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617474

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Sui So et al.
Physical chemistry chemical physics : PCCP, 16(45), 24954-24964 (2014-10-18)
β-Hydroxyperoxyl radicals are formed during atmospheric oxidation of unsaturated volatile organic compounds such as isoprene. They are intermediates in the combustion of alcohols. In these environments the unimolecular isomerization and decomposition of β-hydroxyperoxyl radicals may be of importance, either through
Russell J Chedgy et al.
Phytochemistry, 113, 149-159 (2015-01-07)
Salicinoids are phenolic glycosides (PGs) characteristic of the Salicaceae and are known defenses against insect herbivory. Common examples are salicin, salicortin, tremuloidin, and tremulacin, which accumulate to high concentrations in the leaves and bark of willows and poplars. Although their
Ana Y Mercedes-Camacho et al.
Biochemistry, 52(44), 7707-7713 (2013-10-15)
The Pin1 peptidyl-prolyl isomerase catalyzes isomerization of pSer/pThr-Pro motifs in regulating the cell cycle. Peptide substrates, Ac-Phe-Phe-phosphoSer-Pro-Arg-p-nitroaniline, were synthesized in unlabeled form, and with deuterium-labeled Ser-d3 and Pro-d7 amino acids. Kinetic data were collected as a function of Pin1 concentration
Jose Luis Muñoz-Muñoz et al.
IUBMB life, 65(9), 793-799 (2013-07-31)
A solvent deuterium isotope effect on the inactivation suicide of tyrosinase in its action on o-diphenols (catechol, 4-methylcatechol, and 4-tert-butylcatechol) was observed. This isotope effect, observed during kinetic studies in the transition phase, was higher than that described previously in
Philipp Herwig et al.
Science (New York, N.Y.), 342(6162), 1084-1086 (2013-11-30)
In chemistry and biology, chirality, or handedness, refers to molecules that exist in two spatial configurations that are incongruent mirror images of one another. Almost all biologically active molecules are chiral, and the correct determination of their absolute configuration is
Xianjun Xie et al.
Water environment research : a research publication of the Water Environment Federation, 85(2), 113-123 (2013-03-12)
To better understand the effects of recharge and discharge on the hydrogeochemistry of high levels of arsenic (As) and fluoride (F) in groundwater, environmental isotopic composition (delta2H and delta18O) and chloride (Cl) concentrations were analyzed in 29 groundwater samples collected
Doubly labeled water is a validated and verified reference standard in nutrition research.
Maciej S Buchowski
The Journal of nutrition, 144(5), 573-574 (2014-02-28)
Peter Krumbiegel
Isotopes in environmental and health studies, 47(1), 1-17 (2011-03-11)
Isotope effects are differences in the properties of the isotopes of an element resulting in different reaction rates of a corresponding compound, in equilibrium constants and in the spectra. Shortly after the discovery of stable isotopes of hydrogen, oxygen, and
Jason Lanman et al.
Current opinion in structural biology, 14(2), 181-188 (2004-04-20)
In recent years, advances in mass spectrometry have provided unprecedented knowledge of protein expression within cells. It has become apparent that many proteins function as macromolecular complexes. Structural genomics programs are determining the fold of these proteins at an increasing
Mark E Wood et al.
Organic & biomolecular chemistry, 11(16), 2712-2723 (2013-03-13)
Using C-3 di-deuterated morpholin-2-ones bearing N-2-iodobenzyl and N-3-bromobut-3-enyl radical generating groups, only products derived from the more stabilised C-3, rather than the less stabilised C-5 translocated radicals, were formed after intramolecular 1,5-hydrogen atom transfer, suggesting that any kinetic isotope effect
Sanjaya Singh et al.
mAbs, 7(4), 778-791 (2015-04-24)
Herein, we describe the generation and characterization of BI 655066, a novel, highly potent neutralizing anti-interleukin-23 (IL23) monoclonal antibody in clinical development for autoimmune conditions, including psoriasis and Crohn's disease. IL23 is a key driver of the differentiation, maintenance, and
Justin Jankunas et al.
The Journal of chemical physics, 138(9), 094310-094310 (2013-03-15)
The Photoloc technique has been employed to measure the state-resolved differential cross sections of the HD(v', j(')) product in the reaction H + D2 over a wide range of collision energies and internal states. The experimental results were compared with
Jacob J Kinnun et al.
Biochimica et biophysica acta, 1848(1 Pt B), 246-259 (2014-06-20)
This article reviews the application of solid-state ²H nuclear magnetic resonance (NMR) spectroscopy for investigating the deformation of lipid bilayers at the atomistic level. For liquid-crystalline membranes, the average structure is manifested by the segmental order parameters (SCD) of the
Luh P E K Yuni et al.
Journal of thermal biology, 52, 208-216 (2015-08-13)
The study of energy expenditure between populations of a wide ranging ectothermic species may provide an insight into how organisms respond to variation in environmental conditions. In this study, the energy expenditure of male spotted snow skinks, Niveoscincus ocellatus, living
O V Mosin et al.
Prikladnaia biokhimiia i mikrobiologiia, 49(3), 255-266 (2013-07-26)
A 2H-labeled purine ribonucleoside inosine was microbiologically synthesized (yield, 3.9 g/L of culture liquid) using a deuterium-adapted strain ofthe gram-positive chemoheterotrophic bacterium Bacillus subtilis, cultivated in a heavy water medium with a high degree of deuteration (99.8 at % 2H)
Martin Berggren et al.
Ecology, 95(7), 1947-1959 (2014-08-29)
The importance of terrestrial-derived organic matter for lake zooplankton communities remains debated, partly because little is known about the basic pathways by which allochthonous carbon is transferred to zooplankton, and whether these vary among the major taxonomic and functional groups.
David Pantoja-Uceda et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 234, 190-196 (2013-07-31)
A suite of (13)C-detected NMR pulse sequences to edit the correlation peaks of the CACO and CON spectra according to the amino acid residue type is presented. The pulse sequences exploit the topology of the C(β) carbon and led to
Demidmaa Tuvdendorj et al.
Metabolism: clinical and experimental, 63(12), 1562-1567 (2014-10-14)
The use of stable isotope tracer techniques to measure muscle protein fractional synthesis rate (FSR) has been well established and widely used. The most common method that has been utilized so far is a primed constant infusion (CI) method, which
Jian Cao et al.
The Journal of biological chemistry, 288(3), 1806-1813 (2012-12-05)
The phospholipase A(2) (PLA(2)) superfamily consists of 16 groups and many subgroups and constitutes a diverse set of enzymes that have a common catalytic activity due to convergent evolution. However, different PLA(2) types have unique three-dimensional structures and catalytic residues
Indu Kheterpal et al.
Accounts of chemical research, 39(9), 584-593 (2006-09-20)
The beta-sheet network of the amyloid fibril is a dominant structural feature of this class of protein structures. An attractive way to view the protein misfolding events that lead to the formation of fibrils and other aggregates is to consider
Anthony W Friedline et al.
The journal of physical chemistry. B, 119(44), 14033-14044 (2015-10-06)
Bacterial spores can survive for long periods without nutrients and in harsh environmental conditions. This survival is influenced by the structure of the spore, the presence of protective compounds, and water retention. These compounds, and the physical state of water
José C Rodríguez-Pérez et al.
Physical chemistry chemical physics : PCCP, 15(33), 13940-13950 (2013-07-16)
In this paper we describe a novel combination of Raman spectroscopy, isotope editing and X-ray scattering as a powerful approach to give detailed structural information on aromatic side chains in peptide fibrils. The orientation of the tyrosine residues in fibrils
Rune Gangsøy Kristiansen et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(10), G1024-G1031 (2014-09-27)
Glycine is an important ammoniagenic amino acid, which is increased in acute liver failure (ALF). We have previously shown that L-ornithine phenylacetate (OP) attenuates ammonia rise and intracranial pressure in pigs suffering from ALF but failed to demonstrate a stoichiometric
Eric D Packard et al.
Health physics, 104(6), 633-640 (2013-05-01)
Lawrence Livermore National Laboratory must control potentially activated materials and equipment in accordance with U.S. Department of Energy (DOE) Order 458.1, Radiation Protection of the Public and the Environment, which requires DOE approval of the process used to release volumetrically
Tivadar Orban et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(11), 4579-4588 (2015-07-19)
Age-related macular degeneration (AMD) is a neurodegenerative disease that causes adult-onset blindness. There are 2 forms of this progressive disease: wet and dry. Currently there is no cure for AMD, but several treatment options have started to emerge making early
Nguyen Minh Duc et al.
Journal of the American Society for Mass Spectrometry, 26(5), 808-817 (2015-03-06)
G protein-coupled receptors (GPCRs) have important roles in physiology and pathology, and 40% of drugs currently on the market target GPCRs for the treatment of various diseases. Because of their therapeutic importance, the structural mechanism of GPCR signaling is of
Sandra Brereton
Health physics, 104(6), 544-556 (2013-05-01)
The National Ignition Facility (NIF) at Lawrence Livermore National Laboratory is the world's largest and most energetic laser system for inertial confinement fusion (ICF) and experiments studying high energy density (HED) science. The NIF is a 192-beam, Nd-glass laser facility
Jae-Min Ha et al.
Soft matter, 11(29), 5821-5827 (2015-06-11)
We have investigated the distributions of individually isolated and hydrophilically functionalized single-walled carbon nanotubes (p-SWNTs) in the Pluronic L121-water system at the reverse hexagonal phase using small-angle X-ray scattering (SAXS) and contrast-matched small-angle neutron scattering (SANS) measurements. As the p-SWNT-L121-water
Toshiki Mochizuki et al.
Analytica chimica acta, 773, 76-82 (2013-04-09)
L-Pyroglutamic acid (L-PGA) was evaluated as a chiral labeling reagent for the enantioseparation of chiral amines in terms of separation efficiency by reversed-phase chromatography and detection sensitivity by ESI-MS/MS. Several amines and amino acid methyl esters were used as typical
Heavy drugs draw heavy interest from pharma backers.
Alla Katsnelson
Nature medicine, 19(6), 656-656 (2013-06-08)
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