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Luke A Clifton et al.
Methods in molecular biology (Clifton, N.J.), 974, 119-150 (2013-02-14)
Studying the structure of protein-lipid complexes, be they in vesicles, planar bilayers, monolayers, or nanodiscs, poses two particular challenges. Firstly such complexes are often dynamic. Secondly we need to resolve the lipid and protein structures within the complex. Neutron scattering
Noreen Yaqoob et al.
Toxicology, 323, 70-77 (2014-06-14)
Trichloroethylene (TCE) is widely used as a cleaning and decreasing agent and has been shown to cause liver tumours in rodents and a small incidence of renal tubule tumours in male rats. The basis for the renal tubule injury is
Zhi Liu et al.
PloS one, 10(9), e0137124-e0137124 (2015-09-05)
The nucleotide excision repair of certain bulky DNA lesions is abrogated in some specific non-canonical DNA base sequence contexts, while the removal of the same lesions by the nucleotide excision repair mechanism is efficient in duplexes in which all base
Małgorzata Siwińska et al.
Carbohydrate research, 407, 131-136 (2015-03-17)
Proteus penneri is an opportunistic pathogen, which may cause severe diseases, most frequently urinary tract infections in immunocompromised patients. P. penneri Br 114 exhibiting a good swarming growth ability as an S-form strain was isolated from a wound of a
Anna A DePaoli-Roach et al.
The Journal of biological chemistry, 290(2), 841-850 (2014-11-25)
Glycogen is a branched polymer of glucose that acts as an energy reserve in many cell types. Glycogen contains trace amounts of covalent phosphate, in the range of 1 phosphate per 500-2000 glucose residues depending on the source. The function
Christopher Eginton et al.
Biochemistry, 52(38), 6595-6600 (2013-08-30)
Solvent reorganization can contribute significantly to the energetics of protein-protein interactions. However, our knowledge of the magnitude of the energetic contribution is limited, in part, by a dearth of quantitative experimental measurements. The biotin repressor forms a homodimer as a
Observation of the keto tautomer of D-fructose in D2O using 1H NMR spectroscopy
Barclay T, et al.
Carbohydrate Research, 347(1), 136-141 (2012)
N Ravenscroft et al.
Carbohydrate research, 404, 108-116 (2015-02-11)
Salmonella paratyphi A is increasingly recognized as a common cause of enteric fever cases and there are no licensed vaccines against this infection. Antibodies directed against the O-polysaccharide of the lipopolysaccharide of Salmonella are protective and conjugation of the O-polysaccharide
Jonans Tusiimire et al.
Analytical and bioanalytical chemistry, 407(13), 3627-3635 (2015-03-10)
There is a growing interest in the potential of bee venom in cosmetics as a rejuvenating agent. Products currently on the market do not specify exactly their content of bee venom (BV). Therefore, we developed a method for the detection
Michael Wleklinski et al.
Physical chemistry chemical physics : PCCP, 17(28), 18364-18373 (2015-06-25)
Electrospray ionization of metal salt solutions followed by ambient heating transforms the resulting salt clusters into new species, primarily naked ionic metal clusters. The experiment is done by passing the clusters through a heated coiled loop outside the mass spectrometer
Aurore Flandrin et al.
Journal of mass spectrometry : JMS, 50(12), 1358-1366 (2015-12-05)
Ascorbate is as a potent antioxidant in vivo protecting the organism against oxidative stress. In this process, ascorbate is oxidized in two steps to dehydroascorbate (DHA), which if not efficiently reduced back to ascorbate decomposes irreversibly to a complex mixture
Barbara R Evans et al.
Planta, 242(1), 215-222 (2015-04-22)
The bioenergy crop switchgrass was grown hydroponically from tiller cuttings in 50 % D 2 O to obtain biomass with 34 % deuterium substitution and physicochemical properties similar to those of H 2 O-grown switchgrass controls. Deuterium enrichment of biological
Shunjie Bai et al.
International journal of molecular sciences, 16(4), 8490-8504 (2015-04-18)
Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), is a prescribed and effective antidepressant and generally used for the treatment of depression. Previous studies have revealed that the antidepressant mechanism of fluoxetine was related to astrocytes. However, the therapeutic mechanism underlying
Joanna C Young et al.
Nature communications, 5, 5887-5887 (2014-12-20)
The hallmark of enteropathogenic Escherichia coli (EPEC) infection is the formation of actin-rich pedestal-like structures, which are generated following phosphorylation of the bacterial effector Tir by cellular Src and Abl family tyrosine kinases. This leads to recruitment of the Nck-WIP-N-WASP
Jutta K H Skau et al.
The American journal of clinical nutrition, 101(4), 742-751 (2015-04-04)
Poor nutritional quality of complementary foods often limits growth. Animal source foods, such as milk or meat, are often unaffordable. Local affordable alternatives are needed. We evaluate the efficacy of 2 newly developed, rice-based complementary food products: WinFood (WF) with
Sandra J Veen et al.
Physical review letters, 109(24), 248302-248302 (2013-02-02)
By using the critical Casimir force, we study the attractive strength dependent aggregation of colloids with and without gravity by means of near field scattering. Significant differences were seen between microgravity and ground experiments, both in the structure of the
Eric Bonneau et al.
RNA (New York, N.Y.), 21(9), 1621-1632 (2015-07-01)
As part of an effort to structurally characterize the complete Neurospora VS ribozyme, NMR solution structures of several subdomains have been previously determined, including the internal loops of domains I and VI, the I/V kissing-loop interaction and the III-IV-V junction.
Barry W Hyland et al.
Clinical oral investigations, 19(6), 1395-1404 (2014-11-09)
This study aimed to develop and characterise a new three-component dental whitening formulation which is as effective as the currently used carbamide peroxide but at significantly lower hydrogen peroxide concentrations. The new formulation (Carbamide Plus) was prepared containing hydrogen peroxide
Matthew W Waugh et al.
Biochemistry, 53(34), 5537-5543 (2014-08-22)
The reaction catalyzed by cyanobacterial aldehyde deformylating oxygenase is of interest both because of its potential application to the production of biofuels and because of the highly unusual nature of the deformylation reaction it catalyzes. Whereas the proton in the
Arianna Bertolani et al.
Nature communications, 6, 7574-7574 (2015-07-01)
Amyloid supramolecular assemblies have found widespread exploitation as ordered nanomaterials in a range of applications from materials science to biotechnology. New strategies are, however, required for understanding and promoting mature fibril formation from simple monomer motifs through easy and scalable
Wei Liu et al.
Journal of food science, 80(11), C2413-C2419 (2015-09-30)
The dynamic hydrolysis of tetrasodium pyrophosphate (TSPP), sodium tripolyphosphate (STPP) and polyphosphate compound, which was catalyzed by purified pyrophosphatase (PPase) and myosin- tripolyphosphatase (TPPase) from the silver carp dorsal muscle, was studied using (31) P NMR spectroscopy. In the PPase
Chenchen Qin et al.
Nanoscale, 7(47), 20197-20210 (2015-11-18)
To optimize synergistic cancer therapy, we rationally assemble an inorganic-organic nanocomplex using a folate-modified lipid bilayer spread on photosensitizer-entrapped mesoporous silica nanoparticle (MSN) coated gold nanorods (AuNRs). In this hybrid bioconjugate, the large specific surface area and pore size of
Rostislav Chudnovskiy et al.
PloS one, 9(10), e108408-e108408 (2014-10-09)
To determine the metabolic effects of grapefruit juice consumption we established a model in which C57Bl/6 mice drank 25-50% sweetened GFJ, clarified of larger insoluble particles by centrifugation (cGFJ), ad libitum as their sole source of liquid or isocaloric and
Graeme J Stasiuk et al.
Dalton transactions (Cambridge, England : 2003), 44(11), 4986-4993 (2015-01-22)
Non-invasive imaging of the inflammatory process can provide great insight into a wide variety of disease states, aiding diagnosis, evaluation and effective targeted treatment. During inflammation, blood borne leukocytes are recruited, through a series of activation and adhesion steps, to
The Exchange Reaction of Hydrogen and Deuterium Oxide.
Crist RH and Dalin GA
J. Chem. Phys. , 2(8), 548-548 (1934)
Sabrina D Lamour et al.
PLoS neglected tropical diseases, 9(10), e0004200-e0004200 (2015-10-28)
Human African trypanosomiasis (HAT) remains a major neglected tropical disease in Sub-Saharan Africa. As clinical symptoms are usually non-specific, new diagnostic and prognostic markers are urgently needed to enhance the number of identified cases and optimise treatment. This is particularly
Ilkka Kajala et al.
PloS one, 10(1), e0116418-e0116418 (2015-01-21)
Wheat bran offers health benefits as a baking ingredient, but is detrimental to bread textural quality. Dextran production by microbial fermentation improves sourdough bread volume and freshness, but extensive acid production during fermentation may negate this effect. Enzymatic production of
Yunbin Xiao et al.
International journal of nanomedicine, 10, 1155-1172 (2015-02-25)
Magnetic resonance imaging (MRI) contrast agents based on chitosan derivatives have great potential for diagnosing diseases. However, stable tumor-targeted MRI contrast agents using micelles prepared from high molecular weight chitosan derivatives are seldom reported. In this study, we developed a
Sebastian Trousil et al.
Cancer research, 74(23), 6867-6877 (2014-10-01)
Metabolic rearrangements subsequent to malignant transformation are not well characterized in endometrial cancer. Identification of altered metabolites could facilitate imaging-guided diagnosis, treatment surveillance, and help to identify new therapeutic options. Here, we used high-resolution magic angle spinning magnetic resonance mass
Widya Mulyasasmita et al.
Journal of controlled release : official journal of the Controlled Release Society, 191, 71-81 (2014-05-23)
To translate recent advances in induced pluripotent stem cell biology to clinical regenerative medicine therapies, new strategies to control the co-delivery of cells and growth factors are needed. Building on our previous work designing Mixing-Induced Two-Component Hydrogels (MITCHs) from engineered
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