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Anant B Patel et al.
Journal of neuroscience research, 93(7), 1101-1108 (2015-02-11)
γ-Aminobutyric acid (GABA) clearance from the extracellular space after release from neurons involves reuptake into terminals and astrocytes through GABA transporters (GATs). The relative flows through these two pathways for GABA released from neurons remains unclear. This study determines the
Liset Westera et al.
Blood, 122(13), 2205-2212 (2013-08-16)
Quantitative knowledge of the turnover of different leukocyte populations is a key to our understanding of immune function in health and disease. Much progress has been made thanks to the introduction of stable isotope labeling, the state-of-the-art technique for in
K Didriche et al.
The Journal of chemical physics, 138(10), 104307-104307 (2013-03-22)
Three rovibrational bands of Ar-D2O and two rovibrational bands of Ar-HDO were observed in the 1.5 μm range by continuous wave cavity ringdown spectroscopy. Their analyses led to the determination of rotational constants for the upper states and vibrational shifts
David Bates et al.
PloS one, 9(5), e97220-e97220 (2014-05-14)
In this study we developed, characterized and validated in vitro a functional superparagmagnetic iron-oxide based magnetic resonance contrast agent by conjugating a commercially available iron oxide nanoparticle, Molday ION Rhodamine-B Carboxyl (MIRB), with a deimmunized mouse monoclonal antibody (muJ591) targeting
Dihedral angles of trialanine in D2O determined by combining FTIR and polarized visible Raman spectroscopy
Schweitzer-Stenner R, et al.
Journal of the American Chemical Society, 123(39), 9628-9633 (2001)
Chen Chen et al.
Journal of proteome research, 14(6), 2492-2499 (2015-04-29)
Despite the fact that colorectal cancer (CRC) is one of the most prevalent and deadly cancers in the world, the development of improved and robust biomarkers to enable screening, surveillance, and therapy monitoring of CRC continues to be evasive. In
Omar T Mansour et al.
Journal of colloid and interface science, 454, 35-43 (2015-05-24)
The interaction of amphiphilic block copolymers of the poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) group with small molecule surfactants may be "tuned" by the presence of selected alcohols, with strong interactions leading to substantial changes in (mixed) micelle morphology, whilst weaker
Ji Hyun Ko et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(10), 4540-4549 (2013-03-08)
We used a network approach to assess systems-level abnormalities in motor activation in humans with Parkinson's disease (PD). This was done by measuring the expression of the normal movement-related activation pattern (NMRP), a previously validated activation network deployed by healthy
Lijue Chen et al.
Nanoscale, 7(33), 14080-14092 (2015-08-06)
Acquired drug resistance (ADR) can be developed in colorectal cancer cells after 5-fluorouracil (5-FU) treatment and diminish the effectiveness of chemotherapy. In this work, acquired 5-FU resistance in the colorectal cancer cell line SW480 was obtained with the up-regulation of
Mark A Townley et al.
Chemistry & biodiversity, 9(10), 2159-2174 (2012-10-20)
In northeastern North America, Zygiella atrica often build their orb webs near the ocean. We analyzed individual field-built Z. atrica webs to determine if organic low-molecular-mass solutes (LMM) in their sticky droplets showed any unusual features not previously seen in
Anna A DePaoli-Roach et al.
The Journal of biological chemistry, 290(2), 841-850 (2014-11-25)
Glycogen is a branched polymer of glucose that acts as an energy reserve in many cell types. Glycogen contains trace amounts of covalent phosphate, in the range of 1 phosphate per 500-2000 glucose residues depending on the source. The function
Maggie P Y Lam et al.
The Journal of clinical investigation, 124(4), 1734-1744 (2014-03-13)
Protein temporal dynamics play a critical role in time-dimensional pathophysiological processes, including the gradual cardiac remodeling that occurs in early-stage heart failure. Methods for quantitative assessments of protein kinetics are lacking, and despite knowledge gained from single-protein studies, integrative views
Yong-Kook Kwon et al.
Environmental science and pollution research international, 21(17), 10453-10460 (2014-05-14)
Leachate, generated by the decomposition of animal carcasses, presents many environmental, sanitary, and food safety hazards. However, research on the characteristics of leachate is lacking. In this study, we performed biochemical profiling of leachate from two animal species (pig and
Harsh Sancheti et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(11), 1749-1760 (2014-08-08)
Alzheimer's disease (AD) is characterized by age-dependent biochemical, metabolic, and physiologic changes. These age-dependent changes ultimately converge to impair cognitive functions. This study was carried out to examine the metabolic changes by probing glucose and tricarboxylic acid cycle metabolism in
Dawei Zhao et al.
Biochimica et biophysica acta, 1854(1), 39-45 (2014-12-03)
Arginine has been widely used as low molecular weight additive to promote protein refolding by suppressing aggregate formation. However, methods to investigate the role of arginine in protein refolding are often limited on protein's global conformational properties. Here, hydrogen/deuterium exchange
Yunpeng Bai et al.
Journal of agricultural and food chemistry, 62(47), 11536-11546 (2014-11-06)
This study determined the fate of deoxyanthocyanidins in sorghum sourdoughs. Sourdoughs prepared from the red sorghum variety Town were fermented with the caffeic acid-decarboxylating strains Lactobacillus plantarum FUA3171 and the decarboxylase negative L. casei FUA3166. Deoxyanthocyanidins were analyzed by liquid
Ingrid Torres-Rodríguez et al.
SpringerPlus, 3, 583-583 (2014-10-22)
We report the screening and characterization of EPS produced by LAB identified as Leuconostoc kimchii isolated from pulque, a traditional Mexican fermented, non-distilled alcoholic beverage produced by the fermentation of the sap extracted from several (Agave) maguey species. EPS-producing LAB
Michelle T Ma et al.
Dalton transactions (Cambridge, England : 2003), 44(11), 4884-4900 (2014-10-30)
Due to its long half-life (78 h) and decay properties (77% electron capture, 23% β(+), Emax = 897 keV, Eav = 397 keV, Eγ = 909 keV, Iγ = 100%) (89)Zr is an appealing radionuclide for immunoPET imaging with whole
S Saravanan et al.
Pharmaceutical biology, 53(2), 174-184 (2014-10-08)
Delonix elata (L.) Gamble (Fabaceae) has been used in the Indian traditional medicine system to treat rheumatism and inflammation. To assess the anti-inflammatory effect of Delonix elata flowers and to isolate the active principle. The prompt anti-inflammatory constituent was isolated
Zhaoxia Miao et al.
Analytical and bioanalytical chemistry, 407(12), 3405-3416 (2015-03-31)
Nuclear magnetic resonance (NMR)-based metabolomics can be used directly to identify a variety of metabolites in biological fluids and tissues. Metabolite analysis is an important part of life science and metabolomics research. However, the identification of some metabolites using NMR
Manhong Li et al.
Journal of biomaterials science. Polymer edition, 26(13), 813-827 (2015-07-15)
Captopril-polyethyleneimine (CP) containing low molecular weight polyethyleneimine and anti-angiogenesis drug captopril conjugated via an amide bond was fabricated to modify gold nanoparticles and complex with siRNA to construct siRNA/CP/GNP complexes for the co-delivery of drug and siRNA in anti-angiogenesis breast
Li Chen et al.
Scientific reports, 5, 12892-12892 (2015-08-11)
Pseudomonas syringae is a phytopathogenic bacterium widely spread on terrestrial plants. Sulfodiaminophosphinyl tripeptide Phaseolotoxins (PHTs), produced by P. syringae pv. phaseolicola and P. syringae pv. actinidiae, represent a kind of antimetabolic phytotoxins. PHTs inhibit host cell Ornithine transcarbamylase (OTCase) activity
Anna Turska-Szewczuk et al.
Carbohydrate research, 403, 142-148 (2014-07-20)
The O-specific polysaccharide (OPS) obtained by mild-acid degradation of the lipopolysaccharide from Aeromonas sobria strain Pt312 was studied by sugar and methylation analyses along with 1H and 13C NMR spectroscopy, including 2D 1H,1H COSY, TOCSY, NOESY, 1H-detected 1H,13C HSQC, and
Vittoria Pinto et al.
Journal of pharmaceutical and biomedical analysis, 98, 9-15 (2014-05-31)
Carbohydrate-based vaccines constitute a potent tool for prevention of life-threatening bacterial infectious diseases like meningitis and pneumonia. Group B Streptococcus (GBS) is a major cause of neonatal sepsis and meningitis, particularly in infants born from mothers carrying the bacteria, and
Marek Scholz et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 14(4), 700-713 (2015-01-17)
The present work provides a proof-of-concept that the singlet oxygen-sensitized delayed fluorescence (SOSDF) can be detected from individual living mammalian cells in a time-resolved microscopy experiment. To this end, 3T3 mouse fibroblasts incubated with 100 μM TPPS4 or TMPyP were
Ilkoo Noh et al.
Biomaterials, 53, 763-774 (2015-04-22)
Multi-drug delivery focuses on different signaling pathways in cancer cells that have synergistic anti-proliferative effects. In this study, we developed multi-prodrug nanocarriers (MPDNCs) consisting of poly (l-lysine)-carboxylate PTX (PLL-PTX) and hyaluronic acid-conjugated GEM (HA-GEM) for CD44-targeted synergistic biliary cancer therapy.
Raya Ahmed et al.
PLoS computational biology, 11(10), e1004355-e1004355 (2015-10-06)
Stable isotope labeling is the state of the art technique for in vivo quantification of lymphocyte kinetics in humans. It has been central to a number of seminal studies, particularly in the context of HIV-1 and leukemia. However, there is
Sudipta Chatterjee et al.
Carbohydrate polymers, 123, 432-442 (2015-04-07)
Fish oil-loaded microcapsules were prepared from oil-in-water emulsions using N-stearoyl O-butylglyceryl chitosan as shell material. The emulsions were prepared by both membrane and ultrasonic emulsification processes under variable conditions to examine the effect of the emulsification process and encapsulation conditions
Rui Yu et al.
Toxicological sciences : an official journal of the Society of Toxicology, 146(1), 170-182 (2015-04-24)
Formaldehyde is not only a widely used chemical with well-known carcinogenicity but is also a normal metabolite of living cells. It thus poses unique challenges for understanding risks associated with exposure. N(2-)hydroxymethyl-dG (N(2)-HOMe-dG) is the main formaldehyde-induced DNA mono-adduct, which
Eunkyung Lee et al.
Journal of hazardous materials, 276, 1-9 (2014-05-28)
Overall photodegradation of pharmaceuticals, personal care products (PPCPs) and pharmaceutical metabolites were investigated in order to evaluate their photochemical fate in aquatic environments in various natural organic matter (NOM) enriched solutions. Tested PPCPs exhibited different rates of loss during direct
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