Showing 1-30 of 2984 results for "646563"
Li-Jun Guan et al.
Scientific reports, 5, 10753-10753 (2015-06-02)
(R)-stereospecific amine transaminases (R-ATAs) are important biocatalysts for the production of (R)-amine compounds in a strict stereospecific manner. An improved R-ATA, ATA-117-Rd11, was successfully engineered for the manufacture of sitagliptin, a widely used therapeutic agent for type-2 diabetes. The effects...
Masaru Kurosawa et al.
Human molecular genetics, 24(4), 1092-1105 (2014-10-12)
Huntington's disease (HD) is a dominantly inherited genetic disease caused by mutant huntingtin (htt) protein with expanded polyglutamine (polyQ) tracts. A neuropathological hallmark of HD is the presence of neuronal inclusions of mutant htt. p62 is an important regulatory protein...
Gilbert Eriani et al.
PloS one, 10(6), e0130042-e0130042 (2015-06-13)
Aminoacyl-tRNA synthetases (AARSs) constitute a family of RNA-binding proteins, that participate in the translation of the genetic code, by covalently linking amino acids to appropriate tRNAs. Due to their fundamental importance for cell life, AARSs are likely to be one...
Jennifer A-L M Pirotte et al.
The Journal of experimental biology, 221(Pt 20) (2018-09-13)
Winged aphids are described as hosts of lesser quality for parasitoids because a part of their resources is used to produce wings and associated muscles during their development. Host lipid content is particularly important for parasitoid larvae as they lack...
Aya Muramatsu et al.
Biochemical and biophysical research communications, 463(4), 999-1005 (2015-06-15)
Girdin is an actin-binding protein that has multiple functions in postnatal neural development and cancer progression. We previously showed that Girdin is a regulator of migration for neuroblasts born from neural stem cells in the subventricular zone (SVZ) and the...
Kyung-Hwa Baek et al.
Scientific reports, 5, 17642-17642 (2015-12-04)
The ATPase activities of Hsp70 and Hsc70 are known to be responsible for regulation of various biological processes. However, little is known about the roles of Hsp70 and Hsc70 in modulation of immune responses to antigens. In the present study...
Wen-Chiao Chan et al.
Environmental toxicology and pharmacology, 39(2), 622-627 (2015-02-16)
Complex transcriptional profile of glutathione S-transferase Delta cluster genes occurred in the developmental process of the fruit fly Drosophila melanogaster. The purpose of this project was to quantify the expression levels of Gst Delta class genes altered by aniline exposure...
Masaki Hiramoto et al.
International journal of molecular medicine, 36(1), 222-230 (2015-05-09)
Although recent genome-wide association studies (GWAS) have been extremely successful, it remains a big challenge to functionally annotate disease‑associated single nucleotide polymorphisms (SNPs), as the majority of these SNPs are located in non‑coding regions of the genome. In this study...
Rupendra Mukerjea et al.
Carbohydrate research, 367, 25-28 (2013-01-09)
We have recently found that the dilution of purified potato Starch-Synthases (SS) and Starch-Branching-Enzymes (SBEs), by a glycine buffer (pH 8.5), containing 1.0mM dithiothreitol (DTT) and 0.04% (w/v) polyvinyl alcohol (PVA) 50K, produced a striking and significant increase in activity...
Antonio J López-Farré et al.
British journal of clinical pharmacology, 78(6), 1366-1377 (2014-07-22)
Further to its pivotal role in haemostasis, factor Xa (FXa) promotes effects on the vascular wall. The purpose of the study was to evaluate if FXa modifies the expression level of energy metabolism and oxidative stress-related proteins in femoral arteries...
Yi-Shuai Zhang et al.
Free radical biology & medicine, 83, 115-128 (2015-02-24)
Nuclear myosin regulates gene transcription and this novel function might be modulated through phosphorylation of the myosin regulatory light chain (p-MLC20). Nonmuscle MLC20 (nmMLC20) is also present in the nuclei of cardiomyocytes and a potential nmMLC20 binding sequence has been...
Mariaconcetta Sicurella et al.
PloS one, 9(7), e100844-e100844 (2014-07-18)
Herpes simplex virus types 1 and 2 (HSV1 and HSV2) are common infectious agents in both industrialized and developing countries. They cause recurrent asymptomatic and/or symptomatic infections, and life-threatening diseases and death in newborns and immunocompromised patients. Current treatment for...
Katharine G Harris et al.
PloS one, 10(10), e0141383-e0141383 (2015-10-29)
Unc93b is an endoplasmic reticulum (ER)-resident transmembrane protein that serves to bind and traffic toll-like receptors (TLRs) from the ER to their appropriate subcellular locations for ligand sensing. Because of its role in TLR trafficking, Unc93b is necessary for an...
Calista K L Ng et al.
Human molecular genetics, 24(11), 3163-3171 (2015-02-26)
mRNA decay is an essential and active process that allows cells to continuously adapt gene expression to internal and environmental cues. There are two mRNA degradation pathways: 3' to 5' and 5' to 3'. The DCPS protein is the scavenger...
Shuichi Mori et al.
Bioorganic & medicinal chemistry, 23(4), 803-809 (2015-01-17)
Nonsteroidal progesterone receptor (PR) full antagonists are needed as tools for elucidating the physiological functions of PR and as candidates for treatment of various diseases. We designed and synthesized 1,3-diphenyladamantane derivatives, and investigated their PR-antagonistic activity in comparison with our...
Fei Ye et al.
PloS one, 10(11), e0142082-e0142082 (2015-11-07)
Chronic hepatitis C virus (HCV) infection is one of the leading causes of severe hepatitis. The molecular mechanisms underlying HCV replication and pathogenesis remain unclear. The development of the subgenome replicon model system significantly enhanced study of HCV. However, the...
Ayten Hijazi et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(12), 4968-4977 (2015-08-19)
Developmental exposure to bisphenol A (BPA) is associated with lung dysfunction and diseases. However, it is unknown if this association has a fetal origin. The present study addressed this important question by examining the effects of BPA on fetal lung...
Yuan-yuan Ma et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 63(7), 527-537 (2014-03-08)
Mast cell (MC) degranulation can break peripheral immune tolerance. However, its mechanism remains unclear. Our goal was to study the stabilization of MC membranes by heme oxygenase-1 (HO-1) in order to influence dendritic cell (DC) function. Mast cells and dendritic...
Martin Pattky et al.
Analytical and bioanalytical chemistry, 407(22), 6637-6655 (2015-07-01)
In this study, we characterized unexpected side-products in a commercially synthesized peptide with the sequence RPRTRLHTHRNR. This so-called peptide D3 was selected by mirror phage display against low molecular weight amyloid-β-peptide (Aβ) associated with Alzheimer's disease. Capillary electrophoresis (CE) was...
Hui-Chen Wang et al.
PloS one, 10(5), e0125903-e0125903 (2015-05-02)
Previously, we demonstrated that progesterone (P4) at physiologic levels (5-500 nM) inhibited proliferation in cultured rat aortic smooth muscle cells (RASMCs) through a P4 receptor (PR)-dependent pathway. We also showed that P4-induced cell cycle arrest in RASMCs occurs when the...
Jixun Luo et al.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 128(7), 1407-1419 (2015-04-22)
The distribution of starch synthase I and starch branching enzyme IIb between the starch granule and amyloplast stroma plays an important role in determining endosperm amylose content of cereal grains. Starch synthase IIa (SSIIa) catalyses the polymerisation of intermediate length...
Wei-Na Gao et al.
Scientific reports, 5, 12844-12844 (2015-08-08)
The rat is an important alternative for studying human pathology owing to certain similarities to humans. Glycomic studies on rat serum have revealed that variations in the N-glycans of glycoproteins correlated with disease progression, which is consistent with the findings...
Nida Zaidi et al.
The journal of physical chemistry. B, 118(46), 13025-13036 (2014-10-23)
Sodium dodecyl sulfate (SDS)-glycoprotein interaction serves as a model for a biological membrane. To get mechanistic insight into the interaction of SDS and glycoprotein, the effect of SDS on bovine serum fetuin (BSF) was studied in subcritical micellar concentrations at...
Joaquín Fernández-Irigoyen et al.
Journal of proteomics, 127(Pt B), 395-405 (2015-04-08)
Deep brain stimulation (DBS) is a neurosurgical procedure that provides therapeutic benefits for movement and affective disorders. The nucleus basalis of Meynert (NBM) and substantia nigra (SN) are considered target areas to apply DBS. Even though the degeneration of NBM...
Harin Jung et al.
Plant science : an international journal of experimental plant biology, 236, 304-312 (2015-05-31)
Auxin signaling is a fundamental part of many plant growth processes and stress responses and operates through Aux/IAA protein degradation and the transmission of the signal via auxin response factors (ARFs). A total of 31 Aux/IAA genes have been identified...
Alexandra C N Kingston et al.
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 201(12), 1137-1145 (2015-10-09)
Crayfish have two classes of photoreceptors in the retinas of their reflecting superposition eyes. Long-wavelength-sensitive photoreceptors, comprised of microvilli from R1-7 cells, make up the main rhabdoms. Eighth retinular cells, located distal to the main rhabdoms, house short-wavelength-sensitive photoreceptors. While...
Xin Zheng et al.
Journal of virology, 89(9), 4786-4797 (2015-01-30)
Angiopoietin-1 (ANGPT-1) is a secreted glycoprotein that was first characterized as a ligand of the Tie2 receptor. In a previous study using microarray analysis, we found that the expression of ANGPT-1 was upregulated in Kaposi's sarcoma-associated herpesvirus (KSHV)-infected primary effusion...
Peng Zhao et al.
Methods in molecular biology (Clifton, N.J.), 951, 229-244 (2013-01-09)
As a complex post-translational event, the biosynthesis, structures, and functions of O-linked glycans have attracted research interests in various aspects. The recent development of novel technologies for the analysis of glycans and glycoproteins sheds new insights with regard to determining...
Takahiko Toyonaga et al.
PloS one, 10(8), e0135552-e0135552 (2015-08-15)
Osteopontin (OPN) is a multifunctional protein expressed in a variety of tissues and cells. Recent studies revealed increased OPN expression in the inflamed intestinal tissues of patients with inflammatory bowel disease (IBD). The role of OPN in the pathophysiology of...
Alain Sané et al.
Journal of cellular biochemistry, 116(10), 2270-2282 (2015-04-01)
Sar1B GTPase is a key component of Coat protein complex II (COPII)-coated vesicles that bud from the endoplasmic reticulum to export newly synthesized proteins. The aims of this study were to determine whether Sar1B responds to lipid regulation and to...

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