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Hui Si Audrey Koh et al.
Frontiers in pharmacology, 11, 831-831 (2020-06-26)
Fucoidan refers to a group of sulfated polysaccharide that is commonly obtained from various species of brown seaweed. Fucoidan has gained increased popularity among researchers in the recent years due to its numerous biological activities, including its inhibitory effects against
Sabine Oesterle et al.
BMC biology, 15(1), 100-100 (2017-11-01)
Internal tagging of proteins by inserting small functional peptides into surface accessible permissive sites has proven to be an indispensable tool for basic and applied science. Permissive sites are typically identified by transposon mutagenesis on a case-by-case basis, limiting scalability
Lukas Bammert et al.
Nucleic acids research, 44(20), 9803-9820 (2016-09-08)
Mammalian AATF/Che-1 is essential for embryonic development, however, the underlying molecular mechanism is unclear. By immunoprecipitation of human AATF we discovered that AATF forms a salt-stable protein complex together with neuroguidin (NGDN) and NOL10, and demonstrate that the AATF-NGDN-NOL10 (ANN)
Beeke Wienert et al.
Science (New York, N.Y.), 364(6437), 286-289 (2019-04-20)
CRISPR-Cas genome editing induces targeted DNA damage but can also affect off-target sites. Current off-target discovery methods work using purified DNA or specific cellular models but are incapable of direct detection in vivo. We developed DISCOVER-Seq (discovery of in situ
Yu Yang et al.
International journal of molecular sciences, 21(7) (2020-04-08)
Circadian rhythm is an endogenous, self-sustainable oscillation that participates in regulating organisms' physiological activities. Key to this oscillation is a negative feedback by the main clock components Periods and Cryptochromes that repress the transcriptional activity of BMAL1/CLOCK (defined in the
Jae Kyoo Lee et al.
Quarterly reviews of biophysics, 48(4), 437-444 (2015-11-06)
Using high-resolution mass spectrometry, we have studied the synthesis of isoquinoline in a charged electrospray droplet and the complexation between cytochrome c and maltose in a fused droplet to investigate the feasibility of droplets to drive reactions (both covalent and
Laura I de Eugenio et al.
Biotechnology for biofuels, 10, 161-161 (2017-06-27)
Genomic and proteomic analysis are potent tools for metabolic characterization of microorganisms. Although cellulose usually triggers cellulase production in cellulolytic fungi, the secretion of the different enzymes involved in polymer conversion is subjected to different factors, depending on growth conditions.
Xue Zhao et al.
Carbohydrate polymers, 255, 117503-117503 (2021-01-14)
To determine the internal structure of barley starch without amylopectin isolation, whole starch was hydrolyzed using β-amylase to remove the linear amylose and obtain β-limit dextrins (β-LDs). The β-LDs were treated with extensive α-amylase to prepare α-limit dextrins (α-LDs), and
Shixuan Liu et al.
Science (New York, N.Y.), 371(6524) (2020-11-07)
Vitamin K antagonists are widely used anticoagulants that target vitamin K epoxide reductases (VKOR), a family of integral membrane enzymes. To elucidate their catalytic cycle and inhibitory mechanism, we report 11 x-ray crystal structures of human VKOR and pufferfish VKOR-like
Soheyla Karimi et al.
International journal of biological macromolecules, 156, 648-659 (2020-04-15)
In the present study, a novel magnetic carbon modified with 3-aminopropyltrimethoxysilane (APTMS) using maltose disaccharide molecule as a green capping agent, and a third-generation triazine dendrimer (Fe3O4@C@TD-G3) was then covalently attached to their surface. Eventually, Fe3O4@C@TD-G3 was reacted with graphene
Fabian Bumbak et al.
Biochimica et biophysica acta, 1860(6), 1372-1383 (2018-03-30)
Neurotensin is a 13-residue peptide that acts as a neuromodulator of classical neurotransmitters such as dopamine and glutamate in the mammalian central nervous system, mainly by activating the G protein-coupled receptor (GPCR), neurotensin receptor 1 (NTS1). Agonist binding to GPCRs
Viktor Stein et al.
ACS synthetic biology, 6(7), 1337-1342 (2017-03-16)
The rational construction of synthetic protein switches with predefined input-output parameters constitutes a key goal of synthetic biology with many potential applications ranging from metabolic engineering to diagnostics. Yet, generally applicable strategies to construct tailor-engineered protein switches have so far
Nancy Weiland-Bräuer et al.
Scientific reports, 9(1), 34-34 (2019-01-12)
Multicellular organisms can be regarded as metaorganisms, comprising of a macroscopic host interacting with associated microorganisms. Within this alliance, the host has to ensure attracting beneficial bacteria and defending against pathogens to establish and maintain a healthy homeostasis. Here, we
Kaori Ando et al.
Plant disease, 103(6), 1068-1074 (2019-05-08)
Dasypyrum villosum is a wild relative of common wheat (Triticum aestivum L.) with resistance to Puccinia graminis f. tritici, the causal agent of stem rust, including the highly virulent race TTKSK (Ug99). In order to transfer resistance, T. durum-D. villosum
Małgorzata Korycka-Machała et al.
Cells, 9(3) (2020-03-07)
We have recently found that selected thio-disaccharides possess bactericidal effects against Mycobacterium tuberculosis but not against Escherichia coli or Staphylococcus aureus. Here, we selected spontaneous mutants displaying resistance against the investigated thio-glycoside. According to next-generation sequencing, four of six analyzed
Sercan Ozbek Yazici et al.
Journal of food science and technology, 58(2), 739-751 (2021-02-12)
The aim of study was to optimize fermentation parameters for inulinase production from Rhizopus oryzae by a statistical approach and to carry out purification of inulinase. Five isolated fungal strains were screen out inulin degradation by using Lugol's iodine solution.
Wei Liu et al.
ChemSusChem, 11(13), 2229-2238 (2018-06-20)
The utilization of biomass sugars has received great interesting recently. Herein, we present a highly efficient hybrid solar biomass fuel cell that utilizes thermal- and photocatalysis of solar irradiation and converts biomass sugars into electricity with high power output. The
Rajni Kamboj et al.
Journal of food science and technology, 57(8), 2985-2993 (2020-07-03)
The aim of the study was to quantify sugar profile and rheological behaviour of four Indian honey varieties (Cotton, Coriander, Dalbergia, and Murraya). The effect of temperature (5, 10, 20 and 30 °C) on rheological behaviour of these honey varieties was
Hugo B Cardoso et al.
Food chemistry, 276, 652-661 (2018-11-10)
The aggregation of α-lactalbumin, β-lactoglobulin and β-casein after heating in dry state was studied in absence and presence of saccharides. In absence of saccharides, differences were observed in the extent of aggregation. Differences between the proteins were mostly due to
Begüm D Topçuoğlu et al.
Applied and environmental microbiology, 85(9) (2019-03-03)
Hyperthermophilic methanogens are often H2 limited in hot subseafloor environments, and their survival may be due in part to physiological adaptations to low H2 conditions and interspecies H2 transfer. The hyperthermophilic methanogen Methanocaldococcus jannaschii was grown in monoculture at high
Francisca Nayara Dantas Duarte et al.
Journal of the science of food and agriculture, 97(11), 3712-3719 (2017-01-24)
The prebiotic effects of a cashew apple (Anacardium occidentale L.) agro-industrial byproduct powder (CAP) on different potentially probiotic Lactobacillus strains, namely Lactobacillus acidophilus LA-05, Lactobacillus casei L-26 and Lactobacillus paracasei L-10, were assessed using in vitro experimental models. Accordingly, the
Chenguang Wang et al.
Immunity, 48(4), 675-687 (2018-04-15)
Manganese (Mn) is essential for many physiological processes, but its functions in innate immunity remain undefined. Here, we found that Mn2+ was required for the host defense against DNA viruses by increasing the sensitivity of the DNA sensor cGAS and
D S Liyanage et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 232, 31-41 (2019-02-24)
Endoplasmic reticulum resident protein 44 (ERp44) is a protein disulfide isomerase (PDI) and a member of thioredoxin family, which is involved in several functions such as oxidative folding and polymerization of molecules, carrier protein activity, regulation of the Ca2+ ion
Jiyeon Ko et al.
Fish & shellfish immunology, 58, 622-630 (2016-10-23)
Lysozymes are a family of enzymes that catalyze the hydrolysis of bacterial cell wall, acting as antimicrobial effectors of the innate immune system. In the present study, an ortholog of goose-type lysozyme (ShLysG) from the big-belly seahorse (Hippocampus abdominalis) was
Bin Luo et al.
Current medical science, 40(4), 719-728 (2020-08-31)
Cancer testis (CT) antigens have received particular attention in cancer immunotherapy. OY-TES-1 is a member of CT antigens. This study was to evaluate OY-TES-1 expression and immunogenicity in hepatocelluar carcinoma (HCC). OY-TES-1 mRNA expression was detected in 56 HCC tissues
Yasuyuki Miyake et al.
Nature microbiology, 4(4), 578-586 (2019-01-30)
Influenza A virus is a pathogen of great medical impact. To develop novel antiviral strategies, it is essential to understand the molecular aspects of virus-host cell interactions in detail. During entry, the viral ribonucleoproteins (vRNPs) that carry the RNA genome
Adarsh K Gupta et al.
Viruses, 11(5) (2019-05-30)
Wheat streak mosaic virus (WSMV; genus Tritimovirus; family Potyviridae) is an economically important virus infecting wheat in the Great Plains region of the USA. Previously, we reported that the P1 protein of WSMV acts as a viral suppressor of RNA
Tomoko Kohda et al.
Microbiology and immunology, 61(11), 482-489 (2017-09-13)
Clostridium botulinum produces the highly potent neurotoxin, botulinum neurotoxin (BoNT), which is classified into seven serotypes (A-G); the subtype classification is confirmed by the diversity of amino acid sequences among the serotypes. BoNT from the Osaka05 strain is associated with
Chularat Sakdaronnarong et al.
Biotechnology and applied biochemistry, 67(1), 105-116 (2019-09-17)
In very high gravity (VHG) ethanol fermentation, the rheological properties of native cassava significantly influence heat and mass transfer, mixing energy, and, thus, the yield of all steps. This study investigated the effect of cassava varieties and their harvest times
Meghan E Ramsey et al.
Journal of bacteriology, 196(16), 2954-2968 (2014-06-11)
Neisseria gonorrhoeae uses a type IV secretion system (T4SS) to secrete chromosomal DNA into the medium, and this DNA is effective in transforming other gonococci via natural transformation. In addition, the T4SS is important in the initial stages of biofilm
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