Showing 1-16 of 16 results for "

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Dinah Schick et al.
Analytical and bioanalytical chemistry, 411(25), 6767-6775 (2019-08-20)
Nonylphenols (NP) are ubiquitous in the environment and show toxic effects and estrogenic activity. According to the corresponding framework directive in the field of water quality, isomers of NP (including 4-n-NP and branched 4-NP) are classified as priority hazardous substances...
Tyson Smyth et al.
Bioconjugate chemistry, 25(10), 1777-1784 (2014-09-16)
A method for conjugation of ligands to the surface of exosomes was developed using click chemistry. Copper-catalyzed azide alkyne cycloaddition (click chemistry) is ideal for biocojugation of small molecules and macromolecules to the surface of exosomes, due to fast reaction...
Anna Golunova et al.
Biomacromolecules, 16(4), 1146-1156 (2015-03-03)
The ability to tailor mechanical properties and architecture is crucial in creating macroporous hydrogel scaffolds for tissue engineering. In the present work, a technique for the modification of the pore size and stiffness of acrylamide-based cryogels is demonstrated via the...
Yang Zhang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 960, 52-58 (2014-05-03)
A novel TiO2/diatomite composite (TD) was prepared and then characterized by scanning electron microscope (SEM) and Fourier Transform Infrared (FTIR). The results of SEM showed that after modification, the porous surface of diatomite was covered with TiO2. Both diatomite and...
Zhiguo Li et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(11), 2247-2251 (2014-05-08)
The Cu(I) -catalyzed 1,3-dipolar azide-alkyne cycloaddition (CuAAC) has arisen as one of the most useful chemical transformations for introducing complexity onto surfaces and materials owing to its functional-group tolerance and high yield. However, methods for monitoring such reactions in situ...
Mizuha Sakashita et al.
Bioorganic & medicinal chemistry, 22(19), 5212-5219 (2014-08-27)
Highly efficient drug carriers targeting hepatocyte is needed for treatment for liver diseases such as liver cirrhosis and virus infections. Galactose or N-acetylgalactosamine is known to be recognized and incorporated into the cells through asialoglycoprotein receptor (ASGPR) that is exclusively...
Rossana Canavesi et al.
Journal of pharmaceutical and biomedical analysis, 97, 141-150 (2014-05-28)
Pantethine (d-bis-(N-pantothenyl-β-aminoethyl)-disulfide, PAN), the stable disulfide form of pantetheine, has beneficial effects in vascular diseases being able to decrease the hyperlipidaemia, moderate the platelet function and prevent the lipid peroxidation. Furthermore, recent studies suggested that PAN may be an effective...
Sofia Amadori et al.
Journal of materials science. Materials in medicine, 26(2), 69-69 (2015-01-30)
Sterilization through γ-irradiation has been reported to affect collagen mechanical properties, but its possible effects on gelatin based materials have not been investigated up to now. Herein we report the results of a mechanical, chemical and thermal study performed on...
Elaine L Ferguson et al.
Molecular pharmaceutics, 11(12), 4437-4447 (2014-11-02)
Polymer therapeutics offer potential benefits in the treatment of multidrug resistant (MDR) infections; affording targeted delivery of biologically active agents to the site of inflammation, potential decreases in systemic toxicity, and the retention of antimicrobial activity at the target site....
Yan Wang et al.
Pharmaceutical research, 31(11), 3106-3119 (2014-05-23)
Although Cu complexes have been investigated as anticancer agents, there has been no description of Cu itself as a cancer killing agent. A stealth liposomal Cu formulation (LpCu) was studied in vitro and in vivo. LpCu was evaluated in prostate...
Surendra Vutti et al.
Chembiochem : a European journal of chemical biology, 16(5), 782-791 (2015-03-05)
Stable primary functionalization of metal surfaces plays a significant role in reliable secondary attachment of complex functional molecules used for the interfacing of metal objects and nanomaterials with biological systems. In principle, this can be achieved through chemical reactions either...
Che-Fan Huang et al.
Journal of peptide science : an official publication of the European Peptide Society, 21(2), 114-119 (2015-01-06)
Protein oxidation by reactive oxygen species has been associated with aging and neurodegenerative disorders, and histidine is one of the major oxidation targets due to its metal-chelating property and susceptibility to metal-catalyzed oxidation. 2-Oxohistidine, the major product of histidine oxidation...
Yuan Chen et al.
Biochemical and biophysical research communications, 459(3), 529-533 (2015-03-10)
Apolipoprotein E (ApoE) genotypes are related to clinical presentations in patients with Wilson's disease, indicating that ApoE may play an important role in the disease. However, our understanding of the role of ApoE in Wilson's disease is limited. High copper...
R Freiry et al.
Bulletin of environmental contamination and toxicology, 93(4), 442-445 (2014-08-30)
The sensitivity of Danio rerio to three chemicals was compared at two growth stages [larval (10 ± 2 after hatching) and post-larval (60 ± 4 days after hatching)] based on acute toxicity tests. Thirty-nine 48 h acute toxicity tests were...
Gaulthier Rydzek et al.
ACS nano, 8(5), 5240-5248 (2014-04-18)
Simple preparation methods of chemically versatile and highly functionalizable surfaces remain rare and present a challenging research objective. Here, we demonstrate a simultaneous electropolymerization and electro-click functionalization process (SEEC) for one-pot self-construction of aniline- and naphthalene-based functional polymer films where...
Özge Erdemli et al.
Journal of biomaterials applications, 29(4), 524-542 (2014-05-24)
Anti-tumor necrosis factor α (TNFα) drugs such as etanercept (ETN) have been mostly used in systemic treatment of rheumatoid arthritis. To eliminate the side effects in long-term treatments and to achieve a local sustained anti-inflammatory effect, a controlled drug delivery...