerging evidences indicate that many mechanistic pathways including apoptosis play an important role in the pathogenesis and progression of macrovascular and microvascular complications of diabetes mellitus. The aim of
Si-Yao Ha et al.
Molecular human reproduction, 26(2), 88-100 (2020-01-25)
During gestation, excess palmitate (PA) is enriched in decidua. Both excess PA and decidual dysfunctions are associated with numerous adverse pregnancy outcomes such as gestational diabetes, preeclampsia and preterm birth and intrauterine growth restriction. Here, mRNA data about the effects
Ting Song et al.
British journal of pharmacology, 173(3), 471-483 (2015-10-24)
Although the ongoing clinical trials of ABT-263 and ABT-199 in chronic lymphocytic leukaemia (CLL) have indicated that BH3 mimetics hold considerable promise, understanding the mechanism of CLL resistance to BH3 mimetics remains a challenge. The LD50 values of ABT-737, ABT-263
M J Nyhan et al.
British journal of cancer, 106(4), 711-718 (2012-01-14)
Resistance to chemotherapeutic agents has been associated with a failure of cancer cells to induce apoptosis. Strategies to restore apoptosis have led to the development of BH3 mimetics, which inhibit anti-apoptotic Bcl-2 family members. We examined the sensitivity of three
Monica Pallis et al.
Oncotarget, 8(10), 16220-16232 (2016-04-20)
Direct co-operation between sensitiser molecules BAD and NOXA in mediating apoptosis suggests that therapeutic agents which sensitise to BAD may complement agents which sensitise to NOXA. Dynamic BH3 profiling is a novel methodology that we have applied to the measurement
Stephen D Willis et al.
Molecular biology of the cell, 31(10), 1015-1031 (2020-03-12)
Environmental stress elicits well-orchestrated programs that either restore cellular homeostasis or induce cell death depending on the insult. Nutrient starvation triggers the autophagic pathway that requires the induction of several Autophagy (ATG) genes. Cyclin C-cyclin-dependent kinase (Cdk8) is a component
Shantanu Guha et al.
Chemical reviews, 119(9), 6040-6085 (2019-01-10)
Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer membranes they act upon. Produced by all forms of life, most membrane permeabilizing peptides are used offensively or defensively against the membranes of other organisms. Just as nature has
Aaron Pilotti-Riley et al.
PloS one, 14(6), e0218235-e0218235 (2019-06-25)
Video corroboration of player incurred impacts (PII) using trunk-worn wearable sensors (WS) among national ice-hockey team members. 23 members of the U.S. National (NTDP) U18 team consented to procedures approved by EMU Human Subjects Committee. Bioharness-3 (Zephyr, MD) WS recorded
Atreyee Borthakur et al.
Journal of reproductive immunology, 141, 103155-103155 (2020-06-12)
Polycystic ovarian syndrome is a major factor contributing to the increasing incidence of infertility around the world. The metabolic effects of prolonged exposure to PCOS have been well determined from previous studies and seem to be detrimental in the long
Claus Reimertz et al.
The Journal of cell biology, 162(4), 587-597 (2003-08-13)
Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of ischemic and neurodegenerative disorders. Treatment of human SH-SY5Y neuroblastoma cells with tunicamycin, an inhibitor of protein glycosylation, rapidly induced the expression of target genes of the unfolded protein response.
Mateus Milani et al.
Cell death & disease, 8(1), e2552-e2552 (2017-01-13)
The concept of using BH3 mimetics as anticancer agents has been substantiated by the efficacy of selective drugs, such as Navitoclax and Venetoclax, in treating BCL-2-dependent haematological malignancies. However, most solid tumours depend on MCL-1 for survival, which is highly
Adrian Arendowski et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 36(12), 1521-1527 (2020-08-25)
Renal cell carcinoma is a very aggressive and often fatal disease for which there are no specific biomarkers found to date. The purpose of this work was to find features that differentiate urine metabolic profiles of healthy people and cancer
Sulaiman Mad-Ali et al.
Journal of the science of food and agriculture, 96(6), 2193-2203 (2015-07-15)
Goat skin can be used as an alternative raw material for gelatin production, in which pretreatment conditions can determine the characteristics or properties of the resulting gelatin. The present study aimed to investigate the effect of pretreatment using sodium sulfate
Jiyoon Choi et al.
Journal of microbiology (Seoul, Korea), 58(5), 415-421 (2020-03-30)
Carbapenems are a class of β-lactam antibiotics with a broad antimicrobial activity spectrum. Owing to their sturdy structures resistant to most β-lactamases, they have been regarded as one of the last-resort antibiotics for combating multidrugresistant bacterial infections. However, the emergence
Keith G Ray et al.
Physical chemistry chemical physics : PCCP, 19(34), 22646-22658 (2017-08-11)
Sachio Yamamoto et al.
Analytical and bioanalytical chemistry, 407(5), 1499-1503 (2014-12-01)
A selective separation method using a poly(methylmethacrylate) microchip was developed for 7-amino-4-methylcoumarin-labeled saccharides in a crude reaction mixture. In an alkaline borate buffer, saccharide derivatives formed strong anionic borate complexes. These complexes moved from the cathode to the anode in
Michael Rehman et al.
JCI insight, 4(8) (2019-04-19)
Fibrosis is a hallmark in the pathogenesis of various diseases, with very limited therapeutic solutions. A key event in the fibrotic process is the expression of contractile proteins, including α-smooth muscle actin (αSMA) by fibroblasts, which become myofibroblasts. Here, we
Ye-Jin Kim et al.
Cancer research, 80(7), 1387-1400 (2020-02-02)
The principal unmet need in BRAFV600E-positive melanoma is lack of an adequate therapeutic strategy capable of overcoming resistance to clinically approved targeted therapies against oncogenic BRAF and/or the downstream MEK1/2 kinases. We previously discovered that copper (Cu) is required for
Gopala Krishna Jarugumilli et al.
ACS chemical biology, 13(5), 1130-1136 (2018-04-03)
Lipid-derived electrophiles (LDEs) are reactive metabolites, which can covalently modify proteins and DNA and regulate diverse cellular processes. 2- trans-Hexadecenal (2-HD) is a byproduct of sphingolipid metabolism, involved in cytoskeletal reorganization, DNA damage, and apoptosis. In addition, the loss of
Pavel Ryzhov et al.
Biophysical journal, 119(7), 1324-1334 (2020-09-06)
Bcl-xL is a major inhibitor of apoptosis, a fundamental homeostatic process of programmed cell death that is highly conserved across evolution. Because it plays prominent roles in cancer, Bcl-xL is a major target for anticancer therapy and for studies aimed
Angus D Cowan et al.
Nature structural & molecular biology, 27(11), 1024-1031 (2020-09-16)
BAK and BAX are essential mediators of apoptosis that oligomerize in response to death cues, thereby causing permeabilization of the mitochondrial outer membrane. Their transition from quiescent monomers to pore-forming oligomers involves a well-characterized symmetric dimer intermediate. However, no essential
Yulia Kushnareva et al.
PLoS biology, 10(9), e1001394-e1001394 (2012-10-11)
Bax/Bak-mediated mitochondrial outer membrane permeabilization (MOMP) is essential for "intrinsic" apoptotic cell death. Published studies used synthetic liposomes to reveal an intrinsic pore-forming activity of Bax, but it is unclear how other mitochondrial outer membrane (MOM) proteins might facilitate this
S Iyer et al.
Cell death and differentiation, 22(10), 1665-1675 (2015-03-07)
Bak and Bax mediate apoptotic cell death by oligomerizing and forming a pore in the mitochondrial outer membrane. Both proteins anchor to the outer membrane via a C-terminal transmembrane domain, although its topology within the apoptotic pore is not known.
Fangfang Yang et al.
Cellular and molecular life sciences : CMLS, 77(12), 2387-2406 (2019-09-08)
The stoichiometry and affinity of Bcl-2 family complexes are essential information for understanding how their interactome network is orchestrated to regulate mitochondrial permeabilization and apoptosis. Based on over-expression model system, FRET analysis was used to quantify the protein-protein interactions among
Christine E Hellweg et al.
International journal of molecular sciences, 19(8) (2018-08-01)
Astronauts are exposed to considerable doses of space radiation during long-term space missions. As complete shielding of the highly energetic particles is impracticable, the cellular response to space-relevant radiation qualities has to be understood in order to develop countermeasures and
Alexandra Leonard et al.
The journal of allergy and clinical immunology. In practice, 8(1), 236-247 (2019-08-21)
Atopic dermatitis (AD) is a chronic inflammatory disease with significant local and systemic inflammation and barrier disruption. AD is associated with increased risk of allergen sensitization and skin colonization by Staphylococcus aureus. The heterogeneity of AD is unknown, and its
Xiaofeng Wu et al.
Nature cell biology, 19(10), 1226-1236 (2017-09-26)
Direct interactions between pro- and anti-apoptotic BCL-2 family members form the basis of cell death decision-making at the outer mitochondrial membrane (OMM). Here we report that three anti-apoptotic BCL-2 proteins (MCL-1, BCL-2 and BCL-XL) found untethered from the OMM function
Marzieh Zeinvand-Lorestani et al.
Scientific reports, 8(1), 11960-11960 (2018-08-12)
The key features of type 2 diabetes mellitus (T2DM) caused by high fat diet (HFD) in combination with arsenic (As) exposure (pronounced glucose intolerance despite a significant decrease in insulin resistance) are different from those expected for T2DM. Autophagy has
Qian Nancy Hu et al.
Journal of immunology (Baltimore, Md. : 1950), 194(6), 2643-2653 (2015-02-18)
Negative selection, primarily mediated through clonal deletion of self-reactive thymocytes, is critical for establishing self-tolerance and preventing autoimmunity. Recent studies suggest that the molecular mechanisms of negative selection differ depending on the thymic compartment and developmental stage at which thymocytes
Xiao-Long Wu et al.
Journal of Zhejiang University. Science. B, 21(3), 234-245 (2020-03-07)
Hepatocellular carcinoma (HCC) is a malignant tumor with high morbidity and mortality globally. It accounts for the majority of primary liver cancer cases. Amyloid precursor protein (APP), a cell membrane protein, plays a vital role in the pathogenesis of Alzheimer's
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